Upload Avatar (500 x 500)
Jixi Li
Life Science
Fudan University
Shanghai
Language: Chinese, English
Necroptosis
Pyroptosis
Immune Response
Inflammation
Malignant Tumors
Autoimmune Diseases
Neurodegenerative Diseases
Biochemistry
Structural Biology
Mouse Models
Areas of Focus
- Cell Death and Immune Response
- Pathogen Infection
Work Experience
- 2006-2008 - Postdoc Fellow, Caltech, USA
- 2008-2012 - Postdoc Associate, Cornell Medical School, USA
- 2012-2014 - Research Fellow, Harvard Medical School/Children’s Hospital Boston, USA
- 2014-present - Full Professor, School of Life Sciences, Fudan University
- 2018-present - Adjunct professor, Huashan Hospital affiliated with Fudan University
Academic Background & Achievements
- 2000 - B.S. in Biological Science and Technology, Zhejiang University
- 2003 - M.S. in Biophysics, Zhejiang University
- 2006 - Ph.D. in Genetics, Fudan University
- Chief Scientist of the National Key R&D Project of the Ministry of Science and Technology (2016, 2021)
- Shanghai Outstanding Academic Leader (2020)
- Shanghai Distinguished Professor 'Oriental Scholar' (2014)
Publications
- MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease, Geng L, Gao W, Saiyin H, Li Y, Zeng Y, Zhang Z, Li X, Liu Z, Gao Q, An P, Jiang N, Yu X, Chen X, Li S, Chen L, Lu B, Li, A, Chen G, Shen Y, Zhang H, Tian M, Zhang Z, Li J, 2023
- TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization, Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J, 2022
- E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis, Mei P, Xie F, Pan J, Wang S, Gao W, Ge R, Gao B, Gao S, Chen X, Wang Y, Wu J, Ding C, Li J, 2021
- Systematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma, Gao W, Li Y, Zhang T, Lu J, Pan J, Qi Q, Dong S, Chen X, Su Z, Li J, 2022
- Structural basis of human helicase DDX21 in RNA binding, unwinding, and antiviral signal activation, Chen Z, Li Z, Hu X, Xie F, Kuang S, Zhan B, Gao W, Chen X, Gao S, Li Y, Wang Y, Qian F, Ding C, Gan J, Ji C, Xu XW, Zhou Z, Huang J, He HH, Li J, 2020
- The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-amyloid Signaling Complex, Mompeán M, Li W, Li J, Laage S, Siemer AB, Bozkurt G, Wu H, Mcdermott A, 2018
- Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-kB Signaling, Kleino A, Ramia N, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N, 2017
- Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis, Kuang S, Zheng J, Yang H, Li S, Duan S, Shen Y, Ji C, Gan J, Xu XW, Li J, 2017
- Structural Biology of Innate Immunity, Yin Q, Fu T, Li J, Wu H, 2015
- The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis, Li J, McQuade T, Siemer A, Napetschnig J, Damko E, Hsiao Y, Moquin D, Walz T, Mcdermott A, Chan FK, Wu H, 2012
- Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism, Bao L, Hu J, Zhan B, Chi M, Li Z, Wang S, Shan C, Zhao Z, Guo Y, Ding X, Ji C, Tao S, Ni T, Zhang X, Zhao G, Li J, 2023
- Neutralization of SARS-CoV-2 BQ.1.1 and XBB.1.5 by Breakthrough Infection Sera from Previous and Current Waves in China, Wang X, Jiang S, Jiang S, Li X, Ai J, Lin K, Lv S, Zhang S, Li M, He X, Li D, Li C, Zhao C, Zhao X, Qiao R, Cui Y, Chen Y, Li J, Cai G, Dai L, Hu Z, Zhang W, Zhang Y, Wang P, 2023
- Structural analysis of the housecleaning nucleoside triphosphate pyrophosphohydrolase MazG from Mycobacterium tuberculosis, Wang S, Gao B, Chen A, Zhang Z, Wang S, Lv L, Zhao G, Li J, 2023
- Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis, Zhan B, Gao Y, Gao W, Li Y, Li Z, Qi Q, Lan X, Shen H, Gan J, Zhao G, Li J, 2022
- Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity, Hu Z, Zhang C, Wang S, Gao S, Wei J, Li M, Hou L, Mao H, Wei Y, Qi T, Liu H, Liu D, Lan F, Lu D, Wang H, Li J, Wang Y, 2021
- Crystal structure of human archease, a key cofactor of tRNA splicing ligase complex, Duan S, Gao W, Chen Z, Li Z, Li S, Gan J, Chen X, Li J, 2020
- Structure guided protein engineering increases enzymatic activities of the SGNH family esterases, Li Z, Li L, Huo Y, Chen Z, Zhao Y, Huang J, Jian S, Rong Z, Wu D, Gan J, Hu X, Li J, Xu XW, 2020
- Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues, Chen Y, Liu H, Yang C, Gao Y, Yu X, Chen X, Cui R, Zhen L, Li S, Li X, Ma J, Huang Z, Li J, Gan J, 2019
- Structural insights into DNA degradation by human mitochondrial nuclease MGME1, Yang C, Wu R, Liu H, Chen Y, Gao Y, Chen X, Li Y, Ma J, Li J, Gan J, 2018
- High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads, Liu H, Wang R, Yu X, Shen F, Lan W, Haruehanroengra P, Yao Q, Zhang J, Chen Y, Li S, Wu B, Zheng L, Ma J, Lin J, Cao C, Li J, Sheng J, Gan J, 2018
Awards
- Marine Science and Technology Award of Zhejiang Province (2020)
- Outstanding Talent Program--'Zhuoshi', Fudan University (2020)
- Golden Dragon Fish Synthetic Biologist Award, Fudan University (2020)
- Fosun Pharmaceutical Award, Fudan University (2016, 2017, 2020, 2022)
- Harvard University Chinese Life Sciences Annual Outstanding Research Award (2013)
