Areas of Focus
- Anti-infection drug development
- Antitumor drug development
- Antithrombotic drug development
Work Experience
- 2021-10~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2014-10~2021-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
- 2012-07~2014-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
- 2024-01-01~Present - Nanjing University of Chinese Medicine - Master's Supervisor
Academic Background & Achievements
- 2007-09--2012-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2003-09--2007-06 Bachelor's Degree: Wuhan University
Publications
- Efficient Kilogram-Scale Synthesis of a Novel Oxazolidinone Antibacterial Candidate YG-056SP, 5th Author, 2023
- Improved Synthesis of Key Intermediate of Baloxavir Marboxil, an Anti-Influenza Drug, 4th Author, 2022
- Discovery of Thieno2,3-eindazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability, 5th Author, 2022
- Design, Synthesis, and Biological Evaluation of Novel Pyrimido4,5-bindole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens, 5th Author, 2021
- Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent, 6th Author, 2021
- Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria, 7th Author, 2019
- Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, 1st Author, 2019
- Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria, 6th Author, 2019
- Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzob1,4dioxine, 4th Author, 2019
- Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, 1st Author, 2018
- Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, 2nd Author, 2016
- Synthesis and structure-activity relationship studies of novel 6,6,5 tricyclic oxazolidinone derivatives as potential antibacterial agents, 3rd Author, 2015
- Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel 6,6,5 Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor, 3rd Author, 2014
- Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents, 1st Author, 2013
- Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxazinyl-oxazolidinones Leading to a Promising Antibacterial Agent, 1st Author, 2013
- Design, Synthesis, and Structure-Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterial Agents, 3rd Author, 2011
