Areas of Focus
- Pathogenesis and treatment strategies for Alzheimer's disease, stroke, and depression
- Pharmacology of traditional Chinese medicine
Work Experience
- 2007-03~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher, Group Leader
- 2003-08~2007-03 - Mayo Clinic and Wake Forest University, USA - Postdoctoral Researcher, Research Assistant
- 1998-09~2003-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD
Academic Background & Achievements
- 1998-09--2003-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Publications
- A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice., RSC Med Chem., 2024
- JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways., ACS Chem Neurosci, 2024
- Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques, ACS CHEMICAL NEUROSCIENCE, 2023
- The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression, Eur J Med Chem., 2022
- Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression., Eur J Med Chem., 2022
- Fused-ring β-pyrones from intramolecular C–H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022
- High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice, Front Neurosci, 2022
- PDPOB Exerts Multiaspect Anti-Ischemic Effects Associated with the Regulation of PI3K/AKT and MAPK Signaling Pathways., ACS Chem Neurosci, 2021
- FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway, Int Immunopharmacol, 2021
- Diterpenoids from the seeds of Euphorbia lathyris and their effects on microglial nitric oxide production, FITOTERAPIA, 2021
- Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease, J Med Chem, 2021
- Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry, JOURNAL OF ORGANIC CHEMISTRY, 2021
- Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, JOURNAL OF MEDICINAL CHEMISTRY, 2021
- New sterols from the South China Sea sponges Halichondria sp., FITOTERAPIA, 2021
- An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways, ACTA PHARMACOLOGICA SINICA, 2021
- Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis, NEUROCHEMICAL RESEARCH, 2021
- Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents, JOURNAL OF MEDICINAL CHEMISTRY, 2020
- Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity, ACSCHEMICALNEUROSCIENCE, 2020
- Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri, JOURNAL OF NATURAL PRODUCTS, 2020
- Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent, ACTA PHARMACEUTICA SINICA B, 2020
- advancesinthedevelopmentofimagingprobesandaggregationinhibitorsforalphasynuclein, ACTA PHARMACOLOGICA SINICA, 2020
- 1,5-Hydride Shift-Cyclization versus C(sp 2 )-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines, MOLECULES, 2020
- Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents., J Med Chem., 2020
- Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, Acta Pharmacol Sin., 2019
- Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide, CHEMBIOCHEM, 2019
- Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation., Cell Mol Neurobiol., 2019
- Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents, ACS CHEMICAL NEUROSCIENCE, 2019
- Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2019
- Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression, CELL RESEARCH, 2019
- Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-beta Plaques with Ultrasensitivity and High-Fidelity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019
- A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo, ACTA PHARMACOLOGICA SINICA, 2019
- Neuroprotective Dihydro-beta-agarofuran-Type Sesquiterpenes from the Seeds of Euonymus maackii, JOURNAL OF NATURAL PRODUCTS, 2019
- Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity, FITOTERAPIA, 2019
- Interplay between Alzheimer’s disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, ACTA PHARMACOLOGICA SINICA, 2019
- Lycofargesiines A–F, further Lycopodium alkaloids from the club moss Huperzia fargesii, PHYTOCHEMISTRY, 2019
- Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease, ACS CHEMICAL NEUROSCIENCE, 2019
- Iron dysregulates APP processing accompanying with sAPP alpha cellular retention and beta-secretase inhibition in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2018
- Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe, BIOCONJUGATE CHEMISTRY, 2018
- Iron-induced energy supply deficiency and mitochondrial fragmentation in neurons, JOURNAL OF NEUROCHEMISTRY, 2018
- HPLC-ECD and TDDFT-ECD study of hexahydropyrrolo1,2-aquinoline derivatives, CHIRALITY, 2018
- Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents, PHYTOCHEMISTRY LETTERS, 2018
- Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5), ACS CHEMICAL NEUROSCIENCE, 2018
- Iron dysregulates APP processing accompanying with sAPPa cellular retention and β-secretase inhibition in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2018
- Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment, BIOORGANIC & MEDICINAL CHEMISTRY, 2018
- Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018
- Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholin
Awards
- Sanofi-Aventis - Chinese Academy of Sciences Shanghai Institute of Life Sciences Outstanding Young Talent Award (2010)
- Chinese Pharmacological Society SERVIER Young Pharmacologist Award (2010)
