Professor | Yuhui Sun | Asia Growth Partners

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Name	Yuhui Sun
Contact Information	yhsun@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Yuhui Sun

Contact Information

yhsun@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	1988.9-1992.7 Bachelor in Plant Genetic Breeding, Jiangxi Agricultural University 1997.9-2001.3 Master in Biochemistry and Molecular Biology, Huazhong Agricultural University 2001.3-2004.3 PhD in Biochemistry and Molecular Biology, Shanghai Jiao Tong University
Work Experience	1992.7-1998.9 Research Intern, Biotechnology R&D Center, Jiangxi Agricultural University 1998.9-2002.10 Assistant Researcher, Biotechnology R&D Center, Jiangxi Agricultural University 2002.10-2006.11 Associate Professor, Department of Bioengineering, Jiangxi Agricultural University 2006.11-2009.11 Professor, School of Bioengineering and Technology, Jiangxi Agricultural University 2005.1-2010.5 Royal Society China Fellow, Senior Research Associate, Department of Biochemistry, University of Cambridge 2010.5-present Professor, School of Pharmaceutical Sciences, Wuhan University
Awards	2016 Hubei Province 16th Natural Science Excellent Academic Paper Second Prize 2014 Hubei Province 15th Natural Science Excellent Academic Paper First Prize 2014 Wuhan University Outstanding Candle Navigation Teacher 2014 Sixth Wuhan University Zhu Yubi Medical Prize 2008 National Natural Science Second Prize 2007 Jiangxi Provincial University Science and Technology Achievement First Prize 2006 Jiangxi Provincial Natural Science Second Prize 2006 National Excellent Doctoral Dissertation Nomination Award 2006 Shanghai Graduate Excellent Achievement (Dissertation) Award 2004 Shanghai Science and Technology Progress First Prize

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

1988.9-1992.7 Bachelor in Plant Genetic Breeding, Jiangxi Agricultural University
1997.9-2001.3 Master in Biochemistry and Molecular Biology, Huazhong Agricultural University
2001.3-2004.3 PhD in Biochemistry and Molecular Biology, Shanghai Jiao Tong University

Work Experience

1992.7-1998.9 Research Intern, Biotechnology R&D Center, Jiangxi Agricultural University
1998.9-2002.10 Assistant Researcher, Biotechnology R&D Center, Jiangxi Agricultural University
2002.10-2006.11 Associate Professor, Department of Bioengineering, Jiangxi Agricultural University
2006.11-2009.11 Professor, School of Bioengineering and Technology, Jiangxi Agricultural University
2005.1-2010.5 Royal Society China Fellow, Senior Research Associate, Department of Biochemistry, University of Cambridge
2010.5-present Professor, School of Pharmaceutical Sciences, Wuhan University

Awards

2016 Hubei Province 16th Natural Science Excellent Academic Paper Second Prize
2014 Hubei Province 15th Natural Science Excellent Academic Paper First Prize
2014 Wuhan University Outstanding Candle Navigation Teacher
2014 Sixth Wuhan University Zhu Yubi Medical Prize
2008 National Natural Science Second Prize
2007 Jiangxi Provincial University Science and Technology Achievement First Prize
2006 Jiangxi Provincial Natural Science Second Prize
2006 National Excellent Doctoral Dissertation Nomination Award
2006 Shanghai Graduate Excellent Achievement (Dissertation) Award
2004 Shanghai Science and Technology Progress First Prize

