Zhang Shiyi
Biomedical Engineering
Shanghai Jiao Tong University
Shanghai
Language: English, Chinese
Contact
Anticancer Side Effects Oral Drugs Non-Absorbable Clinical Research Drug Delivery Gastrointestinal Toxicity Chemotherapy Innovation
Areas of Focus
  • Side effects of anticancer drugs
  • Orally non-absorbable drugs
Work Experience
  • 2013-2016 - Massachusetts Institute of Technology - Postdoctoral Researcher
  • 2016-present - Shanghai Jiao Tong University - Associate Professor
Academic Background & Achievements
  • 2004-2008 Bachelor: Peking University
  • 2008-2013 PhD: Washington University in St. Louis
  • 2013-2016 Postdoctoral Research: Massachusetts Institute of Technology
  • National Youth Talent Program Awardee
Publications
  • A Transformable Mucoadhesive Microgel Network for Noninvasive Multimodal Imaging and Radioprotection of a Large Area of the Gastrointestinal Tract, Zhang, S.*, 2023
  • CDK4/6 inhibitor modulating active and quiescent intestinal stem cells for prevention of chemotherapy-induced diarrhea, Zhang, S.*, 2023
  • DNA damage-mediated cellular senescence promotes hand–foot syndrome that can be relieved by thymidine prodrug, Zhang, S.*, 2022
  • Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil, Zhang, S.*, 2022
  • Challenging the fundamental conjectures in nanoparticle drug delivery for chemotherapy treatment of solid cancers, Zhang, S.*, 2022
  • Oral Supramolecular Adsorbent for Preventing Chemo-Induced Gastrointestinal Mucositis & Microbial Dysbiosis and for Enhancing Chemoimmunotherapy, Zhang, S.*, 2022
  • Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy, Zhang, S.*, 2022
  • Prophylactic effect of nitric oxide donors on rat models of EGFR inhibitors induced-cutaneous toxicities, Zhang, S.*, 2022
  • Nitric Oxide in Multikinase Inhibitor-induced Hand-Foot Skin Reaction, Zhang, S.*, 2022
  • GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib, Zhang, S.*, 2021
  • A Nanoantidote Alleviates Glioblastoma Chemotoxicity without Efficacy Compromise, Zhang, S.*, 2021
  • Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders, Zhang, S.*, 2021
  • Oral, Ultra–long-lasting Drug Delivery: Application Toward Malaria Elimination Goals, Zhang, S.*, 2016
  • A pH-responsive Supramolecular Polymer Gel as an Enteric Elastomer for Use in Gastric Devices, Zhang, S.*, 2015
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