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Yu-Fang Zheng
Life Science
Fudan University
Shanghai
Language: Chinese, English
Genetics
Development
Molecular
Biochemistry
Animal Models
Organoid Models
Embryonic Development
Neurological Diseases
Mechanisms
Research
Areas of Focus
- Molecular genetics and developmental mechanisms of major neurological diseases caused by abnormal early embryonic development
Work Experience
- 2004-2007 - Postdoctoral Research: Yale University
- 2007-Present - Researcher: Fudan University
- 2016-Present - Deputy Researcher PI: Fudan University Affiliated Obstetrics and Gynecology Hospital
Academic Background & Achievements
- 1997 - Bachelor's Degree in Biological Sciences and Technology: Tsinghua University
- 1999 - Master's Degree in Biophysics: Tsinghua University
- 2004 - Ph.D. in Physiology, Biophysics, and Molecular Medicine: Cornell University
- 2004-2007 - Postdoctoral Research: Yale University
- 2016 - Deputy Researcher PI: Fudan University Affiliated Obstetrics and Gynecology Hospital
- 2017 - Researcher: Fudan University
- Award: Shanghai Pujiang Talent Program
- Award: Fudan University Zhuoxue Talent Program
Publications
- Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos, Yan L, Yin H, Mi Y, Wu Y, Zheng Y*, 2023
- High glucose causes developmental abnormalities in neuroepithelial cysts with actin and HK1 distribution changes, Peng S, Wu Y, Zheng Y*, 2023
- Parental folate deficiency induces birth defects in mice accompanied with increased de novo mutations, Zhao Y#, Chen D#, Tang J, Zheng Y*, Qi Ji*, Wang H*, 2022
- MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα, Wang Y, Wu Y, Zheng Y*, Wang H*, 2021
- Organoids as a new model system to study neural tube defects, Wu Y, Peng S, Zheng Y*, 2021
- SRPS Associated Protein WDR60 Regulates the Multipolar-to-Bipolar Transition of Migrating Neurons during Cortical Development, Li C, Zheng Y, Zheng Y*, Xu Z*, 2021
- WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways, Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y*, 2020
- Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling, Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH., Qiao B, Wang Y*, Wang H*, Zheng Y*, 2019
- MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors, Wang Y#, Zheng Y#,*, Yang S, Yang Z, Zhang L, He Y, Gong X, Liu D, Finnell R.H., Qiu Z, Du Y*, Wang H*, 2019
- Threshold for neural tube defect risk by accumulated singleton loss-of-function variants, Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.*, Wang H*, 2018
Awards
- Shanghai Pujiang Talent Program
- Fudan University Zhuoxue Talent Program
