Areas of Focus
- Discovery, structural modification, and new drug development of microbial active natural products
- Biosynthesis, regulation, and synthetic biology application of microbial secondary metabolites
Work Experience
- 2022-04 to Present - Chinese Academy of Sciences, Institute of Microbiology - Researcher
- 2016-10 to 2022-02 - University of Warwick - Postdoctoral Researcher
- 2008-07 to 2009-08 - Shenzhen Accord Pharmaceutical Co., Ltd. - QA
Academic Background & Achievements
- 2012-10 to 2016-09 PhD: University of Warwick
- 2009-09 to 2012-03 Master's: Shanghai Jiao Tong University
- 2004-09 to 2008-06 Bachelor's: China Pharmaceutical University
Publications
- Molecular basis for control of antibiotic production by a bacterial hormone, Zhou, Shanshan, Bhukya, Hussain, Malet, Nicolas, Harrison, Peter J, Rea, Dean, Belousoff, Matthew J, Venugopal, Hariprasad, Sydor, Paulina K, Styles, Kathryn M, Song, Lijiang, Cryle, Max J, Alkhalaf, Lona M, Fulop, Vilmos, Challis, Gregory L, Corre, Christophe, 2021
- MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis, Zhou, Shanshan, Malet, Nicolas R, Song, Lijiang, Corre, Christophe, Challis, Gregory L, 2020
- Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group, Zhou, Shanshan, Song, Lijiang, Masschelein, Joleen, Sumang, Felaine A M, Papa, Irene A, Zulaybar, Teofila O, Custodio, Aileen B, Zabala, Daniel, Alcantara, Edwin P, de los Santos, Emmanuel L C, Challis, Gregory L, 2019
- Structural basis for chain release from the enacyloxin polyketide synthase, Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R, Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L C, Manzi, Lucio, Sydorl, Paulina K, Rea, Dean, Zhou, Shanshan, Fulop, Vilmos, Oldham, Neil J, Tsai, ShiouChuan, Challis, Gregory L, Lewandowski, Jozef R, 2019
- Watasemycin biosynthesis in Streptomyces venezuelae: thiazoline C-methylation by a type B radical-SAM methylase homologue, Inahashi, Yuki, Zhou, Shanshan, Bibb, Maureen J, Song, Lijiang, AlBassam, Mahmoud M, Bibb, Mervyn J, Challis, Gregory L, 2017
- Mechanistic insights into class B radical-S-adenosylmethionine methylases: ubiquitous tailoring enzymes in natural product biosynthesis, Zhou, Shanshan, Alkhalaf, Lona M, de los Santos, Emmanuel L C, Challis, Gregory L, 2016
- Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents, Wang, Rubing, Zhang, Xu, Song, Hualong, Zhou, Shanshan, Li, Shaoshun, 2014
- Kinesin Spindle Protein (KSP) Inhibitors in Combination with Chemotherapeutic Agents for Cancer Therapy, Song, Hualong, Zhou, Shanshan, Wang, Rubing, Li, Shaoshun, 2013
- An Efficient Multigram Synthesis of Alkannin and Shikonin, Wang, Rubing, Zhou, Shanshan, Jiang, Hudagula, Zheng, Xiaogang, Zhou, Wen, Li, Shaoshun, 2012
- Cancer Therapeutic Agents Targeting Hypoxia-Inducible Factor-1, Wang, R, Zhou, S, Li, S, 2011
