Professor | Kui Hong | Asia Growth Partners

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Name	Kui Hong
Contact Information	kuihong31@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Kui Hong

Contact Information

kuihong31@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	1984.9-1988.7 Bachelor's Degree in Microbiology from Wuhan University 1988.9-1991.7 Master's Degree in Tropical Crop Product Fermentation from South China Tropical Crop College 1995.9-1998.7 PhD in Microbiology from Nanjing Agricultural University (Tsinghua University) Visiting Scholar at Heriot Watt University and Newcastle University, UK under the Royal Society KC-WONG China Fellowship
Work Experience	2010.12-present Professor at School of Pharmaceutical Sciences, Wuhan University 2006.9-2010.12 Professor at Tropical Biotechnology Research Institute, Chinese Academy of Tropical Agricultural Sciences 2002.5-2006.9 Professor at State Key Laboratory of Tropical Crop Biotechnology, Chinese Academy of Tropical Agricultural Sciences and South China Tropical Agricultural University 2000.4-2002.4 Associate Professor at College of Environment and Plant Protection, South China Tropical Agricultural University 1999.9-2000.4 Deputy Director and Associate Professor at Scientific Research Office, Chinese Academy of Tropical Agricultural Sciences and South China Tropical Agricultural University 1991.7-1999.9 Assistant, Lecturer, and Associate Professor at Processing Department of South China Tropical Crop College (Engineering College of South China Tropical Agricultural University)
Awards	2020 Advanced Female Faculty Member at Wuhan University 2019 Wuhan 'Optics Valley 3551 Talent' 2019 Second Prize in Natural Science of Jiangxi Province (for research on novel natural drugs against multi-drug resistant bacteria and their combined use) 2018 Zhu Yubi Medical Prize from Wuhan University 2016 Outstanding Paper Award in Microbiology 2015 Hubei Province Outstanding Bachelor Thesis Advisor 2012 Hubei Province Outstanding Master Thesis Advisor 2005 New Century Excellent Talents in University by Ministry of Education 2004-2005 UK Royal Society China Fellow 2000-2004 First Hainan Province Outstanding Young Teachers in Colleges and Universities Teaching and Research Award Fund 1999-2000 Backbone Teacher by Ministry of Education 2000 Top Ten Outstanding Youths of Hainan Province

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

1984.9-1988.7 Bachelor's Degree in Microbiology from Wuhan University
1988.9-1991.7 Master's Degree in Tropical Crop Product Fermentation from South China Tropical Crop College
1995.9-1998.7 PhD in Microbiology from Nanjing Agricultural University (Tsinghua University)
Visiting Scholar at Heriot Watt University and Newcastle University, UK under the Royal Society KC-WONG China Fellowship

Work Experience

2010.12-present Professor at School of Pharmaceutical Sciences, Wuhan University
2006.9-2010.12 Professor at Tropical Biotechnology Research Institute, Chinese Academy of Tropical Agricultural Sciences
2002.5-2006.9 Professor at State Key Laboratory of Tropical Crop Biotechnology, Chinese Academy of Tropical Agricultural Sciences and South China Tropical Agricultural University
2000.4-2002.4 Associate Professor at College of Environment and Plant Protection, South China Tropical Agricultural University
1999.9-2000.4 Deputy Director and Associate Professor at Scientific Research Office, Chinese Academy of Tropical Agricultural Sciences and South China Tropical Agricultural University
1991.7-1999.9 Assistant, Lecturer, and Associate Professor at Processing Department of South China Tropical Crop College (Engineering College of South China Tropical Agricultural University)

Awards

2020 Advanced Female Faculty Member at Wuhan University
2019 Wuhan 'Optics Valley 3551 Talent'
2019 Second Prize in Natural Science of Jiangxi Province (for research on novel natural drugs against multi-drug resistant bacteria and their combined use)
2018 Zhu Yubi Medical Prize from Wuhan University
2016 Outstanding Paper Award in Microbiology
2015 Hubei Province Outstanding Bachelor Thesis Advisor
2012 Hubei Province Outstanding Master Thesis Advisor
2005 New Century Excellent Talents in University by Ministry of Education
2004-2005 UK Royal Society China Fellow
2000-2004 First Hainan Province Outstanding Young Teachers in Colleges and Universities Teaching and Research Award Fund
1999-2000 Backbone Teacher by Ministry of Education
2000 Top Ten Outstanding Youths of Hainan Province

