Professor | Zhenhua Zheng | Asia Growth Partners

Name	Zhenhua Zheng
Contact Information	zhengzh@wh.iov.cn
Language ability	Chinese, English
Province	Hubei

Name

Zhenhua Zheng

Contact Information

zhengzh@wh.iov.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2005-09--2011-06 Ph.D. in Science: Wuhan Institute of Virology, Chinese Academy of Sciences 2001-09--2005-06 Bachelor's Degree: Hubei University
Work Experience	2019-09~Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Researcher 2013-09~2019-08 - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Researcher 2011-07~2013-08 - Wuhan Institute of Virology, Chinese Academy of Sciences - Assistant Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2005-09--2011-06 Ph.D. in Science: Wuhan Institute of Virology, Chinese Academy of Sciences
2001-09--2005-06 Bachelor's Degree: Hubei University

Work Experience

2019-09~Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Researcher
2013-09~2019-08 - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Researcher
2011-07~2013-08 - Wuhan Institute of Virology, Chinese Academy of Sciences - Assistant Researcher

Areas of Focus	Virus infection and pathogenic molecular mechanisms Virus-host interactions
Publications	Breast milk transmission and involvement of mammary glands in tick-borne flavivirus infected mice, Yuanjiu Miao, Yue Zheng, Ting Wang, Wenfu Yi, Nailou Zhang, Wanpo Zhang, Zhenhua Zheng, 2024 Identification of novel anti-ZIKV drugs from viral-infection temporal gene expression profiles, Zhang, Nailou, Tan, Zhongyuan, Wei, Jinbo, Zhang, Sai, Liu, Yan, Miao, Yuanjiu, Ding, Qingwen, Yi, Wenfu, Gan, Min, Li, Chunjie, Liu, Bin, Wang, Hanzhong, Zheng, Zhenhua, 2023 An all-in-one assay based on CRISPR/Cas13a and a DNA circuit for rapid and ultrasensitive detection of Echovirus 11, Yixia Yang, Wenfu Yi, Feng Gong, Zhiyou Tan, Xiaoyun Shan, JingJing Qian, Conghua Xie, Xinghu Ji, Zhenhua Zheng, Zhike He, 2023 CRISPR/Cas13a Trans-Cleavage-Triggered Catalytic Hairpin Assembly Assay for Specific and Ultrasensitive SARS-CoV-2 RNA Detection, Yang, Yixia, Yi, Wenfu, Gong, Feng, Tan, Zhiyou, Yang, Yeling, Shan, Xiaoyun, Xie, Conghua, Ji, Xinghu, Zheng, Zhenhua, He, Zhike, 2022 ACE2-independent infection of T lymphocytes by SARS-CoV-2, XuRui Shen, Rong Geng, Qian Li, Ying Chen, ShuFen Li, Qi Wang, Juan Min, Yong Yang, Bei Li, RenDi Jiang, Xi Wang, XiaoShuang Zheng, Yan Zhu, JingKun Jia, XingLou Yang, MeiQin Liu, QianChun Gong, YuLan Zhang, ZhenQiong Guan, HuiLing Li, ZhenHua Zheng, ZhengLi Shi, HuiLan Zhang, Ke Peng, Peng Zhou, 2022 Internal cell-penetrating peptide-mediated internalization enables a chimeric