Professor | Zehong Miao | Asia Growth Partners

Name	Zehong Miao
Contact Information	zhmiao@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Zehong Miao

Contact Information

zhmiao@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2004.10-2006.9 Visiting Fellow: Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, USA 2000.9-2003.7 Ph.D. in Pharmacology: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 1993.9-1996.7 Master's in Pharmacology: Cancer Institute, Chinese Academy of Medical Sciences 1982.9-1988.7 Bachelor's in Medicine: West China University of Medical Sciences
Work Experience	2003.7-Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Group Leader 1988.7-2000.8 - Luzhou Medical College - Assistant Lecturer, Lecturer, Associate Professor
Awards	National Outstanding Youth Fund (2010) Second Prize of National Natural Science Award (2009) Third Prize of WuXi AppTec Life Chemistry Research Award (2009) Selected for Shanghai Pujiang Talent Program (2008) First Prize of Shanghai Natural Science Award (2007) National Excellent Doctoral Dissertation Award (2005) Special Award of the President of the Chinese Academy of Sciences (2004) Excellent Doctoral Dissertation of the Chinese Academy of Sciences (2004) First Prize of Shanghai Pharmaceutical Science and Technology Award (2004) Servier Award of the Chinese Pharmacological Society (2003)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2004.10-2006.9 Visiting Fellow: Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, USA
2000.9-2003.7 Ph.D. in Pharmacology: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1993.9-1996.7 Master's in Pharmacology: Cancer Institute, Chinese Academy of Medical Sciences
1982.9-1988.7 Bachelor's in Medicine: West China University of Medical Sciences

Work Experience

2003.7-Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Group Leader
1988.7-2000.8 - Luzhou Medical College - Assistant Lecturer, Lecturer, Associate Professor

Awards

National Outstanding Youth Fund (2010)
Second Prize of National Natural Science Award (2009)
Third Prize of WuXi AppTec Life Chemistry Research Award (2009)
Selected for Shanghai Pujiang Talent Program (2008)
First Prize of Shanghai Natural Science Award (2007)
National Excellent Doctoral Dissertation Award (2005)
Special Award of the President of the Chinese Academy of Sciences (2004)
Excellent Doctoral Dissertation of the Chinese Academy of Sciences (2004)
First Prize of Shanghai Pharmaceutical Science and Technology Award (2004)
Servier Award of the Chinese Pharmacological Society (2003)

