Professor | Tianyu Zhang | Asia Growth Partners

Name	Tianyu Zhang
Contact Information	zhang_tianyu@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Tianyu Zhang

Contact Information

zhang_tianyu@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2002-08--2005-07 PhD: Chinese Academy of Medical Sciences and Peking Union Medical College 1999-09--2002-07 Master's: Capital Normal University, School of Life Sciences 1995-09--1999-07 Bachelor's: Capital Normal University, School of Life Sciences
Work Experience	2024.04-present - Guangzhou Medical University - Distinguished Mentor 2022.03-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2021.08-present - China-New Zealand Joint Laboratory for Biomedicine and Health - Researcher 2021.06-present - Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences - Visiting Professor 2021.06-present - Key Laboratory of Quality Research and Evaluation of In Vitro Diagnostic Reagents, National Medical Products Administration - Researcher 2021.05-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Deputy Director 2019.12-present - Guangdong-Hong Kong-Macao Joint Laboratory for Respiratory Infectious Diseases - Researcher 2018.08-present - National Key Laboratory of Respiratory Diseases - Group Leader 2018.01-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Key Cultivation Direction Leader 2017.09-present - Guangzhou Chest Hospital - Visiting Professor 2016.09-present - School of Medicine, University of Chinese Academy of Sciences - Professor 2012.01-present - National Key Laboratory of Respiratory Diseases - Co-Director 2011.01-present - National Key Laboratory of Respiratory Diseases - Researcher 2010.09-present - Anhui University - Professor 2010.09-present - University of Science and Technology of China - Professor 2010.09-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
Awards	Guangzhou Education Base Outstanding Graduate Supervisor (2023) Guangzhou Huangpu District Innovation and Entrepreneurship Leading Talent (2022) China Invention Association Invention and Entrepreneurship Award Innovation Award Second Prize (2021) University of Chinese Academy of Sciences Education Foundation Excellent Educator in Life Sciences (2021) Guangzhou Huangpu District Outstanding Talent Guangzhou Branch of Chinese Academy of Sciences Excellent Communist Party Member (2017-2021) China Industry-University-Research Cooperation Promotion Association Innovation Award (2020) National 'Ten Thousand Talents Plan' Leading Talent in Scientific and Technological Innovation (2020) Ministry of Science and Technology Innovation Talent Promotion Plan Young and Middle-aged Leading Talent in Scientific and Technological Innovation (2019) Guangzhou Outstanding Expert (2019) Guangzhou Huangpu District Outstanding Talent (2019) Guangdong Province Fifth Patent Award 'Excellence Award' (2018) Guangdong Special Support Plan Leading Talent in Scientific and Technological Innovation (2016) Chinese Academy of Sciences '****' A Class (2012)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2002-08--2005-07 PhD: Chinese Academy of Medical Sciences and Peking Union Medical College
1999-09--2002-07 Master's: Capital Normal University, School of Life Sciences
1995-09--1999-07 Bachelor's: Capital Normal University, School of Life Sciences

Work Experience

2024.04-present - Guangzhou Medical University - Distinguished Mentor
2022.03-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2021.08-present - China-New Zealand Joint Laboratory for Biomedicine and Health - Researcher
2021.06-present - Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences - Visiting Professor
2021.06-present - Key Laboratory of Quality Research and Evaluation of In Vitro Diagnostic Reagents, National Medical Products Administration - Researcher
2021.05-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Deputy Director
2019.12-present - Guangdong-Hong Kong-Macao Joint Laboratory for Respiratory Infectious Diseases - Researcher
2018.08-present - National Key Laboratory of Respiratory Diseases - Group Leader
2018.01-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Key Cultivation Direction Leader
2017.09-present - Guangzhou Chest Hospital - Visiting Professor
2016.09-present - School of Medicine, University of Chinese Academy of Sciences - Professor
2012.01-present - National Key Laboratory of Respiratory Diseases - Co-Director
2011.01-present - National Key Laboratory of Respiratory Diseases - Researcher
2010.09-present - Anhui University - Professor
2010.09-present - University of Science and Technology of China - Professor
2010.09-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher

Awards

Guangzhou Education Base Outstanding Graduate Supervisor (2023)
Guangzhou Huangpu District Innovation and Entrepreneurship Leading Talent (2022)
China Invention Association Invention and Entrepreneurship Award Innovation Award Second Prize (2021)
University of Chinese Academy of Sciences Education Foundation Excellent Educator in Life Sciences (2021)
Guangzhou Huangpu District Outstanding Talent
Guangzhou Branch of Chinese Academy of Sciences Excellent Communist Party Member (2017-2021)
China Industry-University-Research Cooperation Promotion Association Innovation Award (2020)
National 'Ten Thousand Talents Plan' Leading Talent in Scientific and Technological Innovation (2020)
Ministry of Science and Technology Innovation Talent Promotion Plan Young and Middle-aged Leading Talent in Scientific and Technological Innovation (2019)
Guangzhou Outstanding Expert (2019)
Guangzhou Huangpu District Outstanding Talent (2019)
Guangdong Province Fifth Patent Award 'Excellence Award' (2018)
Guangdong Special Support Plan Leading Talent in Scientific and Technological Innovation (2016)
Chinese Academy of Sciences '****' A Class (2012)

