2000 - 2004: Bachelor of Science, Ningbo University
2004 - 2007: Master of Science, East China Normal University
2007 - 2012: PhD in Biological Systems Engineering, ETH Zurich
Recipient of the ETH Silver Medal
2012 - 2013: Postdoctoral Researcher, Department of Biosystems Science and Engineering, ETH Zurich
2014 - 2021: Researcher and Doctoral Supervisor, School of Life Sciences, East China Normal University
2021 - Present: Senior Researcher, Vice Dean, Doctoral Supervisor, School of Life Sciences, East China Normal University
2013: ETH Silver Medal
2015: National Science Foundation of China Outstanding Young Scientist Grant
2018: Distinguished Young Scientist Award, Science China
2020: National Young Science and Technology Leader Award
Research
Synthetic Biology and Biomedical Engineering Precision and Intelligent Gene Therapy and Cell Therapy for Metabolic Diseases and Cancer
AAV-delivered muscone-induced transgene system for treating chronic diseases in mice via inhalation, Wu X, Yu Y, Wang M, Dai D, Yin J, Liu W, Kong D, Tang S, Meng M, Gao T, Zhang Y, Zhou Y, Guan N, Zhao S, Ye H*, 2024
A programmable protease-based protein secretion platform for therapeutic applications, Xinyi Wang, Liping Kang, Deqiang Kong, Xin Wu, Yang Zhou, Guiling Yu, Di Dai & Haifeng Ye*, 2023
Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice, Wang Y, Xu Y, Tan CW, Qiao L, Chia WN, Zhang H, Huang Q, Deng Z, Wang Z, Wang X, Shen X, Liu C, Pei R, Liu Y, Xue S, Kong D, Anderson DE, Cai F, Zhou P, Wang LF*, Ye H*, 2022
Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy, Yu Y, Wu X, Wang M, Liu W, Zhang L, Zhang Y, Hu Z, Zhou X, Jiang W, Zou Q, Cai F, Ye H*, 2022
A small and highly sensitive red/far-red optogenetic switch for applications in mammals, Yang Zhou, Deqiang Kong, Xinyi Wang, Guiling Yu, Xin Wu, Ningzi Guan, Wilfried Weber & Haifeng Ye*, 2022
Genetic-code-expanded cell-based therapy for treating diabetes in mice, Chao Chen, Guiling Yu, Yujia Huang, Wenhui Cheng, Yuxuan Li, Yi Sun, Haifeng Ye* & Tao Liu*, 2022
Far-red light-activated human islet-like designer cells enable sustained fine-tuned secretion of insulin for glucose control, Guiling Yu, Mingliang Zhang, Ling Gao, Yang Zhou, Longliang Qiao, Jianli Yin, Yiwen Wang, Jian Zhou*, and Haifeng Ye*, 2022
Engineering genetic devices for in vivo control of therapeutic T cell activity triggered by the dietary molecule resveratrol, Linfeng Yang, Jianli Yin, Jiali Wu, Longliang Qiao, Evan M Zhao, Fengfeng Cai, Haifeng Ye*, 2021
A versatile genetic control system in mammalian cells and mice responsive to clinically licensed sodium ferulate, Yi Wang, Shu Liao, Ningzi. Guan, Yuanxiao. Liu, Kaili. Dong, Wilfried Weber, Haifeng Ye*, 2020
A non-invasive far-red light-induced split-Cre recombinase system for controllable genome engineering in mice, Jiali Wu, Meiyan Wang, Xueping Yang, Chengwei Yi, Jian Jiang, Yuanhuan Yu，Haifeng Ye*, 2020
Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors, Yuanhuan Yu, Xin Wu, Ningzi Guan, Jiawei Shao, Huiying Li, Yuxuan Chen, Yuan Ping, Dali Li and Haifeng Ye*, 2020
Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice, Krzysztof Krawczyk, Shuai Xue, Peter Buchmann, Ghislaine Charpin-El-Hamri, Pratik Saxena, Marie-Didiée Hussherr, Jiawei Shao, Haifeng Ye, Mingqi Xie, Martin Fussenegger*, 2020
A green tea–triggered genetic control system for treating diabetes in mice and monkeys, Jianli Yin, Linfeng Yang, Lisha Mou, Kaili Dong, Jian Jiang, Shuai Xue, Ying Xu, Xinyi Wang, Ying Lu, Haifeng Ye*, 2019
A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice, Ying Liu, Ghislaine Charpin-EI Hamri, Haifeng Ye, Martin Fussenegger*, 2018
Immunomimetic Designer Cells Protect Mice from MRSA Infection, Ying Liu, Peng Bai, Anne-Kathrin Woischnig, Ghislaine Charpin-El Hamri, Haifeng Ye, Marc Folcher, Mingqi Xie, Nina Khanna, Martin Fussenegger*, 2018
A synthetic biology-inspired therapeutic strategy for targeting and treating hepatogenous diabetes., Shuai Xue, Jianli Yin, Jiawei Shao, Yuanhuan Yu, Linfeng Yang,Yidan Wang, Mingqi Xie, Martin Fussenegger and Haifeng Ye*, 2017
Self-adjusting synthetic gene circuit for correcting insulin resistance, Haifeng Ye*, Mingqi Xie, Shuai Xue, Ghislaine Charpin-El Hamri, Jianli Yin, Henryk Zulewskiand Martin Fussenegger*, 2017
β-cell-mimetic designer cells provide closed-loop glycemic control, Mingqi Xie, Haifeng Ye, Hui Wang, Ghislaine Charpin-El Hamri, Claude Lormeau, Pratik Saxena, Jörg Stelling* and Martin Fussenegger*, 2016
A synthetic biology-based device prevents liver injury in mice, Peng Bai, Haifeng Ye, Mingqi Xie, Pratik Saxena, Henryk Zulewski, Ghislaine Charpin-El Hamri, Valentin Djonovand，Martin Fussenegger*, 2016
Cosmetics-triggered percutaneous remote control of transgene expression in mice, Wang H, Haifeng Ye, Xie M, Daoud El-Baba M, Fussenegger M*, 2015
Antagonistic control of a dual-input mammalian gene switch by food additives, Mingqi Xie, Haifeng Ye, Hamri GC, Martin Fussenegger*, 2014
Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome, Haifeng Ye, Charpin-El Hamri, G., Zwicky, K., Christen, M., Marc Folcher, Martin Fussenegger*, 2013
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice, Haifeng Ye,Daoud-El Baba, M., Peng, R.W. & Martin Fussenegger*, 2011
Poly(gamma,L-glutamic acid)-cisplatin conjugate effectively inhibits human breast tumor xenografted in nude mice, Haifeng Ye, Jin L, Hu R, Yi Z, Li J, Wu Y, Xi X, Wu Z*, 2006