Areas of Focus	Microbial source natural product biosynthesis mechanisms and synthetic biology research Analysis and drug innovation of biosynthetic pathways of bioactive natural products from microbial sources
Publications	Dissection of 3D chromosome organization in Streptomyces coelicolor A3(2) leads to biosynthetic gene cluster overexpression, Liang Deng, Zhihu Zhao, Lin Liu, Zhiyu Zhong, Wenxinyu Xie, Fan Zhou, Wei Xu, Yubo Zhang, Zixin Deng, Yuhui Sun, 2023 Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition, Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F. Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun, 2023 Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites, Houchao Xu, Anne Wochele, Minghe Luo, Gregor Schnakenburg, Yuhui Sun, Heike Brötz-Oesterhelt, Jeroen S. Dickschat, 2022 Mechanistic insights into dideoxygenation in gentamicin biosynthesis, Sicong Li, Priscila Dos Santos Bury, Fanglu Huang, Junhong Guo, Guo Sun, Anna Reva, Chuan Huang, Xinyun Jian, Yuan Li, Jiahai Zhou, Zixin Deng, Finian J. Leeper, Peter F. Leadlay, Marcio V. B. Dias, Yuhui Sun, 2021 The mechanism of dehydrating bimodules in trans-acyltransferase polyketide biosynthesis: A showcase study on hepatoprotective hangtaimycin, Minghe Luo, Houchao Xu, Yulu Dong, Kun Shen, Junlei Lu, Zhiyong Yin, Miaomiao Qi, Guo Sun, Lingjie Tang, Jin Xiang, Zixin Deng, Jeroen S. Dickschat, Yuhui Sun, 2021 Improving the precision of base editing by bubble hairpin single guide RNA, Zhiwei Hu, Yannan Wang, Qian Liu, Yan Qiu, Zhiyu Zhong, Kangdi Li, Wenhua Li, Zixin Deng, Yuhui Sun, 2021 A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species, Zikang Zhou, Hongzhi Tang, Weiwei Wang, Lige Zhang, Fei Su, Yuanting Wu, Linquan Bai, Sicong Li, Yuhui Sun, Fei Tao, Ping Xu, 2021 Two new streptovaricin derivatives from mutants of Streptomyces spectabilis CCTCC M2017417, Minghe Luo, Yulu Dong, Lingjie Tang, Xu Chen, Zhiwei Hu, Wenxinyu Xie, Zixin Deng, Yuhui Sun, 2021 Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis, Guo Sun, Chaoqun Hu, Qing Mei, Minghe Luo, Xu Chen, Zhengyuan Li, Yuanzhen Liu, Zixin Deng, Zhengyu Zhang, Yuhui Sun, 2020 Cross-module enoylreduction in the azalomycin F polyketide synthase, Guifa Zhai, Wenyan Wang, Wei Xu, Guo Sun, Chaoqun Hu, Xiangming Wu, Zisong Cong, Liang Deng, Yanrong Shi, Peter F. Leadlay, Heng Song, Kui Hong, Zixin Deng, Yuhui Sun, 2020

Areas of Focus

Microbial source natural product biosynthesis mechanisms and synthetic biology research
Analysis and drug innovation of biosynthetic pathways of bioactive natural products from microbial sources

Publications

Dissection of 3D chromosome organization in Streptomyces coelicolor A3(2) leads to biosynthetic gene cluster overexpression, Liang Deng, Zhihu Zhao, Lin Liu, Zhiyu Zhong, Wenxinyu Xie, Fan Zhou, Wei Xu, Yubo Zhang, Zixin Deng, Yuhui Sun, 2023
Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition, Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F. Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun, 2023
Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites, Houchao Xu, Anne Wochele, Minghe Luo, Gregor Schnakenburg, Yuhui Sun, Heike Brötz-Oesterhelt, Jeroen S. Dickschat, 2022
Mechanistic insights into dideoxygenation in gentamicin biosynthesis, Sicong Li, Priscila Dos Santos Bury, Fanglu Huang, Junhong Guo, Guo Sun, Anna Reva, Chuan Huang, Xinyun Jian, Yuan Li, Jiahai Zhou, Zixin Deng, Finian J. Leeper, Peter F. Leadlay, Marcio V. B. Dias, Yuhui Sun, 2021
The mechanism of dehydrating bimodules in trans-acyltransferase polyketide biosynthesis: A showcase study on hepatoprotective hangtaimycin, Minghe Luo, Houchao Xu, Yulu Dong, Kun Shen, Junlei Lu, Zhiyong Yin, Miaomiao Qi, Guo Sun, Lingjie Tang, Jin Xiang, Zixin Deng, Jeroen S. Dickschat, Yuhui Sun, 2021
Improving the precision of base editing by bubble hairpin single guide RNA, Zhiwei Hu, Yannan Wang, Qian Liu, Yan Qiu, Zhiyu Zhong, Kangdi Li, Wenhua Li, Zixin Deng, Yuhui Sun, 2021
A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species, Zikang Zhou, Hongzhi Tang, Weiwei Wang, Lige Zhang, Fei Su, Yuanting Wu, Linquan Bai, Sicong Li, Yuhui Sun, Fei Tao, Ping Xu, 2021
Two new streptovaricin derivatives from mutants of Streptomyces spectabilis CCTCC M2017417, Minghe Luo, Yulu Dong, Lingjie Tang, Xu Chen, Zhiwei Hu, Wenxinyu Xie, Zixin Deng, Yuhui Sun, 2021
Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis, Guo Sun, Chaoqun Hu, Qing Mei, Minghe Luo, Xu Chen, Zhengyuan Li, Yuanzhen Liu, Zixin Deng, Zhengyu Zhang, Yuhui Sun, 2020
Cross-module enoylreduction in the azalomycin F polyketide synthase, Guifa Zhai, Wenyan Wang, Wei Xu, Guo Sun, Chaoqun Hu, Xiangming Wu, Zisong Cong, Liang Deng, Yanrong Shi, Peter F. Leadlay, Heng Song, Kui Hong, Zixin Deng, Yuhui Sun, 2020

Biosynthesis Synthetic Biology Microbial Natural Products Drug Innovation Bioactive Compounds Molecular Genetics Biochemistry Pathway Analysis Metabolic Engineering

Changming Zhao - Wuhan University

Xianghai Cai - University of Chinese Academy of Sciences

Duozhi Chen - University of Chinese Academy of Sciences

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