lysin to target intracellular pathogens, Yang, Hang, Xu, Jingjing, Gong, Yujing, Tang, Yan, Li, Wuyou, Zheng, Zhenhua, Li, Yuhong, He, Jin, Wei, Hongping, 2021 Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses, Yang, Jieyu, Jing, Xuping, Yi, Wenfu, Li, XiaoDan, Yao, Chen, Zhang, Bo, Zheng, Zhenhua, Wang, Hanzhong, Gong, Peng, 2021 Recovery of a Far-Eastern Strain of Tick-Borne Encephalitis Virus with a Full-Length Infectious cDNA Clone, Li, Penghui, Yao, Chen, Wang, Ting, Wu, Tong, Yi, Wenfu, Zheng, Yue, Miao, Yuanjiu, Sun, Jianhong, Tan, Zhongyuan, Liu, Yan, Zhang, Xiaowei, Wang, Hanzhong, Zheng, Zhenhua, 2021 Metabolic labeling of enterovirus 71 with quantum dots for the study of virus receptor usage, Ke, Xianliang, Li, Chunjie, Luo, Dan, Wang, Ting, Liu, Yan, Tan, Zhongyuan, Du, Mingyuan, He, Zhike, Wang, Hanzhong, Zheng, Zhenhua, Zhang, Yuan, 2021 DNAzyme Walker for Homogeneous Detection of Enterovirus EV71 and CVB3, Du, Mingyuan, Zheng, Jiao, Tian, Songbai, Liu, Yucheng, Zheng, Zhenhua, Wang, Hanzhong, Xia, Jianbo, Ji, Xinghu, He, Zhike, 2021 A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice, Ke, Xianliang, Zhang, Yuan, Liu, Yan, Miao, Yuanjiu, Zheng, Caishang, Luo, Dan, Sun, Jianhong, Hu, Qinxue, Xu, Yi, Wang, Hanzhong, Zheng, Zhenhua, 2020 Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study, Luo, Dan, Xia, Zhi, Li, Heng, Tu, Danna, Wang, Ting, Zhang, Wei, Peng, Lu, Yi, Wenfu, Zhang, Sai, Shu, Junhua, Xu, Hui, Li, Yong, Shi, Buyun, Huang, Chengjiao, Tang, Wen, Xiao, Shuna, Shu, Xiaolan, Liu, Yan, Zhang, Yuan, Guo, Shan, Yu, Zhi, Wang, Baoxiang, Gao, Yuan, Hu, Qinxue, Wang, Hanzhong, Song, Xiaohui, Mei, Hong, Zhou, Xiaoqin, Zheng, Zhenhua, 2020 Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model, Luo, Dan, Miao, Yuanjiu, Ke, Xianliang, Tan, Zhongyuan, Hu, Chun, Li, Penghui, Wang, Ting, Zhang, Yuan, Sun, Jianhong, Liu, Yan, Wang, Hanzhong, Zheng, Zhenhua, 2020 In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy, Wang, Ting, Li, Penghui, Zhang, Yuan, Liu, Yan, Tan, Zhongyuan, Sun, Jianhong, Ke, Xianliang, Miao, Yuanjiu, Luo, Dan, Hu, Qinxue, Xu, Fuqiang, Wang, Hanzhong, Zheng, Zhenhua, 2020 Zika virus promotes CCN1 expression via the CaMKII alpha-CREB pathway in astrocytes, Sun, Jianhong, Zhang, Wanpo, Tan, Zhongyuan, Zheng, Caishang, Tang, Yan, Ke, Xianliang, Zhang, Yuan, Liu, Yan, Li, Penghui, Hu, Qinxue, Wang, Hanzhong, Mao, Panyong, Zheng, Zhenhua, 2020 蜱传脑炎病毒感染小鼠脑组织单核细胞趋化蛋白1（MCP-1）、CD68和核因子κB（NF-κB）表达增加, 王倩云, 彭晖, 郑振华, 芦宝静, 2020 One-Step Monitoring of Multiple Enterovirus 71 Infection-Related MicroRNAs Using Core-Satellite Structure of Magnetic Nanobeads and Multicolor