Professor | Wenhu Duan | Asia Growth Partners

Name	Wenhu Duan
Contact Information	whduan@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Wenhu Duan

Contact Information

whduan@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1993-09--1996-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 1990-09--1993-06 Master's: West China University of Medical Sciences 1982-09--1986-06 Bachelor's: China Pharmaceutical University
Work Experience	2000-11--Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher 1997-01--2000-10 - University of Texas College of Pharmacy - Postdoctoral Fellow 1986-07--1990-08 - Changzhou Third Pharmaceutical Factory, Jiangsu - Engineer

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1993-09--1996-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1990-09--1993-06 Master's: West China University of Medical Sciences
1982-09--1986-06 Bachelor's: China Pharmaceutical University

Work Experience

2000-11--Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
1997-01--2000-10 - University of Texas College of Pharmacy - Postdoctoral Fellow
1986-07--1990-08 - Changzhou Third Pharmaceutical Factory, Jiangsu - Engineer

Areas of Focus	Synthesis and biological activity of natural products and derivatives with significant physiological activity Research on new anti-tumor molecular targeted drugs
Publications	Discovery of 10H-Benzobpyrido2,3-e1,4oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase, Zhan, Zhengsheng, Ji, Yinchun, Su, Haixia, Fang, Chen, Peng, Xia, Liu, Qiufeng, Dai, Yang, Lin, Dongze, Xu, Yechun, Ai, Jing, Duan, Wenhu, 2022 Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, Xie, Zuoquan, Wang, Zhen, Fan, Fengying, Zhou, Jinpei, Hu, Zhaoxue, Wang, Qingxia, Wang, Xiyuan, Zeng, Qingzhong, Zhang, Yan, Qiu, Jiaxuan, Zhou, Xiaoqian, Xu, Hui, Bai, Hudagula, Zhan, Zhengsheng, Ding, Jian, Zhang, Huibin, Duan, Wenhu, Yu, Xuekui, Geng, Meiyu, 2022 Discovery of pyrrolo2,3-dpyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation, Xu, Dandan, Sun, Deqiao, Wang, Wei, Peng, Xia, Zhan, Zhengsheng, Ji, Yinchun, Shen, Yanyan, Geng, Meiyu, Ai, Jing, Duan, Wenhu, 2021 Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, Du, Daohai, Xu, Dandan, Zhu, Licheng, Stazi, Giulia, Zwergel, Clemens, Liu, Yanli, Luo, Zhongyuan, Li, Yuanqing, Zhang, Yuanyuan, Zhu, Kongkai, Ding, Yiluan, Liu, Jingqiu, Fan, Shijie, Zhao, Kaiyan, Zhang, Naixia, Kong, Xiangqian, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Valente, Sergio, Min, Jinrong, Duan, Wenhu, Luo, Cheng, 2021 Discovery and structure - activity relationship exploration of pyrazolo 1,5-apyrimidine derivatives as potent FLT3-ITD inhibitors, Chen, Yun, Bai, Gang, Li, Yan, Ning, Yi, Cao, Sufen, Zhou, Jinpei, Ding, Jian, Zhang, Huibin, Xie, Hua, Duan, Wenhu, 2021 Synthesis of triazolotriazine derivatives as c-Met inhibitors, Guo, Yuting, Peng, Xia, Ji, Yinchun, Zhang, Yitong, Ding, Jian, Zhan, Zhengsheng, Ai, Jing, Duan, Wenhu, 2021 Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor, Zhang, Hefeng, Peng, Xia, Dai, Yang, Shao, Jingwei, Ji, Yinchun, Sun, Yiming, Liu, Bo, Cheng, Xu, Ai, Jing, Duan, Wenhu, 2021 DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation, Lv, Jianlu, Wang, Wei, Zhu, Xialin, Xu, Xiaoju, Yan, Qiuying, Lu, Jian, Shi, Xiaofan, Wang, Zhengyu, Zhou, Jinpei, Huang, Xi, Wang, Jiaying, Duan, Wenhu, Shen, Xu, 2020 Design and synthesis of Imidazo1,2-bpyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma, Chen, Yun, Bai, Gang, Ning, Yi, Cai, Shi, Zhang, Tao, Song, Peiran, Zhou, Jinpei, Duan, Wenhu, Ding, Jian, Xie, Hua, Zhang, Huibin, 