Professor | Jiao Shi | Asia Growth Partners

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Name	Jiao Shi
Contact Information	jiaoshi@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Jiao Shi

Contact Information

jiaoshi@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Life Sciences
Academic Background & Achievements	2002 - Bachelor's Degree in Medicine: Southeast University 2005 - Master's Degree in Medicine: Southeast University 2008 - Doctorate in Medicine: Chinese Center for Disease Control and Prevention 2008-2012 - Postdoctoral Research: Shanghai Institute of Nutrition Sciences, Chinese Academy of Sciences 2012-2020 - Assistant Researcher, Associate Researcher: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 2021-present - Junior Researcher: School of Life Sciences, Fudan University Published 34 research papers in international journals Cumulative impact factor nearly 200 Cited nearly 900 times, highest single paper citation over 460 times Hosted multiple national and major research projects
Work Experience	2008-2012 - Shanghai Institute of Nutrition Sciences, Chinese Academy of Sciences - Postdoctoral Research 2012-2020 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher 2021-present - School of Life Sciences, Fudan University - Junior Researcher
Awards	2014 - Member of Youth Innovation Promotion Association, Chinese Academy of Sciences 2014 - Sanofi-Shanghai Institute of Biological Sciences Outstanding Young Talent Award 2018 - National Excellent Youth 2019 - Outstanding Member of Youth Innovation Promotion Association 2020 - Second Prize of Shanghai Medical Science and Technology Award

University/Lab Affiliation and Title

Fudan University

Faculty

Life Sciences

Academic Background & Achievements

2002 - Bachelor's Degree in Medicine: Southeast University
2005 - Master's Degree in Medicine: Southeast University
2008 - Doctorate in Medicine: Chinese Center for Disease Control and Prevention
2008-2012 - Postdoctoral Research: Shanghai Institute of Nutrition Sciences, Chinese Academy of Sciences
2012-2020 - Assistant Researcher, Associate Researcher: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2021-present - Junior Researcher: School of Life Sciences, Fudan University
Published 34 research papers in international journals
Cumulative impact factor nearly 200
Cited nearly 900 times, highest single paper citation over 460 times
Hosted multiple national and major research projects

Work Experience

2008-2012 - Shanghai Institute of Nutrition Sciences, Chinese Academy of Sciences - Postdoctoral Research
2012-2020 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher
2021-present - School of Life Sciences, Fudan University - Junior Researcher

Awards

2014 - Member of Youth Innovation Promotion Association, Chinese Academy of Sciences
2014 - Sanofi-Shanghai Institute of Biological Sciences Outstanding Young Talent Award
2018 - National Excellent Youth
2019 - Outstanding Member of Youth Innovation Promotion Association
2020 - Second Prize of Shanghai Medical Science and Technology Award

Areas of Focus	Cell signaling mechanisms in tumor immunity
Publications	Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells, Meng, Y., Ye, F., Nie, P., Zhao, Q., An, L., Wang, W., Qu, S., Shen, Z., Cao, Z., Zhang, X., Zhang, X., Jiao, S., Wu, D., Zhou, Z., Wei, L., 2023 SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness, Jiao, S., Li, C., Guo, F., Zhang, J., Zhang, H., Cao, Z., Wang, W., Bu, W., Lin, M., Lü, J., Zhou, Z., 2023 A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer, Nie, P., Zhang, W., Meng, Y., Lin, M., Guo, F., Zhang, H., Tong, Z., Wang, M., Chen, F., An, L., Tang, Y., Han, Y., Yu, R., Wang, W., Xu, Y., Wei, Li., Zhou, Z., Jiao, S., 2023 Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers, An, L., Cao, Z., Nie, P., Zhang, H., Tong, Z., Chen, F., Tang, Y., Han, Y., Wang, W., Zhao, Z., Zhao, Q., Yang Y., Xu Y., Fang, G., Shi, L., Xu, H., Ma H., Jiao, S., Zhou, Z., 2022 An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis, Zhang, H., Lin, M., Dong, C., Tang, Y., An, L., Ju, J., Wen, F., Chen, F., Wang, M., Wang, W., Chen, M., Zhao, Y., Li, J., Hou, S. X., Lin, X., Hu, L., Bu, W., Wu, D., Li, L., Jiao, S., Zhou, Z., 2021 Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer, Tang, Y., Fang, G., Guo, F., Zhang, H., Chen, X., An, L., Chen, M., Zhou, L., Wang, W., Ye, T., Zhou, L., Nie, P., Yu, H., Lin, M., Zhao, Y., Lin, X., Yuan, Z., Jiao, S., Zhou, Z., 2020 MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway, An, L., Nie, P., Chen, M., Tang, Y., Zhang, H., Guan, J., Cao, Z., Hou, C., Wang, W., Zhao, Y., Xu, H., Jiao, S., Zhou, Z., 2020 Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling, Tang, Y., Chen, M., Zhou, L., Ma, J., Li, Y., Zhang, H., Shi, Z., Xu, Q., Zhang, X., Gao, Z., Zhao, Y., Cheng, Y., Jiao, S., Zhou, Z., 2019 TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts, Li, Y., Guan, J., Wang, W., Hou, C., Zhou, L., Ma, J., Cheng, Y., Jiao, S., Zhou, Z., 2019 A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors, Wang, T., Wang, D., Yu, H., Feng, B., Zhou, F., Zhang, H., Zhou, L., Jiao, S., Li, Y., 2018 SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin, Sun, W. W., Jiao, S., Sun, L., Zhou, Z., Jin, X., Wang, J. H., 2018 Targeting IRF3 as a YAP agonist therapy against gastric cancer, Jiao, S., Guan, J., Chen, M., Wang, W., Li, C., Wang, Y., Cheng, Y., Zhou, Z., 2018 VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer, Jiao, S., Li, C., Hao, Q., Miao, H., Zhang, L., Li, L., Zhou, Z., 2017 Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy, Wang, D., Wang, T., Liu, J., Yu, H., Jiao, S., Feng, B., Zhou, F., Fu, Y., Yin, Q., Zhang, P., Zhang, Z., Zhou, Z., Li, Y., 2016