Areas of Focus	Tumor Pharmacology
Publications	Discovery of novel 2-phenyl-imidazo1,2-apyridine analogues targeting tubulin polymerization as antiproliferative agents, An, Weiteng, Wang, Wei, Yu, Ting, Zhang, Yongliang, Miao, Zehong, Meng, Tao, Shen, Jingkang, 2016 An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy, Wang, YingQing, Wang, PingYuan, Wang, YuTing, Yang, GuangFu, Zhang, Ao, Miao, ZeHong, 2016 Triptolide Induces Cell Killing in Multidrug-Resistant Tumor Cells via CDK7/RPB1 Rather than XPB or p44, Yi, JunMei, Huan, XiaJuan, Song, ShanShan, Zhou, Hu, Wang, YingQing, Miao, ZeHong, 2016 Design, synthesis, and anticancer activities of new compounds bearing the quinone-pyran-lactone tricyclic pharmacophore, Jiang, Xue, Wang, Meining, Song, Shanshan, Xu, Youjun, Miao, Zehong, Zhang, Ao, 2015 Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells, Yan Wang, JiaXin Li, YingQing Wang, ZeHong Miao, 2015 RhIII-Catalyzed Redox-Neutral C-H Activation of Pyrazolones: An Economical Approach for Synthesis of N-Substituted Indoles, 缪泽鸿, 2015 Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition, JunMei Yi, XiaoFei Zhang, XiaJuan Huan, ShanShan Song, Wei Wang, QianTing Tian, YiMing Sun, Yi Chen, Jian Ding, YingQing Wang, ChunHao Yang, ZeHong Miao, 2015 Fragment-Based Drug Discovery of 2-Thiazolidinones as BRD4 Inhibitors: 2. Structure-Based Optimization, Zhao, Lele, Wang, Yingqing, Cao, Danyan, Chen, Tiantian, Wang, Qi, Li, Yanlian, Xu, Yechun, Zhang, Naixia, Wang, Xin, Chen, Danqi, Chen, Lin, Chen, YueLei, Xia, Guangxin, Shi, Zhe, Liu, YuChih, Lin, Yijyun, Miao, Zehong, Shen, Jingkang, Xiong, Bing, 2015 The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury, Li, JX, Feng, JM, Wang, Y, Li, XH, Chen, XX, Su, Y, Shen, YY, Chen, Y, Xiong, B, Yang, CH, Ding, J, Miao, ZH, 2014 Natrual product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents, 缪泽鸿, 2014 Catalyst-free synthesis of benzofuran-fused pyrido 4,3-dpyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions, Li, Bo, Yue, Zhizhou, Xiang, Haoyue, Lv, Linlin, Song, Shanshan, Miao, Zehong, Yang, Chunhao, 2014 MCL-1 Degradation Mediated by JNK Activation via MEKK1/TAK1-MKK4 Contributes to Anticancer Activity of New Tubulin Inhibitor MT189, Wang, Wei, Wang, YingQing, Meng, Tao, Yi, JunMei, Huan, XiaJuan, Ma, LanPing, Tong, LinJiang, Chen, Yi, Ding, Jian, Shen, JingKang, Miao, ZeHong, 2014 Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribosyl) polymerase-1 (PARP-1) inhibitors, 缪泽鸿, 2014 Rapid Access to α-Carbolines via a One-pot Tandem Reaction of α, β-Unsaturated Ketones with 2-Nitrophenylacetonitrile and the Bioactivities of the Products, 缪泽鸿, 2014 Synthesis and biological evaluation of 6H-pyrido2 ',1 ':2,3 imidazo4,5-c isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization, Meng, Tao, Wang, Wei, Zhang, Zhixiang, Ma, Lanping, Zhang, Yongliang, Miao, Zehong, Shen, Jingkang, 2014 The inhibition of metastasis and growth of breast cancer by blocking the NF-kB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles, 缪泽鸿, 2013 Design and synthesis of pyrido[3,2-a]carbazole derivatives and their analogues as potent antitumor agents, 缪泽鸿, 2013 Marine-Derived Angiogenesis Inhibitors for Cancer Therapy, YingQing Wang, 2013 Tanshinone-1 induces tumor cell killing, enhanced by inhibition of secondary activation of signaling networks, Xu, L, Feng, JM, Li, JX, Zhu, JM, Song, SS, Tong, LJ, Chen, Y, Yang, XY, Shen, YY, Lian, FL, Li, YP, Lin, DH, Ding, J, Miao, ZH, 2013 Design, synthesis and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8h)-ones bearing a longer chain as novel PARP1 inhibitors, 缪泽鸿, 2013 Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II, Manzo, Stefano Giustino, Zhou, ZhaoLi, Wang, YingQing, Marinello, Jessica, He, JinXue, Li, YuanChao, Ding, Jian, Capranico, Giovanni, Miao, ZeHong, 2012 The Conversion Between the CD133+ Cells and the CD133- Cells in the Colon Cancer SW620 Cell Line, 缪泽鸿, 2012 Differential sensitivity of RIP3-proficient and deficient murine fibroblasts to camptothecin anticancer drugs, Jin-xue HE Ying-qing WANG Jian-ming FENG Jia-xin LI Lei XU Xiao-hua LI Wei WANG Xia-juan HUAN Yi JIANG Bing CHEN Ze-hong MIAO, 2012 Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms, Zhou, ZhaoLi, Yang, YaXi, Ding, Jian, Li, YuanChao, Miao, ZeHong, 2012 Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model, Yu, Bing, Li, MeiHong, Wang, Wei, Wang, YingQing, Jiang, Yi, Yang, ShengPing, Yue, JianMin, Ding, Jian, Miao, ZeHong, 2012 Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamide as novel antitumor agents, 缪泽鸿, 2011 Echinoside A, a new marine-derived anticancer saponin, targets topoisomerase II? by unique interference with its DNA binding and catalytic cycle, 缪泽鸿, 2010 MFTZ-1, a novel topoisomerase II poison, reduces constitutive and inducible HIF-1α accumulation and VEGF secretion irrelevant to its topoisomerase II inhibition, 缪泽鸿, 2010 MT7, a novel compound from a combinatorial library, arrests mitosis via

