Areas of Focus
- Precision molecular force fields for intrinsically disordered proteins
- Computer-aided innovative drug discovery
- AI-based protein design
Work Experience
- 2013–Present: Associate Editor, Chemical Biology & Drug Design
- 2015–Present: Associate Editor, Frontiers in Molecular Biosciences
- 2022–Present: Editorial Board Member, Journal of Chemical Information and Modeling
- 2022–Present: Editorial Board Member, International Journal of Molecular Sciences
- 2023–Present: Committee Member, Bioinformatics Society on Biomolecular Structure Prediction and Simulation
Academic Background & Achievements
- Bachelor's Degree: Xi'an Jiaotong University
- Master's Degree: Sichuan University
- PhD: University of Paris VII
- Postdoctoral Research: University of California, Irvine
- Published over 150 SCI papers
Publications
- Algorithm-based Coevolution Network Identification Reveals Key Functional Sectors of the α/β Hydrolase Subfamilies, Z. Wu, H. Liu, L. Xu, H.F. Chen*, Y. Feng*, 2020
- Dynamical Important Residue Network (DIRN): Network Inference via Conformational Change, Q. Li, R. Luo*, H.F. Chen*, 2019
- Well-balanced Force Field ff03CMAP for Folded and Disordered Proteins, Y. Zhang, H. Liu, S. Yang, R. Luo*, H.F. Chen*, 2019
- The IDP-Specific Force Field ff14IDPSFF Improves the Conformer Sampling of Intrinsically Disordered Proteins, D. Song, R. Luo, H.F. Chen*, 2017
- ASD: a comprehensive database of allosteric proteins and modulators, Z. Huang, L. Zhu, Y. Cao, G. Wu, X. Liu, Y. Chen, Q. Wang, T. Shi, Y. Zhao, Y. Wang, W. Li, Y. Li, H.F. Chen*, G. Chen, J. Zhang*, 2011
- Rig-I regulates NF-κB activity through binding to Nf-κb13′-UTR mRNA, H. Zhang, Z. Liu, Y. Sun, J. Zhu, S. Lu, X. Liu, Q. Huang,Y. Xie, H. Zhu, S. Dang, H.F. Chen, G. Zheng, Y. Li, Y. Kuang, J. Fei, S. Chen, Z. Chen, Z.G. Wang*, 2013
- Binding induced folding in p53-MDM2 complex, H.F. Chen, R. Luo*, 2007
- PTMint Database of Experimentally Verified PTM Regulation on Protein-Protein Interaction, X. Hong, N. Li, J. Lv, Y. Zhang, J. Li*, J. Zhang*, H.F. Chen*, 2023
- Phanto-IDP: Compact Model for Precise Intrinsically Disordered Protein Backbone Generation and Enhanced Sampling, J.J. Zhu, Z. Li, H. Tong, Z. Lu, N. Zhang, T. Wei*, H.F. Chen*, 2024
- Balanced Three-point Water Model OPC3-B for Intrinsically Disordered and Ordered Proteins, Z. Pan, J. Mu, H.F. Chen*, 2023
Awards
- 2003: Shanghai Science and Technology Progress First Prize
- 2019: First Prize in Teaching Achievement at Shanghai Jiao Tong University for 'Paper Writing, Standards and Ethics'
- 2020: Third Prize in Teaching at Shanghai Jiao Tong University
- 2022: First Prize as a Mentor in the National College Student Life Science Innovation and Entrepreneurship Competition
- 2023: First Prize as a Mentor in the National College Student Life Science Innovation and Entrepreneurship Competition
- 2023: First Prize as a Mentor in the Shanghai Challenge Cup
- 2015, 2022, 2023: Outstanding Bachelor's Thesis Advisor at Shanghai Jiao Tong University
