2010-present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2010 - University of Minnesota, Department of Pharmacology - Postdoctoral Research Assistant
National Invention Patent (2023): Application of dehydroascorbic acid and 2,3-diketo-L-gulonic acid in cell reprogramming
National Invention Patent (2023): Lentivirus shTet1 and its construction method and application in neural stem cell proliferation
PCT (2021): Composition and its use in enhancing the anti-tumor effect of vitamin C
National Invention Patent (2020): A drug composition that enhances the anti-tumor effect of vitamin C
National Invention Patent (2018): Application of naloxone in regulating Tet1 protein DNA demethylase activity
National Invention Patent (2017): A method to improve the efficiency of somatic cell transdifferentiation into neural cells
National Invention Patent (2016): Method for obtaining neural cells from fibroblasts using serum-free medium
National Invention Patent (2015): Method for obtaining neural cells through transdifferentiation using serum-free medium
National Invention Patent (2014): Application of naloxone in the preparation of drugs to improve spatial learning and memory
Research
Stem Cell Biology Neurobiology
Unraveling the 2,3–diketo–L–gulonic acid–dependent and –independent impacts of L–ascorbic acid on somatic cell reprogramming, Liang L, He M, Zhang Y, Wang C, Qin Z, Li Q, Yang T, Meng F, Zhou Y, Ge H, Song W, Chen S, Dong L, Ren Q, Li C, Guo L, Sun H, Zhang W, Pei D, Zheng H, 2023
Nuclear Localization of TET2 Requires β-catenin Activation and Correlates with Favourable Prognosis in Colorectal Cancer, Li C, He J, Meng F, Wang F, Sun H, Zhang H, Zhang M, Xu Q, Liang L, Li Y, Yang T, He M, Wang T, Lin J, Sun J, Huang Q, Guo L, Zhang X, Mai S, Zheng H, 2023
Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex, Li Y, Yang T, Cheng Y, Hou J, Liu Z, Zhao Y, Chen S, Qin Z, Wang C, Song W, Ge H, Li C, Liang L, Guo L, Sun H, Wu LP, Zheng H, 2023
Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation, Sun J, Yang J, Miao X, Loh HH, Pei D, Zheng H, 2021
Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner, Meng F, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L, Zheng H, 2021
Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming, Zhang M, Li Q, Yang T, Meng F, Lai X, Liang L, Li C, Sun H, Sun J, Zheng H, 2020
Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming, Lai X, Li Q, Wu F, Lin J, Chen J, Zheng H, Guo L, 2020
Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway, Chen J, Liang L, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H, 2020
Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway, Liang L, Chen J, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H, 2020
Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency, Sun H, Yang X, Liang L, Zhang M, Li Y, Chen J, Wang F, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Lin L, Pei D, Zheng H, 2020
Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming, He S, Wang F, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Pang H, Li Y, Huang X, Qin D, Pei D, Sun H, Zheng H, 2019
The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming, Lin L, Liang L, Yang X, Sun H, Li Y, Pei D, Zheng H, 2018
Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells, He S, Sun H, Lin L, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Wang X, Wang F, Zhu F, Chen J, Pei D, Zheng H, 2017
Sequential EMT-MET induces neuronal conversion through Sox2, He S, Chen J, Zhang Y, Zhang M, Yang X, Li Y, Sun H, Lin L, Fan K, Liang L, Feng C, Wang F, Zhang X, Guo Y, Pei D, Zheng H, 2017
Transitions between mesenchymal and epithelial states and the concomitant gene expression changes, Liang L, Sun H, Li L, Zheng H, 2016
The Abilities of ShDNMT1 to Promote Reprogramming are Enhanced by Vitamin C-recused Proliferation, Li L, He S, Zheng H, 2016
Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch, Sun H, Liang L, Li Y, Feng C, Li L, Zhang Y, He S, Pei D, Guo Y, Zheng H, 2016
Meta-Analysis of EMT Datasets Reveals Different Types of EMT, Liang L, Sun H, Zhang W, Zhang M, Yang X, Kuang R, Zheng H, 2016
Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels, Huang Z, Liang L, Li L, Xu M, Li X, Sun H, He S, Lin L, Zhang Y, Song Y, Yang M, Luo Y, Loh HH, Law PY, Zheng D, Zheng H, 2016
MicroRNA-128-3p impaired water maze learning by suppressing Doublecortin expression in both wild type and Aβ-42 infused mice, Chen J, Li W, Li Y, He S, Li L, Liang L, Song Y, Qin D, Zheng H, 2016
Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo, He S, Guo Y, Zhang Y, Li Y, Feng C, Li X, Lin L, Guo L, Wang H, Liu C, Zheng Y, Luo C, Liu Q, Wang F, Sun H, Liang L, Li L, Su H, Chen J, Pei D, Zheng H, 2015
Where cell fate conversions meet Chinese philosophy, Zheng H, Hutchins AP, Pan G, Li Y, Pei D, Pei G, 2014
Transitions between epithelial and mesenchymal states during cell fate conversions, Li X, Pei D, Zheng H, 2014
Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms, Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, Zheng H, 2014
NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction, Zheng H, Zhang Y, Li W, Loh HH, Law PY, 2013
Posttranslation modification of G protein-coupled receptor in relationship to biased agonism, Zheng H, Loh HH, Law PY, 2013
Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming, Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D, Zheng H, 2013
Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans, Zheng H, Zou H, Liu
