Professor | Leqian Yu | Asia Growth Partners

Name	Leqian Yu
Contact Information	leqianyu@ioz.ac.cn
Language ability	Chinese, English, Japanese
Province	Beijing

Name

Leqian Yu

Contact Information

leqianyu@ioz.ac.cn

Language ability

Chinese, English, Japanese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2014-04 to 2018-04: PhD, Kyoto University 2021: Selected as one of MIT Technology Review China's '35 Innovators Under 35' 2021: Work selected as one of Science magazine's 'Top 10 Breakthroughs of 2021'
Work Experience	2022-08 to Present: Researcher, Institute of Zoology, Chinese Academy of Sciences 2018-04 to 2022-07: Postdoctoral Researcher, University of Texas Southwestern Medical Center
Awards	MEXT Scholarship (2013-2017): Japanese Government CRSM Scholarship (2018-2019): Hamon Center for Regenerative Science and Medicine MIT Technology Review TR35 China (2021): 35 Innovators Under 35 Science (2021): Top 10 Breakthroughs of the Year Chinese Academy of Sciences (2021): Top 10 Scientific Advances in China/World

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2014-04 to 2018-04: PhD, Kyoto University
2021: Selected as one of MIT Technology Review China's '35 Innovators Under 35'
2021: Work selected as one of Science magazine's 'Top 10 Breakthroughs of 2021'

Work Experience

2022-08 to Present: Researcher, Institute of Zoology, Chinese Academy of Sciences
2018-04 to 2022-07: Postdoctoral Researcher, University of Texas Southwestern Medical Center

Awards

MEXT Scholarship (2013-2017): Japanese Government
CRSM Scholarship (2018-2019): Hamon Center for Regenerative Science and Medicine
MIT Technology Review TR35 China (2021): 35 Innovators Under 35
Science (2021): Top 10 Breakthroughs of the Year
Chinese Academy of Sciences (2021): Top 10 Scientific Advances in China/World

Areas of Focus	Pluripotent Stem Cells Embryo Models Embryo Development Organ Regeneration
Publications	Blastocyst-like structures generated from human pluripotent stem cells, Yu, L.; Wei, Y.; Duan, J.; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.; Wu, J., 2021 A protocol for the generation of blastocyst-like structures from human pluripotent stem cells, Yu, L.; Wei, Y.; Schmitz, D. A.; Sakurai, M.; Wu, J., 2021 Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Liu, T.; Li, J.; Yu, L.; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.; Gu, Y., 2021 Cell competition constitutes a barrier for interspecies chimerism, Zheng, C.; Hu, Y.; Sakurai, M.; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J., 2021 Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Yu, L.; Wei, Y.; Sun, H.; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J., 2020 Derivation of sheep embryonic stem cells under optimized conditions, Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P .J., 2020 Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Li, J.; Zhang, L.; Yu, L.; Minami, I.; Miyagawa, S.; Hörning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.; Tang, C.; Liu, L., 2020 Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation, Yu, L.; Li, J.; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L., 2019 Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures, Li, R.; Zhong, C.; Yu, Y.; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nuñez-Delicado, E.; Rodriguez Esteban, C.; Wu, J.; Izpisua Belmonte, J. C., 2019 Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells, Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.; Ren B., 2019 Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system, Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.; Wei, H.; Han, J., 2019 Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells, Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.; Kotera, H.; Liu, L., 2018 Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium, Li, J.; Minami, I.; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., 2017 Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.; Chen, Y., 2017 On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Li, X.; Yu, L.; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.; Chen, Y., 2016 Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y., 2016 Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers, Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.; Chen, Y., 2016 Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y., 2016

Areas of Focus

Pluripotent Stem Cells
Embryo Models
Embryo Development
Organ Regeneration

Publications

Blastocyst-like structures generated from human pluripotent stem cells, Yu, L.; Wei, Y.; Duan, J.; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.; Wu, J., 2021
A protocol for the generation of blastocyst-like structures from human pluripotent stem cells, Yu, L.; Wei, Y.; Schmitz, D. A.; Sakurai, M.; Wu, J., 2021
Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Liu, T.; Li, J.; Yu, L.; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.; Gu, Y., 2021
Cell competition constitutes a barrier for interspecies chimerism, Zheng, C.; Hu, Y.; Sakurai, M.; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J., 2021
Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Yu, L.; Wei, Y.; Sun, H.; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J., 2020
Derivation of sheep embryonic stem cells under optimized conditions, Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P .J., 2020
Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Li, J.; Zhang, L.; Yu, L.; Minami, I.; Miyagawa, S.; Hörning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.; Tang, C.; Liu, L., 2020
Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation, Yu, L.; Li, J.; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L., 2019
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures, Li, R.; Zhong, C.; Yu, Y.; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nuñez-Delicado, E.; Rodriguez Esteban, C.; Wu, J.; Izpisua Belmonte, J. C., 2019
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells, Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.; Ren B., 2019
Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system, Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.; Wei, H.; Han, J., 2019
Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells, Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.; Kotera, H.; Liu, L., 2018
Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium, Li, J.; Minami, I.; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., 2017
Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.; Chen, Y., 2017
On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Li, X.; Yu, L.; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.; Chen, Y., 2016
Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y., 2016
Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers, Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.; Chen, Y., 2016
Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y., 2016

Stem Cells Pluripotency Embryogenesis Regenerative Medicine Cell Differentiation Tissue Engineering Developmental Biology Genetic Engineering Biomedical Research Therapeutic Applications

Baoyang Hu - University of Chinese Academy of Sciences

Liu Wang - University of Chinese Academy of Sciences

Xichen Bao - University of Chinese Academy of Sciences

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