Professor | Xiaofei Zhang | Asia Growth Partners

Name	Xiaofei Zhang
Contact Information	zhang_xiaofei@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Xiaofei Zhang

Contact Information

zhang_xiaofei@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2009-04--2013-04 PhD: Leiden University 2005-09--2008-12 Master's: University of Science and Technology of China 2001-09--2005-07 Bachelor's: Anhui Agricultural University
Work Experience	2017-03~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2014-09~2017-03 - Radboud University Nijmegen - Postdoctoral Researcher 2013-09~2014-09 - Leiden University - Postdoctoral Researcher
Awards	Second Prize (2013): Research on the Mechanism of Stem Cell Pluripotency and Reprogramming First Prize (2010): Research on the Mechanism and Technology of Induced Pluripotent Stem Cells

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2009-04--2013-04 PhD: Leiden University
2005-09--2008-12 Master's: University of Science and Technology of China
2001-09--2005-07 Bachelor's: Anhui Agricultural University

Work Experience

2017-03~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2014-09~2017-03 - Radboud University Nijmegen - Postdoctoral Researcher
2013-09~2014-09 - Leiden University - Postdoctoral Researcher

Awards

Second Prize (2013): Research on the Mechanism of Stem Cell Pluripotency and Reprogramming
First Prize (2010): Research on the Mechanism and Technology of Induced Pluripotent Stem Cells

