Professor | Weiliang Xia | Asia Growth Partners

Name	Weiliang Xia
Contact Information	wlxia@sjtu.edu.cn
Language ability	English, Chinese
Province	Shanghai

Name

Weiliang Xia

Contact Information

wlxia@sjtu.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Biomedical Engineering
Academic Background & Achievements	Studied at Tsinghua University, University of Hong Kong, Rockefeller University, and University of California, San Francisco Joined Med-X Research Institute of Shanghai Jiao Tong University in 2008 Honored with the Ministry of Education's Top-notch Student Training Program 2.0 - Outstanding Management Personnel Award
Work Experience	2008 - Present - Shanghai Jiao Tong University, Med-X Research Institute, Biomedical Research and Teaching
Awards	Shanghai Science and Technology Commission's Rising Star Shanghai Jiao Tong University Morning Star Scholar Tang Lixin Outstanding Scholar Second Prize of Chinese Medical Science and Technology Award Second Prize of Shanghai Jiao Tong University Teaching and Educating Collective Award Special Prize of Teaching Achievement Award

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Biomedical Engineering

Academic Background & Achievements

Studied at Tsinghua University, University of Hong Kong, Rockefeller University, and University of California, San Francisco
Joined Med-X Research Institute of Shanghai Jiao Tong University in 2008
Honored with the Ministry of Education's Top-notch Student Training Program 2.0 - Outstanding Management Personnel Award

Work Experience

2008 - Present - Shanghai Jiao Tong University, Med-X Research Institute, Biomedical Research and Teaching

Awards

Shanghai Science and Technology Commission's Rising Star
Shanghai Jiao Tong University Morning Star Scholar
Tang Lixin Outstanding Scholar
Second Prize of Chinese Medical Science and Technology Award
Second Prize of Shanghai Jiao Tong University Teaching and Educating Collective Award
Special Prize of Teaching Achievement Award

Areas of Focus	Mechanisms of lung/prostate cancer progression and treatment resistance, and discovery of novel targets Biology of exosome and applications Role of FGF/FGFR and sirtuin in cancer and tissue repair
Publications	NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation, Cheng Y, Lu X, Li F, Chen Z, Zhang Y, Han Q, Zeng Q, Wu T, Li Z, Lu S, Williams C, Xia W* Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer, Han Q, Xie QR, Li F, Cheng Y, Wu T, Zhang Y, Lu X, Wong AST, Sha J, Xia W, 2021 Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104, Li F, Li Z, Han Q, Chen Y, Ji W, Yang Y, Lu S, Xia W, 2020 βKlotho is identified as a target for theranostics in non-small cell lung cancer, Li F, Li X, Li Z, Ji W, Lu S, Xia W, 2019 Bioglass could increase cell membrane fluidity with ion products to develop its bioactivity, Yan L, Li H, Xia W, 2020 Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes, Cheng Y, Zeng Q, Han Q, Xia W, 2019 Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex, Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W, Gao WQ, 2019 FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer, Wang K, Ji W, Yu Y, Li Z, Niu X, Xia W, Lu S, 2018 The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer, Lu T, Li Z, Yang Y, Ji W, Yu Y, Niu X, Zeng Q, Xia W, Lu S, 2018 Sirt3 deficiency impairs neurovascular recovery in ischemic stroke, Yang X, Geng K, Zhang Y, Zhang J, Shao J, Xia W, 2018 Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice, Zhang T, Yang X, Liu T, Shao J, Fu N, Yan A, Geng K, Xia W, 2017 Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke, Yang X, Geng K, Zhang J, Zhang Y, Shao J, Xia W, 2017 A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases, Xia W, Geng K, 2016 Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal cell death, Shao J, Yang X, Liu T, Zhang T, Xie QR, Xia W, 2016 Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier, Chen Y, Gu H, Zhang DS, Li F, Liu T, Xia W, 2014

Areas of Focus

Mechanisms of lung/prostate cancer progression and treatment resistance, and discovery of novel targets
Biology of exosome and applications
Role of FGF/FGFR and sirtuin in cancer and tissue repair

Publications

NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation, Cheng Y, Lu X, Li F, Chen Z, Zhang Y, Han Q, Zeng Q, Wu T, Li Z, Lu S, Williams C, Xia W*
Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer, Han Q, Xie QR, Li F, Cheng Y, Wu T, Zhang Y, Lu X, Wong AST, Sha J*, Xia W*, 2021
Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104, Li F, Li Z, Han Q, Chen Y, Ji W, Yang Y, Lu S, Xia W*, 2020
βKlotho is identified as a target for theranostics in non-small cell lung cancer, Li F, Li X, Li Z, Ji W, Lu S, Xia W*, 2019
Bioglass could increase cell membrane fluidity with ion products to develop its bioactivity, Yan L, Li H*, Xia W*, 2020
Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes, Cheng Y, Zeng Q, Han Q, Xia W*, 2019
Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex, Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W*, Gao WQ*, 2019
FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer, Wang K, Ji W, Yu Y, Li Z, Niu X, Xia W*, Lu S*, 2018
The Hippo/YAP1 pathway interacts with FGFR1 signaling to maintain stemness in lung cancer, Lu T, Li Z, Yang Y, Ji W, Yu Y, Niu X, Zeng Q, Xia W*, Lu S*, 2018
Sirt3 deficiency impairs neurovascular recovery in ischemic stroke, Yang X, Geng K, Zhang Y, Zhang J, Shao J, Xia W*, 2018
Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice, Zhang T, Yang X, Liu T, Shao J, Fu N, Yan A, Geng K, Xia W*, 2017
Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke, Yang X, Geng K, Zhang J, Zhang Y, Shao J, Xia W*, 2017
A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases, Xia W*, Geng K, 2016
Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal cell death, Shao J, Yang X, Liu T, Zhang T, Xie QR, Xia W*, 2016
Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier, Chen Y, Gu H*, Zhang DS, Li F, Liu T, Xia W*, 2014

Lung Cancer Prostate Cancer Treatment Resistance Novel Targets Exosome Biology Applications Fgf/Fgfr Sirtuin Cancer Tissue Repair

Weiqiang Gao - Shanghai Jiao Tong University

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