2005-09--2010-03 PhD: East China University of Science and Technology
2018-10~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher
2012-11~2018-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher
2012-07~2012-10 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher
2010-06~2012-06 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Postdoctoral Researcher
Chinese Academy of Sciences Youth Innovation Promotion Association Member (2017): Other
Sanofi-Aventis - Chinese Academy of Sciences Shanghai Institute of Life Sciences Outstanding Young Talent Award (2016): Other
Synthesis of an important intermediate of the new class 1 drug 'Letenshu' (LLDT-8) (2012): Second Prize, Municipal Level
Research
Medicinal Chemistry Organic Chemistry
Asymmetric macrocyclization enabled by Rh(III)-catalyzed C-H activation: Enantioenriched macrocyclic inhibitor of Zika virus infection, Chinese Chemical Letters, 2024
Discovery of Highly Potent and Selective Thyroid Hormone Receptor Agonists for the Treatment of Nonalcoholic Steatohepatitis, Journal of Medicinal Chemistry, 2023
Cyclization strategy leads to highly potent Bromodomain and extra-terminal (BET) Bromodomain inhibitors for the treatment of acute liver injury, European Journal of Medicinal Chemistry, 2023
Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/amidation reaction enabled delivery of diverse furoquinazolinones, TETRAHEDRON LETTERS, 2022
Ruthenium(II)-Catalyzed ortho Hydroxymethylation of 6-Arylpurines with Paraformaldehyde via Purine-Directed C-H Activation, Heterocycles, 2022
Discovery of a Potent and Selective Degrader for USP7, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022
Rhodium(III)-Catalyzed Asymmetric 1,2-Carboamidation of Alkenes Enables Access to Chiral 2,3-Dihydro-3-benzofuranmethanamides, ORGANIC LETTERS, 2022
Discovery of novel Thieno2,3-dimidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022
Rh(III)-catalyzed selective C7-H functionalization of indolines with 1,3-enynes enables access to six-membered 1,7-fused indolines, TETRAHEDRON LETTERS, 2021
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021
Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer, BIOORGANIC & MEDICINAL CHEMISTRY, 2021
Recent advances of pharmacological activities and structural modifications of celastrol, 中国药物化学杂志, 2020
Rh(iii)-catalyzed tandem annulative redox-neutral arylation/amidation of aromatic tethered alkenes, CHEMICAL SCIENCE, 2020
Discovery of 8-Methyl-pyrrolo1,2-apyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2020
RUTHENIUM(II)-CATALYZED REGIOSELECTIVE C-H HYDROXYMETHYLATION OF N-ARYL-AZAINDOLES WITH PARAFORMALDEHYDE, HETEROCYCLES, 2020
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2020
Ruthenium(II)-Catalyzed Regioselective Ortho C-H Allenylation of Electron-Rich Aniline and Phenol Derivatives, JOURNAL OF ORGANIC CHEMISTRY, 2020
Ru(II)-catalyzed regioselective C-7 hydroxymethylation of indolines with formaldehyde, TETRAHEDRON LETTERS, 2019
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019
p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization, THERANOSTICS, 2019
Rh(III)-Catalyzed Redox-Neutral Unsymmetrical C-H Alkylation and Amidation Reactions of &ITN&IT-Phenoxyacetamides, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018
Experimental and theoretical studies on rhodium-catalyzed direct CsbndH benzoxylation reaction, TETRAHEDRON LETTERS, 2018
Rhodium-Catalyzed C-H Functionalization of Indoles with Diazo Compounds: Synthesis of Structurally Diverse 2,3-Fused Indoles, ADVANCEDSYNTHESISCATALYSIS, 2018
A Rh(III)-catalyzed redox-neutral C-H alkylation reaction with allylic alcohols by using a traceless oxidizing directing group, ORGANIC CHEMISTRY FRONTIERS, 2018
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2018
Experimental and theoretical studies on rhodium-catalyzed direct C-H benzoxylation reaction, TETRAHEDRON LETTERS, 2018
Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening, ORGANIC & BIOMOLECULAR CHEMISTRY, 2017
Rhodium(iii)-catalyzed alkylation of primary C(sp(3))-H bonds with ��-diazocarbonyl compounds., 2016-01-01
去氢表雄酮衍生物的合成及其抑制神经炎症活性研究, 中国药物化学杂志, 2016
Rhodium(iii)-catalyzed alkyllation of primary c(sp(3))-h bonds with alpha-diazocarbonyl compounds, CHEMICAL COMMUNICATIONS, 2016
Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheals loperamide, Org. Biomol. Chem., 2016
Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide, ORGANIC & BIOMOLECULAR CHEMISTRY, 2016
Chiral discrimination of natural isoflavanones using (R)- and (S)-BINOL as the NMR chiral solvating agents, TETRAHEDRON-ASYMMETRY, 2016
Redox-Neutral Rhodium-Catalyzed C-H Functionalization of Arylamine N-Oxides with Diazo Compounds: Primary C(sp(3))-H/C(sp(2))-H Activation and Oxygen-Atom Transfer, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015
Ir-III-Catalyzed Direct C-7 Amidation of Indolines with Sulfonyl, Acyl, and Aryl Azides at Room Temperature, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2015
Iridium(III)-Catalyzed C-7 Selective C-H Alkynylation of Indolines at Room Temperature, JOURNAL OF ORGANIC CHEMISTRY, 2015
Rh(III)- or Ir(III)-catalyzed ynone synthesis from aldehydes via chelation-assisted C-H bond activation, CHEMICAL COMMUNICATIONS, 2015
A 4+1 Cyclative Capture Approach to 3H-Indole-N-oxides at Room Temperature by Rhodium(III)-Catalyzed C-H Activation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015
Rhodium-Catalyzed Redox-Neutral C-H Functionalization of Arylamine N-Oxides with Diazo Compounds: Primary C(sp3)-H/C(sp2)-H Activation and Oxygen Atom Transfer., Angew.Chem. Int. Ed., 2015
Access to Six- and Seven-Membered 1,7-Fused Indolines via Rh(III)-Catalyzed Redox-Neutral C7-Selective C-H Functionalization of Indolines with Alkynes and Alkenes, JOURNAL OF ORGANIC CHEMISTRY, 2015
Keywords
Drug DesignSynthesisPharmacologyBioactivityChemical BiologyMolecular ModelingTherapeuticsEnzyme InhibitionNatural ProductsMedicinal Chemistry
Area of Focus
Fungi | Secondary Metabolites | Natural Products | Chemistry | Bioactivity | Traditional Chinese Medicine | Marine Biology | Drug Development | Chemical Probes | Environmental Adaptation