Areas of Focus	Mechanisms of Signal Transduction using Proteomics and Related Cell Biology Techniques Functions of Non-Proteasomal Degradation Polyubiquitination and Their Roles in Cell Fate Transition
Publications	The NuRD complex cooperates with SALL4 to orchestrate reprogramming., Bo Wang, Chen Li, Jin Ming, Linlin Wu, Shicai Fang, Yi Huang, Lihui Lin, He Liu, Junqi Kuang, Chengchen Zhao, Xingnan Huang, Huijian Feng, Jing Guo, Xuejie Yang, Liman Guo, Xiaofei Zhang, Jiekai Chen, Jing Liu, Ping Zhu, Duanqing Pei., 2023 Antibody-free approach for ubiquitination profiling by selectively clicking the ubiquitination sites., Sun, Mingwei, Zhang, Qing, Zhao, Baofeng, Huang, Qiuling, Wu, Wenfeng, Fan, Peiyang, Zhang, Lihua, Zhang, Xiaofei., 2023 DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling., Zhang, Ke, Huang, Miaodan, Li, Ang, Wen, Jing, Yan, Lingli, Li, Yunhao, Guo, Liman, Senthil, Kumaran Satyanarayanan, Zhou, Yangyang, Chen, Guobing, Liu, Yong, Zhang, Xiaofei, Yao, Xiaoli, Qin, Dajiang, Su, Huanxing., 2023 H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition., Runxia Lin, Ziwei Zhai, Junqi Kuang, Chuman Wu, Yuxiang Yao, Ruona Shi, Jiangping He, Shuyang Xu, Pengli Li, Yixin Fan, Wei Li, Zichao Wu, Xiaoxi Li, Jin Ming, Jing Guo, Bo Wang, Dongwei Li, Shangtao Cao, Xiaofei Zhang, Yi Li, Duanqing Pei, Jing Liu., 2022 Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture., Mingwei Sun, Xiaofei Zhang., 2022 TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells., Yaping Chen, Xiaofei Zhang., 2022 Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike., Qu, Kun, Chen, Qiuluan, Ciazynska, Katarzyna A, Liu, Banghui, Zhang, Xixi, Wang, Jingjing, He, Yujie, Guan, Jiali, He, Jun, Liu, Tian, Zhang, Xiaofei, Carter, Andrew P, Xiong, Xiaoli, Briggs, John A G., 2022 UBE2O and USP7 co‐regulate RECQL4 ubiquitinylation and homologous recombination‐mediated DNA repair., HUANG QIULING, QIN DAJIANG, Pei Duanqing, Michiel Vermeulen, zhang_xiaofei., 2021 The mTORC1-eIF4F axis controls paused pluripotency., Xu, Xueting, Ahmed, Tanveer, Wang, Lulu, Cao, Xintao, Zhang, Zeyu, Wang, Ming, Lv, Yuan, Kanwal, Shahzina, Tariq, Muqddas, Lin, Runxia, Zhang, Hui, Huang, Yinghua, Peng, Hao, Lin, Danni, Shi, Xue, Geng, Didi, Liu, Baohua, Zhang, Xiaofei, Yi, Wen, Qin, Yan, Esteban, Miguel A, Qin, Baoming., 2021 The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity., Liu, Jiadong, Gao, Mingwei, He, Jiangping, Wu, Kaixin, Lin, Siyuan, Jin, Lingmei, Chen, Yaping, Liu, He, Shi, Junjie, Wang, Xiwei, Chang, Lei, Lin, Yingying, Zhao, YuLi, Zhang, Xiaofei, Zhang, Man, Luo, GuanZheng, Wu, Guangming, Pei, Duanqing, Wang, Jie, Bao, Xichen, Chen, Jiekai., 2021 Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses., Shi, Ruona, Feng, Zhenhuan, Zhang, Xiaofei., 2021 SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-kappa B signalling activation., Shi, Ruona, Shi, Xue, Qin, Dajiang, Tang, Shibing, Vermeulen, Michiel, Zhang, Xiaofei., 2021 Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2., Hou, Linlin, Wei, Yuanjie, Lin, Yingying, Wang, Xiwei, Lai, Yiwei, Yin, Menghui, Chen, Yanpu, Guo, Xiangpeng, Wu, Senbin, Zhu, Yindi, Yuan, Jie, Tariq, Muqddas, Li, Na, Sun, Hao, Wang, Huating, Zhang, Xiaofei, Chen, Jiekai, Bao, Xichen, Jauch, Ralf., 2020 Emerging Roles and Research Tools of Atypical Ubiquitination., Huang, Qiuling, Zhang, Xiaofei., 2020 SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States., Wu, Kaixin, Liu, He, Wang, Yaofeng, He, Jiangping, Xu, Shuyang, Chen, Yaping, Kuang, Junqi, Liu, Jiadong, Guo, Lin, Li, Dongwei, Shi, Ruona, Shen, Li, Wang, Yangming, Zhang, Xiaofei, Wang, Jie, Pei, Duanqing, Chen, Jiekai., 2020 Proteome-wide identification of ubiquitin interactions using UbIA-MS., Zhang, Xiaofei, Smits, Arne H, van Tilburg, Gabrielle B A, Ovaa, Huib, Huber, Wolfgang, Vermeulen, Michiel., 2018 An Interaction Landscape of Ubiquitin Signaling., Zhang, Xiaofei, Smits, Arne H, van Tilburg, Gabrielle B A, Jansen, Pascal W T C, Makowski, Matthew M, Ovaa, Huib, Vermeulen, Michiel., 2017 The regulation of TGF-β/SMAD signaling by protein deubiquitination., Zhang Juan, Zhang Xiaofei, Xie Feng, Zhang Zhengkui, Dam Hans van, Zhang Long, Zhou Fangfang., 2014 UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination., Zhang, Xiaofei, Zhang, Juan, Bauer, Andreas, Zhang, Long, Selinger, Douglas W, Lu, Chris X, ten Dijke, Peter., 2013 Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6., Zhang, Xiaofei, Zhang, Juan, Bauer, Andreas, Zhang, Long, Selinger, Douglas W, Lu, Chris X, ten Dijke, Peter., 2013 Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation., Zhou, FangFang, Zhang, Xiaofei, van Dam, Hans, ten Dijke, Peter, Huang, Huizhe, Zhang, Long., 2012 LRP8 mediates Wnt/ss-catenin signaling and controls osteoblast differentiation., Zhang, Juan, Zhang, Xiaofei, Bauer, Andreas, Zhang, Long, Selinger, Douglas W, Lu, Chris X, ten Dijke, Peter., 2012 VHL Inactivation Induces HEF1 and Aurora Kinase A., Xu, Jianyong, Li, Huapeng, Wang, Bo, Xu, Yan, Yang, Jiayin, Zhang, Xiaofei, Harten, Sarah K, Shukla, Deepa, Maxwell, Patrick H, Pei, Duanqing, Esteban, Miguel A., 2010 Mutations of nuclear localization signals in mNANOG generate dominant negative mutants., ZHANG Juan, ZHANG XiaoFei, PEI DuanQing., 2009 Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein., Zhang, Juan, Zhang, Xiaofei, Guo, Yunqian, Xu, Liangliang, Pei, Duanqing., 2009 Mutations of nuclear localization signals in mNANOG generate dominant negative mutants., ZHANG Juan, ZHANG XiaoFei, PEI DuanQing., 2009 Esrrb Activates Oct4 Transcription and Sustains Self-renewal and Pluripotency in Embryonic Stem Cells., Zhang, Xiaofei, Zhang, Juan, Wang, Tao, Esteban, Miguel A, Pei, Duanqing., 2008 Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein., Zhang Juan, Zhang Xiaofei, Guo Yunqian, Xu Liangliang, Pei Duanqing., 2009

