Professor | Jiangxin Liu | Asia Growth Partners

Name	Jiangxin Liu
Contact Information	liujiangxin@mail.kib.ac.cn
Language ability	Chinese, English
Province	Yunnan

Name

Jiangxin Liu

Contact Information

liujiangxin@mail.kib.ac.cn

Language ability

Chinese, English

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2003-09--2008-07 PhD: University of Science and Technology of China 1999-09--2003-06 Bachelor's: Sichuan University

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2003-09--2008-07 PhD: University of Science and Technology of China
1999-09--2003-06 Bachelor's: Sichuan University

Areas of Focus	Identification and confirmation of new targets of active natural products Screening of active natural products based on drug targets and NMR technology Evaluation of the druggability of active natural products
Publications	Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase, Liu, Jiangxin, Ren, Jian, Yang, Kun, Chen, Shuang, Yang, Xinni, Zhao, Qin-Shi, 2022 Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism, Liu, Jiangxin; Wu, Xing-De; Li, Wenyan; Yuan, Zaifeng; Yang, Kun; Zhao, Qin-Shi, 2021 Eleven undescribed alkaloids from the rhizomes of Sinomenium acutum and their IDO1 and TDO inhibitory activities, Bi, Ran; Yang, Xinni; Zhou, Haofeng; Peng Liyan; Liu, Jiangxin; Zhao Qin-Shi, 2022 NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches, Yang Emily, Yoo Chan, Liu Jiangxin, Wang He, Cao Jun, Li Fay-Wei, Pryer Kathleen M., Sun Tai-ping, Weigel Detlef, Zhou Pei, Chen Meng, 2019 Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum, Nuan Ning, Zhao Qiyu, Duan Zilei, Ji Mengyao, Xing Meichen, Zhu Tengyu, Mwangi James, Rong Mingqiang, Liu Jiangxin, Lai Ren, 2019 A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds, Rong, Mingqiang, Liu, Jiangxin, Zhang, Meilin, Wang, Gan, Zhao,Gang, Wang, Guodong, Zhang, Yaping, Hu, Kaifeng, Lai, Ren, 2016 Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors, Shao, Li-Dong, Su, Jia, Ye, Baixin, Liu, Jiang-Xin, Zuo, Zhi-Li, Li, Yan, Wang, Yue-Ying, Xia, Chengfeng, Zhao, Qin-Shi, 2017 Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat, Liu, Jiangxin; Fan, Shilong; Lee, Chul-Jin; Arno, L Greenleaf; Zhou, Pei, 2013 Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa, Wojtaszek, Jessica, Liu, Jiangxin, Souza, Sanjay, Wang, Su, Xue, yaohua, Walker, Graham C, Zhou, Pei, 2013 Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor, Liu, Jiangxin; Zhang, Jiahai; Yang, Yinshan; Huang, Hongda; Shen, Weiqun; Hu, Qi; Wang, Xingsheng; Wu, Jihui; Shi, Yunyu, 2008

Areas of Focus

Identification and confirmation of new targets of active natural products
Screening of active natural products based on drug targets and NMR technology
Evaluation of the druggability of active natural products

Publications

Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase, Liu, Jiangxin, Ren, Jian, Yang, Kun, Chen, Shuang, Yang, Xinni, Zhao, Qin-Shi, 2022
Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism, Liu, Jiangxin; Wu, Xing-De; Li, Wenyan; Yuan, Zaifeng; Yang, Kun; Zhao, Qin-Shi, 2021
Eleven undescribed alkaloids from the rhizomes of Sinomenium acutum and their IDO1 and TDO inhibitory activities, Bi, Ran; Yang, Xinni; Zhou, Haofeng; Peng Liyan; Liu, Jiangxin; Zhao Qin-Shi, 2022
NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches, Yang Emily, Yoo Chan, Liu Jiangxin, Wang He, Cao Jun, Li Fay-Wei, Pryer Kathleen M., Sun Tai-ping, Weigel Detlef, Zhou Pei, Chen Meng, 2019
Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum, Nuan Ning, Zhao Qiyu, Duan Zilei, Ji Mengyao, Xing Meichen, Zhu Tengyu, Mwangi James, Rong Mingqiang, Liu Jiangxin, Lai Ren, 2019
A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds, Rong, Mingqiang, Liu, Jiangxin, Zhang, Meilin, Wang, Gan, Zhao,Gang, Wang, Guodong, Zhang, Yaping, Hu, Kaifeng, Lai, Ren, 2016
Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors, Shao, Li-Dong, Su, Jia, Ye, Baixin, Liu, Jiang-Xin, Zuo, Zhi-Li, Li, Yan, Wang, Yue-Ying, Xia, Chengfeng, Zhao, Qin-Shi, 2017
Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat, Liu, Jiangxin; Fan, Shilong; Lee, Chul-Jin; Arno, L Greenleaf; Zhou, Pei, 2013
Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa, Wojtaszek, Jessica, Liu, Jiangxin, Souza, Sanjay, Wang, Su, Xue, yaohua, Walker, Graham C, Zhou, Pei, 2013
Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor, Liu, Jiangxin; Zhang, Jiahai; Yang, Yinshan; Huang, Hongda; Shen, Weiqun; Hu, Qi; Wang, Xingsheng; Wu, Jihui; Shi, Yunyu, 2008

Natural Products Drug Targets Nmr Technology Screening Identification Confirmation Evaluation Druggability Active Compounds Research

Sheng Yao - University of Chinese Academy of Sciences

Hui Wang - Wuhan University

Yu Zhang - University of Chinese Academy of Sciences

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