Professor | 何涟 | Asia Growth Partners

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Name	何涟
Contact Information	hel3@sustech.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

何涟

Contact Information

hel3@sustech.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Medical School
Academic Background & Achievements	2004.09 – 2008.06 Bachelor in Biotechnology: Sun Yat-sen University 2008.09 – 2011.06 Master in Molecular Evolution: Sun Yat-sen University 2012.09 – 2018.05 PhD in Medical Science: Texas A&M University
Work Experience	2018.06 – 2022.03 Postdoctoral Researcher at Texas A&M University, Institute of Biosciences and Technology 2022.05 – Present Associate Professor at Southern University of Science and Technology, School of Medicine
Awards	2021 3rd Prize Winner, 34th Annual Symposium, Society of Chinese Bioscientists in America-TX 2021 3rd Prize Winner, Outstanding Poster Awards (Postdoc), Research Symposium, TAMU 2018 Best Poster Award, 2018 FASEB Research Conference 2017 Chinese Government Award for Outstanding Self-financed Students Abroad 2017 Robert and Anabel Bruce Travel Award, TAMU 2017 Texas A&M IBT Travel awards, TAMU 2016 Pre-doctoral Research Fellowship, The Welch Foundation 2016 Outstanding Poster Awards, Gulf Coast Consortia (GCC), Houston 2013 Outstanding Poster Awards, Texas A&M IBT Research Symposium, TAMU

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Medical School

Academic Background & Achievements

2004.09 – 2008.06 Bachelor in Biotechnology: Sun Yat-sen University
2008.09 – 2011.06 Master in Molecular Evolution: Sun Yat-sen University
2012.09 – 2018.05 PhD in Medical Science: Texas A&M University

Work Experience

2018.06 – 2022.03 Postdoctoral Researcher at Texas A&M University, Institute of Biosciences and Technology
2022.05 – Present Associate Professor at Southern University of Science and Technology, School of Medicine

Awards

2021 3rd Prize Winner, 34th Annual Symposium, Society of Chinese Bioscientists in America-TX
2021 3rd Prize Winner, Outstanding Poster Awards (Postdoc), Research Symposium, TAMU
2018 Best Poster Award, 2018 FASEB Research Conference
2017 Chinese Government Award for Outstanding Self-financed Students Abroad
2017 Robert and Anabel Bruce Travel Award, TAMU
2017 Texas A&M IBT Travel awards, TAMU
2016 Pre-doctoral Research Fellowship, The Welch Foundation
2016 Outstanding Poster Awards, Gulf Coast Consortia (GCC), Houston
2013 Outstanding Poster Awards, Texas A&M IBT Research Symposium, TAMU

Areas of Focus	Molecular mechanisms of CRAC calcium ion channel signaling and immunosuppressive drug screening Optogenetics-mediated immune regulation and spatiotemporal precise immunotherapy Development and application of new generation photo/chemogenetic synthetic biology tools and devices Activity regulation and antibody drug development of novel small molecule antibodies
Publications	Optical control of protein delivery and partitioning in the nucleolus, Tan P, Hong T, Cai X, Li W, Huang Y, He L, Zhou Y, 2022 Optophysiology: illuminating cell physiology with optogenetics, Tan P#, He L#, Huang Y, and Zhou Y, 2022 Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth, Xie J, Ma G, Zhou L, He L, Zhang Z, Tan P, Huang Z, Fang S, Wang T, Lee YT, Wen S, Siwko S, Wang L, Liu J, Du Y, Zhang N, Liu X, Han L, Huang Y, Wang R, Wang Y, Zhou Y, and Han W, 2022 Optogenetic control of non-apoptotic cell death, He L#, Huang Z#, Huang K#, Chen R, Nguyen N, Wang R, Cai X, Huang Z, Han G, Zhou Y and Jing J, 2021 Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering, He L#, Tan P#, Zhu L#, Huang K#, Nguyen N, Wang R, Guo L, Li L, Yang Y, Huang Z, Huang Y, Han G, Wang J and Zhou Y, 2021 Design of smart antibody mimetics with photosensitive switches, He L, Tan P, Huang Y, Zhou Y, 2021 Engineering of a bona fide light-operated calcium channel, He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Huang Y, Wang Y, and Zhou Y, 2021 Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style, Wang T#, He L#, Jing J, Lan TH, Hong T, Wang F, Huang Y, Ma G, and Zhou Y, 2021 Engineering supramolecular organizing centers for optogenetic control of innate immune responses, Tan P#, He L#, Zhou Y, 2021 Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling, Ma G#, He L#, Liu S#, Xie J, Huang Z, Jing J, Lee YT, Wang R, Luo H, Han W, Huang Y and Zhou Y, 2020 Expanding the chemogenetic toolbox by circular permutation, Lee YT, He L, and Zhou Y, 2020 Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development, Tan P, He L, Xing C, Mao J, Yu X, Zhu M, Diao L, Han L, Zhou Y, You JM, Wang HY, and Wang RF, 2020 Discovery of small molecule inhibitors of the HSP90-calcineurin-NFAT pathway against glioblastoma, Liu Z#, Li H#, He L#, Yu X, Tian C, Tan P, Li C, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, and Zhou Y, 2019 Identification of molecular determinants that govern distinct STIM2 activation dynamics, Zheng S#, Ma G#, He L#, Zhang T, Li J, Yuan X, Nguyen NT, Huang Y, Zhang X, Gao P, Nwokonko RM, Gill DL, Dong H, Zhou Y, and Wang Y, 2018 Rewiring calcium signaling for precise transcriptional reprogramming, Nguyen NT#, He L#, Martinze-Moczygemba M, Huang Y and Zhou Y, 2018 Optical control of membrane tethering and interorganellar communication at nanoscales, He L#, Jing J#, Zhu L#, Tan P, Ma G, Zhang Q, Nguyen N, Wang J, Zhou Y, Huang Y, 2017 Assembly of the WHIP-TRIM14-PPP6C mitochondrial complex promotes RIG-I-mediated antiviral signaling, Tan P, He L, Cui J, Cao X, Qian C, Lin M, Xing C, Zhu Q, Li Y, Yu X, Wang Y, and Wang RF, 2017 Optogenetic immunomodulation: shedding light on the antitumor immunity, Tan P, He L, Han G, and Zhou Y, 2016 Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation, He L#, Zhang Y#, Ma G#, Tan P#, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Hogan PG, Han G, and Zhou Y, 2015 Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx, Jing J#, He L#, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, and Zhou Y, 2015 Inside-out Ca2+ signaling prompted by STIM1 conformational switch, Ma G#, Wei M#, He L#, Liu C, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Lee MS, Zhou W, Wang J, Wang Y, and Zhou Y, 2015