Areas of Focus

Mechanisms of Signal Transduction using Proteomics and Related Cell Biology Techniques
Functions of Non-Proteasomal Degradation Polyubiquitination and Their Roles in Cell Fate Transition

Publications

The NuRD complex cooperates with SALL4 to orchestrate reprogramming., Bo Wang, Chen Li, Jin Ming, Linlin Wu, Shicai Fang, Yi Huang, Lihui Lin, He Liu, Junqi Kuang, Chengchen Zhao, Xingnan Huang, Huijian Feng, Jing Guo, Xuejie Yang, Liman Guo, Xiaofei Zhang, Jiekai Chen, Jing Liu, Ping Zhu, Duanqing Pei., 2023
Antibody-free approach for ubiquitination profiling by selectively clicking the ubiquitination sites., Sun, Mingwei, Zhang, Qing, Zhao, Baofeng, Huang, Qiuling, Wu, Wenfeng, Fan, Peiyang, Zhang, Lihua, Zhang, Xiaofei., 2023
DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling., Zhang, Ke, Huang, Miaodan, Li, Ang, Wen, Jing, Yan, Lingli, Li, Yunhao, Guo, Liman, Senthil, Kumaran Satyanarayanan, Zhou, Yangyang, Chen, Guobing, Liu, Yong, Zhang, Xiaofei, Yao, Xiaoli, Qin, Dajiang, Su, Huanxing., 2023
H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition., Runxia Lin, Ziwei Zhai, Junqi Kuang, Chuman Wu, Yuxiang Yao, Ruona Shi, Jiangping He, Shuyang Xu, Pengli Li, Yixin Fan, Wei Li, Zichao Wu, Xiaoxi Li, Jin Ming, Jing Guo, Bo Wang, Dongwei Li, Shangtao Cao, Xiaofei Zhang, Yi Li, Duanqing Pei, Jing Liu., 2022
Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture., Mingwei Sun, Xiaofei Zhang., 2022
TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells., Yaping Chen, Xiaofei Zhang., 2022
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike., Qu, Kun, Chen, Qiuluan, Ciazynska, Katarzyna A, Liu, Banghui, Zhang, Xixi, Wang, Jingjing, He, Yujie, Guan, Jiali, He, Jun, Liu, Tian, Zhang, Xiaofei, Carter, Andrew P, Xiong, Xiaoli, Briggs, John A G., 2022
UBE2O and USP7 co‐regulate RECQL4 ubiquitinylation and homologous recombination‐mediated DNA repair., HUANG QIULING, QIN DAJIANG, Pei Duanqing, Michiel Vermeulen, zhang_xiaofei., 2021
The mTORC1-eIF4F axis controls paused pluripotency., Xu, Xueting, Ahmed, Tanveer, Wang, Lulu, Cao, Xintao, Zhang, Zeyu, Wang, Ming, Lv, Yuan, Kanwal, Shahzina, Tariq, Muqddas, Lin, Runxia, Zhang, Hui, Huang, Yinghua, Peng, Hao, Lin, Danni, Shi, Xue, Geng, Didi, Liu, Baohua, Zhang, Xiaofei, Yi, Wen, Qin, Yan, Esteban, Miguel A, Qin, Baoming., 2021
The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity., Liu, Jiadong, Gao, Mingwei, He, Jiangping, Wu, Kaixin, Lin, Siyuan, Jin, Lingmei, Chen, Yaping, Liu, He, Shi, Junjie, Wang, Xiwei, Chang, Lei, Lin, Yingying, Zhao, YuLi, Zhang, Xiaofei, Zhang, Man, Luo, GuanZheng, Wu, Guangming, Pei, Duanqing, Wang, Jie, Bao, Xichen, Chen, Jiekai., 2021
Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses., Shi, Ruona, Feng, Zhenhuan, Zhang, Xiaofei., 2021
SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-kappa B signalling activation., Shi, Ruona, Shi, Xue, Qin, Dajiang, Tang, Shibing, Vermeulen, Michiel, Zhang, Xiaofei., 2021
Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2., Hou, Linlin, Wei, Yuanjie, Lin, Yingying, Wang, Xiwei, Lai, Yiwei, Yin, Menghui, Chen, Yanpu, Guo, Xiangpeng, Wu, Senbin, Zhu, Yindi, Yuan, Jie, Tariq, Muqddas, Li, Na, Sun, Hao, Wang, Huating, Zhang, Xiaofei, Chen, Jiekai, Bao, Xichen, Jauch, Ralf., 2020
Emerging Roles and Research Tools of Atypical Ubiquitination., Huang, Qiuling, Zhang, Xiaofei., 2020
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States., Wu, Kaixin, Liu, He, Wang, Yaofeng, He, Jiangping, Xu, Shuyang, Chen, Yaping, Kuang, Junqi, Liu, Jiadong, Guo, Lin, Li, Dongwei, Shi, Ruona, Shen, Li, Wang, Yangming, Zhang, Xiaofei, Wang, Jie, Pei, Duanqing, Chen, Jiekai., 2020
Proteome-wide identification of ubiquitin interactions using UbIA-MS., Zhang, Xiaofei, Smits, Arne H, van Tilburg, Gabrielle B A, Ovaa, Huib, Huber, Wolfgang, Vermeulen, Michiel., 2018
An Interaction Landscape of Ubiquitin Signaling., Zhang, Xiaofei, Smits, Arne H, van Tilburg, Gabrielle B A, Jansen, Pascal W T C, Makowski, Matthew M, Ovaa, Huib, Vermeulen, Michiel., 2017
The regulation of TGF-β/SMAD signaling by protein deubiquitination., Zhang Juan, Zhang Xiaofei, Xie Feng, Zhang Zhengkui, Dam Hans van, Zhang Long, Zhou Fangfang., 2014
UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination., Zhang, Xiaofei, Zhang, Juan, Bauer, Andreas, Zhang, Long, Selinger, Douglas W, Lu, Chris X, ten Dijke, Peter., 2013
Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6., Zhang, Xiaofei, Zhang, Juan, Bauer, Andreas, Zhang, Long, Selinger, Douglas W, Lu, Chris X, ten Dijke, Peter., 2013
Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation., Zhou, FangFang, Zhang, Xiaofei, van Dam, Hans, ten Dijke, Peter, Huang, Huizhe, Zhang, Long., 2012
LRP8 mediates Wnt/ss-catenin signaling and controls osteoblast differentiation., Zhang, Juan, Zhang, Xiaofei, Bauer, Andreas, Zhang, Long, Selinger, Douglas W, Lu, Chris X, ten Dijke, Peter., 2012
VHL Inactivation Induces HEF1 and Aurora Kinase A., Xu, Jianyong, Li, Huapeng, Wang, Bo, Xu, Yan, Yang, Jiayin, Zhang, Xiaofei, Harten, Sarah K, Shukla, Deepa, Maxwell, Patrick H, Pei, Duanqing, Esteban, Miguel A., 2010
Mutations of nuclear localization signals in mNANOG generate dominant negative mutants., ZHANG Juan, ZHANG XiaoFei, PEI DuanQing., 2009
Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein., Zhang, Juan, Zhang, Xiaofei, Guo, Yunqian, Xu, Liangliang, Pei, Duanqing., 2009
Mutations of nuclear localization signals in mNANOG generate dominant negative mutants., ZHANG Juan, ZHANG XiaoFei, PEI DuanQing., 2009
Esrrb Activates Oct4 Transcription and Sustains Self-renewal and Pluripotency in Embryonic Stem Cells., Zhang, Xiaofei, Zhang, Juan, Wang, Tao, Esteban, Miguel A, Pei, Duanqing., 2008
Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein., Zhang Juan, Zhang Xiaofei, Guo Yunqian, Xu Liangliang, Pei Duanqing., 2009

Signal Transduction Proteomics Cell Biology Polyubiquitination Non-Proteasomal Degradation Cell Fate Mechanisms Techniques Research Biology

Haihua Liang - Southern University of Science and Technology

Jianchao Zhang - Southern University of Science and Technology

Qinglian Guo - Wuhan University

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