Areas of Focus
- Discovery of STING inhibitors for the treatment of autoimmune and inflammatory diseases
Work Experience
- 2021-10 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2016-10 to 2021-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
- 2016-08 to 2016-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
- 2014-07 to 2016-08 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
- 2008-09 to 2014-06 - University of Chinese Academy of Sciences - PhD Student
- 2004-09 to 2008-06 - China Pharmaceutical University - Bachelor's Student
Academic Background & Achievements
- 2008-09 to 2014-06 PhD: University of Chinese Academy of Sciences
- 2004-09 to 2008-06 Bachelor's: China Pharmaceutical University
Publications
- Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma, Acta Pharmaceutica Sinica B, 2023
- Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives, Molecular Diversity, 2023
- Discovery of 10H-Benzobpyrido2,3-e1,4oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase, Journal of Medicinal Chemistry, 2022
- Synthesis of triazolotriazine derivatives as c-Met inhibitors, Molecular Diversity, 2021
- Evaluation of deuterium-labeled JNJ38877605: pharmacokinetic, metabolic, and in vivo antitumor profiles, Chemical Research in Toxicology, 2018
- Discovery of 6-(difluoro(6-(4-fluorophenyl)-1,2,4triazolo4,3-b1,2,4triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor, European Journal of Medicinal Chemistry, 2016
- Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities, Oncotarget, 2016
- Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity, ACS Medicinal Chemistry Letters, 2014
Awards
- Shanghai Science and Technology Commission 'Sailing Program' (2020): Provincial Level
- Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2018): Ministerial Level
- Outstanding Employee of Shanghai Institute of Materia Medica, Chinese Academy of Sciences (2018): Institute Level
