Areas of Focus
- 抗感染药物研发
- 抗肿瘤药物研发
- 抗血栓药物研发
Work Experience
- 2021-10~现在 - 中国科学院上海药物研究所 - 研究员
- 2014-10~2021-09 - 中国科学院上海药物研究所 - 副研究员
- 2012-07~2014-09 - 中国科学院上海药物研究所 - 助理研究员
- 2024-01-01~今 - 南京中医药大学 - 硕士生导师
Academic Background & Achievements
- 2007-09--2012-06 博士学位: 中国科学院上海药物研究所
- 2003-09--2007-06 学士学位: 武汉大学
Publications
- Efficient Kilogram-Scale Synthesis of a Novel Oxazolidinone Antibacterial Candidate YG-056SP, 第5作者, 2023
- Improved Synthesis of Key Intermediate of Baloxavir Marboxil, an Anti-Influenza Drug, 第4作者, 2022
- Discovery of Thieno2,3-eindazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability, 第5作者, 2022
- Design, Synthesis, and Biological Evaluation of Novel Pyrimido4,5-bindole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens, 第5作者, 2021
- Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent, 第6作者, 2021
- Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria, 第7作者, 2019
- Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, 第1作者, 2019
- Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria, 第6作者, 2019
- Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzob1,4dioxine, 第4作者, 2019
- Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, 第1作者, 2018
- Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, 第2作者, 2016
- Synthesis and structure-activity relationship studies of novel 6,6,5 tricyclic oxazolidinone derivatives as potential antibacterial agents, 第3作者, 2015
- Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel 6,6,5 Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor, 第3作者, 2014
- Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents, 第1作者, 2013
- Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxazinyl-oxazolidinones Leading to a Promising Antibacterial Agent, 第1作者, 2013
- Design, Synthesis, and Structure-Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterial Agents, 第3作者, 2011
