Areas of Focus
- Development and functional regulation mechanisms of ILC2 cells
- High-throughput screening of new targets for tumor immunotherapy using CRISPR/Cas9
- Regeneration and mechanisms of T cells
Work Experience
- 2019.04-present, Tongji University, School of Life Sciences and Technology, Professor
- 2018.02-present, Tongji University, Shanghai First Maternity and Infant Hospital, Researcher
- 2017.09-2019.04, Tongji University, School of Life Sciences and Technology, Distinguished Researcher
- 2013.02-2017.12, University of Cambridge Sanger Institute, Postdoctoral Researcher
Academic Background & Achievements
- 2006-2012 Joint PhD program: Huazhong Agricultural University - University of Cambridge
- Identified key transcription factor Bcl11a for B cell development and hematopoietic stem cell maintenance
Publications
- Single-cell RNA-seq identifies a PD-1(hi) ILC progenitor and defines its development pathway, Yu Y et al., 2016
- The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development, Yu Y et al., 2015
- Bcl11a is essential for lymphoid development and negatively regulates p53, Yu Y et al., 2012