Quantum Dots, Wang, JiaJia, Zheng, Caishang, Jiang, YongZhong, Zheng, Zhenhua, Lin, Miao, Lin, Yi, Zhang, ZhiLing, Wang, Hanzhong, Pang, DaiWen, 2020 Dissecting the Cell Entry Pathway of Baculovirus by Single-Particle Tracking and Quantitative Electron Microscopic Analysis, Qin, Fujun, Xu, Congrui, Hu, Jia, Lei, Chengfeng, Zheng, Zhenhua, Peng, Ke, Wang, Hanzhong, Sun, Xiulian, 2019 Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, Wei, Chunyu, Zheng, Caishang, Sun, Jianhong, Luo, Dan, Tang, Yan, Zhang, Yuan, Ke, Xianliang, Liu, Yan, Zheng, Zhenhua, Wang, Hanzhong, 2019 Target-Induced Cascade Amplification for Homogeneous Virus Detection, Du, Mingyuan, Mao, Guobin, Tian, Songbai, Liu, Yucheng, Zheng, Jiao, Ke, Xianliang, Zheng, Zhenhua, Wang, Hanzhong, Ji, Xinghu, He, Zhike, 2019 Multifunctional Cellular Beacons with in Situ Synthesized Quantum Dots Make Pathogen Detectable with the Naked Eye, Wang, JiaJia, Lin, Yi, Jiang, YongZhong, Zheng, Zhenhua, Xie, HaiYan, Lv, Cheng, Chen, ZhiLiang, Xiong, LingHong, Zhang, ZhiLing, Wang, Hanzhong, Pang, DaiWen, 2019 ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells, Tan, Zhongyuan, Zhang, Wanpo, Sun, Jianhong, Fu, Zuquan, Ke, Xianliang, Zheng, Caishang, Zhang, Yuan, Li, Penghui, Liu, Yan, Hu, Qinxue, Wang, Hanzhong, Zheng, Zhenhua, 2018 Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking, Lv, Cheng, Lin, Yi, Sun, EnZe, Tang, Bo, Ao, Jian, Wang, JiaJia, Zhang, ZhiLing, Zheng, Zhenhua, Wang, Hanzhong, Pang, DaiWen, 2018 Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, Chunyu Wei, Caishang Zheng, Jianhong Sun, Dan Luo, Yan Tang, Yuan Zhang, Xianliang Ke, Yan Liu, Zhenhua Zheng, Hanzhong Wang, 2018 SpyCatcher-SpyTag mediated in situ labelling of progeny baculovirus with quantum dots for tracking viral infection in living cells, Ke, Xianliang, Zhang, Yuan, Zheng, Fangliang, Liu, Yan, Zheng, Zhenhua, Xu, Yi, Wang, Hanzhong, 2018 Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models, Li, Penghui, Ke, Xianliang, Wang, Ting, Tan, Zhongyuan, Luo, Dan, Miao, Yuanjiu, Sun, Jianhong, Zhang, Yuan, Liu, Yan, Hu, Qinxue, Xu, Fuqiang, Wang, Hanzhong, Zheng, Zhenhua, 2018 The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP), Xie, Li, Lu, Baojing, Zheng, Zhenhua, Miao, Yuanjiu, Liu, Yan, Zhang, Yuan, Zheng, Caishang, Ke, Xianliang, Hu, Qinxue, Wang, Hanzhong, 2018 An improved method for identifying SUMOylation sites of viral proteins, Liu, Yan, Tan, Zhongyuan, Shu, Bo, Zhang, Yuan, Zheng, Caishang, Ke, Xianliang, Chen, Xi, Wang, Hanzhong, Zheng, Zhenhua, 2017 MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication, Zheng, Caishang, Zheng, Zhenhua