Areas of Focus

Molecular mechanisms of CRAC calcium ion channel signaling and immunosuppressive drug screening
Optogenetics-mediated immune regulation and spatiotemporal precise immunotherapy
Development and application of new generation photo/chemogenetic synthetic biology tools and devices
Activity regulation and antibody drug development of novel small molecule antibodies

Publications

Optical control of protein delivery and partitioning in the nucleolus, Tan P*, Hong T, Cai X, Li W, Huang Y, He L*, Zhou Y*, 2022
Optophysiology: illuminating cell physiology with optogenetics, Tan P#, He L#, Huang Y, and Zhou Y, 2022
Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth, Xie J, Ma G, Zhou L, He L, Zhang Z, Tan P, Huang Z, Fang S, Wang T, Lee YT, Wen S, Siwko S, Wang L, Liu J, Du Y, Zhang N, Liu X, Han L, Huang Y, Wang R, Wang Y, Zhou Y, and Han W, 2022
Optogenetic control of non-apoptotic cell death, He L#, Huang Z#, Huang K#, Chen R, Nguyen N, Wang R, Cai X, Huang Z, Han G, Zhou Y and Jing J, 2021
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering, He L#, Tan P#, Zhu L#, Huang K#, Nguyen N, Wang R, Guo L, Li L, Yang Y, Huang Z, Huang Y, Han G, Wang J and Zhou Y, 2021
Design of smart antibody mimetics with photosensitive switches, He L*, Tan P, Huang Y*, Zhou Y*, 2021
Engineering of a bona fide light-operated calcium channel, He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Huang Y, Wang Y, and Zhou Y, 2021
Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style, Wang T#, He L#, Jing J, Lan TH, Hong T, Wang F, Huang Y, Ma G, and Zhou Y, 2021
Engineering supramolecular organizing centers for optogenetic control of innate immune responses, Tan P#, He L#, Zhou Y, 2021
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling, Ma G#, He L#, Liu S#, Xie J, Huang Z, Jing J, Lee YT, Wang R, Luo H, Han W, Huang Y and Zhou Y, 2020
Expanding the chemogenetic toolbox by circular permutation, Lee YT, He L*, and Zhou Y*, 2020
Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development, Tan P, He L, Xing C, Mao J, Yu X, Zhu M, Diao L, Han L, Zhou Y, You JM, Wang HY, and Wang RF, 2020
Discovery of small molecule inhibitors of the HSP90-calcineurin-NFAT pathway against glioblastoma, Liu Z#, Li H#, He L#, Yu X, Tian C, Tan P, Li C, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, and Zhou Y, 2019
Identification of molecular determinants that govern distinct STIM2 activation dynamics, Zheng S#, Ma G#, He L#, Zhang T, Li J, Yuan X, Nguyen NT, Huang Y, Zhang X, Gao P, Nwokonko RM, Gill DL, Dong H, Zhou Y, and Wang Y, 2018
Rewiring calcium signaling for precise transcriptional reprogramming, Nguyen NT#, He L#, Martinze-Moczygemba M, Huang Y and Zhou Y, 2018
Optical control of membrane tethering and interorganellar communication at nanoscales, He L#, Jing J#, Zhu L#, Tan P, Ma G, Zhang Q, Nguyen N, Wang J, Zhou Y, Huang Y, 2017
Assembly of the WHIP-TRIM14-PPP6C mitochondrial complex promotes RIG-I-mediated antiviral signaling, Tan P, He L, Cui J, Cao X, Qian C, Lin M, Xing C, Zhu Q, Li Y, Yu X, Wang Y, and Wang RF, 2017
Optogenetic immunomodulation: shedding light on the antitumor immunity, Tan P, He L, Han G, and Zhou Y, 2016
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation, He L#, Zhang Y#, Ma G#, Tan P#, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Hogan PG, Han G, and Zhou Y, 2015
Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx, Jing J#, He L#, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, and Zhou Y, 2015
Inside-out Ca2+ signaling prompted by STIM1 conformational switch, Ma G#, Wei M#, He L#, Liu C, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Lee MS, Zhou W, Wang J, Wang Y, and Zhou Y, 2015

Crac Calcium Ion Signaling Immunosuppressive Drug Screening Optogenetics Immune Regulation Immunotherapy Synthetic Biology Antibody Development

Tianyu Zhang - University of Chinese Academy of Sciences

Shaobo Ke - Wuhan University

Ju Qiu - University of Chinese Academy of Sciences

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