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Xuemai Tong
Basic Medical Sciences
Shanghai Jiao Tong University
Shanghai
Language: English, Chinese
Tumors
Fatty Liver
Diabetes
Metabolic Diseases
Regulation Mechanisms
Transketolase
Pentose Phosphate Pathway
Mondo Family Transcription Factors
Tumor Microenvironment
Metabolism
Areas of Focus
- Regulation mechanisms of metabolic diseases such as tumors, fatty liver, and diabetes
Work Experience
- 2010-Present - Shanghai Jiao Tong University School of Medicine - Principal Investigator
Academic Background & Achievements
- 2006 - PhD in Biochemistry: Johns Hopkins University School of Medicine
- Postdoctoral Research in Tumor Biology: University of Pennsylvania School of Medicine
- Joined Shanghai Jiao Tong University School of Medicine in May 2010
- Published in journals like Nature Metabolism, Gastroenterology, and Nature Immunology
- Recipient of National Excellent Young Scientists Fund
- Recipient of Ministry of Education's New Century Excellent Talents Support Program
- Recipient of Shanghai High-Level Talent
- Recipient of Shanghai Youth Science and Technology Star
Publications
- Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics, Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, Figge DA, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H, Li B, Tong X, 2022
- Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis, Wang Z, Qiu Z, Hua S, Yang W, Chen Y, Huang F, Fan Y, Tong L, Xu T, Tong X, Yang K, Jin W, 2022
- Insulin signaling establishes a developmental trajectory of adipose regulatory T cells, Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B, 2021
- TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis, Tian N, Hu L, Lu Y, Tong L, Feng M, Liu Q, Li Y, Zhu Y, Wu L, Ji Y, Zhang P, Xu T, Tong X, 2021
- MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment, Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B, Tong X, 2021
- Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis, Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X, 2020
- The Role of the Pentose Phosphate Pathway in Diabetes and Cancer, Ge T, Yang J, Zhou S, Wang Y, Li Y, Tong X, 2020
- The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines, Li M, Zhang X, Lu Y, Meng S, Quan H, Hou P, Tong P, Chai D, Gao X, Zheng J, Tong X, Bai J, 2020
- The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation, Li Y, Yang D, Tian N, Zhang P, Zhu Y, Meng J, Feng M, Lu Y, Liu Q, Tong L, Hu L, Zhang L, Yang JY, Wu L, Tong X, 2019
- Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides, Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH, Tong X, 2019
- Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN, Ran H, Zhu Y, Deng R, Zhang Q, Liu X, Feng M, Zhong J, Lin S, Tong X, Su Q, 2018
Awards
- National Excellent Young Scientists Fund
- Ministry of Education's New Century Excellent Talents Support Program
- Shanghai High-Level Talent
- Shanghai Youth Science and Technology Star
