Professor | Chunhao Yang | Asia Growth Partners

Name	Chunhao Yang
Contact Information	chyang@mail.shcnc.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Chunhao Yang

Contact Information

chyang@mail.shcnc.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1988-1992: Bachelor's Degree in Chemistry, Suzhou University 1992-1995: Master's Degree in Chemistry, East China Normal University 2000-2003: Ph.D. in Chemistry, Shanghai Institute of Materia Medica
Work Experience	2008.8-2009.1: Visiting Scholar, Georgia State University

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1988-1992: Bachelor's Degree in Chemistry, Suzhou University
1992-1995: Master's Degree in Chemistry, East China Normal University
2000-2003: Ph.D. in Chemistry, Shanghai Institute of Materia Medica

Work Experience

2008.8-2009.1: Visiting Scholar, Georgia State University

Areas of Focus	Antitumor Drugs Anti-Osteoporosis Drugs Novel Bioactive Heterocycles and Their Synthesis Methodology
Publications	Synthesis and biological evaluation of pyrazole-fused oleanolic acid derivatives as novel inhibitors of inflammatory and osteoclast differentiation, Yuanyuan Yu, Wenlong Yuan, Jiaqi Yuan, Wenhui Wei, Qian He, Xiaofei Zhang, Shijun He, Chunhao Yang, 2023 Ru-Catalyzed Defluorinative Alkylation or Catalyst-Free Hydroalkylation of gem-Difluoroalkenes Enabled by Visible Light, Liu, Fangran, Zhuang, Zhen, Qun, Qun, Zhang, Xiaofei, Yang, Chunhao, 2022 Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-?B Ligand, Yang, Kai, Li, Shunyao, Wang, Tianqi, Yan, Xueming, He, Qian, Ning, Ruonan, Xu, Xing, Yao, Wei, Zhang, Xiaofei, Yang, Chunhao, Jiang, Min, Deng, Lianfu, 2022 Design, synthesis, and biological evaluations of substituted pyrazoles as pyrrolomycin analogues against staphylococcal biofilm, Huan, Xiang, Wang, Yanhui, Peng, Xiaofeng, Xie, Shanshan, He, Qian, Zhang, Xiaofei, Lan, Lefu, Yang, Chunhao, 2022 Photoredox-catalysed regioselective synthesis of C-4-alkylated pyridines with N-(acyloxy)phthalimides, Zhang, Zhucheng, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2022 Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S)), Fang, Haotian, Wu, Yingming, Xiao, Qitao, He, Dongbo, Zhou, Tongrui, Liu, Wenzhong, Yang, ChunHao, Xie, Yuli, 2022 特效重金属解毒剂的故事, 杨春皓, 2022 Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment, Wang, Jie, Wei, Wenhui, Zhang, Xiaofei, Cao, Shiqi, Hu, Bintao, Ye, Yang, Jiang, Min, Wang, Tianqi, Zuo, Jianping, He, Shijun, Yang, Chunhao, 2021 Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides †, Jiaqi Yuan, Xiaofei Zhang, Chunhao Yang, 2021 Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo2,1-f1,2,4triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors, Xiang, HaoYue, Wang, Xiang, Chen, YanHong, Zhang, Xi, Tan, Cun, Wang, Yi, Su, Yi, Gao, ZhiWei, Chen, XiaoYan, Xiong, Bing, Gao, ZhaoBing, Chen, Yi, Ding, Jian, Meng, LingHua, Yang, ChunHao, 2021 Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling, Zhang, Lanfei, Zhang, Xiaofei, Cui, Yongmei, Yang, Chunhao, 2021 Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells, Wang, Yuxiang, Zhang, Xu, Ma, Qingyang, Hu, Landian, Zhang, Xi, Wang, Yi, Xu, Lan, Yang, Chunhao, Tan, Cun, Kong, Xiangyin, Ding, Jian, Meng, Linghua, 2021 Synthesis of 2-alkyl-chroman-4-ones via cascade alkylation-dechlorination of 3-chlorochromones, Li, Shunyao, Zhang, Lanfei, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2021 Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides, Yuan, Jiaqi, Zhang, Xiaofei, Yang, Chunhao, 2021 Identification of 