Areas of Focus
- Synthesis and biological activity of natural products and derivatives with significant physiological activity
- Research on new anti-tumor molecular targeted drugs
Work Experience
- 2000-11--Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 1997-01--2000-10 - University of Texas College of Pharmacy - Postdoctoral Fellow
- 1986-07--1990-08 - Changzhou Third Pharmaceutical Factory, Jiangsu - Engineer
Academic Background & Achievements
- 1993-09--1996-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1990-09--1993-06 Master's: West China University of Medical Sciences
- 1982-09--1986-06 Bachelor's: China Pharmaceutical University
Publications
- Discovery of 10H-Benzobpyrido2,3-e1,4oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase, Zhan, Zhengsheng, Ji, Yinchun, Su, Haixia, Fang, Chen, Peng, Xia, Liu, Qiufeng, Dai, Yang, Lin, Dongze, Xu, Yechun, Ai, Jing, Duan, Wenhu, 2022
- Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, Xie, Zuoquan, Wang, Zhen, Fan, Fengying, Zhou, Jinpei, Hu, Zhaoxue, Wang, Qingxia, Wang, Xiyuan, Zeng, Qingzhong, Zhang, Yan, Qiu, Jiaxuan, Zhou, Xiaoqian, Xu, Hui, Bai, Hudagula, Zhan, Zhengsheng, Ding, Jian, Zhang, Huibin, Duan, Wenhu, Yu, Xuekui, Geng, Meiyu, 2022
- Discovery of pyrrolo2,3-dpyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation, Xu, Dandan, Sun, Deqiao, Wang, Wei, Peng, Xia, Zhan, Zhengsheng, Ji, Yinchun, Shen, Yanyan, Geng, Meiyu, Ai, Jing, Duan, Wenhu, 2021
- Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, Du, Daohai, Xu, Dandan, Zhu, Licheng, Stazi, Giulia, Zwergel, Clemens, Liu, Yanli, Luo, Zhongyuan, Li, Yuanqing, Zhang, Yuanyuan, Zhu, Kongkai, Ding, Yiluan, Liu, Jingqiu, Fan, Shijie, Zhao, Kaiyan, Zhang, Naixia, Kong, Xiangqian, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Valente, Sergio, Min, Jinrong, Duan, Wenhu, Luo, Cheng, 2021
- Discovery and structure - activity relationship exploration of pyrazolo 1,5-apyrimidine derivatives as potent FLT3-ITD inhibitors, Chen, Yun, Bai, Gang, Li, Yan, Ning, Yi, Cao, Sufen, Zhou, Jinpei, Ding, Jian, Zhang, Huibin, Xie, Hua, Duan, Wenhu, 2021
- Synthesis of triazolotriazine derivatives as c-Met inhibitors, Guo, Yuting, Peng, Xia, Ji, Yinchun, Zhang, Yitong, Ding, Jian, Zhan, Zhengsheng, Ai, Jing, Duan, Wenhu, 2021
- Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor, Zhang, Hefeng, Peng, Xia, Dai, Yang, Shao, Jingwei, Ji, Yinchun, Sun, Yiming, Liu, Bo, Cheng, Xu, Ai, Jing, Duan, Wenhu, 2021
- DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation, Lv, Jianlu, Wang, Wei, Zhu, Xialin, Xu, Xiaoju, Yan, Qiuying, Lu, Jian, Shi, Xiaofan, Wang, Zhengyu, Zhou, Jinpei, Huang, Xi, Wang, Jiaying, Duan, Wenhu, Shen, Xu, 2020
- Design and synthesis of Imidazo1,2-bpyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma, Chen, Yun, Bai, Gang, Ning, Yi, Cai, Shi, Zhang, Tao, Song, Peiran, Zhou, Jinpei, Duan, Wenhu, Ding, Jian, Xie, Hua, Zhang, Huibin, 2020
- A potent pyrimidinone Axl inhibitor DW17401, Zhang, Hefeng, Peng, Xia, Ji, Yinchun, Dai, Yang, Shen, Yanyan, Ai, Jing, Duan, Wenhu, 2020
- DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice, Xu, Xu, Wang, Wei, Wang, Zhengyu, Lv, Jianlu, Xu, Xiaoju, Xu, Jiawen, Yang, Juanzhen, Zhu, Xialin, Lu, Yin, Duan, Wenhu, Huang, Xi, Wang, Jiaying, Zhou, Jinpei, Shen, Xu, 2020
- DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation, Jianlu Lv, Wei Wang, Xialin Zhu, Xiaoju Xu, Qiuying Yan, Jian Lu, Xiaofan Shi, Zhengyu Wang, Jinpei Zhou, Xi Huang, Jiaying Wang, Wenhu Duan, Xu Shen, 2020
- Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity, Zhu, Kongkai, Shao, Jingwei, Tao, Hongrui, Yan, Xue, Luo, Cheng, Zhang, Hua, Duan, Wenhu, 2019
- Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α, Zheng, BaiNan, Ding, ChenHong, Chen, ShiJie, Zhu, Kongkai, Shao, Jingwei, Feng, Jifeng, Xu, WenPing, Cai, LingYan, Zhu, ChangPeng, Duan, Wenhu, Ding, Jin, Zhang, Xin, Luo, Cheng, Xie, WeiFen, 2019
- Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation, Shao, Jingwei, Zhu, Kongkai, Du, Daohai, Zhang, Yuanyuan, Tao, Hongrui, Chen, Zhifeng, Jiang, Hualiang, Chen, Kaixian, Luo, Cheng, Duan, Wenhu, 2019
- Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles, Zhan, Zhengsheng, Peng, Xia, Sun, Yiming, Ai, Jing, Duan, Wenhu, 2018
- Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors (vol 61, pg 9085, 2018), Wang, Yuming, Li, Lijun, Fan, Jun, Dai, Yang, Jiang, Alan, Geng, Meiyu, Ai, Jing, Duan, Wenhu, 2018
- Synthesis and Bioevaluation of Shikonin Derivatives, Cao, Sufen, Zhang, Jiangang, Duan, Wenhu, 2018
- Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation, Wang, Zhengyu, Shi, Xiaofan, Zhang, Huan, Yu, Liang, Cheng, Yanhua, Zhang, Hefeng, Zhang, Huibin, Zhou, Jinpei, Chen, Jing, Shen, Xu, Duan, Wenhu, 2017
- Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization, Mao, Ruifeng, Shao, Jingwei, Zhu, Kongkai, Zhang, Yuanyuan, Ding, Hong, Zhang, Chenhua, Shi, Zhe, Jiang, Hualiang, Sun, Dequn, Duan, Wenhu, Luo, Cheng, 2017
- Discovery of 6-(difluoro(6-(4-fluorophenyl)-1,2,4triazolo4,3-b 1,2,4triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor, Zhan, Zhengsheng, Peng, Xia, Liu, Qiufeng, Chen, Fang, Ji, Yinchun, Yao, Shanyan, Xi, Yong, Lin, Yipeng, Chen, Tiantian, Xu, Yechun, Ai, Jing, Geng, Meiyu, Duan, Wenhu, 2016
- DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo, Li, Mengyuan, Lv, Yongcong, Tong, Linjiang, Peng, Ting, Qu, Rong, Zhang, Tao, Sun, Yiming, Chen, Yi, Wei, Lixin, Geng, Meiyu, Duan, Wenhu, Xie, Hua, Ding, Jian, 2016
- Microwave assisted solvent-free CsbndH amination by silica-supported manganese dioxide, Cao, Sufen, Duan, Wenhu, 2016
- Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors, Fan, Jun, Dai, Yang, Shao, Jingwei, Peng, Xia, Wang, Chen, Cao, Sufen, Zhao, Bin, Ai, Jing, Geng, Meiyu, Duan, Wenhu, 2016
- Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors: Design, Synthesis, and Biological Evaluation, Yan, Wei, Huang, Zhaoru, Wang, Zhengyu, Cao, Sufen, Tong, Linjiang, Zhang, Tao, Wang, Chen, Zhou, Lin, Ding, Jian, Luo, Cheng, Zhou, Jinpei, Xie, Hua, Duan, Wenhu, 2016
- Microwave assisted solvent-free C-H amination by silica-supported manganese dioxide, Cao, Sufen, Duan, Wenhu, 2016
- Discovery of Substituted 1H-Pyrazolo3,4-bpyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors, Zhao, Bin, Li, Yixuan, Xu, Pan, Dai, Yang, Luo, Cheng, Sun, Yiming, Ai, Jing, Geng, Meiyu,
