Sanofi-Excellent Young Talent Award (2017): Institute Level
Shanghai Talent Development Fund (2016): Provincial Level
Ministry of Science and Technology and Gates Foundation 'Grand Challenge Young Scientist' Award (2015): Ministerial Level
Chinese Medical Science Award, Second Prize (2008): Ministerial Level
Shanghai Science and Technology Award, Third Prize (2008): Provincial Level
Shanghai Medical Science Award, Second Prize (2008): Other
Research
Structure and function of G protein-coupled receptors Small molecule drug screening for G protein-coupled receptors
Dimerization and antidepressant recognition at noradrenaline transporter, 11th Author, 2024
A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM, 11th Author, 2024
Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling, 11th Author, 2024
Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins, 11th Author, 2024
Single-cell transcriptomics reveals the role of antigen presentation in liver metastatic breast cancer, 7th Author, 2024
High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways, 11th Author, 2024
A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease, 12th Author, 2024
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists, 11th Author, 2023
Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4), 11th Author, 2023
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds, 11th Author, 2023
Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors, 11th Author, 2023
Molecular basis of signal transduction mediated by the human GIPR splice variants, 11th Author, 2023
GPCR activation and GRK2 assembly by a biased intracellular agonist, 11th Author, 2023
Structural insights into the interaction of three Y-shaped ligands with PI3Kα, 11th Author, 2023
Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7, 11th Author, 2023
Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1, 9th Author, 2023
Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα), 5th Author, 2023
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, 11th Author, 2023
Structural analysis of the dual agonism at GLP-1R and GCGR, 11th Author, 2023
Modulating effects of RAMPs on signaling profiles of the glucagon receptor family, 11th Author, 2022
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, 11th Author, 2022
A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2, 11th Author, 2022
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors, 11th Author, 2022
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis, 11th Author, 2022
Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24, 11th Author, 2022
Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα, 11th Author, 2022
Structural insights into ligand recognition and selectivity of somatostatin receptors, 11th Author, 2022
Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα, 11th Author, 2022
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors, 11th Author, 2022
A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds, 11th Author, 2022
An emerging direction in glucagon-based therapy, 2nd Author, 2022
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists, 11th Author, 2021
Structures of the human cholecystokinin receptors bound to agonists and antagonists, 5th Author, 2021
Constitutive signal bias mediated by the human GHRHR splice variant 1, 11th Author, 2021
W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319, 11th Author, 2021
Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening, 11th Author, 2021
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor, 2nd Author, 2021
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, 11th Author, 2021
Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4, 17th Author, 2021
Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor, 11th Author, 2021
G protein-coupled receptors: structure- and function-based drug discovery, 1st Author, 2021
GPR160 is a potential biomarker associated with prostate cancer, 11th Author, 2021
Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver & ndash;alpha-cell axis, 11th Author, 2021
Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation, 11th Author
Keywords
G Protein-Coupled ReceptorsStructureFunctionSmall MoleculesDrug ScreeningPharmacologyBiochemistryMolecular BiologyReceptor SignalingTherapeutics
