Areas of Focus
- Antitumor Drugs
- Anti-Osteoporosis Drugs
- Novel Bioactive Heterocycles and Their Synthesis Methodology
Work Experience
- 2008.8-2009.1: Visiting Scholar, Georgia State University
Academic Background & Achievements
- 1988-1992: Bachelor's Degree in Chemistry, Suzhou University
- 1992-1995: Master's Degree in Chemistry, East China Normal University
- 2000-2003: Ph.D. in Chemistry, Shanghai Institute of Materia Medica
Publications
- Synthesis and biological evaluation of pyrazole-fused oleanolic acid derivatives as novel inhibitors of inflammatory and osteoclast differentiation, Yuanyuan Yu, Wenlong Yuan, Jiaqi Yuan, Wenhui Wei, Qian He, Xiaofei Zhang, Shijun He, Chunhao Yang, 2023
- Ru-Catalyzed Defluorinative Alkylation or Catalyst-Free Hydroalkylation of gem-Difluoroalkenes Enabled by Visible Light, Liu, Fangran, Zhuang, Zhen, Qun, Qun, Zhang, Xiaofei, Yang, Chunhao, 2022
- Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-?B Ligand, Yang, Kai, Li, Shunyao, Wang, Tianqi, Yan, Xueming, He, Qian, Ning, Ruonan, Xu, Xing, Yao, Wei, Zhang, Xiaofei, Yang, Chunhao, Jiang, Min, Deng, Lianfu, 2022
- Design, synthesis, and biological evaluations of substituted pyrazoles as pyrrolomycin analogues against staphylococcal biofilm, Huan, Xiang, Wang, Yanhui, Peng, Xiaofeng, Xie, Shanshan, He, Qian, Zhang, Xiaofei, Lan, Lefu, Yang, Chunhao, 2022
- Photoredox-catalysed regioselective synthesis of C-4-alkylated pyridines with N-(acyloxy)phthalimides, Zhang, Zhucheng, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2022
- Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S)), Fang, Haotian, Wu, Yingming, Xiao, Qitao, He, Dongbo, Zhou, Tongrui, Liu, Wenzhong, Yang, ChunHao, Xie, Yuli, 2022
- 特效重金属解毒剂的故事, 杨春皓, 2022
- Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment, Wang, Jie, Wei, Wenhui, Zhang, Xiaofei, Cao, Shiqi, Hu, Bintao, Ye, Yang, Jiang, Min, Wang, Tianqi, Zuo, Jianping, He, Shijun, Yang, Chunhao, 2021
- Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides †, Jiaqi Yuan, Xiaofei Zhang, Chunhao Yang, 2021
- Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo2,1-f1,2,4triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors, Xiang, HaoYue, Wang, Xiang, Chen, YanHong, Zhang, Xi, Tan, Cun, Wang, Yi, Su, Yi, Gao, ZhiWei, Chen, XiaoYan, Xiong, Bing, Gao, ZhaoBing, Chen, Yi, Ding, Jian, Meng, LingHua, Yang, ChunHao, 2021
- Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling, Zhang, Lanfei, Zhang, Xiaofei, Cui, Yongmei, Yang, Chunhao, 2021
- Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells, Wang, Yuxiang, Zhang, Xu, Ma, Qingyang, Hu, Landian, Zhang, Xi, Wang, Yi, Xu, Lan, Yang, Chunhao, Tan, Cun, Kong, Xiangyin, Ding, Jian, Meng, Linghua, 2021
- Synthesis of 2-alkyl-chroman-4-ones via cascade alkylation-dechlorination of 3-chlorochromones, Li, Shunyao, Zhang, Lanfei, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2021
- Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides, Yuan, Jiaqi, Zhang, Xiaofei, Yang, Chunhao, 2021
- Identification of 2-substituted pyrrolo1,2-bpyridazine derivatives as new PARP-1 inhibitors, Xiang, HaoYue, Chen, JianYang, Huan, XiaJuan, Chen, Yi, Gao, Zhaobing, Ding, Jian, Miao, ZeHong, Yang, ChunHao, 2021
- A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones, Liu, Fangran, Zhang, Xiaofei, Qian, Qun, Yang, Chunhao, 2020
- Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides (vol 18, pg 6162, 2020), Dai, Tianzi, Cui, Chen, Qi, Xueyu, Cheng, Yanshu, He, Qian, Zhang, Xiaofei, Luo, Xiaomin, Yang, Chunhao, 2020
- Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo 2,1-f 1,2,4 triazine derivatives, Xiang, HaoYue, Chen, YanHong, Wang, Yi, Zhang, Xi, Ding, Jian, Meng, LingHua, Yang, ChunHao, 2020
- Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses Kras-mutated non-small cell lung cancer, Wang, Yuxiang, Li, Xian, Liu, Xueling, Wang, Bobo, Chen, Yi, Yang, Chunhao, Ding, Jian, Meng, Linghua, 2020
- Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides, Dai, Tianzi, Cui, Chen, Qi, Xueyu, Cheng, Yanshu, He, Qian, Zhang, Xiaofei, Luo, Xiaomin, Yang, Chunhao, 2020
- Pd-Catalyzed intramolecular C-H activation and C-S formation to synthesize pyrazolo5,1-bbenzothiazoles without an additional oxidant, Peng, Yingyuan, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2019
- Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds, Peng, Xiaofeng, Zhang, Xiaofei, Li, Shunyao, Lu, Yunfu, Lan, Lefu, Yang, Chunhao, 2019
- Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3K alpha inhibition in breast cancer, Liu, XueLing, Wang, BoBo, Wang, Yi, Wang, YuXiang, Yang, Chunhao, Tan, Cun, Zhang, Xi, He, Qiaojun, Ding, Jian, Meng, LingHua, 2019
- Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer, Wang, Yuxiang, Li, Xian, Liu, Xueling, Chen, Yi, Yang, Chunhao, Tan, Cun, Wang, Bobo, Sun, Yiming, Zhang, Xi, Gao, Yinglei, Ding, Jian, Meng, Linghua, 2019
- Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta2,1-b:3,4-b 'diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent, Peng, Lei, Zhang, Xiaofei, Yang, Chunhao, 2019
- HRAS(G12s) mutant mediates resistance to a PI3K alpha inhibitor CYH33 in esophageal squamous cell carcinomas, Wang, Yuxiang, Zhang, Xu, Ma, Qingyang, Zhang, Xi, Yang, Chunhao, Tan, Cun, Hu, Landing, Ding, Jian, Meng, Linghua, 2019
- Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes, Peng, Yingyuan, Zhang, Xiaofei, Qi, Xueyu, He, Qian, Zhang, Bin, Hao, Jian, Yang, Chunhao, 2019
- Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-kappa B Ligand (RANKL)-Receptor Activator of Nuclear Factor-kappa B (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization, Jiang, Min, Peng, Lei, Yang, Kai, Wang, Tianqi, Yan, Xueming, Jiang, Tao, Xu, Jianrong, Qi, Jin, Zhou, Hanbing, Qian, Niandong, Zhou, Qi, Chen, Bo, Xu, Xing, Deng, Lianfu, Yang, Chunhao, 2019
- One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones, Yuan, Jiaqi, He, Qian, Song, Shanshan, Zhang, Xiaofei, Miao, Zehong, Yang, Chunhao, 2019
- A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen-Dependent Bone Loss, Jiang, Min, Wang, Tianqi, Yan, Xueming, Liu, Zhuochao, Yan, Yufei, Yang, Kai, Qi, Jin, Zhou, Hanbing, Qian, Niandong, Zhou, Qi, Chen, Bo, Xu, Xing, Xi, Xiaobing, Yang, Chunhao, Deng, Lianfu, 2019
- Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer, Wang Yuxiang, Li Xian, Liu Xueling, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding, Linghua Meng, 2019
- Substituent-Oriented Synthesis of Substituted Pyrazoles/Chromeno3,2-cpyrazoles via Sequential Reactions of Chromones/3-Chlorochromones and Tosylhydrazones, Dai, Tianzi, Li, Qunyi, Zhang,
