2009 - PhD in Molecular and Developmental Biology: University of Cincinnati
Published 26 papers in international academic journals such as Developmental Cell, PNAS, and Nature Communications
Editorial board member of the journal 'Genetics'
Currently undertaking projects funded by the National Natural Science Foundation, major research plans, and key R&D plans of the Ministry of Science and Technology
2010-2016 - Harvard Medical School, Howard Hughes Medical Institute - Postdoctoral Researcher
2016-2020 - Shanghai Institute of Plant Physiology and Ecology, CAS - Researcher and Group Leader
2021-Present - Fudan University, School of Life Sciences - Researcher
2019 - National Youth Top Talent
2019 - Shanghai Overseas High-Level Talent
2017 - Shanghai Pujiang Talent Plan
2014 - Charles A. King Trust Postdoctoral Fellowship
2012 - Damon Runyon Cancer Research Fellowship
2005 - Albert J. Ryan Fellowship
2005 - American Heart Association (AHA) Doctoral Fellowship
Research
RNA modification-mediated development and metabolism research
Role of Hakai in m6A modification pathway in Drosophila, Wang, Y., Zhang, L., Ren, H., Ma, L., Guo, J., Mao, D., Lu, Z., Lu, L. and Yan, D., 2021
Large-Scale Transgenic Drosophila Resource Collections for Loss- And Gain-of-Function Studies, Zirin, J., Hu, Y., Liu, L., Yang-Zhou, D., Colbeth, R., Yan, D., Ewen-Campen, B., Tao, R., Vogt, E., VanNest, S., Cavers, C., Villalta, C., Comjean, A., Sun, J., Wang, X., Jia, Y., Zhu, R., Peng, P., Yu, J., Shen, D., Qiu, Y., Ayisi, L., Ragoowansi, H., Fenton, E., Efrem, S., Parks, A., Saito, K., Kondo, S., Perkins, L., Mohr, S., Ni, J. and Perrimon, N., 2020
Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly, Silver, J., Wirtz-Peitz, F., Simoes, S., Pellikka, M., Yan, D., Binari, R., Nishimura, T., Li, Y., Harris, T., Perrimon, N. and Tepass, U., 2019
Xio is a novel component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex, Guo, J., Tang, H., Li, J., Perrimon, N. and Yan, D., 2018
Bombyx mori histone methyltransferase BmAsh2 is essential for silkworm piRNA-mediated sex determination, Li, Z., You, L., Yan, D., James, A. Huang, Y. and Tan A., 2018
The m6A pathway facilitates sex determination in Drosophila, Kan, L., Grozhik, A., Vedanayagam, J., Patil, D., Pang, N., Lim, K., Huang, Y., Joseph, B., Lin, C., Despic, V., Guo, J., Yan, D., Kondo, S., Deng, W., Dedon, P., Jaffrey, S. and Lai, E., 2017
Spenito is required for sex determination in Drosophila melangaster, Yan, D. and Perrimon, N., 2015
Histone H1-Mediated Epigenetic Regulation Controls Germline Stem Cell Self-Renewal by Modulating the Acetylation of H4 Lysine 16, Sun, J., Wei, H., Xu, J., Chang, J., Yang, Z., Ren, X., Lv, W., Liu, L., Pan, L., Wang, X., Qiao, H., Zhu, B., Ji, J., Yan, D., Xie, T., Sun, F. and Ni, J., 2015
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation, Perkins, L., Holderbaum, L., Tao, R., Hu, Y., Sopko, R., McCall, K., Yang-Zhou, D., Flockhart, I., Binari, R., Shim, H., Miller, A., Housden, A., Foos, M., Randklev, S., Kelley, C., Namgyal, P., Villalta, C., Liu, L., Jiang, X., Huan-Huan, Q., Xia, W., Fujiyama, A., Toyoda, A, Ayers, K., Blum, A., Czech, B., Neumuller, R., Yan, D., Cavallaro, A., Hibbard, K., Hall, D., Cooley, L., Hannon, G., Lehmann, R., Parks, A., Mohr, S., Ueda, R., Kondo, S., Ni, J. and Perrimon, N., 2015
Genome-Wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila, Zeng, X., Han, L., Singh S., Liu, H., Neumüller, R., Yan, D., Hu, Y., Liu, Y., Liu W., Lin, X. and Hou, S., 2015
A sharp end to sugary Wingless travels, Droujinine, I., Yan, D. and Perrimon, N., 2014
A regulatory network of Drosophila germline stem cell self-renewal, Yan, D., Neumuller, R., Buckner, M., Ayers, K., Li, H., Hu, Y., Yang-Zhou, D., Pan, L., Wang, X., Kelley, C., Vinayagam, A., Binari, R., Randklev, S., Perkins, L., Xie, T., Cooley, L. and Perrimon, N., 2014
Depleting Gene Activities in Early Drosophila Embryos with the “Maternal-Gal4–shRNA” System, Staller, M., Yan, D., Randklev, S., Bragdon, M., Wunderlich, Z., Tao, R., Perkins, L., DePace, A. and Perrimon, N., 2013
Proteomic and functional genomic landscape of receptor tyrosine kinase and Ras/ERK signaling, Friedman, A., Tucker, G., Singh, R., Yan, D., Arunachalam, V., Hu, Y., Binari, R., Hong, P., Sun, X., Porto, M., Pacifico, S., Murali, T., Finley, R., Asara, J., Berger, B. and Perrimon, N., 2011
The cell-surface proteins Dally-like and Ihog differentially regulate Hh signaling strength and range during development, Yan, D., Wu, Y., Yang, Y., Belenkaya, T., Tang, X. and Lin, X., 2010
The core protein of glypican Dally-like determines its biphasic activity in Wingless morphogen signaling, Yan, D., Wu, Y., Feng, Y., Lin, S. and Lin, X., 2009
Shaping morphogen gradient by proteoglycans, Yan, D and Lin, X., 2009
Opposing roles for glypicans in Hedgehog signalling, Yan, D and Lin, X., 2008
The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network, Belenkaya, T., Wu, Y., Tang, X., Zhou, B., Cheng, L., Sharma, Y., Yan, D., Selva, E. and Lin, X., 2008
Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis, Yan, D. and Lin, X., 2007
Drosophila Glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc, Han, C., Yan, D., Belenkaya, T. and Lin, X., 2005
Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos, Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C.C, Lin, X. and Heasman, J., 2005
Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis and is controlled by glypican members of heparan sulfate proteoglycans, Belenkaya, T., Han, C., Yan, D., Opoka, R.J., Khodoun, M., Liu, H. and Lin, X., 2004
Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1, Yang, L., Yan, D., Bruggeman, M., Du, H. and Yan, C., 2004
Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung, Yang, L., Yan, D., Yan, C. and Du, H., 2003
An enhancer region determines hSP-B gene expression in bronchiolar and ATII epithelial cells in transgenic mice, Yang, L., Naltner, A., Kreiner, A., Yan, D., Cowen, A., Du, H. and Yan, C., 2003
Area of Focus
Bioinformatics | High-Throughput | Multi-Omics | Data Modeling | Alternative Splicing | Disease | Development | Rna | Therapeutic | Splicing-Related
