Areas of Focus
- Establishing new drug screening evaluation models and studying drug mechanisms of action
- Developing rapid clinical diagnostic techniques for live bacterial infections and drug sensitivity testing
- Developing new therapeutic vaccines and new biological therapies
- Synthetic biology research related to the diagnosis and treatment of pathogenic bacteria
- Development of related scientific research instruments and equipment
Work Experience
- 2024.04-present - Guangzhou Medical University - Distinguished Mentor
- 2022.03-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
- 2021.08-present - China-New Zealand Joint Laboratory for Biomedicine and Health - Researcher
- 2021.06-present - Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences - Visiting Professor
- 2021.06-present - Key Laboratory of Quality Research and Evaluation of In Vitro Diagnostic Reagents, National Medical Products Administration - Researcher
- 2021.05-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Deputy Director
- 2019.12-present - Guangdong-Hong Kong-Macao Joint Laboratory for Respiratory Infectious Diseases - Researcher
- 2018.08-present - National Key Laboratory of Respiratory Diseases - Group Leader
- 2018.01-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Key Cultivation Direction Leader
- 2017.09-present - Guangzhou Chest Hospital - Visiting Professor
- 2016.09-present - School of Medicine, University of Chinese Academy of Sciences - Professor
- 2012.01-present - National Key Laboratory of Respiratory Diseases - Co-Director
- 2011.01-present - National Key Laboratory of Respiratory Diseases - Researcher
- 2010.09-present - Anhui University - Professor
- 2010.09-present - University of Science and Technology of China - Professor
- 2010.09-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
Academic Background & Achievements
- 2002-08--2005-07 PhD: Chinese Academy of Medical Sciences and Peking Union Medical College
- 1999-09--2002-07 Master's: Capital Normal University, School of Life Sciences
- 1995-09--1999-07 Bachelor's: Capital Normal University, School of Life Sciences
Publications
- Novel derivatives of quinoxaline-2-carboxylic acid 1,4-dioxides as antimycobacterial agents: mechanistic studies and therapeutic potential, Tianyu Zhang, 2024
- Distribution of common and rare drug resistance patterns in Mycobacterium tuberculosis clinical isolates revealed by GenoType MTBDRplus and MTBDRsl assay, Tianyu Zhang, 2024
- Bactericidal and Sterilizing Efficacy of Sudapyridine-Clofazimine-TB47 Combined with Linezolid, and/or Pyrazinamide in a Murine Model of Tuberculosis, Tianyu Zhang, 2024
- Synthesis and Biological Evaluation of 2-(Tetrazol-5-yl)sulfonylacetamides as Inhibitors of Mycobacterium tuberculosis, Tianyu Zhang, 2024
- EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin, Tianyu Zhang, 2024
- Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis, Tianyu Zhang, 2024
- Efficient Mutasynthesis of “Non-Natural” Antitubercular Ilamycins with Low Cytotoxicity, Tianyu Zhang, 2024
- 3-Methoxy-2-phenylimidazo[1,2-b]pyridazines Highly Active Against Mycobacterium tuberculosis and Mycobacterium marinum, Tianyu Zhang, 2024
- Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir, Tianyu Zhang, 2024
- Indole propionic acid is an effective substrate for tryptophanyl-tRNA synthetase in Mycobacterium tuberculosis, Tianyu Zhang, 2024
- Amino acid 17 in QRDR of Gyrase A plays a key role in fluoroquinolones susceptibility in Mycobacteria, Tianyu Zhang, 2024
- Iterative Methylation Leads to 3-Methylchuangxinmycin Production in Actinoplanes tsinanensis CPCC 200056, Tianyu Zhang, 2023
- A recombinant Mycobacterium smegmatis-based surface display system for developing the T cell-based COVID-19 vaccine, Tianyu Zhang, 2023
- Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001, Tianyu Zhang, 2023
- Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against Mycobacterium tuberculosis, Tianyu Zhang, 2023
- Expanding the Chemical Diversity of Grisechelins via Heterologous Expression, Tianyu Zhang, 2023
- Discovery of N-(1-(6-oxo-1,6-dihydropyrimidine)-pyrazole) acetamide derivatives as novel noncovalent DprE1 inhibitors against Mycobacterium tuberculosis, Tianyu Zhang, 2023
- Expanding structural diversity of 5′-aminouridine moiety of sansanmycin via mutational biosynthesis, Tianyu Zhang, 2023
Awards
- Guangzhou Education Base Outstanding Graduate Supervisor (2023)
- Guangzhou Huangpu District Innovation and Entrepreneurship Leading Talent (2022)
- China Invention Association Invention and Entrepreneurship Award Innovation Award Second Prize (2021)
- University of Chinese Academy of Sciences Education Foundation Excellent Educator in Life Sciences (2021)
- Guangzhou Huangpu District Outstanding Talent
- Guangzhou Branch of Chinese Academy of Sciences Excellent Communist Party Member (2017-2021)
- China Industry-University-Research Cooperation Promotion Association Innovation Award (2020)
- National 'Ten Thousand Talents Plan' Leading Talent in Scientific and Technological Innovation (2020)
- Ministry of Science and Technology Innovation Talent Promotion Plan Young and Middle-aged Leading Talent in Scientific and Technological Innovation (2019)
- Guangzhou Outstanding Expert (2019)
- Guangzhou Huangpu District Outstanding Talent (2019)
- Guangdong Province Fifth Patent Award 'Excellence Award' (2018)
- Guangdong Special Support Plan Leading Talent in Scientific and Technological Innovation (2016)
- Chinese Academy of Sciences '****' A Class (2012)
