Professor | Xin Liu | Asia Growth Partners

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Name	Xin Liu
Contact Information	lx@whu.edu.cn
Language ability	English, Chinese
Province	Hubei

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Name

Xin Liu

Contact Information

lx@whu.edu.cn

Language ability

English, Chinese

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	1994—1998 Bachelor's in Life Sciences, Wuhan University 2000—2005 Master's and PhD in Microbiology, Wuhan University 2005—2008 Postdoctoral Research, Harvard Medical School/Beth Israel Hospital, USA
Work Experience	2009—2016 Associate Professor, School of Pharmacy, Wuhan University 2016—Present Professor, Doctoral Supervisor, Wuhan University
Awards	2012 Yellow Crane Talent 2014 Second Prize, Young Teacher Lecture Competition, School of Pharmacy, Wuhan University 2015 Hubei Province Outstanding Bachelor Thesis Advisor, Advanced Female Worker of Wuhan University 2016 Outstanding Contribution Award, Medical Department, Wuhan University 2017 Second Prize, Wuhan University Teaching Achievement Award (Participant) 2018 Third Prize, Hubei Province Higher Education Teaching Achievement Award (Participant)

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

1994—1998 Bachelor's in Life Sciences, Wuhan University
2000—2005 Master's and PhD in Microbiology, Wuhan University
2005—2008 Postdoctoral Research, Harvard Medical School/Beth Israel Hospital, USA

Work Experience

2009—2016 Associate Professor, School of Pharmacy, Wuhan University
2016—Present Professor, Doctoral Supervisor, Wuhan University

Awards

2012 Yellow Crane Talent
2014 Second Prize, Young Teacher Lecture Competition, School of Pharmacy, Wuhan University
2015 Hubei Province Outstanding Bachelor Thesis Advisor, Advanced Female Worker of Wuhan University
2016 Outstanding Contribution Award, Medical Department, Wuhan University
2017 Second Prize, Wuhan University Teaching Achievement Award (Participant)
2018 Third Prize, Hubei Province Higher Education Teaching Achievement Award (Participant)

Areas of Focus	Regulation of angiogenesis in tumors Anti-tumor drugs and related mechanisms Antiviral drugs and related mechanisms
Publications	A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis, Hou S, Niu G, Liu X, Bourbon PM, Zhang D, Cui P, Zhao K, Zhao D, Zeng H, 2021 Feeding Recombinant E. coli with GSTmBmKTX Fusion Protein Increases the Fecundity and Lifespan of Caenorhabditis elegans, Xu J, Jiang Y, Wan L, Wang Q, Huang Z, Liu Y, Wu Y, Chen Z, Liu X, 2017 rBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans, Chen L, Zhang J, Xu J, Wan L, Teng K, Xiang J, Zhang R, Huang Z, Liu Y, Li W, Liu X, 2016 Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer, Teng K, Deng C, Xu J, Men Q, Lei T, Di D, Liu T, Li W, Liu X, 2016 Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans, Chen J, Zhang J, Xiang Y, Xiang L, Liu Y, He X, Zhou X, Liu X, Huang Z, 2016 Preclinical Evaluation of an Epidermal Growth Factor Receptor-Targeted Doxorubicin-Peptide Conjugate: Toxicity, Biodistribution, and Efficacy in Mice, Yang F, Ai W, Jiang F, Liu X, Huang Z, Ai S, 2016 Characterization of the transcriptional activation domains of human TEF3-1 (transcription enhancer factor 3 isoform 1), Qiao C, Jiang Y, Deng C, Huang Z, Teng K, Chen L, Liu X, 2015 Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells, Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X, Li W, 2015 Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species, Wang H, Liu T, Li L, Wang Q, Yu C, Liu X, Li W, 2015 Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo, Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X, 2015 Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor, Liu X, Zhao D, James L, Li J, Zeng H, 2011 Transcription Enhancer Factor 3 (TEF3) Mediates the Expression of Down Syndrome Candidate Region 1 Isoform 1 (DSCR1-1L) in Endothelial Cells, Liu X, Zhao D, Qin L, Li J, Zeng H, 2008 Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway, Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H, 2006 Expression of SLAM (CDw150) on SF9 cell surface mediates Measles Viral infection in the nonpermissive cells through SLAM/MVH interaction, Liu X, Zhou W, Qi Y, 2005 Development of viral vectors for gene therapy for chronic pain, Huang Y, Liu X, Dong L, Liu Z, He X, Liu W, 2011 Hemagglutinin protein of measles virus induces apoptosis of HeLa cells via bot extrinsic and intrinsic pathways, Yi C, Liu X, Liu Y, Lu S, Qi Y, 2013 ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells, Li J, Chen Y, Wan J, Liu X, Yu C, Li W, 2014 Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells, Ai S, Jia T, Ai W, Duan J, Liu Y, Chen J, Liu X, Yang F, Tian Y, Huang Z, 2013 Biological evaluation of a novel Doxorubicin-peptide conjugate for targeted delivery to EGF receptor-overexpressing tumor cells, Ai S, Duan J, Liu X, Bock S, Tian Y, Huang Z, 2011 Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21, Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W, 2015

