Professor | Bin Guo | Asia Growth Partners

Name	Bin Guo
Contact Information	guobin@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Bin Guo

Contact Information

guobin@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2007-09--2012-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 2003-09--2007-06 Bachelor's Degree: Wuhan University
Work Experience	2021-10~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher 2014-10~2021-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher 2012-07~2014-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher 2024-01-01~Present - Nanjing University of Chinese Medicine - Master's Supervisor

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2007-09--2012-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2003-09--2007-06 Bachelor's Degree: Wuhan University

Work Experience

2021-10~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
2014-10~2021-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
2012-07~2014-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
2024-01-01~Present - Nanjing University of Chinese Medicine - Master's Supervisor

Areas of Focus	Anti-infection drug development Antitumor drug development Antithrombotic drug development
Publications	Efficient Kilogram-Scale Synthesis of a Novel Oxazolidinone Antibacterial Candidate YG-056SP, 5th Author, 2023 Improved Synthesis of Key Intermediate of Baloxavir Marboxil, an Anti-Influenza Drug, 4th Author, 2022 Discovery of Thieno2,3-eindazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability, 5th Author, 2022 Design, Synthesis, and Biological Evaluation of Novel Pyrimido4,5-bindole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens, 5th Author, 2021 Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent, 6th Author, 2021 Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria, 7th Author, 2019 Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, 1st Author, 2019 Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria, 6th Author, 2019 Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzob1,4dioxine, 4th Author, 2019 Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, 1st Author, 2018 Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, 2nd Author, 2016 Synthesis and structure-activity relationship studies of novel 6,6,5 tricyclic oxazolidinone derivatives as potential antibacterial agents, 3rd Author, 2015 Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel 6,6,5 Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor, 3rd Author, 2014 Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents, 1st Author, 2013 Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxazinyl-oxazolidinones Leading to a Promising Antibacterial Agent, 1st Author, 2013 Design, Synthesis, and Structure-Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterial Agents, 3rd Author, 2011

Areas of Focus

Anti-infection drug development
Antitumor drug development
Antithrombotic drug development

Publications

Efficient Kilogram-Scale Synthesis of a Novel Oxazolidinone Antibacterial Candidate YG-056SP, 5th Author, 2023
Improved Synthesis of Key Intermediate of Baloxavir Marboxil, an Anti-Influenza Drug, 4th Author, 2022
Discovery of Thieno2,3-eindazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability, 5th Author, 2022
Design, Synthesis, and Biological Evaluation of Novel Pyrimido4,5-bindole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens, 5th Author, 2021
Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent, 6th Author, 2021
Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria, 7th Author, 2019
Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, 1st Author, 2019
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria, 6th Author, 2019
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzob1,4dioxine, 4th Author, 2019
Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, 1st Author, 2018
Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, 2nd Author, 2016
Synthesis and structure-activity relationship studies of novel 6,6,5 tricyclic oxazolidinone derivatives as potential antibacterial agents, 3rd Author, 2015
Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel 6,6,5 Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor, 3rd Author, 2014
Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents, 1st Author, 2013
Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxazinyl-oxazolidinones Leading to a Promising Antibacterial Agent, 1st Author, 2013
Design, Synthesis, and Structure-Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterial Agents, 3rd Author, 2011

Anti-Infection Antitumor Antithrombotic Drug Development Small Molecules Innovative Drugs Research Pharmaceuticals Medicinal Chemistry Clinical Research

Yang Fu - Southern University of Science and Technology

Changming Zhao - Wuhan University

Xuebing Li - University of Chinese Academy of Sciences

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