2-substituted pyrrolo1,2-bpyridazine derivatives as new PARP-1 inhibitors, Xiang, HaoYue, Chen, JianYang, Huan, XiaJuan, Chen, Yi, Gao, Zhaobing, Ding, Jian, Miao, ZeHong, Yang, ChunHao, 2021 A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones, Liu, Fangran, Zhang, Xiaofei, Qian, Qun, Yang, Chunhao, 2020 Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides (vol 18, pg 6162, 2020), Dai, Tianzi, Cui, Chen, Qi, Xueyu, Cheng, Yanshu, He, Qian, Zhang, Xiaofei, Luo, Xiaomin, Yang, Chunhao, 2020 Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo 2,1-f 1,2,4 triazine derivatives, Xiang, HaoYue, Chen, YanHong, Wang, Yi, Zhang, Xi, Ding, Jian, Meng, LingHua, Yang, ChunHao, 2020 Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses Kras-mutated non-small cell lung cancer, Wang, Yuxiang, Li, Xian, Liu, Xueling, Wang, Bobo, Chen, Yi, Yang, Chunhao, Ding, Jian, Meng, Linghua, 2020 Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides, Dai, Tianzi, Cui, Chen, Qi, Xueyu, Cheng, Yanshu, He, Qian, Zhang, Xiaofei, Luo, Xiaomin, Yang, Chunhao, 2020 Pd-Catalyzed intramolecular C-H activation and C-S formation to synthesize pyrazolo5,1-bbenzothiazoles without an additional oxidant, Peng, Yingyuan, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2019 Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds, Peng, Xiaofeng, Zhang, Xiaofei, Li, Shunyao, Lu, Yunfu, Lan, Lefu, Yang, Chunhao, 2019 Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3K alpha inhibition in breast cancer, Liu, XueLing, Wang, BoBo, Wang, Yi, Wang, YuXiang, Yang, Chunhao, Tan, Cun, Zhang, Xi, He, Qiaojun, Ding, Jian, Meng, LingHua, 2019 Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer, Wang, Yuxiang, Li, Xian, Liu, Xueling, Chen, Yi, Yang, Chunhao, Tan, Cun, Wang, Bobo, Sun, Yiming, Zhang, Xi, Gao, Yinglei, Ding, Jian, Meng, Linghua, 2019 Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta2,1-b:3,4-b 'diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent, Peng, Lei, Zhang, Xiaofei, Yang, Chunhao, 2019 HRAS(G12s) mutant mediates resistance to a PI3K alpha inhibitor CYH33 in esophageal squamous cell carcinomas, Wang, Yuxiang, Zhang, Xu, Ma, Qingyang, Zhang, Xi, Yang, Chunhao, Tan, Cun, Hu, Landing, Ding, Jian, Meng, Linghua, 2019 Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes, Peng, Yingyuan, Zhang, Xiaofei, Qi, Xueyu, He, Qian, Zhang, Bin, Hao, Jian, Yang, Chunhao, 2019 Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-kappa B Ligand (RANKL)-Receptor Activator of Nuclear Factor-kappa B (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization, Jiang, Min, Peng, Lei, Yang, Kai, Wang, Tianqi, Yan, Xueming, Jiang, Tao, Xu, Jianrong, Qi, Jin, Zhou, Hanbing, Qian, Niandong, Zhou, Qi, Chen, Bo, Xu, Xing, Deng, Lianfu, Yang, Chunhao, 2019 One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones, Yuan, Jiaqi, He, Qian, Song, Shanshan, Zhang, Xiaofei, Miao, Zehong, Yang, Chunhao, 2019 A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen-Dependent Bone Loss, Jiang, Min, Wang, Tianqi, Yan, Xueming, Liu, Zhuochao, Yan, Yufei, Yang, Kai, Qi, Jin, Zhou, Hanbing, Qian, Niandong, Zhou, Qi, Chen, Bo, Xu, Xing, Xi, Xiaobing, Yang, Chunhao, Deng, Lianfu, 2019 Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer, Wang Yuxiang, Li Xian, Liu Xueling, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding, Linghua Meng, 2019 Substituent-Oriented Synthesis of Substituted Pyrazoles/Chromeno3,2-cpyrazoles via Sequential Reactions of Chromones/3-Chlorochromones and Tosylhydrazones, Dai, Tianzi, Li, Qunyi, Zhang,

