Professor | Xuemai Tong | Asia Growth Partners

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Name	Xuemai Tong
Contact Information	jdb@shsmu.edu.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Xuemai Tong

Contact Information

jdb@shsmu.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2006 - PhD in Biochemistry: Johns Hopkins University School of Medicine Postdoctoral Research in Tumor Biology: University of Pennsylvania School of Medicine Joined Shanghai Jiao Tong University School of Medicine in May 2010 Published in journals like Nature Metabolism, Gastroenterology, and Nature Immunology Recipient of National Excellent Young Scientists Fund Recipient of Ministry of Education's New Century Excellent Talents Support Program Recipient of Shanghai High-Level Talent Recipient of Shanghai Youth Science and Technology Star
Work Experience	2010-Present - Shanghai Jiao Tong University School of Medicine - Principal Investigator
Awards	National Excellent Young Scientists Fund Ministry of Education's New Century Excellent Talents Support Program Shanghai High-Level Talent Shanghai Youth Science and Technology Star

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2006 - PhD in Biochemistry: Johns Hopkins University School of Medicine
Postdoctoral Research in Tumor Biology: University of Pennsylvania School of Medicine
Joined Shanghai Jiao Tong University School of Medicine in May 2010
Published in journals like Nature Metabolism, Gastroenterology, and Nature Immunology
Recipient of National Excellent Young Scientists Fund
Recipient of Ministry of Education's New Century Excellent Talents Support Program
Recipient of Shanghai High-Level Talent
Recipient of Shanghai Youth Science and Technology Star

Work Experience

2010-Present - Shanghai Jiao Tong University School of Medicine - Principal Investigator

Awards

National Excellent Young Scientists Fund
Ministry of Education's New Century Excellent Talents Support Program
Shanghai High-Level Talent
Shanghai Youth Science and Technology Star

Areas of Focus	Regulation mechanisms of metabolic diseases such as tumors, fatty liver, and diabetes
Publications	Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics, Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, Figge DA, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H, Li B, Tong X, 2022 Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis, Wang Z, Qiu Z, Hua S, Yang W, Chen Y, Huang F, Fan Y, Tong L, Xu T, Tong X, Yang K, Jin W, 2022 Insulin signaling establishes a developmental trajectory of adipose regulatory T cells, Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B, 2021 TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis, Tian N, Hu L, Lu Y, Tong L, Feng M, Liu Q, Li Y, Zhu Y, Wu L, Ji Y, Zhang P, Xu T, Tong X, 2021 MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment, Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B, Tong X, 2021 Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis, Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X, 2020 The Role of the Pentose Phosphate Pathway in Diabetes and Cancer, Ge T, Yang J, Zhou S, Wang Y, Li Y, Tong X, 2020 The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines, Li M, Zhang X, Lu Y, Meng S, Quan H, Hou P, Tong P, Chai D, Gao X, Zheng J, Tong X, Bai J, 2020 The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation, Li Y, Yang D, Tian N, Zhang P, Zhu Y, Meng J, Feng M, Lu Y, Liu Q, Tong L, Hu L, Zhang L, Yang JY, Wu L, Tong X, 2019 Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides, Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH, Tong X, 2019 Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN, Ran H, Zhu Y, Deng R, Zhang Q, Liu X, Feng M, Zhong J, Lin S, Tong X, Su Q, 2018

Areas of Focus

Regulation mechanisms of metabolic diseases such as tumors, fatty liver, and diabetes

Publications

Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics, Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, Figge DA, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H, Li B, Tong X, 2022
Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis, Wang Z, Qiu Z, Hua S, Yang W, Chen Y, Huang F, Fan Y, Tong L, Xu T, Tong X, Yang K, Jin W, 2022
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells, Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B, 2021
TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis, Tian N, Hu L, Lu Y, Tong L, Feng M, Liu Q, Li Y, Zhu Y, Wu L, Ji Y, Zhang P, Xu T, Tong X, 2021
MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment, Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B, Tong X, 2021
Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis, Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X, 2020
The Role of the Pentose Phosphate Pathway in Diabetes and Cancer, Ge T, Yang J, Zhou S, Wang Y, Li Y, Tong X, 2020
The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines, Li M, Zhang X, Lu Y, Meng S, Quan H, Hou P, Tong P, Chai D, Gao X, Zheng J, Tong X, Bai J, 2020
The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation, Li Y, Yang D, Tian N, Zhang P, Zhu Y, Meng J, Feng M, Lu Y, Liu Q, Tong L, Hu L, Zhang L, Yang JY, Wu L, Tong X, 2019
Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides, Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH, Tong X, 2019
Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN, Ran H, Zhu Y, Deng R, Zhang Q, Liu X, Feng M, Zhong J, Lin S, Tong X, Su Q, 2018

Tumors Fatty Liver Diabetes Metabolic Diseases Regulation Mechanisms Transketolase Pentose Phosphate Pathway Mondo Family Transcription Factors Tumor Microenvironment Metabolism

Guoheng Xu - Peking University

Jinpeng Sun - Peking University

Rui Chen - Wuhan University

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