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Fan Yang
Medical School
Zhejiang University
Zhejiang
Language: English, Chinese
Membrane Protein
Dynamic Conformational Changes
Trp Channels
Trpv1
Trpm8
Pain Relief
Protein 3D Structure
Biomacromolecules
Rational Design
Ion Channels
Areas of Focus
- Membrane Protein Function and Dynamic Conformational Changes
- Rational Design of Biomacromolecules Based on Protein 3D Structure
Work Experience
- 2012.11-2017.6 - University of California, Davis - Postdoctoral Researcher
- 2017.6-present - Zhejiang University School of Medicine - Researcher
Academic Background & Achievements
- 2006.09-2012.06 Ph.D. in Physiology: University of California, Davis
- 2002.09-2006.06 Bachelor's in Life Sciences: Zhejiang University
- Member of the Ion Channel and Receptor Subcommittee of the Chinese Neuroscience Society
- Deputy Secretary-General of the Ion Channel and Receptor Subcommittee of the Chinese Neuroscience Society
- Standing Committee Member of the Biotoxin Professional Committee of the Chinese Society of Toxicology
- Recipient of the National Excellent Young Scientists Fund
- Recipient of the Zhejiang Provincial Excellent Young Scientists Fund
Publications
- Structures and mechanisms of the Arabidopsis auxin transporter PIN3, Su NN., Zhu A., Tao X., Ding Z J., Chang S., Ye F., Zhang Y., Zhao C., Chen Q., Wang J., Zhou C Y., Guo Y., Jiao S., Zhang S., Wen H., Ma L., Ye S., Zheng S J., F. Yang, Wu S, Guo JT, 2022
- Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands, Su NN., WX. Zhen, H. Zhang, LY. Xu, YT Jin, XY. Chen, C. Zhao, QR. Wang, XY. Wang, SW. Li, H. Wen, W. Yang, JT. Guo, F. Yang, 2022
- Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia, Zhang, H., JJ. Lin, YK. Xie, XZ. Song, JY. Sun, BL. Zhang, YK. Qi, ZZ. Xu, F. Yang, 2023
- Rational design of a modality-specific inhibitor of TRPM8 channel against oxaliplatin-induced cold allodynia, A. Aierken, YK. Xie, WQ. Dong, A. Apaer, JJ. Lin, ZH. Zhao, SL. Yang, ZZ. Xu, F. Yang, 2021
- De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects, Xu, L., Zhang, H., Y. Wang, X. Lu, Z. Zhao, C. Ma, S. Yang, V. Yarov-Yarovoy, YH. Tian, J. Zheng, F. Yang, 2021
Awards
- National Excellent Young Scientists Fund: Recipient
- Zhejiang Provincial Excellent Young Scientists Fund: Recipient
