Professor | Xin Xie | Asia Growth Partners

Name	Xin Xie
Contact Information	xxie@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Xin Xie

Contact Information

xxie@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	Graduate Degree: Doctorate

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

Graduate Degree: Doctorate

Areas of Focus	Receptor Pharmacology
Publications	Cryo-EM structures of orphan GPR21 signaling complexes, Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu, 2023 Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation, Mengmeng Jiang, Ren Guo, Yan Ai, Gang Wang, Peilan Tang, Xiaohui Jia, Bingqing He, Qianting Yuan, Xin Xie, 2023 Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation, Guo, Ren, Jia, Xiaohui, Ding, Zhenbin, Wang, Gang, Jiang, Mengmeng, Li, Bing, Chen, Shanshan, Xia, Bingqing, Zhang, Qing, Liu, Jian, Zheng, Ruting, Gao, Zhaobing, Xie, Xin, 2022 GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages, Zhang, Qing, Chen, Linhai, Yang, Hui, Fang, Youchen, Wang, Siwei, Wang, Min, Yuan, Qianting, Wu, Wei, Zhang, Yangming, Liu, Zhanju, Nan, Fajun, Xie, Xin, 2022 IL6 supports long-term expansion of hepatocytes in vitro, Guo, Ren, Jiang, Mengmeng, Wang, Gang, Li, Bing, Jia, Xiaohui, Ai, Yan, Chen, Shanshan, Tang, Peilan, Liu, Aijie, Yuan, Qianting, Xie, Xin, 2022 Recent progress in assays for GPCR drug discovery, Guo, Shimeng, Zhao, Tingting, Yun, Ying, Xie, Xin, 2022 Molecular recognition of morphine and fentanyl by the human μ-opioid receptor, Youwen Zhuang, Yue Wang, Bingqing He, Xinheng He, X Edward Zhou, Shimeng Guo, Qidi Rao, Jiaqi Yang, Jinyu Liu, Qingtong Zhou, Xiaoxi Wang, Mingliang Liu, Weiyi Liu, Xiangrui Jiang, Dehua Yang, Hualiang Jiang, Jingshan Shen, Karsten Melcher, Hong Chen, Yi Jiang, Xi Cheng, MingWei Wang, Xin Xie, H Eric Xu, 2022 Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors, Duan, Jia, Shen, DanDan, Zhao, Tingting, Guo, Shimeng, He, Xinheng, Yin, Wanchao, Xu, Peiyu, Ji, Yujie, Chen, LiNan, Liu, Jinyu, Zhang, Huibing, Liu, Qiufeng, Shi, Yi, Cheng, Xi, Jiang, Hualiang, Xu, H Eric, Zhang, Yan, Xie, Xin, Jiang, Yi, 2022 Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119, Xu, Peiyu, Huang, Sijie, Guo, Shimeng, Yun, Ying, Cheng, Xi, He, Xinheng, Cai, Pengjun, Lan, Yuan, Zhou, Hu, Jiang, Hualiang, Jiang, Yi, Xie, Xin, Xu, H Eric, 2022 Structures of adenosine receptor A(2B)R bound to endogenous and synthetic agonists, Cai, Hongmin, Xu, Youwei, Guo, Shimeng, He, Xinheng, Sun, Jun, Li, Xin, Li, Changyao, Yin, Wanchao, Cheng, Xi, Jiang, Hualiang, Xu, H Eric, Xie, Xin, Jiang, Yi, 2022 The Aurora Kinase Inhibitor CYC116 Promotes the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells, Ji, Sijia, Tu, Wanzhi, Huang, Chenwen, Chen, Ziyang, Ren, Xinyue, He, Bingqing, Ding, Xiaoyan, Chen, Yuelei, Xie, Xin, 2022 The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination, Suo, Na, He, Bingqing, Cui, Shihao, Yang, Ying, Wang, Min, Yuan, Qianting, Xie, Xin, 2022 Spermine alleviates experimental autoimmune encephalomyelitis via regulating T cell activation and differentiation, Zheng, Ruting, Kong, Miaomiao, Wang, Siwei, He, Bingqing, Xie, Xin, 2022 Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis, Chen, LinHai, Zhang, Qing, Xiao, YuFeng, Fang, YouChen, Xie, Xin, Nan, FaJun, 2022 Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media, Zeng, Peng, Hua, Qiuhong, Gong, Junyuan, Shi, Changjie, Pi, Xiaoping, Xie, Xin, Zhang, Ru, 2021 GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes, Wang, Congcong, Zhang, YuFang, Guo, Shimeng, Zhao, Quan, Zeng, Yanping, Xie, Zhicheng, Xie, Xin, Lu, Boxun, Hu, Youhong, 