Professor | Yong Shen | Asia Growth Partners

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Name	Yong Shen
Contact Information	yongshen@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Yong Shen

Contact Information

yongshen@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	1983 - Bachelor's degree in Human and Animal Physiology: Nanjing University 1986 - Master's degree in Physiology: Shanghai Institute of Physiology, Chinese Academy of Sciences 1989 - PhD in Psychobiology and Neuroscience: State University of New York
Work Experience	1993 - Joined Abbott Labs as Senior Molecular Neuropharmacologist and Group Leader 1997 - Director and Senior Scientist at Sun Health Research Institute, Arizona 2000 - Director of Hardman Laboratory for Molecular and Cellular Neurobiology 2006 - Co-Director of SunHealth Asia-Pacific Medical Research Center 2010 - Director at Roskamp Institute, Florida
Awards	Zenith Award in Alzheimer's Disease Outstanding Contributor to Alzheimer Research 2009 - Changjiang Scholar Award Program

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

1983 - Bachelor's degree in Human and Animal Physiology: Nanjing University
1986 - Master's degree in Physiology: Shanghai Institute of Physiology, Chinese Academy of Sciences
1989 - PhD in Psychobiology and Neuroscience: State University of New York

Work Experience

1993 - Joined Abbott Labs as Senior Molecular Neuropharmacologist and Group Leader
1997 - Director and Senior Scientist at Sun Health Research Institute, Arizona
2000 - Director of Hardman Laboratory for Molecular and Cellular Neurobiology
2006 - Co-Director of SunHealth Asia-Pacific Medical Research Center
2010 - Director at Roskamp Institute, Florida

Awards

Zenith Award in Alzheimer's Disease
Outstanding Contributor to Alzheimer Research
2009 - Changjiang Scholar Award Program

Areas of Focus	Molecular mechanisms of brain function and diseases Molecular pathology and drug discovery for neurodegenerative and psychiatric diseases Early clinical diagnostic markers for brain diseases
Publications	Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease., Yang LB, Lindholm K, Yan R, Citron M, Xia W, Beach T, Sue L, Wong P, Price D, Li R, Shen Y., 2003 Aβ load is correlated with elevated BACE activity in sporadic Alzheimer patients., Li R, Yang LB, Lindholm K, Yan R, Citron M, Beach T, Sue L, Subbagh M, Cai H, Wong P, Price D, Shen Y., 2004 TNF death receptor signaling cascade is required for amyloid-protein induced neuron death., Li R., Lindholm K, Yang LB, Konishi Y, Hampel H, Zhang, D. Shen Y., 2004 Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model., Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, Harada N, Zhong Z, Shen Y, Li R., 2005 High Levels of β-Secretase (BACE1) in Cerebrospinal Fluid as a Predictor of Risk in Mild Cognitive Impairment, the early stage of Alzheimer’s Disease., Zhong, Z., Ewers, M., Teipel, S., Büger, K., Wallin, A., Blennow, K., Hampel, H., and Shen Y., 2007 Deletion of TNF death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer’s mice., HeP, ZhongZ, LindholmK, BerningL, LeeW, LemereC, StaufenbielM, LiR and Shen Y., 2007 Depletion of GGA3 stabilizes BACE and enhances β-secretase activity., Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE., 2007 Increased CSF-BACE1 activity is associated with ApoE-ε4 genotype in subjects with mild cognitive impairment (MCI) and Alzheimer's disease., Ewers M, Zhong Z, Bürger K, Wallin A, Blennow K, Teipel SJ, Shen Y, Hampel H., 2008 Interruption of β-catenin signaling reduces neurogenesis in Alzheimer’s disease’s brains., He, P. and Shen Y., 2009 A specific ELISA for measuring amyloid β-protein oligomers in human plasma and the brains of Alzheimer patients., Xia W., Yang T., Imelda M. Smith I. M., Shen Y., Walsh D. M. and Selkoe, D. J., 2009 Acetylation of tau inhibits Its degradation and contributes to tauopathy., Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Li Gan L., 2010 Genetic Deletion of TNF Receptor Suppresses Excitatory Synaptic Transmission via Reducing AMPA Receptor Synaptic Localization in Cortical Neurons., HeP, LiuQ, WuJ and Shen Y., 2011 Depletion of GGA1 and GGA3 mediates post-injury elevation of BACE1., Walker KR, Kang EL, Whalen MJ, Shen Y and Tesco G., 2012 Bid Signal Pathway Components are identified in the Temporal Cortex in Brains with Parkinson’s disease dementia., JiangH, HeP, AdlerCH,ShillH,BeachTG, Li, R, and ShenY., 2012 β-secretase: Its Biology as a Therapeutic Target in Diseases., Wang H, Li R and Shen Y., 2013 Long-term treatment of TNF inhibitor, thalidomide, ameliorates Alzheimer-like pathology through inhibition of β-secretasein a mouse model of Alzheimer’s disease., HeP, ChengX, StaufenbielM, LiR and Shen Y., 2013 MicroRNA-205 regulates the Expression of Parkinson’s disease-related Leucine-rich Repeat Kinase 2 Protein., Cho HJ, Jin SM, Ding J, Xie C, Yu J, Parisiadou L, Sun L, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans J-M, He P, Troncoso J, Shen Y, Cai H., 2013 Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy., Cheng X, He P, Yao H, Dong Q, Li R, Shen Y., 2014 Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα., Jiang H, He P, Xie J, Staufenbiel M, Li R, Shen Y., 2014 Deficiency of GDNF receptor GFRα1 in Alzheimer Neurons Results In Neuronal Death., KonishiY, YangLB, HeP, LindholmK, LuB, Li Rand Shen Y., 2014 Targeting TNF: A therapeutic strategy for Alzheimer’s disease., Cheng X, Shen Y and Li R., 2014