2020 A potent pyrimidinone Axl inhibitor DW17401, Zhang, Hefeng, Peng, Xia, Ji, Yinchun, Dai, Yang, Shen, Yanyan, Ai, Jing, Duan, Wenhu, 2020 DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice, Xu, Xu, Wang, Wei, Wang, Zhengyu, Lv, Jianlu, Xu, Xiaoju, Xu, Jiawen, Yang, Juanzhen, Zhu, Xialin, Lu, Yin, Duan, Wenhu, Huang, Xi, Wang, Jiaying, Zhou, Jinpei, Shen, Xu, 2020 DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation, Jianlu Lv, Wei Wang, Xialin Zhu, Xiaoju Xu, Qiuying Yan, Jian Lu, Xiaofan Shi, Zhengyu Wang, Jinpei Zhou, Xi Huang, Jiaying Wang, Wenhu Duan, Xu Shen, 2020 Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity, Zhu, Kongkai, Shao, Jingwei, Tao, Hongrui, Yan, Xue, Luo, Cheng, Zhang, Hua, Duan, Wenhu, 2019 Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α, Zheng, BaiNan, Ding, ChenHong, Chen, ShiJie, Zhu, Kongkai, Shao, Jingwei, Feng, Jifeng, Xu, WenPing, Cai, LingYan, Zhu, ChangPeng, Duan, Wenhu, Ding, Jin, Zhang, Xin, Luo, Cheng, Xie, WeiFen, 2019 Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation, Shao, Jingwei, Zhu, Kongkai, Du, Daohai, Zhang, Yuanyuan, Tao, Hongrui, Chen, Zhifeng, Jiang, Hualiang, Chen, Kaixian, Luo, Cheng, Duan, Wenhu, 2019 Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles, Zhan, Zhengsheng, Peng, Xia, Sun, Yiming, Ai, Jing, Duan, Wenhu, 2018 Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors (vol 61, pg 9085, 2018), Wang, Yuming, Li, Lijun, Fan, Jun, Dai, Yang, Jiang, Alan, Geng, Meiyu, Ai, Jing, Duan, Wenhu, 2018 Synthesis and Bioevaluation of Shikonin Derivatives, Cao, Sufen, Zhang, Jiangang, Duan, Wenhu, 2018 Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation, Wang, Zhengyu, Shi, Xiaofan, Zhang, Huan, Yu, Liang, Cheng, Yanhua, Zhang, Hefeng, Zhang, Huibin, Zhou, Jinpei, Chen, Jing, Shen, Xu, Duan, Wenhu, 2017 Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization, Mao, Ruifeng, Shao, Jingwei, Zhu, Kongkai, Zhang, Yuanyuan, Ding, Hong, Zhang, Chenhua, Shi, Zhe, Jiang, Hualiang, Sun, Dequn, Duan, Wenhu, Luo, Cheng, 2017 Discovery of 6-(difluoro(6-(4-fluorophenyl)-1,2,4triazolo4,3-b 1,2,4triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor, Zhan, Zhengsheng, Peng, Xia, Liu, Qiufeng, Chen, Fang, Ji, Yinchun, Yao, Shanyan, Xi, Yong, Lin, Yipeng, Chen, Tiantian, Xu, Yechun, Ai, Jing, Geng, Meiyu, Duan, Wenhu, 2016 DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo, Li, Mengyuan, Lv, Yongcong, Tong, Linjiang, Peng, Ting, Qu, Rong, Zhang, Tao, Sun, Yiming, Chen, Yi, Wei, Lixin, Geng, Meiyu, Duan, Wenhu, Xie, Hua, Ding, Jian, 2016 Microwave assisted solvent-free CsbndH amination by silica-supported manganese dioxide, Cao, Sufen, Duan, Wenhu, 2016 Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors, Fan, Jun, Dai, Yang, Shao, Jingwei, Peng, Xia, Wang, Chen, Cao, Sufen, Zhao, Bin, Ai, Jing, Geng, Meiyu, Duan, Wenhu, 2016 Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors: Design, Synthesis, and Biological Evaluation, Yan, Wei, Huang, Zhaoru, Wang, Zhengyu, Cao, Sufen, Tong, Linjiang, Zhang, Tao, Wang, Chen, Zhou, Lin, Ding, Jian, Luo, Cheng, Zhou, Jinpei, Xie, Hua, Duan, Wenhu, 2016 Microwave assisted solvent-free C-H amination by silica-supported manganese dioxide, Cao, Sufen, Duan, Wenhu, 2016 Discovery of Substituted 1H-Pyrazolo3,4-bpyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors, Zhao, Bin, Li, Yixuan, Xu, Pan, Dai, Yang, Luo, Cheng, Sun, Yiming, Ai, Jing, Geng, Meiyu,

