Professor | 郭彬 | 数字化转型顾问

Name	郭彬
Contact Information	guobin@simm.ac.cn
Language ability	中文, 英语
Province	上海

Name

郭彬

Contact Information

guobin@simm.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2007-09--2012-06 博士学位: 中国科学院上海药物研究所 2003-09--2007-06 学士学位: 武汉大学
Work Experience	2021-10~现在 - 中国科学院上海药物研究所 - 研究员 2014-10~2021-09 - 中国科学院上海药物研究所 - 副研究员 2012-07~2014-09 - 中国科学院上海药物研究所 - 助理研究员 2024-01-01~今 - 南京中医药大学 - 硕士生导师

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2007-09--2012-06 博士学位: 中国科学院上海药物研究所
2003-09--2007-06 学士学位: 武汉大学

Work Experience

2021-10~现在 - 中国科学院上海药物研究所 - 研究员
2014-10~2021-09 - 中国科学院上海药物研究所 - 副研究员
2012-07~2014-09 - 中国科学院上海药物研究所 - 助理研究员
2024-01-01~今 - 南京中医药大学 - 硕士生导师

Areas of Focus	抗感染药物研发抗肿瘤药物研发抗血栓药物研发
Publications	Efficient Kilogram-Scale Synthesis of a Novel Oxazolidinone Antibacterial Candidate YG-056SP, 第5作者, 2023 Improved Synthesis of Key Intermediate of Baloxavir Marboxil, an Anti-Influenza Drug, 第4作者, 2022 Discovery of Thieno2,3-eindazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability, 第5作者, 2022 Design, Synthesis, and Biological Evaluation of Novel Pyrimido4,5-bindole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens, 第5作者, 2021 Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent, 第6作者, 2021 Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria, 第7作者, 2019 Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, 第1作者, 2019 Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria, 第6作者, 2019 Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzob1,4dioxine, 第4作者, 2019 Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, 第1作者, 2018 Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, 第2作者, 2016 Synthesis and structure-activity relationship studies of novel 6,6,5 tricyclic oxazolidinone derivatives as potential antibacterial agents, 第3作者, 2015 Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel 6,6,5 Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor, 第3作者, 2014 Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents, 第1作者, 2013 Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxazinyl-oxazolidinones Leading to a Promising Antibacterial Agent, 第1作者, 2013 Design, Synthesis, and Structure-Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterial Agents, 第3作者, 2011

Areas of Focus

抗感染药物研发
抗肿瘤药物研发
抗血栓药物研发

Publications

Efficient Kilogram-Scale Synthesis of a Novel Oxazolidinone Antibacterial Candidate YG-056SP, 第5作者, 2023
Improved Synthesis of Key Intermediate of Baloxavir Marboxil, an Anti-Influenza Drug, 第4作者, 2022
Discovery of Thieno2,3-eindazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability, 第5作者, 2022
Design, Synthesis, and Biological Evaluation of Novel Pyrimido4,5-bindole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens, 第5作者, 2021
Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent, 第6作者, 2021
Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria, 第7作者, 2019
Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, 第1作者, 2019
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria, 第6作者, 2019
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzob1,4dioxine, 第4作者, 2019
Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, 第1作者, 2018
Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, 第2作者, 2016
Synthesis and structure-activity relationship studies of novel 6,6,5 tricyclic oxazolidinone derivatives as potential antibacterial agents, 第3作者, 2015
Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel 6,6,5 Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor, 第3作者, 2014
Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents, 第1作者, 2013
Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxazinyl-oxazolidinones Leading to a Promising Antibacterial Agent, 第1作者, 2013
Design, Synthesis, and Structure-Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterial Agents, 第3作者, 2011

抗感染抗肿瘤抗血栓药物研发小分子创新药物研究药品药物化学临床研究

朱尤庆 - 武汉大学

Area of Focus
癌症 | 肿瘤 | 胃肠 | 消化系统 | 粘膜 | 免疫 | 研究 | 临床研究 | 肿瘤学 | 免疫学

尹君 - 武汉大学

王媛 - 武汉大学

Area of Focus
消化道 | 肿瘤 | 微Rna | 机制 | 研究 | 临床研究 | 生理学 | 肿瘤学 | 分子生物学 | 基因调控

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