Professor | 赵昌明 | 数字化转型顾问

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Name	赵昌明
Contact Information	cmzhao03@whu.edu.cn
Language ability	中文, 英语
Province	湖北省

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Name

赵昌明

Contact Information

cmzhao03@whu.edu.cn

Language ability

中文, 英语

Province

湖北省

University/Lab Affiliation and Title	武汉大学
Faculty	Medical School
Academic Background & Achievements	2001.9---2007.12, 博士: 华中农业大学，生命科学技术学院 1997.9---2001.7, 本科: 华中农业大学，生命科学技术学院波士顿大学，化学系，访问学者
Work Experience	2020.12---现在, 武汉大学药学院, 教授 2012.1---2020.11, 武汉大学药学院, 副教授

University/Lab Affiliation and Title

武汉大学

Faculty

Medical School

Academic Background & Achievements

2001.9---2007.12, 博士: 华中农业大学，生命科学技术学院
1997.9---2001.7, 本科: 华中农业大学，生命科学技术学院
波士顿大学，化学系，访问学者

Work Experience

2020.12---现在, 武汉大学药学院, 教授
2012.1---2020.11, 武汉大学药学院, 副教授

Areas of Focus	天然产物生物合成合成生物学抗感染、抗肿瘤、抗衰老天然产物的作用机制
Publications	Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023 Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation, Chen L, Zhang LS, Ye C, Zhou H, Liu B, Gao B, Deng Z, Zhao C, He C, Dickinson BC, 2023 Nitrogen-Nitrogen bond formation reactions involved in natural product biosynthesis, Chen L, Deng Z, Zhao C, 2021 Biochemical characterization of a multifunctional mononuclear nonheme iron enzyme (PtlD) in neopentalenoketolactone biosynthesis, Deng Q, Liu Y, Chen L, Xu M, Naowarojna N, Lee N, Chen L, Zhu D, Hong X, Deng Z, Liu P, Zhao C, 2019 Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production, Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C, 2019 Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019 Mini-Review: Ergothioneine and ovothiol biosyntheses, an unprecedented trans-sulfur strategy in natural product biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018 Use of a tyrosine analogue to modulate the two activities of a nonheme iron enzyme OvoA in ovothiol biosynthesis, cysteine oxidation versus oxidative C-S bond formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018 Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers, Deng Q, Zhou L, Luo M, Deng Z, Zhao C, 2017 Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins, Li M, Chen L, Deng Z, Zhao C, 2016 Ornithine transcarbamylase ArgK plays a dual role for the self-defense of phaseolotoxin producing Pseudomonas syringae pv.phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015 Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent “iterative strategy” underlying the pyrrole polymerization, Hao C, Huang S, Deng Z, Zhao C, Yu Y, 2014 Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection, Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW, 2013 Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster, Zhao C, Huang T, Chen W, Deng Z, 2010 L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Song C, Yu Z, Sun M, 2008 N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A producing strain Bacillus cereus, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2008 Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2007

Areas of Focus

天然产物生物合成
合成生物学
抗感染、抗肿瘤、抗衰老天然产物的作用机制

Publications

Ergothioneine and its congeners: Anti-ageing mechanisms and pharmacophore biosynthesis, Chen L, Zhang L, Ye X, Deng Z, Zhao C, 2023
Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation, Chen L, Zhang LS, Ye C, Zhou H, Liu B, Gao B, Deng Z, Zhao C, He C, Dickinson BC, 2023
Nitrogen-Nitrogen bond formation reactions involved in natural product biosynthesis, Chen L, Deng Z, Zhao C, 2021
Biochemical characterization of a multifunctional mononuclear nonheme iron enzyme (PtlD) in neopentalenoketolactone biosynthesis, Deng Q, Liu Y, Chen L, Xu M, Naowarojna N, Lee N, Chen L, Zhu D, Hong X, Deng Z, Liu P, Zhao C, 2019
Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production, Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C, 2019
Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr), Chen L, Naowarojna N, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C, Liu P, 2019
Mini-Review: Ergothioneine and ovothiol biosyntheses, an unprecedented trans-sulfur strategy in natural product biosynthesis, Naowarojna N, Cheng R, Chen L, Quill M, Xu M, Zhao C, Liu P, 2018
Use of a tyrosine analogue to modulate the two activities of a nonheme iron enzyme OvoA in ovothiol biosynthesis, cysteine oxidation versus oxidative C-S bond formation, Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P, 2018
Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers, Deng Q, Zhou L, Luo M, Deng Z, Zhao C, 2017
Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins, Li M, Chen L, Deng Z, Zhao C, 2016
Ornithine transcarbamylase ArgK plays a dual role for the self-defense of phaseolotoxin producing Pseudomonas syringae pv.phaseolicola, Chen L, Li P, Deng Z, Zhao C, 2015
Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent “iterative strategy” underlying the pyrrole polymerization, Hao C, Huang S, Deng Z, Zhao C, Yu Y, 2014
Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection, Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW, 2013
Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster, Zhao C, Huang T, Chen W, Deng Z, 2010
L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Song C, Yu Z, Sun M, 2008
N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A producing strain Bacillus cereus, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2008
Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520, Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M, 2007

生物合成酶学天然产物小分子抗衰老抗肿瘤抗感染合成生物学作用机制生物活性化合物

洪葵 - 武汉大学

耿长安 - 中国科学院大学

郭明全 - 中国科学院大学

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