Areas of Focus

Cell signaling mechanisms in tumor immunity

Publications

Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells, Meng, Y., Ye, F., Nie, P., Zhao, Q., An, L., Wang, W., Qu, S., Shen, Z., Cao, Z., Zhang, X., Zhang, X., Jiao, S., Wu, D., Zhou, Z., Wei, L., 2023
SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness, Jiao, S., Li, C., Guo, F., Zhang, J., Zhang, H., Cao, Z., Wang, W., Bu, W., Lin, M., Lü, J., Zhou, Z., 2023
A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer, Nie, P., Zhang, W., Meng, Y., Lin, M., Guo, F., Zhang, H., Tong, Z., Wang, M., Chen, F., An, L., Tang, Y., Han, Y., Yu, R., Wang, W., Xu, Y., Wei, Li., Zhou, Z., Jiao, S., 2023
Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers, An, L., Cao, Z., Nie, P., Zhang, H., Tong, Z., Chen, F., Tang, Y., Han, Y., Wang, W., Zhao, Z., Zhao, Q., Yang Y., Xu Y., Fang, G., Shi, L., Xu, H., Ma H., Jiao, S., Zhou, Z., 2022
An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis, Zhang, H., Lin, M., Dong, C., Tang, Y., An, L., Ju, J., Wen, F., Chen, F., Wang, M., Wang, W., Chen, M., Zhao, Y., Li, J., Hou, S. X., Lin, X., Hu, L., Bu, W., Wu, D., Li, L., Jiao, S., Zhou, Z., 2021
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer, Tang, Y., Fang, G., Guo, F., Zhang, H., Chen, X., An, L., Chen, M., Zhou, L., Wang, W., Ye, T., Zhou, L., Nie, P., Yu, H., Lin, M., Zhao, Y., Lin, X., Yuan, Z., Jiao, S., Zhou, Z., 2020
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway, An, L., Nie, P., Chen, M., Tang, Y., Zhang, H., Guan, J., Cao, Z., Hou, C., Wang, W., Zhao, Y., Xu, H., Jiao, S., Zhou, Z., 2020
Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling, Tang, Y., Chen, M., Zhou, L., Ma, J., Li, Y., Zhang, H., Shi, Z., Xu, Q., Zhang, X., Gao, Z., Zhao, Y., Cheng, Y., Jiao, S., Zhou, Z., 2019
TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts, Li, Y., Guan, J., Wang, W., Hou, C., Zhou, L., Ma, J., Cheng, Y., Jiao, S., Zhou, Z., 2019
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors, Wang, T., Wang, D., Yu, H., Feng, B., Zhou, F., Zhang, H., Zhou, L., Jiao, S., Li, Y., 2018
SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin, Sun, W. W., Jiao, S., Sun, L., Zhou, Z., Jin, X., Wang, J. H., 2018
Targeting IRF3 as a YAP agonist therapy against gastric cancer, Jiao, S., Guan, J., Chen, M., Wang, W., Li, C., Wang, Y., Cheng, Y., Zhou, Z., 2018
VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer, Jiao, S., Li, C., Hao, Q., Miao, H., Zhang, L., Li, L., Zhou, Z., 2017
Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy, Wang, D., Wang, T., Liu, J., Yu, H., Jiao, S., Feng, B., Zhou, F., Fu, Y., Yin, Q., Zhang, P., Zhang, Z., Zhou, Z., Li, Y., 2016

Tumor Immunity Cell Signaling Gastric Cancer Immune Response Cell Interaction Immune Checkpoints Organ Communication Brain-Gut Axis Molecular Typing Immune Microenvironment

Shui Wang - Shanghai Normal University

Min Qian - East China Normal University

Shuhua Chen - Central South University

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