Areas of Focus
- 病理学与病理生理学 - 细胞死亡与免疫代谢
- 细胞生物学 - 细胞死亡与免疫代谢
Work Experience
- 2013-04~现在 - 中国科学院上海营养与健康研究所 - 研究员/课题组长
- 2012-04~2013-04 - 费城儿童医院 - 博士后
- 2006-02~2012-03 - 托马斯杰斐逊大学 - 博士后
Academic Background & Achievements
- 2000-09--2005-07 博士学位: 中科院上海生科院
- 1993-09--1997-07 学士学位: 山东大学生命科学学院
Publications
- ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression, 第11作者, 2023
- A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis, 第30作者, 2023
- Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development, 第26作者, 2022
- Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia, 第11作者, 2022
- Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development, 第11作者, 2022
- Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease, 第11作者, 2020
- Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition, 第8作者, 2020
- Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer, 第23作者, 2020
- A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression, 第8作者, 2020
- Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation, 第11作者, 2020
- Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3, 第0作者, 2019
- MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses, 第11作者, 2019
- Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis, 第11作者, 2019
- Neonatal lethality and recycling defect of transferrin receptor in mice with Syntaxin12/13 disruption, 第7作者, 2019
- Metabolic benefits of inhibition of p38 alpha in white adipose tissue in obesity, 第12作者, 2018
- Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME, 第11作者, 2018
- Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis, 第11作者, 2018
- Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME, 第2作者, 2018
- RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice, 第11作者, 2017
- RIP1 kinase activity-dependent roles in embryonic development of Fadd -deficient mice, 第11作者, 2017
- RIP1 kinase activity-dependent roles in embryonic development of Fadd -deficient mice, 第11作者, 2017
- Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation, 第11作者, 2017
- A novel sgRNA selection system for CRISPR-Cas9 in mammalian cells, 第11作者, 2016
- MLKL and FADD are Critical for Suppressing Progressive Lymphoaccumulative Disease and Activating NLRP3 Inflammasome, 第11作者, 2016
- Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-��B and MAPK in macrophages, 第11作者, 2016
- Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-kappa B and MAPK in macrophages
Awards
- 专利 (2020): sgRNA筛选系统和方法, 专利号: CN106636154B