Areas of Focus

Tumor Pharmacology

Publications

Discovery of novel 2-phenyl-imidazo1,2-apyridine analogues targeting tubulin polymerization as antiproliferative agents, An, Weiteng, Wang, Wei, Yu, Ting, Zhang, Yongliang, Miao, Zehong, Meng, Tao, Shen, Jingkang, 2016
An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy, Wang, YingQing, Wang, PingYuan, Wang, YuTing, Yang, GuangFu, Zhang, Ao, Miao, ZeHong, 2016
Triptolide Induces Cell Killing in Multidrug-Resistant Tumor Cells via CDK7/RPB1 Rather than XPB or p44, Yi, JunMei, Huan, XiaJuan, Song, ShanShan, Zhou, Hu, Wang, YingQing, Miao, ZeHong, 2016
Design, synthesis, and anticancer activities of new compounds bearing the quinone-pyran-lactone tricyclic pharmacophore, Jiang, Xue, Wang, Meining, Song, Shanshan, Xu, Youjun, Miao, Zehong, Zhang, Ao, 2015
Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells, Yan Wang, JiaXin Li, YingQing Wang, ZeHong Miao, 2015
RhIII-Catalyzed Redox-Neutral C-H Activation of Pyrazolones: An Economical Approach for Synthesis of N-Substituted Indoles, 缪泽鸿, 2015
Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition, JunMei Yi, XiaoFei Zhang, XiaJuan Huan, ShanShan Song, Wei Wang, QianTing Tian, YiMing Sun, Yi Chen, Jian Ding, YingQing Wang, ChunHao Yang, ZeHong Miao, 2015
Fragment-Based Drug Discovery of 2-Thiazolidinones as BRD4 Inhibitors: 2. Structure-Based Optimization, Zhao, Lele, Wang, Yingqing, Cao, Danyan, Chen, Tiantian, Wang, Qi, Li, Yanlian, Xu, Yechun, Zhang, Naixia, Wang, Xin, Chen, Danqi, Chen, Lin, Chen, YueLei, Xia, Guangxin, Shi, Zhe, Liu, YuChih, Lin, Yijyun, Miao, Zehong, Shen, Jingkang, Xiong, Bing, 2015
The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury, Li, JX, Feng, JM, Wang, Y, Li, XH, Chen, XX, Su, Y, Shen, YY, Chen, Y, Xiong, B, Yang, CH, Ding, J, Miao, ZH, 2014
Natrual product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents, 缪泽鸿, 2014
Catalyst-free synthesis of benzofuran-fused pyrido 4,3-dpyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions, Li, Bo, Yue, Zhizhou, Xiang, Haoyue, Lv, Linlin, Song, Shanshan, Miao, Zehong, Yang, Chunhao, 2014
MCL-1 Degradation Mediated by JNK Activation via MEKK1/TAK1-MKK4 Contributes to Anticancer Activity of New Tubulin Inhibitor MT189, Wang, Wei, Wang, YingQing, Meng, Tao, Yi, JunMei, Huan, XiaJuan, Ma, LanPing, Tong, LinJiang, Chen, Yi, Ding, Jian, Shen, JingKang, Miao, ZeHong, 2014
Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribosyl) polymerase-1 (PARP-1) inhibitors, 缪泽鸿, 2014
Rapid Access to α-Carbolines via a One-pot Tandem Reaction of α, β-Unsaturated Ketones with 2-Nitrophenylacetonitrile and the Bioactivities of the Products, 缪泽鸿, 2014
Synthesis and biological evaluation of 6H-pyrido2 ',1 ':2,3 imidazo4,5-c isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization, Meng, Tao, Wang, Wei, Zhang, Zhixiang, Ma, Lanping, Zhang, Yongliang, Miao, Zehong, Shen, Jingkang, 2014
The inhibition of metastasis and growth of breast cancer by blocking the NF-kB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles, 缪泽鸿, 2013
Design and synthesis of pyrido[3,2-a]carbazole derivatives and their analogues as potent antitumor agents, 缪泽鸿, 2013
Marine-Derived Angiogenesis Inhibitors for Cancer Therapy, YingQing Wang, 2013
Tanshinone-1 induces tumor cell killing, enhanced by inhibition of secondary activation of signaling networks, Xu, L, Feng, JM, Li, JX, Zhu, JM, Song, SS, Tong, LJ, Chen, Y, Yang, XY, Shen, YY, Lian, FL, Li, YP, Lin, DH, Ding, J, Miao, ZH, 2013
Design, synthesis and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8h)-ones bearing a longer chain as novel PARP1 inhibitors, 缪泽鸿, 2013
Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II, Manzo, Stefano Giustino, Zhou, ZhaoLi, Wang, YingQing, Marinello, Jessica, He, JinXue, Li, YuanChao, Ding, Jian, Capranico, Giovanni, Miao, ZeHong, 2012
The Conversion Between the CD133+ Cells and the CD133- Cells in the Colon Cancer SW620 Cell Line, 缪泽鸿, 2012
Differential sensitivity of RIP3-proficient and deficient murine fibroblasts to camptothecin anticancer drugs, Jin-xue HE Ying-qing WANG Jian-ming FENG Jia-xin LI Lei XU Xiao-hua LI Wei WANG Xia-juan HUAN Yi JIANG Bing CHEN Ze-hong MIAO, 2012
Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms, Zhou, ZhaoLi, Yang, YaXi, Ding, Jian, Li, YuanChao, Miao, ZeHong, 2012
Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model, Yu, Bing, Li, MeiHong, Wang, Wei, Wang, YingQing, Jiang, Yi, Yang, ShengPing, Yue, JianMin, Ding, Jian, Miao, ZeHong, 2012
Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamide as novel antitumor agents, 缪泽鸿, 2011
Echinoside A, a new marine-derived anticancer saponin, targets topoisomerase II? by unique interference with its DNA binding and catalytic cycle, 缪泽鸿, 2010
MFTZ-1, a novel topoisomerase II poison, reduces constitutive and inducible HIF-1α accumulation and VEGF secretion irrelevant to its topoisomerase II inhibition, 缪泽鸿, 2010
MT7, a novel compound from a combinatorial library, arrests mitosis via

Tumor Pharmacology Antitumor New Drug Research Hypoxia Response Dna Damage Repair Drug Resistance Cellular Level Molecular Level Intervention Research

Lixia Miao - Wuhan University

Xin Liu - Wuhan University

Liguang Lou - University of Chinese Academy of Sciences

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