Areas of Focus

Virus infection and pathogenic molecular mechanisms
Virus-host interactions

Publications

Breast milk transmission and involvement of mammary glands in tick-borne flavivirus infected mice, Yuanjiu Miao, Yue Zheng, Ting Wang, Wenfu Yi, Nailou Zhang, Wanpo Zhang, Zhenhua Zheng, 2024
Identification of novel anti-ZIKV drugs from viral-infection temporal gene expression profiles, Zhang, Nailou, Tan, Zhongyuan, Wei, Jinbo, Zhang, Sai, Liu, Yan, Miao, Yuanjiu, Ding, Qingwen, Yi, Wenfu, Gan, Min, Li, Chunjie, Liu, Bin, Wang, Hanzhong, Zheng, Zhenhua, 2023
An all-in-one assay based on CRISPR/Cas13a and a DNA circuit for rapid and ultrasensitive detection of Echovirus 11, Yixia Yang, Wenfu Yi, Feng Gong, Zhiyou Tan, Xiaoyun Shan, JingJing Qian, Conghua Xie, Xinghu Ji, Zhenhua Zheng, Zhike He, 2023
CRISPR/Cas13a Trans-Cleavage-Triggered Catalytic Hairpin Assembly Assay for Specific and Ultrasensitive SARS-CoV-2 RNA Detection, Yang, Yixia, Yi, Wenfu, Gong, Feng, Tan, Zhiyou, Yang, Yeling, Shan, Xiaoyun, Xie, Conghua, Ji, Xinghu, Zheng, Zhenhua, He, Zhike, 2022
ACE2-independent infection of T lymphocytes by SARS-CoV-2, XuRui Shen, Rong Geng, Qian Li, Ying Chen, ShuFen Li, Qi Wang, Juan Min, Yong Yang, Bei Li, RenDi Jiang, Xi Wang, XiaoShuang Zheng, Yan Zhu, JingKun Jia, XingLou Yang, MeiQin Liu, QianChun Gong, YuLan Zhang, ZhenQiong Guan, HuiLing Li, ZhenHua Zheng, ZhengLi Shi, HuiLan Zhang, Ke Peng, Peng Zhou, 2022
Internal cell-penetrating peptide-mediated internalization enables a chimeric lysin to target intracellular pathogens, Yang, Hang, Xu, Jingjing, Gong, Yujing, Tang, Yan, Li, Wuyou, Zheng, Zhenhua, Li, Yuhong, He, Jin, Wei, Hongping, 2021
Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses, Yang, Jieyu, Jing, Xuping, Yi, Wenfu, Li, XiaoDan, Yao, Chen, Zhang, Bo, Zheng, Zhenhua, Wang, Hanzhong, Gong, Peng, 2021
Recovery of a Far-Eastern Strain of Tick-Borne Encephalitis Virus with a Full-Length Infectious cDNA Clone, Li, Penghui, Yao, Chen, Wang, Ting, Wu, Tong, Yi, Wenfu, Zheng, Yue, Miao, Yuanjiu, Sun, Jianhong, Tan, Zhongyuan, Liu, Yan, Zhang, Xiaowei, Wang, Hanzhong, Zheng, Zhenhua, 2021
Metabolic labeling of enterovirus 71 with quantum dots for the study of virus receptor usage, Ke, Xianliang, Li, Chunjie, Luo, Dan, Wang, Ting, Liu, Yan, Tan, Zhongyuan, Du, Mingyuan, He, Zhike, Wang, Hanzhong, Zheng, Zhenhua, Zhang, Yuan, 2021
DNAzyme Walker for Homogeneous Detection of Enterovirus EV71 and CVB3, Du, Mingyuan, Zheng, Jiao, Tian, Songbai, Liu, Yucheng, Zheng, Zhenhua, Wang, Hanzhong, Xia, Jianbo, Ji, Xinghu, He, Zhike, 2021
A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice, Ke, Xianliang, Zhang, Yuan, Liu, Yan, Miao, Yuanjiu, Zheng, Caishang, Luo, Dan, Sun, Jianhong, Hu, Qinxue, Xu, Yi, Wang, Hanzhong, Zheng, Zhenhua, 2020
Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study, Luo, Dan, Xia, Zhi, Li, Heng, Tu, Danna, Wang, Ting, Zhang, Wei, Peng, Lu, Yi, Wenfu, Zhang, Sai, Shu, Junhua, Xu, Hui, Li, Yong, Shi, Buyun, Huang, Chengjiao, Tang, Wen, Xiao, Shuna, Shu, Xiaolan, Liu, Yan, Zhang, Yuan, Guo, Shan, Yu, Zhi, Wang, Baoxiang, Gao, Yuan, Hu, Qinxue, Wang, Hanzhong, Song, Xiaohui, Mei, Hong, Zhou, Xiaoqin, Zheng, Zhenhua, 2020
Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model, Luo, Dan, Miao, Yuanjiu, Ke, Xianliang, Tan, Zhongyuan, Hu, Chun, Li, Penghui, Wang, Ting, Zhang, Yuan, Sun, Jianhong, Liu, Yan, Wang, Hanzhong, Zheng, Zhenhua, 2020
