Weiqiang Gao
gao.weiqiang@sjtu.edu.cn
English, Chinese
Shanghai
Shanghai Jiao Tong University
Biomedical Engineering
  • 1982 - Bachelor's Degree: Nanjing University
  • 1989 - PhD: Columbia University
  • Selected for CUSBEA program
  • Received National Natural Science Foundation of China's Overseas Outstanding Young Scholar Award in 2003
  • 1993-2010 - Genentech, USA: Scientist/Laboratory Director, Senior Scientist
  • 2010-present - Renji Hospital: Director of Stem Cell Research Center
  • 2003: National Natural Science Foundation of China's Overseas Outstanding Young Scholar
Stem Cell and Tissue Development and Repair
Tumor Development and Progression (including Cancer Stem Cells)
  • Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling, Yang R, Wang M, Wang J, Huang X, Yang R, Gao WQ, 2015
  • SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway, Quan Y, Wang N, Chen Q, Xu J, Cheng W, Di M, Xia W, Gao W-Q, 2015
  • A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis, Zhu HH, Zhuang G, Gao W-Q, 2015
  • CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer, Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao W-Q, 2015
  • Concise Reviews: Patient-Derived Stem Cell Research for Monogenic Disorders, Qin Y, Gao W-Q, 2015
  • MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway, Chang YL, Zhou PJ, Wei L, Li W, Ji Z, Fang YX, Gao W-Q, 2015
  • Autocrine activation of CHRM3 promotes prostate cancer growth and castration resistance via CaM/CaMKK-mediated phosphorylation of Akt, Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R, Gao WQ, 2015
  • Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis, Liu W, Wu H, Chen L, Wen Y, Kong X, Gao WQ, 2015
  • Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition, Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu HH, Gao WQ, 2015
  • Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer, Qin Y, Qin J, Zhou C, Li J, Gao WQ, 2015
  • TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer, Li X, Liu Y, Chen W, Fang Y, Xu H, Zhu H, Chu M, Li W, Zhuang G, Gao WQ, 2014
  • TRIM59 Is Up-Regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of P53, Zhou Z, Ji Z, Wang Y, Li J, Cao H, Zhu HH, Gao WQ, 2014
  • Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages, Wang J, Zhu HH, Chu M, Liu Y, Zhang C, Liu G, Yang X, Yang R, Gao WQ, 2014
  • Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rat, Li J, Tang YH, Wang YT, Tang RB, Jiang WF, Yang GY, Gao WQ, 2014
  • SKA1 overexpression promotes centriole over duplication, centrosome amplification and prostate tumorigenesis, Li J, Xuan JW, Khatamianfar V, Valiyewa F, Moussa M, Sadek A, Yang BB, Dong BJ, Huang YR, Gao WQ, 2014
  • Roles of miRNAs during prostate tumorigenesis and tumor progression, Fang, Y and Gao W-Q, 2013
  • Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy, Sun Y, Wang BE, Leong KG, Yue P, Li L, Jhunjhunwala S, Chen D, Seo K, Modrusan Z, Gao WQ, Settleman J, Johnson L, 2012
  • COP1 is a tumour suppressor that causes degradation of ETS transcription factors, Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R, Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM, 2011
  • Generation of a prostate from a single adult stem cell, Leong KG, Wang BE, Johnson L, Gao WQ, 2008
  • Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells, Leow CC, Romero MS, Ross S, Polakis P, Gao WQ, 2004
  • Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression, Shou J, Soriano R, Hayward SW, Cunha GR, Williams PM, Gao WQ, 2002
  • Dynamics of notch expression during murine prostate development and tumorigenesis, Shou J, Ross S, Koeppen H, de Sauvage FJ, Gao WQ, 2001
  • Hes1 is a negative regulator of inner ear hair cell differentiation, Zheng JL, Gao WQ, 2000
  • Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears, Zheng JL, Gao WQ, 2000
  • Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors, Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM, 2000
  • Immunocytochemical and morphological evidence for intracellular self-repair as an important contributor to mammalian hair cell recovery, Zheng JL, Keller G, Gao WQ, 1999
  • Induction of cell proliferation by fibroblast and insulin-like growth factors in pure rat inner ear epithelial cell cultures, Zheng JL, Gao WQ, 1997
  • Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker, Zheng JL, Gao WQ, 1997
  • Neurotrophin-4/5 enhances survival of cultured spiral ganglion neurons and protects them from cisplatin neurotoxicity, Zheng JL, Stewart RR, Gao WQ, 1995
  • Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy, Gao WQ, Dybdal N, Shinsky N, Murnane A, Schmelzer C, Siegel M, Keller G, Hefti F, Phillips HS, Winslow JW, 1995
  • Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation, Gao WQ, Hatten ME, 1995
  • Immortalizing oncogenes subvert the establishment of granule cell identity in developing cerebellum, Gao WQ, Hatten ME, 1994
  • Neuronal differentiation rescued by implantation of Weaver granule cell precursors into wild-type cerebellar cortex, Gao WQ, Liu XL, Hatten ME, 1993
  • The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation, Gao WQ, Liu XL, Hatten ME, 1992
  • Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro, Gao WQ, Macagno ER, 1991
  • Axon extension and retraction by leech neurons: severing early projections to peripheral targets prevents normal retraction of other projections, Gao WQ, Macagno ER, 1988
Stem Cells Tissue Repair Development Cancer Tumor Progression Cancer Stem Cells Diagnosis Targeted Therapy Neural Injury Inner Ear Hair Cell Regeneration

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