2021 Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor, Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xinheng He, Jia Guo, Wanchao Yin, H Eric Xu, Xin Xie, Yi Jiang, 2021 Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2, Che, Jinxin, Wang, Zhilong, Shen, Zheyuan, Zhuang, Weihao, Ying, Huazhou, Hu, Yongzhou, Hu, Youhong, Xie, Xin, Dong, Xiaowu, 2021 Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice, Yun, Ying, Zhang, Chenlu, Guo, Shimeng, Liang, Xiaoying, Lan, Yuan, Wang, Min, Zhuo, Ning, Yin, Jianpeng, Liu, Huanan, Gu, Min, Li, Jing, Xie, Xin, Nan, Fajun, 2021 The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity, Martensson, Jonas, Sundqvist, Martina, Manandhar, Asmita, Leremias, Loukas, Zhang, Linjie, Ulven, Trond, Xie, Xin, Bjorkman, Lena, Forsman, Huamei, 2021 Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52, Ma, Mengna, Guo, Shimeng, Lin, Xi, Li, Shanshan, Wu, Yiran, Zeng, Yanping, Hu, Youhong, Zhao, Suwen, Xu, Fei, Xie, Xin, Shui, Wenqing, 2020 Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists, Chen, LinHai, Zhang, Qing, Xie, Xin, Nan, FaJun, 2020 Structural basis of GPBAR activation and bile acid recognition, Yang, Fan, Mao, Chunyou, Guo, Lulu, Lin, Jingyu, Ming, Qianqian, Xiao, Peng, Wu, Xiang, Shen, Qingya, Guo, Shimeng, Shen, DanDan, Lu, Ruirui, Zhang, Linqi, Huang, Shenming, Ping, Yuqi, Zhang, Chenlu, Ma, Cheng, Zhang, Kai, Liang, Xiaoying, Shen, Yuemao, Nan, Fajun, Yi, Fan, Luca, Vincent C, Zhou, Jiuyao, Jiang, Changtao, Sun, JinPeng, Xie, Xin, Yu, Xiao, Zhang, Yan, 2020 Structural basis of ligand recognition and self-activation of orphan GPR52, Lin, Xi, Li, Mingyue, Wang, Niandong, Wu, Yiran, Luo, Zhipu, Guo, Shimeng, Han, GyeWon, Li, Shaobai, Yue, Yang, Wei, Xiaohu, Xie, Xin, Chen, Yong, Zhao, Suwen, Wu, Jian, Lei, Ming, Xu, Fei, 2020 Targeting beta 2 subunit of Na+/K+-ATPase induces glioblastoma cell apoptosis through elevation of intracellular Ca2+, Li, Shirong, Dai, Zhi, Yang, Dong, Li, Wenxuan, Dai, Hongjuan, Sun, Bin, Liu, Xiuyun, Xie, Xin, Xu, Rong, Zhao, Xudong, 2019 RepSox, a small molecule inhibitor of the TGF beta receptor, induces brown adipogenesis and browning of white adipocytes, Tu, Wanzhi, Fu, Yanbin, Xie, Xin, 2019 Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases, Suo, Na, Guo, Yue, He, Bingqing, Gu, Haifeng, Xie, Xin, 2019 Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination, Cui Xue, Guo Yue, Fang Jiahui, Shi Changjie, Suo Na, Zhang Ru, Xie Xin, 2019 Deficiency of beta-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases, Cai, Yingying, Yang, Cuixia, Yu, Xiaohan, Qian, Jie, Dai, Min, Wang, Yan, Qin, Chaoyan, Lai, Weiming, Chen, Shuai, Wang, Tingting, Zhou, Jinfeng, Ma, Ningjia, Zhang, Yue, Zhang, Ru, Shen, Nan, Xie, Xin, Du, Changsheng, 2019 Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor, Tang Wei, Guo Ren, Shen Shijun, Zheng Yang, Lu Yuting, Jiang Mengmeng, Cui Xue, Jiang Cizhong, Xie Xin, 2019 Bifunctional Chimera That Coordinately Targets Human Immunodeficiency Virus 1 Envelope gp120 and the Host-Cell CCR5 Coreceptor at the Virus-Cell Interface, Rashad, Adel A, Song, LiRui, Holmes, Andrew P, Acharya, Kriti, Zhang, Shiyu, Wang, ZhiLong, Gary, Ebony, Xie, Xin, Pirrone, Vanessa, Kutzler, Michele A, Long, YaQiu, Chaiken, Irwin, 2018 Vitamin C promotes oligodendrocytes generation and remyelination, Guo, Yue, Suo, Na, Cui, Xue, Yuan, Qianting, Xie, Xin, 2018 Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice, Fang YouChen, Zheng Yang, Zheng Qing, Li Jing, Xie Xin, 2018 Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining, Zhang, Minjie, Wang, Liu, An, Ke, Cai, Jun

