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Yuhui Sun
Medical School
Wuhan University
Hubei
Language: Chinese, English
Biosynthesis
Synthetic Biology
Microbial
Natural Products
Drug Innovation
Bioactive Compounds
Molecular Genetics
Biochemistry
Pathway Analysis
Metabolic Engineering
Areas of Focus
- Microbial source natural product biosynthesis mechanisms and synthetic biology research
- Analysis and drug innovation of biosynthetic pathways of bioactive natural products from microbial sources
Work Experience
- 1992.7-1998.9 Research Intern, Biotechnology R&D Center, Jiangxi Agricultural University
- 1998.9-2002.10 Assistant Researcher, Biotechnology R&D Center, Jiangxi Agricultural University
- 2002.10-2006.11 Associate Professor, Department of Bioengineering, Jiangxi Agricultural University
- 2006.11-2009.11 Professor, School of Bioengineering and Technology, Jiangxi Agricultural University
- 2005.1-2010.5 Royal Society China Fellow, Senior Research Associate, Department of Biochemistry, University of Cambridge
- 2010.5-present Professor, School of Pharmaceutical Sciences, Wuhan University
Academic Background & Achievements
- 1988.9-1992.7 Bachelor in Plant Genetic Breeding, Jiangxi Agricultural University
- 1997.9-2001.3 Master in Biochemistry and Molecular Biology, Huazhong Agricultural University
- 2001.3-2004.3 PhD in Biochemistry and Molecular Biology, Shanghai Jiao Tong University
Publications
- Dissection of 3D chromosome organization in Streptomyces coelicolor A3(2) leads to biosynthetic gene cluster overexpression, Liang Deng, Zhihu Zhao, Lin Liu, Zhiyu Zhong, Wenxinyu Xie, Fan Zhou, Wei Xu, Yubo Zhang, Zixin Deng, Yuhui Sun, 2023
- Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition, Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F. Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun, 2023
- Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites, Houchao Xu, Anne Wochele, Minghe Luo, Gregor Schnakenburg, Yuhui Sun, Heike Brötz-Oesterhelt, Jeroen S. Dickschat, 2022
- Mechanistic insights into dideoxygenation in gentamicin biosynthesis, Sicong Li, Priscila Dos Santos Bury, Fanglu Huang, Junhong Guo, Guo Sun, Anna Reva, Chuan Huang, Xinyun Jian, Yuan Li, Jiahai Zhou, Zixin Deng, Finian J. Leeper, Peter F. Leadlay, Marcio V. B. Dias, Yuhui Sun, 2021
- The mechanism of dehydrating bimodules in trans-acyltransferase polyketide biosynthesis: A showcase study on hepatoprotective hangtaimycin, Minghe Luo, Houchao Xu, Yulu Dong, Kun Shen, Junlei Lu, Zhiyong Yin, Miaomiao Qi, Guo Sun, Lingjie Tang, Jin Xiang, Zixin Deng, Jeroen S. Dickschat, Yuhui Sun, 2021
- Improving the precision of base editing by bubble hairpin single guide RNA, Zhiwei Hu, Yannan Wang, Qian Liu, Yan Qiu, Zhiyu Zhong, Kangdi Li, Wenhua Li, Zixin Deng, Yuhui Sun, 2021
- A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species, Zikang Zhou, Hongzhi Tang, Weiwei Wang, Lige Zhang, Fei Su, Yuanting Wu, Linquan Bai, Sicong Li, Yuhui Sun, Fei Tao, Ping Xu, 2021
- Two new streptovaricin derivatives from mutants of Streptomyces spectabilis CCTCC M2017417, Minghe Luo, Yulu Dong, Lingjie Tang, Xu Chen, Zhiwei Hu, Wenxinyu Xie, Zixin Deng, Yuhui Sun, 2021
- Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis, Guo Sun, Chaoqun Hu, Qing Mei, Minghe Luo, Xu Chen, Zhengyuan Li, Yuanzhen Liu, Zixin Deng, Zhengyu Zhang, Yuhui Sun, 2020
- Cross-module enoylreduction in the azalomycin F polyketide synthase, Guifa Zhai, Wenyan Wang, Wei Xu, Guo Sun, Chaoqun Hu, Xiangming Wu, Zisong Cong, Liang Deng, Yanrong Shi, Peter F. Leadlay, Heng Song, Kui Hong, Zixin Deng, Yuhui Sun, 2020
Awards
- 2016 Hubei Province 16th Natural Science Excellent Academic Paper Second Prize
- 2014 Hubei Province 15th Natural Science Excellent Academic Paper First Prize
- 2014 Wuhan University Outstanding Candle Navigation Teacher
- 2014 Sixth Wuhan University Zhu Yubi Medical Prize
- 2008 National Natural Science Second Prize
- 2007 Jiangxi Provincial University Science and Technology Achievement First Prize
- 2006 Jiangxi Provincial Natural Science Second Prize
- 2006 National Excellent Doctoral Dissertation Nomination Award
- 2006 Shanghai Graduate Excellent Achievement (Dissertation) Award
- 2004 Shanghai Science and Technology Progress First Prize