Areas of Focus	Marine microbiology drug discovery Pharmacological evaluation and preclinical research of anti-tumor drugs
Publications	Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent, Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K, 2022 A marine-derived small molecule induces immunogenic cell death against triple-negative breast cancer through ER stress-CHOP pathway, Wen H, Zhong Y, Yin Y, Qin K, Yang L, Li D, Yu W, Yang C, Deng Z, Hong K, 2022 The Biosynthesis and Transport of Ophiobolins in Aspergillus ustus 094102, Yan, J.; Pang, J.; Liang, J.; Yu, W.; Liao, X.; Aobulikasimu, A.; Yi, X.; Yin, Y.; Deng, Z.; Hong K, 2022 Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment, Liang JJ, Yu WL, Yang L, Xie BH, Qin KM, Yin YP, Yan JJ, Gong S, Liu TY, Zhou HB, Hong K, 2022 Genome Mining Reveals a Multiproduct Sesterterpenoid Biosynthetic Gene Cluster in Aspergillus ustus, Guo J, Cai YS, Cheng F, Yang C, Zhang W, Yu W, Yan J, Deng Z, Hong K, 2021 New Ophiobolins from the Deep-Sea Derived Fungus Aspergillus sp. WHU0154 and Their Anti-Inflammatory Effects, Ding, W.; Uvarani, C.; Wang, F.; Xue, Y.; Wu, N.; He, L.; Tian, D.; Chen, M.; Zhang, Y.; Hong, K.; Tang, J, 2020 New pyrones and their analogs from the marine mangrove derived Aspergillus sp. DM94 with antibacterial activity against Helicobacter pylori, Gou, X; Jia, J; Xue, Y; Ding, W; Dong, Z; Tian, D; Chen, M; Bi, H; Hong, K; Tang, J, 2020 Bioactive molecules from mangrove Streptomyces qinglanensis 172205, Xu, D.; Tian, E.; Kong, F.; Hong, K, 2020 Production of terpenoids by synthetic biology approaches, ZhangC, HongK, 2020 Toxicity, pharmacokinetics, and gut microbiome of oral administration of sesterterpene MHO7 derived from a marine fungus, Tian W, Yang L, Wu D, Deng Z and Hong K, 2019 Production of sesterterpene ophiobolin by a bifunctional terpene synthase in Escherichia coli, Yuan W, Lv S, Chen L, Zhao Y, Deng Z, Hong K, 2019 Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader, Zhao Y, Zhao C, Lu J, Wu J, Li C, Hu Z, Tian W, Yang L, Xiang J, Zhou H, Deng Z, Huang J, Hong K, 2019 Streptomyces Polaris sp. nov. and Streptomyces septentrionalis sp. nov., isolated from frozen soil, Kamjam M, Nopnakorn P, Zhang L, Peng F, Deng Z, Hong K, 2019 Identification of enzymes involved in sesterterpene biosynthesis in marine fungi, Yan J, Guo J, Yuan W, Mai W, Hong K, 2018

Areas of Focus

Marine microbiology drug discovery
Pharmacological evaluation and preclinical research of anti-tumor drugs

Publications

Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent, Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K, 2022
A marine-derived small molecule induces immunogenic cell death against triple-negative breast cancer through ER stress-CHOP pathway, Wen H, Zhong Y, Yin Y, Qin K, Yang L, Li D, Yu W, Yang C, Deng Z, Hong K, 2022
The Biosynthesis and Transport of Ophiobolins in Aspergillus ustus 094102, Yan, J.; Pang, J.; Liang, J.; Yu, W.; Liao, X.; Aobulikasimu, A.; Yi, X.; Yin, Y.; Deng, Z.; Hong K, 2022
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment, Liang JJ, Yu WL, Yang L, Xie BH, Qin KM, Yin YP, Yan JJ, Gong S, Liu TY, Zhou HB, Hong K, 2022
Genome Mining Reveals a Multiproduct Sesterterpenoid Biosynthetic Gene Cluster in Aspergillus ustus, Guo J, Cai YS, Cheng F, Yang C, Zhang W, Yu W, Yan J, Deng Z, Hong K, 2021
New Ophiobolins from the Deep-Sea Derived Fungus Aspergillus sp. WHU0154 and Their Anti-Inflammatory Effects, Ding, W.; Uvarani, C.; Wang, F.; Xue, Y.; Wu, N.; He, L.; Tian, D.; Chen, M.; Zhang, Y.; Hong, K.; Tang, J, 2020
New pyrones and their analogs from the marine mangrove derived Aspergillus sp. DM94 with antibacterial activity against Helicobacter pylori, Gou, X; Jia, J; Xue, Y; Ding, W; Dong, Z; Tian, D; Chen, M; Bi, H; Hong, K; Tang, J, 2020
Bioactive molecules from mangrove Streptomyces qinglanensis 172205, Xu, D.; Tian, E.; Kong, F.; Hong, K, 2020
Production of terpenoids by synthetic biology approaches, ZhangC, HongK, 2020
Toxicity, pharmacokinetics, and gut microbiome of oral administration of sesterterpene MHO7 derived from a marine fungus, Tian W, Yang L, Wu D, Deng Z and Hong K, 2019
Production of sesterterpene ophiobolin by a bifunctional terpene synthase in Escherichia coli, Yuan W, Lv S, Chen L, Zhao Y, Deng Z, Hong K, 2019
Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader, Zhao Y, Zhao C, Lu J, Wu J, Li C, Hu Z, Tian W, Yang L, Xiang J, Zhou H, Deng Z, Huang J, Hong K, 2019
Streptomyces Polaris sp. nov. and Streptomyces septentrionalis sp. nov., isolated from frozen soil, Kamjam M, Nopnakorn P, Zhang L, Peng F, Deng Z, Hong K, 2019
Identification of enzymes involved in sesterterpene biosynthesis in marine fungi, Yan J, Guo J, Yuan W, Mai W, Hong K, 2018

Marine Microbiology Drug Discovery Pharmacology Preclinical Research Anti-Tumor Medicinal Chemistry Natural Products Drug Resistance Pharmacokinetics Mechanism Of Action

Changming Zhao - Wuhan University

You-Sheng Cai - Wuhan University

Wenhu Duan - University of Chinese Academy of Sciences

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