Areas of Focus

Antitumor Drugs
Anti-Osteoporosis Drugs
Novel Bioactive Heterocycles and Their Synthesis Methodology

Publications

Synthesis and biological evaluation of pyrazole-fused oleanolic acid derivatives as novel inhibitors of inflammatory and osteoclast differentiation, Yuanyuan Yu, Wenlong Yuan, Jiaqi Yuan, Wenhui Wei, Qian He, Xiaofei Zhang, Shijun He, Chunhao Yang, 2023
Ru-Catalyzed Defluorinative Alkylation or Catalyst-Free Hydroalkylation of gem-Difluoroalkenes Enabled by Visible Light, Liu, Fangran, Zhuang, Zhen, Qun, Qun, Zhang, Xiaofei, Yang, Chunhao, 2022
Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-?B Ligand, Yang, Kai, Li, Shunyao, Wang, Tianqi, Yan, Xueming, He, Qian, Ning, Ruonan, Xu, Xing, Yao, Wei, Zhang, Xiaofei, Yang, Chunhao, Jiang, Min, Deng, Lianfu, 2022
Design, synthesis, and biological evaluations of substituted pyrazoles as pyrrolomycin analogues against staphylococcal biofilm, Huan, Xiang, Wang, Yanhui, Peng, Xiaofeng, Xie, Shanshan, He, Qian, Zhang, Xiaofei, Lan, Lefu, Yang, Chunhao, 2022
Photoredox-catalysed regioselective synthesis of C-4-alkylated pyridines with N-(acyloxy)phthalimides, Zhang, Zhucheng, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2022
Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S)), Fang, Haotian, Wu, Yingming, Xiao, Qitao, He, Dongbo, Zhou, Tongrui, Liu, Wenzhong, Yang, ChunHao, Xie, Yuli, 2022
特效重金属解毒剂的故事, 杨春皓, 2022
Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment, Wang, Jie, Wei, Wenhui, Zhang, Xiaofei, Cao, Shiqi, Hu, Bintao, Ye, Yang, Jiang, Min, Wang, Tianqi, Zuo, Jianping, He, Shijun, Yang, Chunhao, 2021
Regioselective Pd-catalyzed α-alkylation of furans using alkyl iodides †, Jiaqi Yuan, Xiaofei Zhang, Chunhao Yang, 2021
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo2,1-f1,2,4triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors, Xiang, HaoYue, Wang, Xiang, Chen, YanHong, Zhang, Xi, Tan, Cun, Wang, Yi, Su, Yi, Gao, ZhiWei, Chen, XiaoYan, Xiong, Bing, Gao, ZhaoBing, Chen, Yi, Ding, Jian, Meng, LingHua, Yang, ChunHao, 2021
Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling, Zhang, Lanfei, Zhang, Xiaofei, Cui, Yongmei, Yang, Chunhao, 2021
Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells, Wang, Yuxiang, Zhang, Xu, Ma, Qingyang, Hu, Landian, Zhang, Xi, Wang, Yi, Xu, Lan, Yang, Chunhao, Tan, Cun, Kong, Xiangyin, Ding, Jian, Meng, Linghua, 2021
Synthesis of 2-alkyl-chroman-4-ones via cascade alkylation-dechlorination of 3-chlorochromones, Li, Shunyao, Zhang, Lanfei, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2021
Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides, Yuan, Jiaqi, Zhang, Xiaofei, Yang, Chunhao, 2021
Identification of 2-substituted pyrrolo1,2-bpyridazine derivatives as new PARP-1 inhibitors, Xiang, HaoYue, Chen, JianYang, Huan, XiaJuan, Chen, Yi, Gao, Zhaobing, Ding, Jian, Miao, ZeHong, Yang, ChunHao, 2021
A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones, Liu, Fangran, Zhang, Xiaofei, Qian, Qun, Yang, Chunhao, 2020
Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides (vol 18, pg 6162, 2020), Dai, Tianzi, Cui, Chen, Qi, Xueyu, Cheng, Yanshu, He, Qian, Zhang, Xiaofei, Luo, Xiaomin, Yang, Chunhao, 2020
Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo 2,1-f 1,2,4 triazine derivatives, Xiang, HaoYue, Chen, YanHong, Wang, Yi, Zhang, Xi, Ding, Jian, Meng, LingHua, Yang, ChunHao, 2020
Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses Kras-mutated non-small cell lung cancer, Wang, Yuxiang, Li, Xian, Liu, Xueling, Wang, Bobo, Chen, Yi, Yang, Chunhao, Ding, Jian, Meng, Linghua, 2020
Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides, Dai, Tianzi, Cui, Chen, Qi, Xueyu, Cheng, Yanshu, He, Qian, Zhang, Xiaofei, Luo, Xiaomin, Yang, Chunhao, 2020
Pd-Catalyzed intramolecular C-H activation and C-S formation to synthesize pyrazolo5,1-bbenzothiazoles without an additional oxidant, Peng, Yingyuan, He, Qian, Zhang, Xiaofei, Yang, Chunhao, 2019
Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds, Peng, Xiaofeng, Zhang, Xiaofei, Li, Shunyao, Lu, Yunfu, Lan, Lefu, Yang, Chunhao, 2019
Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3K alpha inhibition in breast cancer, Liu, XueLing, Wang, BoBo, Wang, Yi, Wang, YuXiang, Yang, Chunhao, Tan, Cun, Zhang, Xi, He, Qiaojun, Ding, Jian, Meng, LingHua, 2019
Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer, Wang, Yuxiang, Li, Xian, Liu, Xueling, Chen, Yi, Yang, Chunhao, Tan, Cun, Wang, Bobo, Sun, Yiming, Zhang, Xi, Gao, Yinglei, Ding, Jian, Meng, Linghua, 2019
Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta2,1-b:3,4-b 'diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent, Peng, Lei, Zhang, Xiaofei, Yang, Chunhao, 2019
HRAS(G12s) mutant mediates resistance to a PI3K alpha inhibitor CYH33 in esophageal squamous cell carcinomas, Wang, Yuxiang, Zhang, Xu, Ma, Qingyang, Zhang, Xi, Yang, Chunhao, Tan, Cun, Hu, Landing, Ding, Jian, Meng, Linghua, 2019
Metal-Free Access to (E/Z)-alpha-Fluorovinyl Phosphorus Compounds from gem-Difluorostyrenes, Peng, Yingyuan, Zhang, Xiaofei, Qi, Xueyu, He, Qian, Zhang, Bin, Hao, Jian, Yang, Chunhao, 2019
Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-kappa B Ligand (RANKL)-Receptor Activator of Nuclear Factor-kappa B (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization, Jiang, Min, Peng, Lei, Yang, Kai, Wang, Tianqi, Yan, Xueming, Jiang, Tao, Xu, Jianrong, Qi, Jin, Zhou, Hanbing, Qian, Niandong, Zhou, Qi, Chen, Bo, Xu, Xing, Deng, Lianfu, Yang, Chunhao, 2019
One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones, Yuan, Jiaqi, He, Qian, Song, Shanshan, Zhang, Xiaofei, Miao, Zehong, Yang, Chunhao, 2019
A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen-Dependent Bone Loss, Jiang, Min, Wang, Tianqi, Yan, Xueming, Liu, Zhuochao, Yan, Yufei, Yang, Kai, Qi, Jin, Zhou, Hanbing, Qian, Niandong, Zhou, Qi, Chen, Bo, Xu, Xing, Xi, Xiaobing, Yang, Chunhao, Deng, Lianfu, 2019
Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer, Wang Yuxiang, Li Xian, Liu Xueling, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding, Linghua Meng, 2019
Substituent-Oriented Synthesis of Substituted Pyrazoles/Chromeno3,2-cpyrazoles via Sequential Reactions of Chromones/3-Chlorochromones and Tosylhydrazones, Dai, Tianzi, Li, Qunyi, Zhang,

Antitumor Drugs Anti-Osteoporosis Bioactive Heterocycles Synthesis Methodology Chemistry Pharmaceutical Research

Lixia Miao - Wuhan University

Haibing Zhou - Wuhan University

Peng Liu - Wuhan University

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