Areas of Focus
- Mechanism of Gain-of-Function of Tumor-Related Mutant p53
- Screening and Pharmacological Study of Small Molecule Compounds Targeting Mutant p53 Signaling Pathway
Work Experience
- 2019-04 to Present - Chinese Academy of Sciences Kunming Institute of Botany - Researcher
- 2018-10 to 2019-03 - Rutgers University New Jersey Cancer Institute - Postdoctoral Researcher
- 2011-12 to 2013-09 - University of Medicine and Dentistry of New Jersey - Visiting Scholar
Academic Background & Achievements
- 2013-09 to 2018-10 Ph.D. in Pharmacology: Rutgers University, New Jersey, USA
- 2010-09 to 2012-12 Master's in Clinical Medicine: Shandong University School of Medicine
- 2004-09 to 2010-06 Bachelor's in Medicine: Shandong University School of Medicine
Publications
- Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation., Xiaolong Gao, Yuhan Zhao, et al., 2024
- Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis., Xu Yang, Yuhan Zhao, et al., 2024
- Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress., Yinyuan Wang, Yuhan Zhao, et al., 2023
- Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta., Jinliang Li, Yuhan Zhao, et al., 2023
- Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells against oxidative stress., Zhenpeng Niu, Yuhan Zhao, et al., 2023
- Antifeedant Mechanism of Dodonaea viscosa Saponin A Isolated from the Seeds of Dodonaea viscosa., Hang Yu, Yuhan Zhao, et al., 2022
- Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium., Mingxian Lan, Yuhan Zhao, et al., 2022
- Identification of limonoids from Walsura yunnanensis and evaluation of their cytotoxicity against cancer cell lines., Yueqin Zhao, Yuhan Zhao, et al., 2022
- Tumor suppressor p53 regulates intestinal type 2 immunity., ChunYuan Chang, Yuhan Zhao, et al., 2021
- Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells., Ruiran Wei, Yuhan Zhao, et al., 2021
- Tagitinin F诱导MDA-MB-231细胞凋亡作用机制研究., 娟 Wang, 赵逾涵, et al., 2021
- LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome., Huaying Wang, Yuhan Zhao, et al., 2020
- Inhibitory activities of flavonoids from Eupatorium adenophorum against acetylcholinesterase., Mengyue Li, Yuhan Zhao, et al., 2020
- LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome., Huaying Wang, Yuhan Zhao, et al., 2020
- A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models., Yuhan Zhao, et al., 2018
- Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer., WeiGang Qiu, Yuhan Zhao, et al., 2017
- MicroRNA Control of p53., Juan Liu, Yuhan Zhao, et al., 2017
- Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression., Juan Liu, Yuhan Zhao, et al., 2017
- Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy., Xuetian Yue, Yuhan Zhao, et al., 2017
- Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction., Xuetian Yue, Yuhan Zhao, et al., 2016
- A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis., Xuetian Yue, Yuhan Zhao, et al., 2016
- Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression., Cen Zhang, Yuhan Zhao, et al., 2016
- A novel mutant p53 binding partener BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis., Yuhan Zhao, 2016
- microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis., Cen Zhang, Yuhan Zhao, et al., 2016
- Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function., Yuhan Zhao, et al., 2015
- BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function., Xuetian Yue, Yuhan Zhao, et al., 2015
- HIF-2α mediates hypoxia-induced LIF expression in human colorectal cancer cells., Lihua Wu, Yuhan Zhao, et al., 2015
- Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53., Yuhan Zhao, et al., 2015
- Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma., Juan Liu, Yuhan Zhao, et al., 2014
- LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway., Xiaoyan Li, Yuhan Zhao, et al., 2014
- LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers., Haiyang Yu, Yuhan Zhao, et al., 2014
- The regulation of MDM2 oncogene and its impact on human cancers., Yuhan Zhao, et al., 2014
- Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis., Tongsen Zheng, Yuhan Zhao, et al., 2013
- Inhibition of metadherin sensitizes breast cancer cells to AZD6244., Xiaoli Kong, Yuhan Zhao, et al., 2012
- 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-kappa B through miR-146a., Xiaoyan Li, Yuhan Zhao, et al., 2012
- Metadherin Mediates Lipopolysaccharide-Induced Migration and Invasion of Breast Cancer Cells., Yuhan Zhao, et al., 2011
Awards
- National Outstanding Self-Financed International Student Scholarship (2017): National Level
- NIH F99 Award (2017): Institutional Level
- Aaron Shatkin Scholarship (2016): First Prize, Rutgers University
- National Scholarship (2007): National Level
- Shandong University Outstanding Student Scholarship (2007): First Prize, Institutional Level
