Areas of Focus
- GPCR signaling pathways and major disease relevance and new drug discovery
- Small molecule compounds regulating stem cell fate and new drug discovery
Work Experience
- 2004 - Present: National Center for Drug Screening, Head of Model Establishment II Department
- Postdoctoral research in neurobiology at New Jersey Medical School
Academic Background & Achievements
- 1996 - Bachelor of Science: Peking University, Chemistry
- 2002 - PhD: University of Medicine and Dentistry of New Jersey, Neuroscience
- Received support from the Chinese Academy of Sciences 'Hundred Talents Program'
- Received funding from the Ministry of Education and the Ministry of Human Resources
Publications
- Small molecule compound induces chromatin de-condensation and facilitate induced pluripotent stem cell generation, Xiaoyuan Wei, Yueting Chen, Yongyu Xu, Yang Zan, Ru Zhang, Min Wang, Qiuhong Hua, Haifeng Gu, Fajun Nan, Xin Xie, 2014
- Proliferation rate of somatic cells affects reprogramming efficiency, Yongyu Xu, Xiaoyuan Wei, Min Wang, Ru Zhang, Yanbin Fu, Mingzhe Xing, Qiuhong Hua, Xin Xie, 2013
- Aurintricarboxylic Acid Ameliorates Experimental Autoimmune Encephalomyelitis by Blocking Chemokine-mediated Pathogenic Cell Migration and Infiltration, Feifei Zhang, Wei Wei, Hui Chai, Xin Xie, 2013
- Blocking A2B Adenosine Receptor alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and TH-17 Differentiation, Wei Wei, Changsheng Du, Jie Lv, Guixian Zhao, Zhenxin Li, Zhiying Wu, György Haskó, Xin Xie, 2013
- Stress-mediated p38 activation promotes somatic cell reprogramming, Xinxiu Xu, Quan Wang, Yuan Long, Ru Zhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie, 2013
- The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis, Jie Lv, Changsheng Du, Wei Wei, Zhiying Wu, Guixian Zhao, Zhenxin Li, Xin Xie, 2012
- G Protein-Coupled Receptors as Therapeutic Targets for Multiple Sclerosis, Chang-Sheng Du, Xin Xie, 2012
- Novel object recognition as a facile behavior test for evaluating drug effects in AβPP/PS1 Alzheimer’s mouse model, Ru Zhang, Guizhen Xue, Shaodeng Wang, Lihong Zhang, Changjie Shi, Xin Xie, 2012
- Antiasthmatic Drugs Targeting the Cysteinyl Leukotriene Receptor 1 Alleviate Central Nervous System Inflammatory Cell Infiltration and Pathogenesis of Experimental Autoimmune Encephalomyelitis, Liefeng Wang, Changsheng Du, Jie Lv, Wei Wei, Ye Cui, Xin Xie, 2011
- Lithium, an anti-Psychotic Drug, Greatly Enhances the Generation of Induced Pluripotent Stem Cells, Quan Wang, Xinxiu Xu, Jun Li, Jing Liu, Haifeng Gu, Ru Zhang, Jiekai Chen, Yin Kuang, Jian Fei, Cong Jiang, Ping Wang, Duanqing Pei, Sheng Ding, Xin Xie, 2011
- Intact Mdm2 E3 Ligase Activity Is Required for the Cytosolic Localization and Function of β-Arrestin2, Chenlei Yin, Ru Zhang, Yongyu Xu, Qiuyan Chen, Xin Xie, 2011
- Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors, He X, Fang L, Wang J, Yi Y, Zhang S, Xie X, 2008
Awards
- National Candidate for the New Century Millions of Talents Project
- Outstanding Young Scientific and Technological Innovation Talent of the Shanghai Branch of the Chinese Academy of Sciences
- Shanghai Excellent Academic Leader
- Shanghai March 8th Red Banner Holder
- Expert with Special Government Allowance of the State Council
- 2013 - Tenth National Outstanding Young Female Scientist Award