Areas of Focus	Establishing new drug screening evaluation models and studying drug mechanisms of action Developing rapid clinical diagnostic techniques for live bacterial infections and drug sensitivity testing Developing new therapeutic vaccines and new biological therapies Synthetic biology research related to the diagnosis and treatment of pathogenic bacteria Development of related scientific research instruments and equipment
Publications	Novel derivatives of quinoxaline-2-carboxylic acid 1,4-dioxides as antimycobacterial agents: mechanistic studies and therapeutic potential, Tianyu Zhang, 2024 Distribution of common and rare drug resistance patterns in Mycobacterium tuberculosis clinical isolates revealed by GenoType MTBDRplus and MTBDRsl assay, Tianyu Zhang, 2024 Bactericidal and Sterilizing Efficacy of Sudapyridine-Clofazimine-TB47 Combined with Linezolid, and/or Pyrazinamide in a Murine Model of Tuberculosis, Tianyu Zhang, 2024 Synthesis and Biological Evaluation of 2-(Tetrazol-5-yl)sulfonylacetamides as Inhibitors of Mycobacterium tuberculosis, Tianyu Zhang, 2024 EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin, Tianyu Zhang, 2024 Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis, Tianyu Zhang, 2024 Efficient Mutasynthesis of “Non-Natural” Antitubercular Ilamycins with Low Cytotoxicity, Tianyu Zhang, 2024 3-Methoxy-2-phenylimidazo[1,2-b]pyridazines Highly Active Against Mycobacterium tuberculosis and Mycobacterium marinum, Tianyu Zhang, 2024 Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir, Tianyu Zhang, 2024 Indole propionic acid is an effective substrate for tryptophanyl-tRNA synthetase in Mycobacterium tuberculosis, Tianyu Zhang, 2024 Amino acid 17 in QRDR of Gyrase A plays a key role in fluoroquinolones susceptibility in Mycobacteria, Tianyu Zhang, 2024 Iterative Methylation Leads to 3-Methylchuangxinmycin Production in Actinoplanes tsinanensis CPCC 200056, Tianyu Zhang, 2023 A recombinant Mycobacterium smegmatis-based surface display system for developing the T cell-based COVID-19 vaccine, Tianyu Zhang, 2023 Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001, Tianyu Zhang, 2023 Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against Mycobacterium tuberculosis, Tianyu Zhang, 2023 Expanding the Chemical Diversity of Grisechelins via Heterologous Expression, Tianyu Zhang, 2023 Discovery of N-(1-(6-oxo-1,6-dihydropyrimidine)-pyrazole) acetamide derivatives as novel noncovalent DprE1 inhibitors against Mycobacterium tuberculosis, Tianyu Zhang, 2023 Expanding structural diversity of 5′-aminouridine moiety of sansanmycin via mutational biosynthesis, Tianyu Zhang, 2023

Areas of Focus

Establishing new drug screening evaluation models and studying drug mechanisms of action
Developing rapid clinical diagnostic techniques for live bacterial infections and drug sensitivity testing
Developing new therapeutic vaccines and new biological therapies
Synthetic biology research related to the diagnosis and treatment of pathogenic bacteria
Development of related scientific research instruments and equipment

Publications

Novel derivatives of quinoxaline-2-carboxylic acid 1,4-dioxides as antimycobacterial agents: mechanistic studies and therapeutic potential, Tianyu Zhang, 2024
Distribution of common and rare drug resistance patterns in Mycobacterium tuberculosis clinical isolates revealed by GenoType MTBDRplus and MTBDRsl assay, Tianyu Zhang, 2024
Bactericidal and Sterilizing Efficacy of Sudapyridine-Clofazimine-TB47 Combined with Linezolid, and/or Pyrazinamide in a Murine Model of Tuberculosis, Tianyu Zhang, 2024
Synthesis and Biological Evaluation of 2-(Tetrazol-5-yl)sulfonylacetamides as Inhibitors of Mycobacterium tuberculosis, Tianyu Zhang, 2024
EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin, Tianyu Zhang, 2024
Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis, Tianyu Zhang, 2024
Efficient Mutasynthesis of “Non-Natural” Antitubercular Ilamycins with Low Cytotoxicity, Tianyu Zhang, 2024
3-Methoxy-2-phenylimidazo[1,2-b]pyridazines Highly Active Against Mycobacterium tuberculosis and Mycobacterium marinum, Tianyu Zhang, 2024
Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir, Tianyu Zhang, 2024
Indole propionic acid is an effective substrate for tryptophanyl-tRNA synthetase in Mycobacterium tuberculosis, Tianyu Zhang, 2024
Amino acid 17 in QRDR of Gyrase A plays a key role in fluoroquinolones susceptibility in Mycobacteria, Tianyu Zhang, 2024
Iterative Methylation Leads to 3-Methylchuangxinmycin Production in Actinoplanes tsinanensis CPCC 200056, Tianyu Zhang, 2023
A recombinant Mycobacterium smegmatis-based surface display system for developing the T cell-based COVID-19 vaccine, Tianyu Zhang, 2023
Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001, Tianyu Zhang, 2023
Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against Mycobacterium tuberculosis, Tianyu Zhang, 2023
Expanding the Chemical Diversity of Grisechelins via Heterologous Expression, Tianyu Zhang, 2023
Discovery of N-(1-(6-oxo-1,6-dihydropyrimidine)-pyrazole) acetamide derivatives as novel noncovalent DprE1 inhibitors against Mycobacterium tuberculosis, Tianyu Zhang, 2023
Expanding structural diversity of 5′-aminouridine moiety of sansanmycin via mutational biosynthesis, Tianyu Zhang, 2023

Drug Screening Evaluation Models Drug Mechanisms Clinical Diagnostics Bacterial Infections Drug Sensitivity Therapeutic Vaccines Biological Therapies Synthetic Biology Research Instruments

何涟 - Southern University of Science and Technology

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