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Xin Liu
Medical School
Wuhan University
Hubei
Language: English, Chinese
Angiogenesis
Tumor
Vascular
Drug Development
Mechanisms
Antitumor
Therapy
Pharmacology
Molecular Biology
Clinical Research
Areas of Focus
- Regulation of angiogenesis in tumors
- Anti-tumor drugs and related mechanisms
- Antiviral drugs and related mechanisms
Work Experience
- 2009—2016 Associate Professor, School of Pharmacy, Wuhan University
- 2016—Present Professor, Doctoral Supervisor, Wuhan University
Academic Background & Achievements
- 1994—1998 Bachelor's in Life Sciences, Wuhan University
- 2000—2005 Master's and PhD in Microbiology, Wuhan University
- 2005—2008 Postdoctoral Research, Harvard Medical School/Beth Israel Hospital, USA
Publications
- A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis, Hou S, Niu G, Liu X, Bourbon PM, Zhang D, Cui P, Zhao K, Zhao D, Zeng H, 2021
- Feeding Recombinant E. coli with GSTmBmKTX Fusion Protein Increases the Fecundity and Lifespan of Caenorhabditis elegans, Xu J, Jiang Y, Wan L, Wang Q, Huang Z, Liu Y, Wu Y, Chen Z, Liu X, 2017
- rBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans, Chen L, Zhang J, Xu J, Wan L, Teng K, Xiang J, Zhang R, Huang Z, Liu Y, Li W, Liu X, 2016
- Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer, Teng K, Deng C, Xu J, Men Q, Lei T, Di D, Liu T, Li W, Liu X, 2016
- Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans, Chen J, Zhang J, Xiang Y, Xiang L, Liu Y, He X, Zhou X, Liu X, Huang Z, 2016
- Preclinical Evaluation of an Epidermal Growth Factor Receptor-Targeted Doxorubicin-Peptide Conjugate: Toxicity, Biodistribution, and Efficacy in Mice, Yang F, Ai W, Jiang F, Liu X, Huang Z, Ai S, 2016
- Characterization of the transcriptional activation domains of human TEF3-1 (transcription enhancer factor 3 isoform 1), Qiao C, Jiang Y, Deng C, Huang Z, Teng K, Chen L, Liu X, 2015
- Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells, Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X, Li W, 2015
- Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species, Wang H, Liu T, Li L, Wang Q, Yu C, Liu X, Li W, 2015
- Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo, Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X, 2015
- Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor, Liu X, Zhao D, James L, Li J, Zeng H, 2011
- Transcription Enhancer Factor 3 (TEF3) Mediates the Expression of Down Syndrome Candidate Region 1 Isoform 1 (DSCR1-1L) in Endothelial Cells, Liu X, Zhao D, Qin L, Li J, Zeng H, 2008
- Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway, Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H, 2006
- Expression of SLAM (CDw150) on SF9 cell surface mediates Measles Viral infection in the nonpermissive cells through SLAM/MVH interaction, Liu X, Zhou W, Qi Y, 2005
- Development of viral vectors for gene therapy for chronic pain, Huang Y, Liu X, Dong L, Liu Z, He X, Liu W, 2011
- Hemagglutinin protein of measles virus induces apoptosis of HeLa cells via bot extrinsic and intrinsic pathways, Yi C, Liu X, Liu Y, Lu S, Qi Y, 2013
- ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells, Li J, Chen Y, Wan J, Liu X, Yu C, Li W, 2014
- Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells, Ai S, Jia T, Ai W, Duan J, Liu Y, Chen J, Liu X, Yang F, Tian Y, Huang Z, 2013
- Biological evaluation of a novel Doxorubicin-peptide conjugate for targeted delivery to EGF receptor-overexpressing tumor cells, Ai S, Duan J, Liu X, Bock S, Tian Y, Huang Z, 2011
- Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21, Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W, 2015
Awards
- 2012 Yellow Crane Talent
- 2014 Second Prize, Young Teacher Lecture Competition, School of Pharmacy, Wuhan University
- 2015 Hubei Province Outstanding Bachelor Thesis Advisor, Advanced Female Worker of Wuhan University
- 2016 Outstanding Contribution Award, Medical Department, Wuhan University
- 2017 Second Prize, Wuhan University Teaching Achievement Award (Participant)
- 2018 Third Prize, Hubei Province Higher Education Teaching Achievement Award (Participant)
