Professor | Wang Rui | Asia Growth Partners

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Name	Wang Rui
Contact Information	wangrui218@163.com
Language ability	Chinese, English
Province	Jiangsu

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Name

Wang Rui

Contact Information

wangrui218@163.com

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Medical School
Academic Background & Achievements	1994-1999: Bachelor's Degree in Medicine, Fourth Military Medical University 2002-2005: Master's Degree in Medicine, Fourth Military Medical University 2005-2008: Doctorate in Medicine, Fourth Military Medical University 2008-2010: Postdoctoral Research, Jinling Hospital, Nanjing University Hosted and participated in 5 National Natural Science Foundation projects Hosted Jiangsu Outstanding Youth Fund project Jiangsu Key Medical Talent Jiangsu '333 High-Level Talent Training Project' third level training object
Work Experience	2011-present: Deputy Director of Oncology Department, Jinling Hospital, Nanjing University 2011-present: Doctoral Supervisor, Nanjing University Medical School
Awards	Military Medical Achievement Second Prize (2013): Research on Molecular Targets and Drug Resistance Intervention Strategies for Personalized Treatment of Lung Adenocarcinoma Military Medical Achievement Second Prize (2012): Research on Methylation Profiles of Tumor Suppressor Genes Related to Non-Small Cell Lung Cancer

University/Lab Affiliation and Title

Nanjing University

Faculty

Medical School

Academic Background & Achievements

1994-1999: Bachelor's Degree in Medicine, Fourth Military Medical University
2002-2005: Master's Degree in Medicine, Fourth Military Medical University
2005-2008: Doctorate in Medicine, Fourth Military Medical University
2008-2010: Postdoctoral Research, Jinling Hospital, Nanjing University
Hosted and participated in 5 National Natural Science Foundation projects
Hosted Jiangsu Outstanding Youth Fund project
Jiangsu Key Medical Talent
Jiangsu '333 High-Level Talent Training Project' third level training object

Work Experience

2011-present: Deputy Director of Oncology Department, Jinling Hospital, Nanjing University
2011-present: Doctoral Supervisor, Nanjing University Medical School

Awards

Military Medical Achievement Second Prize (2013): Research on Molecular Targets and Drug Resistance Intervention Strategies for Personalized Treatment of Lung Adenocarcinoma
Military Medical Achievement Second Prize (2012): Research on Methylation Profiles of Tumor Suppressor Genes Related to Non-Small Cell Lung Cancer

Areas of Focus	Molecular Mechanisms of Gene Expression Regulation Epigenetic Molecular Mechanisms of Malignant Tumor Phenotypes
Publications	FOXM1-Mediated LINC-ROR Regulates the Proliferation and Sensitivity to Sorafenib in Hepatocellular Carcinoma, Zhi Y, Abudoureyimu M, Zhou H, Wang T, Feng B, Wang R, Chu X, 2019 Recent progress in the emerging role of exosome in hepatocellular carcinoma, Abudoureyimu M, Zhou H, Zhi Y, Wang T, Feng B, Wang R, Chu X, 2019 Aurora-a confers radioresistance in human hepatocellular carcinoma by activating NF-κB signaling pathway, Shen ZT, Chen Y, Huang GC, Zhu XX, Wang R, Chen LB, 2019 Regulation and functions of MicroRNA-149 in human cancers, Zhi Y, Zhou H, Mubalake A, Chen Y, Zhang B, Zhang K, Chu X, Wang R, 2018 Non-coding RNAs: Emerging Regulators of Sorafenib Resistance in Hepatocellular Carcinoma, Lai Y, Feng B, Abudoureyimu M, Zhi Y, Zhou H, Wang T, Chu X, Chen P, Wang R, 2019 Oncolytic Adenovirus-A Nova for Gene-Targeted Oncolytic Viral Therapy in HCC, Abudoureyimu M, Lai Y, Tian C, Wang T, Wang R, Chu X, 2019 PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib, Zhang K, Chen J, Zhou H, Chen Y, Zhi Y, Zhang B, Chen L, Chu X, Wang R, Zhang C, 2018 A Novel Aurora-A Inhibitor (MLN8237) Synergistically Enhances the Antitumor Activity of Sorafenib in Hepatocellular Carcinoma, Zhang K, Wang T, Zhou H, Feng B, Chen Y, Zhi Y, Wang R, 2018 Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression, Chen Y, Shen Z, Zhi Y, Zhou H, Zhang K, Wang T, Feng B, Chen Y, Song H, Wang R, Chu X, 2018 The lincRNA-ROR/miR-145 axis promotes invasion and metastasis in hepatocellular carcinoma via induction of epithelial-mesenchymal transition by targeting ZEB2, Li C, Lu L, Feng B, Zhang K, Han S, Hou D, Chen L, Chu X, Wang R, 2017 Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma, Zhang B, Han S, Feng B, Chu X, Chen L, Wang R, 2017 Notch-1 Confers Chemoresistance in Lung Adenocarcinoma to Taxanes through AP-1/microRNA-451 Mediated Regulation of MDR-1, Huang J, Chen Y, Li J, Zhang K, Chen J, Chen D, Feng B, Song H, Feng J, Wang R, Chen L, 2016 Non-small-cell lung cancer and miRNAs: novel biomarkers and promising tools for treatment, Feng B, Zhang K, Wang R, Chen L, 2015 MicroRNA-451 induces epithelial-mesenchymal transition in docetaxel-resistant lung adenocarcinoma cells by targeting proto-oncogene c-Myc, Chen D, Huang J, Zhang K, Pan B, Chen J, De W, Wang R, Chen L, 2014 Expression of Notch-1 and its clinical significance in different histological subtypes of human lung adenocarcinoma, Huang J, Song H, Liu B, Yu B, Wang R, Chen L, 2013 Inhibition of ZEB1 reverses EMT and chemoresistance in docetaxel-resistant human lung adenocarcinoma cell line, Ren J, Chen Y, Song H, Chen L, Wang R, 2013

