Areas of Focus
- Pathology and Pathophysiology - Cell Death and Immune Metabolism
- Cell Biology - Cell Death and Immune Metabolism
Work Experience
- 2013-04~Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher/Group Leader
- 2012-04~2013-04 - Children's Hospital of Philadelphia - Postdoctoral Researcher
- 2006-02~2012-03 - Thomas Jefferson University - Postdoctoral Researcher
Academic Background & Achievements
- 2000-09--2005-07 PhD: Shanghai Institute of Biological Sciences, Chinese Academy of Sciences
- 1993-09--1997-07 Bachelor's Degree: Shandong University, School of Life Sciences
Publications
- ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression, 11th Author, 2023
- A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis, 30th Author, 2023
- Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development, 26th Author, 2022
- Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia, 11th Author, 2022
- Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development, 11th Author, 2022
- Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease, 11th Author, 2020
- Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition, 8th Author, 2020
- Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer, 23rd Author, 2020
- A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression, 8th Author, 2020
- Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation, 11th Author, 2020
- Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3, 0th Author, 2019
- MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses, 11th Author, 2019
- Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis, 11th Author, 2019
- Neonatal lethality and recycling defect of transferrin receptor in mice with Syntaxin12/13 disruption, 7th Author, 2019
- Metabolic benefits of inhibition of p38 alpha in white adipose tissue in obesity, 12th Author, 2018
- Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME, 11th Author, 2018
- Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis, 11th Author, 2018
- Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME, 2nd Author, 2018
- RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice, 11th Author, 2017
- RIP1 kinase activity-dependent roles in embryonic development of Fadd -deficient mice, 11th Author, 2017
- RIP1 kinase activity-dependent roles in embryonic development of Fadd -deficient mice, 11th Author, 2017
- Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation, 11th Author, 2017
- A novel sgRNA selection system for CRISPR-Cas9 in mammalian cells, 11th Author, 2016
- MLKL and FADD are Critical for Suppressing Progressive Lymphoaccumulative Disease and Activating NLRP3 Inflammasome, 11th Author, 2016
- Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-��B and MAPK in macrophages, 11th Author, 2016
- Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-kappa B and MAPK in macrophages, 11th Author, 2016
- MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome, 11th Author, 2016
- Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality, 11th Author, 2016
Awards
- Patent (2020): sgRNA screening system and method, Patent No: CN106636154B