Areas of Focus

Regulation of angiogenesis in tumors
Anti-tumor drugs and related mechanisms
Antiviral drugs and related mechanisms

Publications

A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis, Hou S, Niu G, Liu X, Bourbon PM, Zhang D, Cui P, Zhao K, Zhao D, Zeng H, 2021
Feeding Recombinant E. coli with GSTmBmKTX Fusion Protein Increases the Fecundity and Lifespan of Caenorhabditis elegans, Xu J, Jiang Y, Wan L, Wang Q, Huang Z, Liu Y, Wu Y, Chen Z, Liu X, 2017
rBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans, Chen L, Zhang J, Xu J, Wan L, Teng K, Xiang J, Zhang R, Huang Z, Liu Y, Li W, Liu X, 2016
Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer, Teng K, Deng C, Xu J, Men Q, Lei T, Di D, Liu T, Li W, Liu X, 2016
Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans, Chen J, Zhang J, Xiang Y, Xiang L, Liu Y, He X, Zhou X, Liu X, Huang Z, 2016
Preclinical Evaluation of an Epidermal Growth Factor Receptor-Targeted Doxorubicin-Peptide Conjugate: Toxicity, Biodistribution, and Efficacy in Mice, Yang F, Ai W, Jiang F, Liu X, Huang Z, Ai S, 2016
Characterization of the transcriptional activation domains of human TEF3-1 (transcription enhancer factor 3 isoform 1), Qiao C, Jiang Y, Deng C, Huang Z, Teng K, Chen L, Liu X, 2015
Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells, Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X, Li W, 2015
Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species, Wang H, Liu T, Li L, Wang Q, Yu C, Liu X, Li W, 2015
Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo, Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X, 2015
Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor, Liu X, Zhao D, James L, Li J, Zeng H, 2011
Transcription Enhancer Factor 3 (TEF3) Mediates the Expression of Down Syndrome Candidate Region 1 Isoform 1 (DSCR1-1L) in Endothelial Cells, Liu X, Zhao D, Qin L, Li J, Zeng H, 2008
Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway, Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H, 2006
Expression of SLAM (CDw150) on SF9 cell surface mediates Measles Viral infection in the nonpermissive cells through SLAM/MVH interaction, Liu X, Zhou W, Qi Y, 2005
Development of viral vectors for gene therapy for chronic pain, Huang Y, Liu X, Dong L, Liu Z, He X, Liu W, 2011
Hemagglutinin protein of measles virus induces apoptosis of HeLa cells via bot extrinsic and intrinsic pathways, Yi C, Liu X, Liu Y, Lu S, Qi Y, 2013
ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells, Li J, Chen Y, Wan J, Liu X, Yu C, Li W, 2014
Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells, Ai S, Jia T, Ai W, Duan J, Liu Y, Chen J, Liu X, Yang F, Tian Y, Huang Z, 2013
Biological evaluation of a novel Doxorubicin-peptide conjugate for targeted delivery to EGF receptor-overexpressing tumor cells, Ai S, Duan J, Liu X, Bock S, Tian Y, Huang Z, 2011
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21, Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W, 2015

Angiogenesis Tumor Vascular Drug Development Mechanisms Antitumor Therapy Pharmacology Molecular Biology Clinical Research

An Ping - Wuhan University

Lixia Miao - Wuhan University

Bin Guo - University of Chinese Academy of Sciences

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