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Changming Zhao
Medical School
Wuhan University
Hubei
Language: Chinese, English
Biosynthesis
Enzymology
Natural Products
Small Molecules
Anti-Aging
Anti-Tumor
Anti-Infection
Synthetic Biology
Mechanisms Of Action
Bioactive Compounds
Areas of Focus
- Natural product biosynthesis
- Synthetic biology
- Mechanisms of action in anti-infection, anti-tumor, and anti-aging natural products
Work Experience
- 2020.12---now, Wuhan University, School of Pharmaceutical Sciences, Professor
- 2012.1---2020.11, Wuhan University, School of Pharmaceutical Sciences, Associate Professor
Academic Background & Achievements
- 2001.9---2007.12, PhD: Huazhong Agricultural University, College of Life Science and Technology
- 1997.9---2001.7, Bachelor: Huazhong Agricultural University, College of Life Science and Technology
- Visiting Scholar at Boston University, Chemistry Department
Publications
- Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023
- Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation, Chen L, Zhang LS, Ye C, Zhou H, Liu B, Gao B, Deng Z, Zhao C, He C, Dickinson BC, 2023
- Nitrogen-Nitrogen bond formation reactions involved in natural product biosynthesis, Chen L, Deng Z, Zhao C, 2021
- Biochemical characterization of a multifunctional mononuclear nonheme iron enzyme (PtlD) in neopentalenoketolactone biosynthesis, Deng Q, Liu Y, Chen L, Xu M, Naowarojna N, Lee N, Chen L, Zhu D, Hong X, Deng Z, Liu P, Zhao C, 2019
- Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production, Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C, 2019
- Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019
- Mini-Review: Ergothioneine and ovothiol biosyntheses, an unprecedented trans-sulfur strategy in natural product biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018
- Use of a tyrosine analogue to modulate the two activities of a nonheme iron enzyme OvoA in ovothiol biosynthesis, cysteine oxidation versus oxidative C-S bond formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018
- Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers, Deng Q, Zhou L, Luo M, Deng Z, Zhao C, 2017
- Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins, Li M, Chen L, Deng Z, Zhao C, 2016
- Ornithine transcarbamylase ArgK plays a dual role for the self-defense of phaseolotoxin producing Pseudomonas syringae pv.phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015
- Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent “iterative strategy” underlying the pyrrole polymerization, Hao C, Huang S, Deng Z, Zhao C, Yu Y, 2014
- Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection, Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW, 2013
- Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster, Zhao C, Huang T, Chen W, Deng Z, 2010
- L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Song C, Yu Z, Sun M, 2008
- N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A producing strain Bacillus cereus, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2008
- Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M
