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赵昌明
Medical School
武汉大学
湖北省
Language: 中文, 英语
生物合成
酶学
天然产物
小分子
抗衰老
抗肿瘤
抗感染
合成生物学
作用机制
生物活性化合物
Areas of Focus
- 天然产物生物合成
- 合成生物学
- 抗感染、抗肿瘤、抗衰老天然产物的作用机制
Work Experience
- 2020.12---现在, 武汉大学药学院, 教授
- 2012.1---2020.11, 武汉大学药学院, 副教授
Academic Background & Achievements
- 2001.9---2007.12, 博士: 华中农业大学，生命科学技术学院
- 1997.9---2001.7, 本科: 华中农业大学，生命科学技术学院
- 波士顿大学，化学系，访问学者
Publications
- Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023
- Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation, Chen L, Zhang LS, Ye C, Zhou H, Liu B, Gao B, Deng Z, Zhao C, He C, Dickinson BC, 2023
- Nitrogen-Nitrogen bond formation reactions involved in natural product biosynthesis, Chen L, Deng Z, Zhao C, 2021
- Biochemical characterization of a multifunctional mononuclear nonheme iron enzyme (PtlD) in neopentalenoketolactone biosynthesis, Deng Q, Liu Y, Chen L, Xu M, Naowarojna N, Lee N, Chen L, Zhu D, Hong X, Deng Z, Liu P, Zhao C, 2019
- Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production, Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C, 2019
- Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019
- Mini-Review: Ergothioneine and ovothiol biosyntheses, an unprecedented trans-sulfur strategy in natural product biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018
- Use of a tyrosine analogue to modulate the two activities of a nonheme iron enzyme OvoA in ovothiol biosynthesis, cysteine oxidation versus oxidative C-S bond formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018
- Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers, Deng Q, Zhou L, Luo M, Deng Z, Zhao C, 2017
- Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins, Li M, Chen L, Deng Z, Zhao C, 2016
- Ornithine transcarbamylase ArgK plays a dual role for the self-defense of phaseolotoxin producing Pseudomonas syringae pv.phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015
- Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent “iterative strategy” underlying the pyrrole polymerization, Hao C, Huang S, Deng Z, Zhao C, Yu Y, 2014
- Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection, Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW, 2013
- Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster, Zhao C, Huang T, Chen W, Deng Z, 2010
- L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Song C, Yu Z, Sun M, 2008
- N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A producing strain Bacillus cereus, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2008
- Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2007
