Areas of Focus
- Structure and function of G protein-coupled receptors
- Small molecule drug screening for G protein-coupled receptors
Work Experience
- 2017-10 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2012-10 to 2017-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
- 2012-03 to 2012-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
- 2010-01 to 2012-02 - Shanghai Jiao Tong University School of Medicine - Postdoctoral Researcher
- 2005-09 to 2009-12 - Shanghai Institute of Life Sciences, Chinese Academy of Sciences - Ph.D. Student
- 2002-09 to 2005-07 - South China Normal University - Master's Student
- 1997-09 to 2002-07 - Yantai Normal University - Bachelor's Student
Academic Background & Achievements
- 2005-09 to 2009-12 Ph.D.: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- 2002-09 to 2005-07 Master's: South China Normal University
- 1997-09 to 2002-07 Bachelor's: Yantai Normal University
Publications
- Dimerization and antidepressant recognition at noradrenaline transporter, 11th Author, 2024
- A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM, 11th Author, 2024
- Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling, 11th Author, 2024
- Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins, 11th Author, 2024
- Single-cell transcriptomics reveals the role of antigen presentation in liver metastatic breast cancer, 7th Author, 2024
- High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways, 11th Author, 2024
- A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease, 12th Author, 2024
- Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists, 11th Author, 2023
- Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4), 11th Author, 2023
- A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds, 11th Author, 2023
- Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors, 11th Author, 2023
- Molecular basis of signal transduction mediated by the human GIPR splice variants, 11th Author, 2023
- GPCR activation and GRK2 assembly by a biased intracellular agonist, 11th Author, 2023
- Structural insights into the interaction of three Y-shaped ligands with PI3Kα, 11th Author, 2023
- Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7, 11th Author, 2023
- Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1, 9th Author, 2023
- Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα), 5th Author, 2023
- Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, 11th Author, 2023
- Structural analysis of the dual agonism at GLP-1R and GCGR, 11th Author, 2023
- Modulating effects of RAMPs on signaling profiles of the glucagon receptor family, 11th Author, 2022
- Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, 11th Author, 2022
- A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2, 11th Author, 2022
- Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors, 11th Author, 2022
- GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis, 11th Author, 2022
- Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24, 11th Author, 2022
- Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα, 11th Author, 2022
- Structural insights into ligand recognition and selectivity of somatostatin receptors, 11th Author, 2022
- Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα, 11th Author, 2022
- Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors, 11th Author, 2022
- A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds, 11th Author, 2022
- An emerging direction in glucagon-based therapy, 2nd Author, 2022
- Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists, 11th Author, 2021
- Structures of the human cholecystokinin receptors bound to agonists and antagonists, 5th Author, 2021
- Constitutive signal bias mediated by the human GHRHR splice variant 1, 11th Author, 2021
- W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319, 11th Author, 2021
- Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening, 11th Author, 2021
- Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor, 2nd Author, 2021
- Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, 11th Author, 2021
- Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4, 17th Author, 2021
- Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor, 11th Author, 2021
- G protein-coupled receptors: structure- and function-based drug discovery, 1st Author, 2021
- GPR160 is a potential biomarker associated with prostate cancer, 11th Author, 2021
- Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver & ndash;alpha-cell axis, 11th Author, 2021
- Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation, 11th Author
Awards
- Shanghai Outstanding Academic Leader (2023): Provincial Level
- Sanofi-Excellent Young Talent Award (2017): Institute Level
- Shanghai Talent Development Fund (2016): Provincial Level
- Ministry of Science and Technology and Gates Foundation 'Grand Challenge Young Scientist' Award (2015): Ministerial Level
- Chinese Medical Science Award, Second Prize (2008): Ministerial Level
- Shanghai Science and Technology Award, Third Prize (2008): Provincial Level
- Shanghai Medical Science Award, Second Prize (2008): Other
