Areas of Focus
- Development of new drug formulations
- Research on injectable lipid carrier formulations
- Traditional Chinese medicine formulations
Work Experience
- 2023-06~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Group Leader
- 2016-10~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher
- 2016-10~2017-10 - University of California, San Diego - Visiting Scholar
- 2011-11~2016-10 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher
- 2010-08~2011-10 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher
- 2008-07~2010-07 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Postdoctoral Researcher
Academic Background & Achievements
- 2004-09--2008-06 PhD: Shenyang Pharmaceutical University
- 2000-09--2004-06 Bachelor's: Shenyang Pharmaceutical University
Publications
- CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity, 6th Author, 2022
- Tumour-derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour-homing and intracellular freeway transportation, 9th Author, Corresponding Author, 2022
- Cell Membrane-Camouflaged Nanocarriers with Biomimetic Deformability of Erythrocytes for Ultralong Circulation and Enhanced Cancer Therapy, 9th Author, Corresponding Author, 2022
- Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy, 11th Author, Corresponding Author, 2022
- Preparation of Mesenchymal Stem Cell Exosome-thermosensitive Hydrogel and Its Application in Epidermal Wound Repair, 3rd Author, 2021
- Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel, 7th Author, Corresponding Author, 2021
- Effect of phosphatidylcholine on the stability and lipolysis of nanoemulsion drug delivery systems, 6th Author, Corresponding Author, 2020
- MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy, 10th Author, 2020
- Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells (vol 38, pg 290, 2020), 2nd Author, Corresponding Author, 2020
- Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy, 14th Author, 2020
- Stepwise targeting and responsive lipid-coated nanoparticles for enhanced tumor cell sensitivity and hepatocellular carcinoma therapy, 6th Author, Corresponding Author, 2020
- NPC1L1-Targeted Cholesterol-Grafted Poly(beta-Amino Ester)/pDNA Complexes for Oral Gene Delivery, 7th Author, 2019
- Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery, 12th Author, 2019
- 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro, 3rd Author, 2019
- Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation, 8th Author, Corresponding Author, 2018
- Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers, 11th Author, 2018
- Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA, 2nd Author, 2018
- Liquid crystalline nanoparticles for siRNA delivery, 7th Author, 2017
- Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma, 2nd Author, Corresponding Author, 2017
- Delivery of acetylthevetin B,an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells, 2nd Author, Corresponding Author, 2017
- Remote Loading of Small-Molecule Therapeutics into Cholesterol-Enriched Cell-Membrane-Derived Vesicles, 1st Author, 2017
- Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site, 7th Author, 2017
- Synthesis of glucuronic acid derivatives via the efficient and selective removal of a C6 methyl group, 3rd Author, 2017
- Thermosensitive Liposomal Codelivery of HSA-Paclitaxel and HSA-Ellagic Acid Complexes for Enhanced Drug Perfusion and Efficacy Against Pancreatic Cancer, 6th Author, 2017
- Spray-dried powders enhance vaginal siRNA delivery by potentially modulating the mucus molecular sieve structure, 2nd Author, 2015
- Smart lipid capped mesoporous silica nanoparticles with tumor extracellular pH activated charge-conversion property for deep hepatocellular carcinoma penetration, 1st Author, 2015
- Targeting exosomal miRNA with pH-sensitive liposome coated chitosan-siRNA nanoparticles for inhibition of hepatocellular carcinoma metastasis, 2nd Author, 2015
- Biodegradable mesoporous calcium-magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering, 1st Author, 2015
- Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid, 5th Author, 2015
- Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity, 2nd Author, 2015
- Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor, 4th Author, Corresponding Author, 2014
- Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells, 1st Author, 2014
- Role of phospholipids and copolymers in enhancing stability and controlling degradation of intravenous lipid emulsions, 2nd Author, 2013
- Novel pH-Sensitive Lipid-Polymer Composite Microspheres of 10-Hydroxycamptothecin Exhibiting Colon-Specific Biodistribution and Reduced Systemic Absorption, 4th Author, 2013
- Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells, 1st Author, 2012
- 基于转运蛋白BCRP的PEO-PPO-PEO胶束制备及其降低伊立替康消化道毒性的研究, 1st Author, 2012
- 伊立替康PEO-PPO-PEO胶束的制备和表征及其降低药物消化道毒性的机制研究, 1st Author, 2012
- Novel NSAIDs ophthalmic formulation: Flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect, 4th Author, 2011
- Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique, 3rd Author, 2011
- An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione, 5th Author, 2011
- Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test, 3rd Author, Corresponding Author, 2011
- Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability, 6th Author, 2010
- Absorption enhancement of adefovir dipivoxil by incorporating MCT and ethyl oleate complex oil phase in emulsion, 3rd Author, 2010
- Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailability, 5th Author, 2010
- Effect of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) micelles on pharmacokinetics and intestinal toxicity of irinotecan hydrochloride: potential involvement of breast cancer resistance protein (ABCG2), 2nd Author, 2010
Awards
- Mingzhu Elite Talent (2023): City Level
- Youth Innovation Promotion Association of CAS (2015): Institute Level
- Young Pharmaceutical Scientist Award (2015): Other
- Sanofi-Youth Talent Award of Shanghai Institute of Life Sciences, CAS (2014): Institute Level
