Areas of Focus
- Stem Cell and Cell Reprogramming
- Regulatory Mechanisms in Mammalian Early Embryo Development
- Mechanisms of Somatic Cell Reprogramming (Cloning and Induced Pluripotent Stem Cells)
- Regulatory Mechanisms in Human Primordial Germ Cell Development
- Human Placental Development and Pregnancy-Related Disease Research
- Disease Model Construction and Research Based on CRISPR/Cas9 Gene Editing Technology
Work Experience
- 2023.1-present: Tongji University, School of Life Sciences and Technology, Tenured Professor
- 2020.12-present: Tongji University, School of Life Sciences and Technology, Professor
- 2017.12-2020.12: Tongji University, School of Life Sciences and Technology, Associate Professor
- 2014.10-2017.11: Tongji University, School of Life Sciences and Technology, Assistant Professor
- 2014.2-2014.10: Tongji University, Advanced Research Institute for Translational Medicine, Assistant Researcher
Academic Background & Achievements
- 2009-2014: PhD in Biochemistry and Molecular Biology, Beijing Union Medical College, Beijing Institute of Life Sciences
- Published research in prestigious journals including Nature and Cell Stem Cell
Publications
- Resetting histone modifications during human prenatal germline development, Gao R, Zeng S, Yang D, Li X, Liu W, Gao Y, Bai D, Zhang L, Chen C, Kang Y, Wang B, Hong W, Wang M, Yin J, Wang H, Deng Q, Gao S, Zhang Y, Chen J, 2023
- BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding, Wang M, Zhao K, Liu M, Wang M, Qiao Z, Yi S, Jiang Y, Kou X, Zhao Y, Yin J, Li T, Wang H, Jiang C, Gao S, Chen J, 2022
- Chromatin architecture reorganization during somatic cell reprogramming, Zhao K, Wang M, Gao S, Chen J, 2021
- Dux-mediated corrections of aberrant H3K9ac during 2-cell genome activation optimized efficiency of somatic cell nuclear transfer, Guang Y, Zhang L, Liu W, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S, Chen J, Jiang C, 2021
- A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020
- The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
- Mammalian haploid stem cells: establishment, engineering and applications, He W, Chen J, Gao S, 2019
- Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1, Li Y, Zhang Z, Chen J, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu G, Wang Z, Wang H, Gao S, Zhu B, 2018
- Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs, Gao H, Gao R, Zhang L, Xiu W, Zang R, Wang H, Zhang Y, Chen J, Gao Y, Gao S, 2019
- Accurate annotation of accessible chromatin in mouse and human primordial germ cells, Li J, Shen S, Chen J, Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C, Gao S, 2018
- Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b, He W, Zhang X, Zhang Y, Zheng W, Xiong Z, Hu X, Wang M, Zhang L, Zhao K, Qiao Z, Lai W, Lv C, Kou X, Zhao Y, Yin J, Liu W, Jiang Y, Chen M, Xu R, Le R, Li C, Wang H, Wan X, Wang H, Han Z, Jiang C, Gao S, Chen J, 2018
- Additive-effect pattern of both ZP2 and ZP3 in human and mouse, Liu W, Bai D, Chen J, Gao S, 2017
- Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility, Liu W, Li K, Bai D, Yin J, Tang Y, Chi F, Zhang L, Wang Y, Pan J, Liang S, Guo Y, Ruan J, Kou X, Zhao Y, Wang H, Chen J, Teng X, Gao S, 2017
- Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state, Gao R, Xiu W, Zhang L, Zang R, Yang L, Wang C, Wang M, Wang M, Yi L, Tang Y, Gao Y, Wang H, Xi J, Liu W, Wang Y, Wen X, Yu Y, Zhang Y, Chen L, Chen J, Gao S, 2017
- Maternal Sall4 Is Indispensable for Epigenetic Maturation of Mouse Oocytes, Xu K, Chen X, Yang H, Xu Y, He Y, Wang C, Huang H, Liu B, Liu W, Li J, Kou X, Zhao Y, Zhao K, Zhang L, Hou Z, Wang H, Wang H, Li J, Fan H, Wang F, Gao Y, Zhang Y, Chen J, Gao S, 2017
- The combination of Tet1 with Oct4 generates high-quality mouse induced pluripotent stem cells (iPSCs), Chen J, Gao Y, Huang H, Xu K, Chen X, Jiang Y, Li H, Gao S, Tao Y, Wang H, Zhang Y, Wang H, Cai T, Gao S, 2015
- The fused in sarcoma protein forms cytoplasmic aggregates in motor neurons derived from integration-free induced pluripotent stem cells generated from a patient with familial amyotrophic lateral sclerosis carrying the FUS-P525L mutation, Liu X, Chen J, Liu W, Li X, Chen Q, Liu T, Gao S, Deng M, 2015
- Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming, Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, Gao S, 2013
Awards
- 2020: Second Prize of the National Natural Science Award
- 2019: First Prize of the Ministry of Education Natural Science Award
- 2022: Member of the 'National College Huang Danian Style Teacher Team'
- 2022: 'My Favorite Mentor in the Eyes of Graduate Students' at Tongji University
- 2022: 'Youth May Fourth Medal' at Tongji University
- 2020: Outstanding Teacher Award of Tongji University Talent Education Award
