2008-08~2012-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
Research
Discovery of novel active natural products with unique structures Research on the pharmacological basis of traditional Chinese medicine Discovery, structural modification, and optimization of natural lead compounds
Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis, zhenyu lv, Jiao Meng, Sheng Yao, Fu Xiao, Shilong Li, Haoyang Shi, Chen Cui, Kaixian Chen, Xiaoming Luo, Yang Ye, Chang Chen, 2023
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment, Qing Wang, Sheng Yao, Ze-xian Yang, Chen Zhou, Yu Zhang, Ye Zhang, Lei Zhang, Jin-Tian Li, Zhi-Jian Xu, Wei-Liang Zhu, Nai-Xia Zhang, Yang Ye, Lin-Yin Feng, 2023
Flavonoids from the roots and rhizomes of Sophoratonkinensis and their in vitro anti-SARS-CoV-2 activity, Zhuo LI, Hang XIE, Chunping TANG, Lu FENG, Changqiang KE, Yechun XU, Haixia SU, Sheng YAO, Yang YE, 2023
Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel, Wang, Qiaoqiao, Wang, Long, Zhang, Wenbo, Tang, Chunping, Chen, Xueqin, Zheng, Yueming, Yao, Sheng, Gao, Zhaobing, Ye, Yang, 2023
Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities, Hu, Bintao, Li, Han, Tang, Chunping, Ke, ChangQiang, Geng, Meiyu, Yao, Sheng, Xie, Zuoquan, Ye, Yang, 2022
Fused-ring α-pyrones from intramolecular C–H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation, Yingle Mao, Jiaomeng Li, Chunping Tang, Biao Ma, Zhijian Xu, Changqiang Ke, Lu Feng, Haiyan Zhang, Sheng Yao, HuiXiong Dai, Yang Ye, 2022
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein, Wang, Lin, Wu, Yan, Yao, Sheng, Ge, Huan, Zhu, Ya, Chen, Kun, Chen, Wenzhang, Zhang, Yi, Zhu, Wei, Wang, Hongyang, Guo, Yu, Ma, Peixiang, Ren, Pengxuan, Zhang, Xianglei, Li, Huiqiong, Ali, Mohammad A, Xu, Wenqing, Jiang, Hualiang, Zhang, Leike, Zhu, Lili, Ye, Yang, Shang, Weijuan, Bai, Fang, 2022
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease, Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun, 2021
Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri, Yang, Yue, Gong, Qi, Wang, Wei, Mao, YingLe, Wang, XiaoRong, Yao, Sheng, Zhang, HaiYan, Tang, Chunping, Ye, Yang, 2020
Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy, Ren, YongMei, Zhou, ShuaiZhen, Zhang, Tian, Qian, Meijia, Zhang, Rui, Yao, Sheng, Zhu, Hong, Tang, Chunping, Lin, Ligen, Ye, Yang, 2020
Tricarabrols A-C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from Carpesium faberi, Yuan, Jie, Wen, Xuelan, Ke, ChangQiang, Zhang, Tian, Lin, Ligen, Yao, Sheng, Goodpaster, Jason D, Tang, Chunping, Ye, Yang, 2020
Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain, Pan, Lijia, Nie, Litong, Yao, Sheng, Bi, Aiwei, Ye, Yang, Wu, Yeming, Tan, Zhen, Wu, Zhixiang, 2020
Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening, Guo Wei, Yao Sheng, Sun Pu, Yang Tianbiao, Tang Chunping, Zheng Mingyue, Ye Yang, Meng Linghua, 2020
3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells, Hui Shan, Sheng Yao, Yang Ye, Qiang Yu, 2019
Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration, Liu Meng, Yuan Jie, Hu Wenjuan, Ke Changqiang, Zhang Yifan, Ye Yang, Zhong Dafang, Zhao Guangrong, Yao Sheng, Liu Jia, 2019
A lipid-soluble extract of Pinellia pedatisecta Schott enhances antitumor T cell responses by restoring tumor-associated dendritic cell activation and maturation, Wang, Yumeng, Huang, Haixia, Yao, Sheng, Li, Guiling, Xu, Congjian, Ye, Yang, Gui, Suiqi, 2019
Pyrrole-Hemoglobin Adducts, a More Feasible Potential Biomarker of Pyrrolizidine Alkaloid Exposure, Ma, Jiang, Ruan, Jianqing, Chen, Xinmeng, Li, Dongping, Yao, Sheng, Fu, Peter P, Ye, Yang, Gao, Hong, Wang, Jiyao, Lin, Ge, 2019
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells, Shan, Hui, Yao, Sheng, Ye, Yang, Yu, Qiang, 2019
Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi, Zhu, NanLin, Tang, Chunping, Xu, Chenghui, Ke, ChangQiang, Lin, Ge, Jenis, Janar, Yao, Sheng, Liu, Hongchun, Ye, Yang, 2019
Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity, Feng, Zheling, Chen, Shixin, Wang, Wei, Feng, Lu, Dong, Yanyan, Zou, Yiping, Ke, Changqiang, Tang, Chunping, Yao, Sheng, Zhang, Haiyan, Gan, Lishe, Ye, Yang, Lin, Ligen, 2019
Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer, Wang Yuwei, Tang Chunping, Yao Sheng, Lai Huanling, Li Runze, Xu Jiahui, Wang Qianqian, Fan Xing Xing, Wu Qi Biao, LaiHan, Leung Elaine, Ye Yang, Yao Xiaojun, 2019
Tetramerized Sesquiterpen
Keywords
Natural ProductsActive CompoundsUnique StructuresPharmacological BasisTraditional Chinese MedicineLead CompoundsStructural ModificationOptimizationDiscoveryResearch
