Professor | Changming Zhao | Asia Growth Partners

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Name	Changming Zhao
Contact Information	cmzhao03@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Changming Zhao

Contact Information

cmzhao03@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2001.9---2007.12, PhD: Huazhong Agricultural University, College of Life Science and Technology 1997.9---2001.7, Bachelor: Huazhong Agricultural University, College of Life Science and Technology Visiting Scholar at Boston University, Chemistry Department
Work Experience	2020.12---now, Wuhan University, School of Pharmaceutical Sciences, Professor 2012.1---2020.11, Wuhan University, School of Pharmaceutical Sciences, Associate Professor

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2001.9---2007.12, PhD: Huazhong Agricultural University, College of Life Science and Technology
1997.9---2001.7, Bachelor: Huazhong Agricultural University, College of Life Science and Technology
Visiting Scholar at Boston University, Chemistry Department

Work Experience

2020.12---now, Wuhan University, School of Pharmaceutical Sciences, Professor
2012.1---2020.11, Wuhan University, School of Pharmaceutical Sciences, Associate Professor

Areas of Focus	Natural product biosynthesis Synthetic biology Mechanisms of action in anti-infection, anti-tumor, and anti-aging natural products
Publications	Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023 Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation, Chen L, Zhang LS, Ye C, Zhou H, Liu B, Gao B, Deng Z, Zhao C, He C, Dickinson BC, 2023 Nitrogen-Nitrogen bond formation reactions involved in natural product biosynthesis, Chen L, Deng Z, Zhao C, 2021 Biochemical characterization of a multifunctional mononuclear nonheme iron enzyme (PtlD) in neopentalenoketolactone biosynthesis, Deng Q, Liu Y, Chen L, Xu M, Naowarojna N, Lee N, Chen L, Zhu D, Hong X, Deng Z, Liu P, Zhao C, 2019 Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production, Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C, 2019 Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019 Mini-Review: Ergothioneine and ovothiol biosyntheses, an unprecedented trans-sulfur strategy in natural product biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018 Use of a tyrosine analogue to modulate the two activities of a nonheme iron enzyme OvoA in ovothiol biosynthesis, cysteine oxidation versus oxidative C-S bond formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018 Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers, Deng Q, Zhou L, Luo M, Deng Z, Zhao C, 2017 Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins, Li M, Chen L, Deng Z, Zhao C, 2016 Ornithine transcarbamylase ArgK plays a dual role for the self-defense of phaseolotoxin producing Pseudomonas syringae pv.phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015 Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent “iterative strategy” underlying the pyrrole polymerization, Hao C, Huang S, Deng Z, Zhao C, Yu Y, 2014 Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection, Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW, 2013 Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster, Zhao C, Huang T, Chen W, Deng Z, 2010 L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Song C, Yu Z, Sun M, 2008 N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A producing strain Bacillus cereus, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2008 Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M

Areas of Focus

Natural product biosynthesis
Synthetic biology
Mechanisms of action in anti-infection, anti-tumor, and anti-aging natural products

Publications

Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023
Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation, Chen L, Zhang LS, Ye C, Zhou H, Liu B, Gao B, Deng Z, Zhao C, He C, Dickinson BC, 2023
Nitrogen-Nitrogen bond formation reactions involved in natural product biosynthesis, Chen L, Deng Z, Zhao C, 2021
Biochemical characterization of a multifunctional mononuclear nonheme iron enzyme (PtlD) in neopentalenoketolactone biosynthesis, Deng Q, Liu Y, Chen L, Xu M, Naowarojna N, Lee N, Chen L, Zhu D, Hong X, Deng Z, Liu P, Zhao C, 2019
Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production, Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C, 2019
Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019
Mini-Review: Ergothioneine and ovothiol biosyntheses, an unprecedented trans-sulfur strategy in natural product biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018
Use of a tyrosine analogue to modulate the two activities of a nonheme iron enzyme OvoA in ovothiol biosynthesis, cysteine oxidation versus oxidative C-S bond formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018
Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers, Deng Q, Zhou L, Luo M, Deng Z, Zhao C, 2017
Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins, Li M, Chen L, Deng Z, Zhao C, 2016
Ornithine transcarbamylase ArgK plays a dual role for the self-defense of phaseolotoxin producing Pseudomonas syringae pv.phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015
Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent “iterative strategy” underlying the pyrrole polymerization, Hao C, Huang S, Deng Z, Zhao C, Yu Y, 2014
Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection, Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW, 2013
Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster, Zhao C, Huang T, Chen W, Deng Z, 2010
L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Song C, Yu Z, Sun M, 2008
N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A producing strain Bacillus cereus, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2008
Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M

Biosynthesis Enzymology Natural Products Small Molecules Anti-Aging Anti-Tumor Anti-Infection Synthetic Biology Mechanisms Of Action Bioactive Compounds

Bin Guo - University of Chinese Academy of Sciences

Kui Hong - Wuhan University

You-Sheng Cai - Wuhan University

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