Areas of Focus

Molecular mechanisms of brain function and diseases
Molecular pathology and drug discovery for neurodegenerative and psychiatric diseases
Early clinical diagnostic markers for brain diseases

Publications

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease., Yang LB, Lindholm K, Yan R, Citron M, Xia W, Beach T, Sue L, Wong P, Price D, Li R, Shen Y., 2003
Aβ load is correlated with elevated BACE activity in sporadic Alzheimer patients., Li R, Yang LB, Lindholm K, Yan R, Citron M, Beach T, Sue L, Subbagh M, Cai H, Wong P, Price D, Shen Y., 2004
TNF death receptor signaling cascade is required for amyloid-protein induced neuron death., Li R., Lindholm K, Yang LB, Konishi Y, Hampel H, Zhang, D. Shen Y., 2004
Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model., Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, Harada N, Zhong Z, Shen Y, Li R., 2005
High Levels of β-Secretase (BACE1) in Cerebrospinal Fluid as a Predictor of Risk in Mild Cognitive Impairment, the early stage of Alzheimer’s Disease., Zhong, Z., Ewers, M., Teipel, S., Büger, K., Wallin, A., Blennow, K., Hampel, H., and Shen Y., 2007
Deletion of TNF death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer’s mice., HeP, ZhongZ, LindholmK, BerningL, LeeW, LemereC, StaufenbielM, LiR and Shen Y., 2007
Depletion of GGA3 stabilizes BACE and enhances β-secretase activity., Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE., 2007
Increased CSF-BACE1 activity is associated with ApoE-ε4 genotype in subjects with mild cognitive impairment (MCI) and Alzheimer's disease., Ewers M, Zhong Z, Bürger K, Wallin A, Blennow K, Teipel SJ, Shen Y, Hampel H., 2008
Interruption of β-catenin signaling reduces neurogenesis in Alzheimer’s disease’s brains., He, P. and Shen Y., 2009
A specific ELISA for measuring amyloid β-protein oligomers in human plasma and the brains of Alzheimer patients., Xia W., Yang T., Imelda M. Smith I. M., Shen Y., Walsh D. M. and Selkoe, D. J., 2009
Acetylation of tau inhibits Its degradation and contributes to tauopathy., Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Li Gan L., 2010
Genetic Deletion of TNF Receptor Suppresses Excitatory Synaptic Transmission via Reducing AMPA Receptor Synaptic Localization in Cortical Neurons., HeP, LiuQ, WuJ and Shen Y., 2011
Depletion of GGA1 and GGA3 mediates post-injury elevation of BACE1., Walker KR, Kang EL, Whalen MJ, Shen Y and Tesco G., 2012
Bid Signal Pathway Components are identified in the Temporal Cortex in Brains with Parkinson’s disease dementia., JiangH, HeP, AdlerCH,ShillH,BeachTG, Li, R, and ShenY., 2012
β-secretase: Its Biology as a Therapeutic Target in Diseases., Wang H, Li R and Shen Y., 2013
Long-term treatment of TNF inhibitor, thalidomide, ameliorates Alzheimer-like pathology through inhibition of β-secretasein a mouse model of Alzheimer’s disease., HeP, ChengX, StaufenbielM, LiR and Shen Y., 2013
MicroRNA-205 regulates the Expression of Parkinson’s disease-related Leucine-rich Repeat Kinase 2 Protein., Cho HJ, Jin SM, Ding J, Xie C, Yu J, Parisiadou L, Sun L, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans J-M, He P, Troncoso J, Shen Y, Cai H., 2013
Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy., Cheng X, He P, Yao H, Dong Q, Li R, Shen Y., 2014
Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα., Jiang H, He P, Xie J, Staufenbiel M, Li R, Shen Y., 2014
Deficiency of GDNF receptor GFRα1 in Alzheimer Neurons Results In Neuronal Death., KonishiY, YangLB, HeP, LindholmK, LuB, Li Rand Shen Y., 2014
Targeting TNF: A therapeutic strategy for Alzheimer’s disease., Cheng X, Shen Y and Li R., 2014

Neurodegenerative Diseases Psychiatric Diseases Molecular Mechanisms Gene Expression Drug Discovery Clinical Diagnostics Alzheimer'S Parkinson'S Neuroimmunology Brain Function

Xie Xin - Tongji University

Ping Yo - Shanghai Jiao Tong University

Chao Chen - Central South University

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