Areas of Focus

Synthesis and biological activity of natural products and derivatives with significant physiological activity
Research on new anti-tumor molecular targeted drugs

Publications

Discovery of 10H-Benzobpyrido2,3-e1,4oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase, Zhan, Zhengsheng, Ji, Yinchun, Su, Haixia, Fang, Chen, Peng, Xia, Liu, Qiufeng, Dai, Yang, Lin, Dongze, Xu, Yechun, Ai, Jing, Duan, Wenhu, 2022
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, Xie, Zuoquan, Wang, Zhen, Fan, Fengying, Zhou, Jinpei, Hu, Zhaoxue, Wang, Qingxia, Wang, Xiyuan, Zeng, Qingzhong, Zhang, Yan, Qiu, Jiaxuan, Zhou, Xiaoqian, Xu, Hui, Bai, Hudagula, Zhan, Zhengsheng, Ding, Jian, Zhang, Huibin, Duan, Wenhu, Yu, Xuekui, Geng, Meiyu, 2022
Discovery of pyrrolo2,3-dpyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation, Xu, Dandan, Sun, Deqiao, Wang, Wei, Peng, Xia, Zhan, Zhengsheng, Ji, Yinchun, Shen, Yanyan, Geng, Meiyu, Ai, Jing, Duan, Wenhu, 2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, Du, Daohai, Xu, Dandan, Zhu, Licheng, Stazi, Giulia, Zwergel, Clemens, Liu, Yanli, Luo, Zhongyuan, Li, Yuanqing, Zhang, Yuanyuan, Zhu, Kongkai, Ding, Yiluan, Liu, Jingqiu, Fan, Shijie, Zhao, Kaiyan, Zhang, Naixia, Kong, Xiangqian, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Valente, Sergio, Min, Jinrong, Duan, Wenhu, Luo, Cheng, 2021
Discovery and structure - activity relationship exploration of pyrazolo 1,5-apyrimidine derivatives as potent FLT3-ITD inhibitors, Chen, Yun, Bai, Gang, Li, Yan, Ning, Yi, Cao, Sufen, Zhou, Jinpei, Ding, Jian, Zhang, Huibin, Xie, Hua, Duan, Wenhu, 2021
Synthesis of triazolotriazine derivatives as c-Met inhibitors, Guo, Yuting, Peng, Xia, Ji, Yinchun, Zhang, Yitong, Ding, Jian, Zhan, Zhengsheng, Ai, Jing, Duan, Wenhu, 2021
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor, Zhang, Hefeng, Peng, Xia, Dai, Yang, Shao, Jingwei, Ji, Yinchun, Sun, Yiming, Liu, Bo, Cheng, Xu, Ai, Jing, Duan, Wenhu, 2021
DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation, Lv, Jianlu, Wang, Wei, Zhu, Xialin, Xu, Xiaoju, Yan, Qiuying, Lu, Jian, Shi, Xiaofan, Wang, Zhengyu, Zhou, Jinpei, Huang, Xi, Wang, Jiaying, Duan, Wenhu, Shen, Xu, 2020
Design and synthesis of Imidazo1,2-bpyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma, Chen, Yun, Bai, Gang, Ning, Yi, Cai, Shi, Zhang, Tao, Song, Peiran, Zhou, Jinpei, Duan, Wenhu, Ding, Jian, Xie, Hua, Zhang, Huibin, 2020
A potent pyrimidinone Axl inhibitor DW17401, Zhang, Hefeng, Peng, Xia, Ji, Yinchun, Dai, Yang, Shen, Yanyan, Ai, Jing, Duan, Wenhu, 2020
DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice, Xu, Xu, Wang, Wei, Wang, Zhengyu, Lv, Jianlu, Xu, Xiaoju, Xu, Jiawen, Yang, Juanzhen, Zhu, Xialin, Lu, Yin, Duan, Wenhu, Huang, Xi, Wang, Jiaying, Zhou, Jinpei, Shen, Xu, 2020
DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation, Jianlu Lv, Wei Wang, Xialin Zhu, Xiaoju Xu, Qiuying Yan, Jian Lu, Xiaofan Shi, Zhengyu Wang, Jinpei Zhou, Xi Huang, Jiaying Wang, Wenhu Duan, Xu Shen, 2020
