Professor | Jinpeng Sun | Asia Growth Partners

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Name	Jinpeng Sun
Contact Information	sunjinpeng@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Jinpeng Sun

Contact Information

sunjinpeng@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1993-1998: Bachelor in Biology and Computer Science, University of Science and Technology of China 1998-2001: Master's Degree, University of Science and Technology of China 2001-2007: PhD, Albert Einstein College of Medicine, Supervisor: Zhong-yin Zhang Postdoctoral Researcher at Duke University, Supervisors: Robert J. Lefkowitz, James B.
Work Experience	2007-2011: Postdoctoral Researcher, Duke University Current: Professor at Peking University, Director of the Department of Biophysics
Awards	2018: National Outstanding Youth Fund (Pharmacology) 2023: New Keystone Project Researcher 2022: Tan Jiazhen Life Science Innovation Award 2022: Second Prize of Chinese Medical Science and Technology Award (Medical Science and Technology) 2023: Third National Innovation Competition Award

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1993-1998: Bachelor in Biology and Computer Science, University of Science and Technology of China
1998-2001: Master's Degree, University of Science and Technology of China
2001-2007: PhD, Albert Einstein College of Medicine, Supervisor: Zhong-yin Zhang
Postdoctoral Researcher at Duke University, Supervisors: Robert J. Lefkowitz, James B.

Work Experience

2007-2011: Postdoctoral Researcher, Duke University
Current: Professor at Peking University, Director of the Department of Biophysics

Awards

2018: National Outstanding Youth Fund (Pharmacology)
2023: New Keystone Project Researcher
2022: Tan Jiazhen Life Science Innovation Award
2022: Second Prize of Chinese Medical Science and Technology Award (Medical Science and Technology)
2023: Third National Innovation Competition Award

Areas of Focus	GPCR ligand discovery and interaction mechanisms GPCR roles in metabolic diseases like diabetes, reproduction, hearing, kidney diseases, and bone development Pharmacological theories of GPCR preferential signaling Transmembrane signaling in tissue reconstitution
Publications	Structural and signaling mechanism of TAAR1 enabled preferential agonist design, Sun JP et al., 2023 Ligand recognition and G-protein coupling of trace amine receptor TAAR1, Sun JP et al., 2023 Structural basis of amine odorant perception by a mammal olfactory receptor, Sun JP et al., 2023 Unsaturated bond recognition leads to biased signal in a fatty acid receptor, Sun JP et al., 2023 Structural basis for the tethered peptide activation of adhesion GPCRs, Sun JP et al., 2022 Structure, function and pharmacology of human itch receptor complexes, Sun JP et al., 2021 Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex, Sun JP et al., 2021 Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4, Sun JP et al., 2022 Structural basis of GPBAR activation and bile acid recognition, Sun JP et al., 2020 Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes, Sun JP et al., 2021 Cryo-EM structure of the X-linked acrogigantism-related orphan GPR101-Gs complex enabled identification of ligands with rejuvenating potential, Sun JP et al., 2023 Structures of the ADGRG2-Gs complex in apo and ligand-bound forms, Sun JP et al., 2022 Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin, Sun JP et al., 2018 Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism, Sun JP et al., 2022 Functional screening and rational design of compounds targeting GPR132 to treat diabetes, Sun JP et al., 2023 Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification, Sun JP et al., 2022 Progesterone activates GPR126 to promote breast cancer development via the Gi pathway, Sun JP et al., 2022 Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths, Sun JP et al., 2023 Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways, Sun JP et al., 2021 Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade, Sun JP et al., 2021 Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity, Sun JP et al., 2022 Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury, Sun JP et al., 2021 The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes, Sun JP et al., 2014 Ligand recognition and G protein coupling of the human itch receptor MRGPRX1, Sun JP et al., 2023 Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2, Sun JP et al., 2021 DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe, Sun JP et al., 2020 Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury, Sun JP et al., 2018 Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling, Sun JP et al., 2017 Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR, Sun JP et al., 2015 Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design, Sun JP et al., 2021 Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E2 receptor 2 (EP2), Sun JP et al., 2021 Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment, Sun JP et al., 2023 In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals, Sun JP et al., 2020 Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues, Sun JP et al., 2017

Areas of Focus

GPCR ligand discovery and interaction mechanisms
GPCR roles in metabolic diseases like diabetes, reproduction, hearing, kidney diseases, and bone development
Pharmacological theories of GPCR preferential signaling
Transmembrane signaling in tissue reconstitution

Publications

Structural and signaling mechanism of TAAR1 enabled preferential agonist design, Sun JP et al., 2023
Ligand recognition and G-protein coupling of trace amine receptor TAAR1, Sun JP et al., 2023
Structural basis of amine odorant perception by a mammal olfactory receptor, Sun JP et al., 2023
Unsaturated bond recognition leads to biased signal in a fatty acid receptor, Sun JP et al., 2023
Structural basis for the tethered peptide activation of adhesion GPCRs, Sun JP et al., 2022
Structure, function and pharmacology of human itch receptor complexes, Sun JP et al., 2021
Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex, Sun JP et al., 2021
Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4, Sun JP et al., 2022
Structural basis of GPBAR activation and bile acid recognition, Sun JP et al., 2020
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes, Sun JP et al., 2021
Cryo-EM structure of the X-linked acrogigantism-related orphan GPR101-Gs complex enabled identification of ligands with rejuvenating potential, Sun JP et al., 2023
Structures of the ADGRG2-Gs complex in apo and ligand-bound forms, Sun JP et al., 2022
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin, Sun JP et al., 2018
Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism, Sun JP et al., 2022
Functional screening and rational design of compounds targeting GPR132 to treat diabetes, Sun JP et al., 2023
Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification, Sun JP et al., 2022
Progesterone activates GPR126 to promote breast cancer development via the Gi pathway, Sun JP et al., 2022
Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths, Sun JP et al., 2023
Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways, Sun JP et al., 2021
Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade, Sun JP et al., 2021
Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity, Sun JP et al., 2022
Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury, Sun JP et al., 2021
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes, Sun JP et al., 2014
Ligand recognition and G protein coupling of the human itch receptor MRGPRX1, Sun JP et al., 2023
Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2, Sun JP et al., 2021
DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe, Sun JP et al., 2020
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury, Sun JP et al., 2018
Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling, Sun JP et al., 2017
Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR, Sun JP et al., 2015
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design, Sun JP et al., 2021
Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E2 receptor 2 (EP2), Sun JP et al., 2021
Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment, Sun JP et al., 2023
In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals, Sun JP et al., 2020
Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues, Sun JP et al., 2017

Gpcr Ligand Discovery Interaction Metabolic Diseases Diabetes Pharmacology Signaling Transmembrane Tissue Reconstitution

Tie Lu - Peking University

Rui Chen - Wuhan University

Ping Jie - Wuhan University

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