In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy, Wang, Ting, Li, Penghui, Zhang, Yuan, Liu, Yan, Tan, Zhongyuan, Sun, Jianhong, Ke, Xianliang, Miao, Yuanjiu, Luo, Dan, Hu, Qinxue, Xu, Fuqiang, Wang, Hanzhong, Zheng, Zhenhua, 2020
Zika virus promotes CCN1 expression via the CaMKII alpha-CREB pathway in astrocytes, Sun, Jianhong, Zhang, Wanpo, Tan, Zhongyuan, Zheng, Caishang, Tang, Yan, Ke, Xianliang, Zhang, Yuan, Liu, Yan, Li, Penghui, Hu, Qinxue, Wang, Hanzhong, Mao, Panyong, Zheng, Zhenhua, 2020
蜱传脑炎病毒感染小鼠脑组织单核细胞趋化蛋白1（MCP-1）、CD68和核因子κB（NF-κB）表达增加, 王倩云, 彭晖, 郑振华, 芦宝静, 2020
One-Step Monitoring of Multiple Enterovirus 71 Infection-Related MicroRNAs Using Core-Satellite Structure of Magnetic Nanobeads and Multicolor Quantum Dots, Wang, JiaJia, Zheng, Caishang, Jiang, YongZhong, Zheng, Zhenhua, Lin, Miao, Lin, Yi, Zhang, ZhiLing, Wang, Hanzhong, Pang, DaiWen, 2020
Dissecting the Cell Entry Pathway of Baculovirus by Single-Particle Tracking and Quantitative Electron Microscopic Analysis, Qin, Fujun, Xu, Congrui, Hu, Jia, Lei, Chengfeng, Zheng, Zhenhua, Peng, Ke, Wang, Hanzhong, Sun, Xiulian, 2019
Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, Wei, Chunyu, Zheng, Caishang, Sun, Jianhong, Luo, Dan, Tang, Yan, Zhang, Yuan, Ke, Xianliang, Liu, Yan, Zheng, Zhenhua, Wang, Hanzhong, 2019
Target-Induced Cascade Amplification for Homogeneous Virus Detection, Du, Mingyuan, Mao, Guobin, Tian, Songbai, Liu, Yucheng, Zheng, Jiao, Ke, Xianliang, Zheng, Zhenhua, Wang, Hanzhong, Ji, Xinghu, He, Zhike, 2019
Multifunctional Cellular Beacons with in Situ Synthesized Quantum Dots Make Pathogen Detectable with the Naked Eye, Wang, JiaJia, Lin, Yi, Jiang, YongZhong, Zheng, Zhenhua, Xie, HaiYan, Lv, Cheng, Chen, ZhiLiang, Xiong, LingHong, Zhang, ZhiLing, Wang, Hanzhong, Pang, DaiWen, 2019
ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells, Tan, Zhongyuan, Zhang, Wanpo, Sun, Jianhong, Fu, Zuquan, Ke, Xianliang, Zheng, Caishang, Zhang, Yuan, Li, Penghui, Liu, Yan, Hu, Qinxue, Wang, Hanzhong, Zheng, Zhenhua, 2018
Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking, Lv, Cheng, Lin, Yi, Sun, EnZe, Tang, Bo, Ao, Jian, Wang, JiaJia, Zhang, ZhiLing, Zheng, Zhenhua, Wang, Hanzhong, Pang, DaiWen, 2018
Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, Chunyu Wei, Caishang Zheng, Jianhong Sun, Dan Luo, Yan Tang, Yuan Zhang, Xianliang Ke, Yan Liu, Zhenhua Zheng, Hanzhong Wang, 2018
SpyCatcher-SpyTag mediated in situ labelling of progeny baculovirus with quantum dots for tracking viral infection in living cells, Ke, Xianliang, Zhang, Yuan, Zheng, Fangliang, Liu, Yan, Zheng, Zhenhua, Xu, Yi, Wang, Hanzhong, 2018
Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models, Li, Penghui, Ke, Xianliang, Wang, Ting, Tan, Zhongyuan, Luo, Dan, Miao, Yuanjiu, Sun, Jianhong, Zhang, Yuan, Liu, Yan, Hu, Qinxue, Xu, Fuqiang, Wang, Hanzhong, Zheng, Zhenhua, 2018
The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP), Xie, Li, Lu, Baojing, Zheng, Zhenhua, Miao, Yuanjiu, Liu, Yan, Zhang, Yuan, Zheng, Caishang, Ke, Xianliang, Hu, Qinxue, Wang, Hanzhong, 2018
An improved method for identifying SUMOylation sites of viral proteins, Liu, Yan, Tan, Zhongyuan, Shu, Bo, Zhang, Yuan, Zheng, Caishang, Ke, Xianliang, Chen, Xi, Wang, Hanzhong, Zheng, Zhenhua, 2017
MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication, Zheng, Caishang, Zheng, Zhenhua

Virus Infection Pathogenic Molecular Mechanisms Host Interactions Virology Immunology Biochemistry

Jianchao Zhang - Southern University of Science and Technology

Ji Yanxiao - Wuhan University

Xin Chen - Wuhan University

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