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Zhang Aihua
Medical School
Nanjing University
Jiangsu
Language: Chinese, English
Chronic Kidney Disease
Acute Kidney Injury
Pediatric Nephrology
Mitochondrial Dysfunction
Oxidative Stress
Renal Fibrosis
Gene Diagnosis
Early Intervention
Inflammation
Cellular Mechanisms
Areas of Focus
- Pediatric Nephrology
Academic Background & Achievements
- National Outstanding Youth Science Fund Recipient
- Expert enjoying special government allowances from the State Council
- Leading Talent in Science and Technology Innovation by the Ministry of Science and Technology
- Jiangsu Province Distinguished Professor
- First-level training object of Jiangsu Province '333 Project'
- Deputy Director of the Children's Hospital Affiliated to Nanjing Medical University/Head of Nephrology
- Director of the Key Laboratory of Major Pediatric Diseases Research in Jiangsu Province
- Director of the Pediatric Research Institute of Nanjing Medical University
Publications
- Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI, Corresponding Author, 2020
- Response to comment on 'Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI', Corresponding Author, 2021
- Dimethyl fumarate prevents ferroptosis to attenuate acute kidney injury by acting on NRF2, Corresponding Author, 2021
- Reduced Lon protease 1 expression in podocytes contributes to the pathogenesis of podocytopathy, Corresponding Author, 2021
- MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation, Corresponding Author, 2019
- Functional Characterization of PHEX Gene Variants in Children With X-Linked Hypophosphatemic Rickets Shows No Evidence of Genotype-Phenotype Correlation, Corresponding Author, 2020
- Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease, Corresponding Author, 2022
- Isoliquiritin Ameliorates Cisplatin-Induced Renal Proximal Tubular Cell Injury by Antagonizing Apoptosis, Oxidative Stress and Inflammation, Corresponding Author, 2022
- Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases, Corresponding Author, 2022
- Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury, Corresponding Author, 2022
- mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1, Corresponding Author, 2022
- Computational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis, Corresponding Author, 2021
- Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6 Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction, Corresponding Author, 2021
- Roxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS, Corresponding Author, 2021
- SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation, Corresponding Author, 2021
- Blocking AURKA with MK-5108 attenuates renal fibrosis in chronic kidney disease, Corresponding Author, 2021
- Anti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability, Corresponding Author, 2021
- Clinical and Functional Characterization of Novel INSR Variants in Two Families With Severe Insulin Resistance Syndrome, Corresponding Author, 2021
- Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury, Corresponding Author, 2021
- The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction, Corresponding Author, 2021
- Multi-centre study of the clinical features and gene variant spectrum of Gitelman syndrome in Chinese children, Corresponding Author, 2021
- Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation, Corresponding Author, 2021
- Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway, Corresponding Author, 2021
- Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity, Corresponding Author, 2021
- Targeting microsomal prostaglandin E synthase 1 to develop drugs treating the inflammatory diseases, Corresponding Author, 2021
- The emerging role of MEIS1 in cell proliferation and differentiation, Corresponding Author, 2020
- Mitochondrial Dysfunction and the AKI to CKD Transition, Corresponding Author, 2020
- miR-214 Protects Against Uric Acid-Induced Endothelial Cell Apoptosis, Corresponding Author, 2020
- LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments, Corresponding Author, 2020
- New Criterion to Evaluate Acute-on-Chronic Kidney Injury Based on the Creatinine Reference Change, Corresponding Author, 2020
- Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells, Corresponding Author, 2020
- Chinese
Awards
- First Prize of Medical New Technology Introduction Award of Jiangsu Provincial Health and Family Planning Commission (2021): Application of Minigene Technology in Gene Diagnosis of Rare Genetic Diseases in Children
- First Prize of Medical New Technology Introduction Award of Jiangsu Province (2018): Application of Next-Generation Sequencing Technology in the Diagnosis of Rare Genetic Diseases in Children
- Second Prize of National Women's and Children's Health Science and Technology Award (2017): Study on the Role of Oxidative Stress in the Pathogenesis and Early Intervention of Chronic Kidney Disease in Children
- Second Prize of Jiangsu Medical Science and Technology Award (2016): Study on the Key Mechanisms and Early Diagnosis and Treatment of Chronic Kidney Disease in Children
- Second Prize of Jiangsu Provincial Science and Technology Award (2014): Study on the Role and Intervention of Oxidative Stress in the Occurrence and Progression of Chronic Kidney Disease
- First Prize of the Ministry of Education Natural Science Award (2014): Study on the Key Mechanisms and Diagnostic Markers of Chronic Kidney Disease Progression
- Song Qingling Pediatric Medicine Award (2013): Study on the Role of Oxidative Stress in the Pathogenesis and Early Intervention of Chronic Kidney Disease in Children
- Third Prize of Jiangsu Provincial Science and Technology Progress Award (2010): Study on the Cellular and Molecular Mechanisms and Intervention of Renal Fibrosis
- Second Prize of Jiangsu Medical Science and Technology Award (2010): Study on the Role of JNK Signaling Pathway Activation in the Pathogenesis and Early Diagnosis of Chronic Kidney Disease in Children
- Third Prize of Jiangsu Provincial Science and Technology Progress Award (2009): Study on the Role of Oxidative Stress-Mediated MAPK Signaling Pathway Activation in Chronic Kidney Disease in Children