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity, Zhu, Kongkai, Shao, Jingwei, Tao, Hongrui, Yan, Xue, Luo, Cheng, Zhang, Hua, Duan, Wenhu, 2019
Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α, Zheng, BaiNan, Ding, ChenHong, Chen, ShiJie, Zhu, Kongkai, Shao, Jingwei, Feng, Jifeng, Xu, WenPing, Cai, LingYan, Zhu, ChangPeng, Duan, Wenhu, Ding, Jin, Zhang, Xin, Luo, Cheng, Xie, WeiFen, 2019
Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation, Shao, Jingwei, Zhu, Kongkai, Du, Daohai, Zhang, Yuanyuan, Tao, Hongrui, Chen, Zhifeng, Jiang, Hualiang, Chen, Kaixian, Luo, Cheng, Duan, Wenhu, 2019
Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles, Zhan, Zhengsheng, Peng, Xia, Sun, Yiming, Ai, Jing, Duan, Wenhu, 2018
Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors (vol 61, pg 9085, 2018), Wang, Yuming, Li, Lijun, Fan, Jun, Dai, Yang, Jiang, Alan, Geng, Meiyu, Ai, Jing, Duan, Wenhu, 2018
Synthesis and Bioevaluation of Shikonin Derivatives, Cao, Sufen, Zhang, Jiangang, Duan, Wenhu, 2018
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation, Wang, Zhengyu, Shi, Xiaofan, Zhang, Huan, Yu, Liang, Cheng, Yanhua, Zhang, Hefeng, Zhang, Huibin, Zhou, Jinpei, Chen, Jing, Shen, Xu, Duan, Wenhu, 2017
Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization, Mao, Ruifeng, Shao, Jingwei, Zhu, Kongkai, Zhang, Yuanyuan, Ding, Hong, Zhang, Chenhua, Shi, Zhe, Jiang, Hualiang, Sun, Dequn, Duan, Wenhu, Luo, Cheng, 2017
Discovery of 6-(difluoro(6-(4-fluorophenyl)-1,2,4triazolo4,3-b 1,2,4triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor, Zhan, Zhengsheng, Peng, Xia, Liu, Qiufeng, Chen, Fang, Ji, Yinchun, Yao, Shanyan, Xi, Yong, Lin, Yipeng, Chen, Tiantian, Xu, Yechun, Ai, Jing, Geng, Meiyu, Duan, Wenhu, 2016
DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo, Li, Mengyuan, Lv, Yongcong, Tong, Linjiang, Peng, Ting, Qu, Rong, Zhang, Tao, Sun, Yiming, Chen, Yi, Wei, Lixin, Geng, Meiyu, Duan, Wenhu, Xie, Hua, Ding, Jian, 2016
Microwave assisted solvent-free CsbndH amination by silica-supported manganese dioxide, Cao, Sufen, Duan, Wenhu, 2016
Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors, Fan, Jun, Dai, Yang, Shao, Jingwei, Peng, Xia, Wang, Chen, Cao, Sufen, Zhao, Bin, Ai, Jing, Geng, Meiyu, Duan, Wenhu, 2016
Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors: Design, Synthesis, and Biological Evaluation, Yan, Wei, Huang, Zhaoru, Wang, Zhengyu, Cao, Sufen, Tong, Linjiang, Zhang, Tao, Wang, Chen, Zhou, Lin, Ding, Jian, Luo, Cheng, Zhou, Jinpei, Xie, Hua, Duan, Wenhu, 2016
Microwave assisted solvent-free C-H amination by silica-supported manganese dioxide, Cao, Sufen, Duan, Wenhu, 2016
Discovery of Substituted 1H-Pyrazolo3,4-bpyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors, Zhao, Bin, Li, Yixuan, Xu, Pan, Dai, Yang, Luo, Cheng, Sun, Yiming, Ai, Jing, Geng, Meiyu,

Natural Products Derivatives Physiological Activity Synthesis Biological Activity Anti-Tumor Molecular Targets Drug Research Pharmacology Chemistry

Changming Zhao - Wuhan University

Kui Hong - Wuhan University

You-Sheng Cai - Wuhan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us