Areas of Focus

Receptor Pharmacology

Publications

Cryo-EM structures of orphan GPR21 signaling complexes, Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu, 2023
Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation, Mengmeng Jiang, Ren Guo, Yan Ai, Gang Wang, Peilan Tang, Xiaohui Jia, Bingqing He, Qianting Yuan, Xin Xie, 2023
Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation, Guo, Ren, Jia, Xiaohui, Ding, Zhenbin, Wang, Gang, Jiang, Mengmeng, Li, Bing, Chen, Shanshan, Xia, Bingqing, Zhang, Qing, Liu, Jian, Zheng, Ruting, Gao, Zhaobing, Xie, Xin, 2022
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages, Zhang, Qing, Chen, Linhai, Yang, Hui, Fang, Youchen, Wang, Siwei, Wang, Min, Yuan, Qianting, Wu, Wei, Zhang, Yangming, Liu, Zhanju, Nan, Fajun, Xie, Xin, 2022
IL6 supports long-term expansion of hepatocytes in vitro, Guo, Ren, Jiang, Mengmeng, Wang, Gang, Li, Bing, Jia, Xiaohui, Ai, Yan, Chen, Shanshan, Tang, Peilan, Liu, Aijie, Yuan, Qianting, Xie, Xin, 2022
Recent progress in assays for GPCR drug discovery, Guo, Shimeng, Zhao, Tingting, Yun, Ying, Xie, Xin, 2022
Molecular recognition of morphine and fentanyl by the human μ-opioid receptor, Youwen Zhuang, Yue Wang, Bingqing He, Xinheng He, X Edward Zhou, Shimeng Guo, Qidi Rao, Jiaqi Yang, Jinyu Liu, Qingtong Zhou, Xiaoxi Wang, Mingliang Liu, Weiyi Liu, Xiangrui Jiang, Dehua Yang, Hualiang Jiang, Jingshan Shen, Karsten Melcher, Hong Chen, Yi Jiang, Xi Cheng, MingWei Wang, Xin Xie, H Eric Xu, 2022
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors, Duan, Jia, Shen, DanDan, Zhao, Tingting, Guo, Shimeng, He, Xinheng, Yin, Wanchao, Xu, Peiyu, Ji, Yujie, Chen, LiNan, Liu, Jinyu, Zhang, Huibing, Liu, Qiufeng, Shi, Yi, Cheng, Xi, Jiang, Hualiang, Xu, H Eric, Zhang, Yan, Xie, Xin, Jiang, Yi, 2022
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119, Xu, Peiyu, Huang, Sijie, Guo, Shimeng, Yun, Ying, Cheng, Xi, He, Xinheng, Cai, Pengjun, Lan, Yuan, Zhou, Hu, Jiang, Hualiang, Jiang, Yi, Xie, Xin, Xu, H Eric, 2022
Structures of adenosine receptor A(2B)R bound to endogenous and synthetic agonists, Cai, Hongmin, Xu, Youwei, Guo, Shimeng, He, Xinheng, Sun, Jun, Li, Xin, Li, Changyao, Yin, Wanchao, Cheng, Xi, Jiang, Hualiang, Xu, H Eric, Xie, Xin, Jiang, Yi, 2022
The Aurora Kinase Inhibitor CYC116 Promotes the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells, Ji, Sijia, Tu, Wanzhi, Huang, Chenwen, Chen, Ziyang, Ren, Xinyue, He, Bingqing, Ding, Xiaoyan, Chen, Yuelei, Xie, Xin, 2022
The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination, Suo, Na, He, Bingqing, Cui, Shihao, Yang, Ying, Wang, Min, Yuan, Qianting, Xie, Xin, 2022
Spermine alleviates experimental autoimmune encephalomyelitis via regulating T cell activation and differentiation, Zheng, Ruting, Kong, Miaomiao, Wang, Siwei, He, Bingqing, Xie, Xin, 2022
Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis, Chen, LinHai, Zhang, Qing, Xiao, YuFeng, Fang, YouChen, Xie, Xin, Nan, FaJun, 2022
Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media, Zeng, Peng, Hua, Qiuhong, Gong, Junyuan, Shi, Changjie, Pi, Xiaoping, Xie, Xin, Zhang, Ru, 2021
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes, Wang, Congcong, Zhang, YuFang, Guo, Shimeng, Zhao, Quan, Zeng, Yanping, Xie, Zhicheng, Xie, Xin, Lu, Boxun, Hu, Youhong, 2021
Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor, Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xinheng He, Jia Guo, Wanchao Yin, H Eric Xu, Xin Xie, Yi Jiang, 2021
Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2, Che, Jinxin, Wang, Zhilong, Shen, Zheyuan, Zhuang, Weihao, Ying, Huazhou, Hu, Yongzhou, Hu, Youhong, Xie, Xin, Dong, Xiaowu, 2021
Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice, Yun, Ying, Zhang, Chenlu, Guo, Shimeng, Liang, Xiaoying, Lan, Yuan, Wang, Min, Zhuo, Ning, Yin, Jianpeng, Liu, Huanan, Gu, Min, Li, Jing, Xie, Xin, Nan, Fajun, 2021
The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity, Martensson, Jonas, Sundqvist, Martina, Manandhar, Asmita, Leremias, Loukas, Zhang, Linjie, Ulven, Trond, Xie, Xin, Bjorkman, Lena, Forsman, Huamei, 2021
Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52, Ma, Mengna, Guo, Shimeng, Lin, Xi, Li, Shanshan, Wu, Yiran, Zeng, Yanping, Hu, Youhong, Zhao, Suwen, Xu, Fei, Xie, Xin, Shui, Wenqing, 2020
Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists, Chen, LinHai, Zhang, Qing, Xie, Xin, Nan, FaJun, 2020
Structural basis of GPBAR activation and bile acid recognition, Yang, Fan, Mao, Chunyou, Guo, Lulu, Lin, Jingyu, Ming, Qianqian, Xiao, Peng, Wu, Xiang, Shen, Qingya, Guo, Shimeng, Shen, DanDan, Lu, Ruirui, Zhang, Linqi, Huang, Shenming, Ping, Yuqi, Zhang, Chenlu, Ma, Cheng, Zhang, Kai, Liang, Xiaoying, Shen, Yuemao, Nan, Fajun, Yi, Fan, Luca, Vincent C, Zhou, Jiuyao, Jiang, Changtao, Sun, JinPeng, Xie, Xin, Yu, Xiao, Zhang, Yan, 2020
Structural basis of ligand recognition and self-activation of orphan GPR52, Lin, Xi, Li, Mingyue, Wang, Niandong, Wu, Yiran, Luo, Zhipu, Guo, Shimeng, Han, GyeWon, Li, Shaobai, Yue, Yang, Wei, Xiaohu, Xie, Xin, Chen, Yong, Zhao, Suwen, Wu, Jian, Lei, Ming, Xu, Fei, 2020
Targeting beta 2 subunit of Na+/K+-ATPase induces glioblastoma cell apoptosis through elevation of intracellular Ca2+, Li, Shirong, Dai, Zhi, Yang, Dong, Li, Wenxuan, Dai, Hongjuan, Sun, Bin, Liu, Xiuyun, Xie, Xin, Xu, Rong, Zhao, Xudong, 2019
RepSox, a small molecule inhibitor of the TGF beta receptor, induces brown adipogenesis and browning of white adipocytes, Tu, Wanzhi, Fu, Yanbin, Xie, Xin, 2019
Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases, Suo, Na, Guo, Yue, He, Bingqing, Gu, Haifeng, Xie, Xin, 2019
Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination, Cui Xue, Guo Yue, Fang Jiahui, Shi Changjie, Suo Na, Zhang Ru, Xie Xin, 2019
Deficiency of beta-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases, Cai, Yingying, Yang, Cuixia, Yu, Xiaohan, Qian, Jie, Dai, Min, Wang, Yan, Qin, Chaoyan, Lai, Weiming, Chen, Shuai, Wang, Tingting, Zhou, Jinfeng, Ma, Ningjia, Zhang, Yue, Zhang, Ru, Shen, Nan, Xie, Xin, Du, Changsheng, 2019
Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor, Tang Wei, Guo Ren, Shen Shijun, Zheng Yang, Lu Yuting, Jiang Mengmeng, Cui Xue, Jiang Cizhong, Xie Xin, 2019
Bifunctional Chimera That Coordinately Targets Human Immunodeficiency Virus 1 Envelope gp120 and the Host-Cell CCR5 Coreceptor at the Virus-Cell Interface, Rashad, Adel A, Song, LiRui, Holmes, Andrew P, Acharya, Kriti, Zhang, Shiyu, Wang, ZhiLong, Gary, Ebony, Xie, Xin, Pirrone, Vanessa, Kutzler, Michele A, Long, YaQiu, Chaiken, Irwin, 2018
Vitamin C promotes oligodendrocytes generation and remyelination, Guo, Yue, Suo, Na, Cui, Xue, Yuan, Qianting, Xie, Xin, 2018
Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice, Fang YouChen, Zheng Yang, Zheng Qing, Li Jing, Xie Xin, 2018
Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining, Zhang, Minjie, Wang, Liu, An, Ke, Cai, Jun

Receptor Pharmacology Gpr21 Gpr84 Gpcr Drug Discovery Cell Biology Molecular Biology Signal Transduction Therapeutics

Jin Tang Dong - Southern University of Science and Technology

Wanqiu Li - Southern University of Science and Technology

Jialing Liu - Southern University of Science and Technology

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