2000 - B.S. in Biological Science and Technology, Zhejiang University
2003 - M.S. in Biophysics, Zhejiang University
2006 - Ph.D. in Genetics, Fudan University
Chief Scientist of the National Key R&D Project of the Ministry of Science and Technology (2016, 2021)
Shanghai Outstanding Academic Leader (2020)
Shanghai Distinguished Professor 'Oriental Scholar' (2014)
2006-2008 - Postdoc Fellow, Caltech, USA
2008-2012 - Postdoc Associate, Cornell Medical School, USA
2012-2014 - Research Fellow, Harvard Medical School/Children’s Hospital Boston, USA
2014-present - Full Professor, School of Life Sciences, Fudan University
2018-present - Adjunct professor, Huashan Hospital affiliated with Fudan University
Marine Science and Technology Award of Zhejiang Province (2020)
Outstanding Talent Program--'Zhuoshi', Fudan University (2020)
Golden Dragon Fish Synthetic Biologist Award, Fudan University (2020)
Fosun Pharmaceutical Award, Fudan University (2016, 2017, 2020, 2022)
Harvard University Chinese Life Sciences Annual Outstanding Research Award (2013)
Research
Cell Death and Immune Response Pathogen Infection
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease, Geng L, Gao W, Saiyin H, Li Y, Zeng Y, Zhang Z, Li X, Liu Z, Gao Q, An P, Jiang N, Yu X, Chen X, Li S, Chen L, Lu B, Li, A, Chen G, Shen Y, Zhang H, Tian M, Zhang Z, Li J, 2023
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization, Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J, 2022
E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis, Mei P, Xie F, Pan J, Wang S, Gao W, Ge R, Gao B, Gao S, Chen X, Wang Y, Wu J, Ding C, Li J, 2021
Systematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma, Gao W, Li Y, Zhang T, Lu J, Pan J, Qi Q, Dong S, Chen X, Su Z, Li J, 2022
Structural basis of human helicase DDX21 in RNA binding, unwinding, and antiviral signal activation, Chen Z, Li Z, Hu X, Xie F, Kuang S, Zhan B, Gao W, Chen X, Gao S, Li Y, Wang Y, Qian F, Ding C, Gan J, Ji C, Xu XW, Zhou Z, Huang J, He HH, Li J, 2020
The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-amyloid Signaling Complex, Mompeán M, Li W, Li J, Laage S, Siemer AB, Bozkurt G, Wu H, Mcdermott A, 2018
Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-kB Signaling, Kleino A, Ramia N, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N, 2017
Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis, Kuang S, Zheng J, Yang H, Li S, Duan S, Shen Y, Ji C, Gan J, Xu XW, Li J, 2017
Structural Biology of Innate Immunity, Yin Q, Fu T, Li J, Wu H, 2015
The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis, Li J, McQuade T, Siemer A, Napetschnig J, Damko E, Hsiao Y, Moquin D, Walz T, Mcdermott A, Chan FK, Wu H, 2012
Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism, Bao L, Hu J, Zhan B, Chi M, Li Z, Wang S, Shan C, Zhao Z, Guo Y, Ding X, Ji C, Tao S, Ni T, Zhang X, Zhao G, Li J, 2023
Neutralization of SARS-CoV-2 BQ.1.1 and XBB.1.5 by Breakthrough Infection Sera from Previous and Current Waves in China, Wang X, Jiang S, Jiang S, Li X, Ai J, Lin K, Lv S, Zhang S, Li M, He X, Li D, Li C, Zhao C, Zhao X, Qiao R, Cui Y, Chen Y, Li J, Cai G, Dai L, Hu Z, Zhang W, Zhang Y, Wang P, 2023
Structural analysis of the housecleaning nucleoside triphosphate pyrophosphohydrolase MazG from Mycobacterium tuberculosis, Wang S, Gao B, Chen A, Zhang Z, Wang S, Lv L, Zhao G, Li J, 2023
Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis, Zhan B, Gao Y, Gao W, Li Y, Li Z, Qi Q, Lan X, Shen H, Gan J, Zhao G, Li J, 2022
Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity, Hu Z, Zhang C, Wang S, Gao S, Wei J, Li M, Hou L, Mao H, Wei Y, Qi T, Liu H, Liu D, Lan F, Lu D, Wang H, Li J, Wang Y, 2021
Crystal structure of human archease, a key cofactor of tRNA splicing ligase complex, Duan S, Gao W, Chen Z, Li Z, Li S, Gan J, Chen X, Li J, 2020
Structure guided protein engineering increases enzymatic activities of the SGNH family esterases, Li Z, Li L, Huo Y, Chen Z, Zhao Y, Huang J, Jian S, Rong Z, Wu D, Gan J, Hu X, Li J, Xu XW, 2020
Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues, Chen Y, Liu H, Yang C, Gao Y, Yu X, Chen X, Cui R, Zhen L, Li S, Li X, Ma J, Huang Z, Li J, Gan J, 2019
Structural insights into DNA degradation by human mitochondrial nuclease MGME1, Yang C, Wu R, Liu H, Chen Y, Gao Y, Chen X, Li Y, Ma J, Li J, Gan J, 2018
High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads, Liu H, Wang R, Yu X, Shen F, Lan W, Haruehanroengra P, Yao Q, Zhang J, Chen Y, Li S, Wu B, Zheng L, Ma J, Lin J, Cao C, Li J, Sheng J, Gan J, 2018
