Professor | Haiyan Zhang | Asia Growth Partners

Name	Haiyan Zhang
Contact Information	hzhang@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Haiyan Zhang

Contact Information

hzhang@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1998-09--2003-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Work Experience	2007-03~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher, Group Leader 2003-08~2007-03 - Mayo Clinic and Wake Forest University, USA - Postdoctoral Researcher, Research Assistant 1998-09~2003-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD
Awards	Sanofi-Aventis - Chinese Academy of Sciences Shanghai Institute of Life Sciences Outstanding Young Talent Award (2010) Chinese Pharmacological Society SERVIER Young Pharmacologist Award (2010)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1998-09--2003-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Work Experience

2007-03~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher, Group Leader
2003-08~2007-03 - Mayo Clinic and Wake Forest University, USA - Postdoctoral Researcher, Research Assistant
1998-09~2003-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD

Awards

Sanofi-Aventis - Chinese Academy of Sciences Shanghai Institute of Life Sciences Outstanding Young Talent Award (2010)
Chinese Pharmacological Society SERVIER Young Pharmacologist Award (2010)

Areas of Focus	Pathogenesis and treatment strategies for Alzheimer's disease, stroke, and depression Pharmacology of traditional Chinese medicine
Publications	A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice., RSC Med Chem., 2024 JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways., ACS Chem Neurosci, 2024 Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques, ACS CHEMICAL NEUROSCIENCE, 2023 The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression, Eur J Med Chem., 2022 Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression., Eur J Med Chem., 2022 Fused-ring β-pyrones from intramolecular C–H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022 High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice, Front Neurosci, 2022 PDPOB Exerts Multiaspect Anti-Ischemic Effects Associated with the Regulation of PI3K/AKT and MAPK Signaling Pathways., ACS Chem Neurosci, 2021 FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway, Int Immunopharmacol, 2021 Diterpenoids from the seeds of Euphorbia lathyris and their effects on microglial nitric oxide production, FITOTERAPIA, 2021 Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease, J Med Chem, 2021 Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry, JOURNAL OF ORGANIC CHEMISTRY, 2021 Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, JOURNAL OF MEDICINAL CHEMISTRY, 2021 New sterols from the South China Sea sponges Halichondria sp., FITOTERAPIA, 2021 An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways, ACTA PHARMACOLOGICA SINICA, 2021 Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis, NEUROCHEMICAL RESEARCH, 2021 Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents, JOURNAL OF MEDICINAL CHEMISTRY, 2020 Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity, ACSCHEMICALNEUROSCIENCE, 2020 Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri, JOURNAL OF NATURAL PRODUCTS, 2020 Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent, ACTA PHARMACEUTICA SINICA B, 2020 advancesinthedevelopmentofimagingprobesandaggregationinhibitorsforalphasynuclein, ACTA PHARMACOLOGICA SINICA, 2020 1,5-Hydride Shift-Cyclization versus C(sp 2 )-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines, MOLECULES, 2020 Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents., J Med Chem., 2020 Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, Acta Pharmacol Sin., 2019 Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide, CHEMBIOCHEM, 2019 Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation., Cell Mol Neurobiol., 2019 Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents, ACS CHEMICAL NEUROSCIENCE, 2019 Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2019 Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression, CELL RESEARCH, 2019 Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-beta Plaques with Ultrasensitivity and High-Fidelity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019 A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo, ACTA PHARMACOLOGICA SINICA, 2019 Neuroprotective Dihydro-beta-agarofuran-Type Sesquiterpenes from the Seeds of Euonymus maackii, JOURNAL OF NATURAL PRODUCTS, 2019 Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity, FITOTERAPIA, 2019 Interplay between Alzheimer’s disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, ACTA PHARMACOLOGICA SINICA, 2019 Lycofargesiines A–F, further Lycopodium alkaloids from the club moss Huperzia fargesii, PHYTOCHEMISTRY, 2019 Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease, ACS CHEMICAL NEUROSCIENCE, 2019 Iron dysregulates APP processing accompanying with sAPP alpha cellular retention and beta-secretase inhibition in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2018 Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe, BIOCONJUGATE CHEMISTRY, 2018 Iron-induced energy supply deficiency and mitochondrial fragmentation in neurons, JOURNAL OF NEUROCHEMISTRY, 2018 HPLC-ECD and TDDFT-ECD study of hexahydropyrrolo1,2-aquinoline derivatives, CHIRALITY, 2018 Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents, PHYTOCHEMISTRY LETTERS, 2018 Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5), ACS CHEMICAL NEUROSCIENCE, 2018 Iron dysregulates APP processing accompanying with sAPPa cellular retention and β-secretase inhibition in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2018 Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment, BIOORGANIC & MEDICINAL CHEMISTRY, 2018 Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018 Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholin

Areas of Focus

Pathogenesis and treatment strategies for Alzheimer's disease, stroke, and depression
Pharmacology of traditional Chinese medicine

Publications

A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice., RSC Med Chem., 2024
JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways., ACS Chem Neurosci, 2024
Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques, ACS CHEMICAL NEUROSCIENCE, 2023
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression, Eur J Med Chem., 2022
Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression., Eur J Med Chem., 2022
Fused-ring β-pyrones from intramolecular C–H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022
High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice, Front Neurosci, 2022
PDPOB Exerts Multiaspect Anti-Ischemic Effects Associated with the Regulation of PI3K/AKT and MAPK Signaling Pathways., ACS Chem Neurosci, 2021
FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway, Int Immunopharmacol, 2021
Diterpenoids from the seeds of Euphorbia lathyris and their effects on microglial nitric oxide production, FITOTERAPIA, 2021
Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease, J Med Chem, 2021
Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry, JOURNAL OF ORGANIC CHEMISTRY, 2021
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, JOURNAL OF MEDICINAL CHEMISTRY, 2021
New sterols from the South China Sea sponges Halichondria sp., FITOTERAPIA, 2021
An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways, ACTA PHARMACOLOGICA SINICA, 2021
Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis, NEUROCHEMICAL RESEARCH, 2021
Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents, JOURNAL OF MEDICINAL CHEMISTRY, 2020
Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity, ACSCHEMICALNEUROSCIENCE, 2020
Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri, JOURNAL OF NATURAL PRODUCTS, 2020
Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent, ACTA PHARMACEUTICA SINICA B, 2020
advancesinthedevelopmentofimagingprobesandaggregationinhibitorsforalphasynuclein, ACTA PHARMACOLOGICA SINICA, 2020
1,5-Hydride Shift-Cyclization versus C(sp 2 )-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines, MOLECULES, 2020
Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents., J Med Chem., 2020
Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, Acta Pharmacol Sin., 2019
Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide, CHEMBIOCHEM, 2019
Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation., Cell Mol Neurobiol., 2019
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents, ACS CHEMICAL NEUROSCIENCE, 2019
Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2019
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression, CELL RESEARCH, 2019
Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-beta Plaques with Ultrasensitivity and High-Fidelity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019
A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo, ACTA PHARMACOLOGICA SINICA, 2019
Neuroprotective Dihydro-beta-agarofuran-Type Sesquiterpenes from the Seeds of Euonymus maackii, JOURNAL OF NATURAL PRODUCTS, 2019
Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity, FITOTERAPIA, 2019
Interplay between Alzheimer’s disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, ACTA PHARMACOLOGICA SINICA, 2019
Lycofargesiines A–F, further Lycopodium alkaloids from the club moss Huperzia fargesii, PHYTOCHEMISTRY, 2019
Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease, ACS CHEMICAL NEUROSCIENCE, 2019
Iron dysregulates APP processing accompanying with sAPP alpha cellular retention and beta-secretase inhibition in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2018
Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe, BIOCONJUGATE CHEMISTRY, 2018
Iron-induced energy supply deficiency and mitochondrial fragmentation in neurons, JOURNAL OF NEUROCHEMISTRY, 2018
HPLC-ECD and TDDFT-ECD study of hexahydropyrrolo1,2-aquinoline derivatives, CHIRALITY, 2018
Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents, PHYTOCHEMISTRY LETTERS, 2018
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5), ACS CHEMICAL NEUROSCIENCE, 2018
Iron dysregulates APP processing accompanying with sAPPa cellular retention and β-secretase inhibition in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2018
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment, BIOORGANIC & MEDICINAL CHEMISTRY, 2018
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholin

Alzheimer'S Disease Stroke Depression Pathogenesis Treatment Strategies Traditional Chinese Medicine Pharmacology Neurodegenerative Diseases Mechanisms Therapeutics

Jiahuan Xiao - Wuhan University

Yajie Wang - Wuhan University

Zhihao Wang - Wuhan University

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