Areas of Focus

Molecular Mechanisms of Gene Expression Regulation
Epigenetic Molecular Mechanisms of Malignant Tumor Phenotypes

Publications

FOXM1-Mediated LINC-ROR Regulates the Proliferation and Sensitivity to Sorafenib in Hepatocellular Carcinoma, Zhi Y, Abudoureyimu M, Zhou H, Wang T, Feng B, Wang R, Chu X, 2019
Recent progress in the emerging role of exosome in hepatocellular carcinoma, Abudoureyimu M, Zhou H, Zhi Y, Wang T, Feng B, Wang R, Chu X, 2019
Aurora-a confers radioresistance in human hepatocellular carcinoma by activating NF-κB signaling pathway, Shen ZT, Chen Y, Huang GC, Zhu XX, Wang R, Chen LB, 2019
Regulation and functions of MicroRNA-149 in human cancers, Zhi Y, Zhou H, Mubalake A, Chen Y, Zhang B, Zhang K, Chu X, Wang R, 2018
Non-coding RNAs: Emerging Regulators of Sorafenib Resistance in Hepatocellular Carcinoma, Lai Y, Feng B, Abudoureyimu M, Zhi Y, Zhou H, Wang T, Chu X, Chen P, Wang R, 2019
Oncolytic Adenovirus-A Nova for Gene-Targeted Oncolytic Viral Therapy in HCC, Abudoureyimu M, Lai Y, Tian C, Wang T, Wang R, Chu X, 2019
PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib, Zhang K, Chen J, Zhou H, Chen Y, Zhi Y, Zhang B, Chen L, Chu X, Wang R, Zhang C, 2018
A Novel Aurora-A Inhibitor (MLN8237) Synergistically Enhances the Antitumor Activity of Sorafenib in Hepatocellular Carcinoma, Zhang K, Wang T, Zhou H, Feng B, Chen Y, Zhi Y, Wang R, 2018
Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression, Chen Y, Shen Z, Zhi Y, Zhou H, Zhang K, Wang T, Feng B, Chen Y, Song H, Wang R, Chu X, 2018
The lincRNA-ROR/miR-145 axis promotes invasion and metastasis in hepatocellular carcinoma via induction of epithelial-mesenchymal transition by targeting ZEB2, Li C, Lu L, Feng B, Zhang K, Han S, Hou D, Chen L, Chu X, Wang R, 2017
Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma, Zhang B, Han S, Feng B, Chu X, Chen L, Wang R, 2017
Notch-1 Confers Chemoresistance in Lung Adenocarcinoma to Taxanes through AP-1/microRNA-451 Mediated Regulation of MDR-1, Huang J, Chen Y, Li J, Zhang K, Chen J, Chen D, Feng B, Song H, Feng J, Wang R, Chen L, 2016
Non-small-cell lung cancer and miRNAs: novel biomarkers and promising tools for treatment, Feng B, Zhang K, Wang R, Chen L, 2015
MicroRNA-451 induces epithelial-mesenchymal transition in docetaxel-resistant lung adenocarcinoma cells by targeting proto-oncogene c-Myc, Chen D, Huang J, Zhang K, Pan B, Chen J, De W, Wang R, Chen L, 2014
Expression of Notch-1 and its clinical significance in different histological subtypes of human lung adenocarcinoma, Huang J, Song H, Liu B, Yu B, Wang R, Chen L, 2013
Inhibition of ZEB1 reverses EMT and chemoresistance in docetaxel-resistant human lung adenocarcinoma cell line, Ren J, Chen Y, Song H, Chen L, Wang R, 2013

Gene Expression Molecular Regulation Epigenetics Tumor Malignant Phenotype Aurora-A Hif-1Α Mir-129-3P Microrna Lncrna

Zhang Zhiqian - Southern University of Science and Technology

Songmei Liu - Wuhan University

Feng Li - Wuhan University

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