Areas of Focus
- Computational Biochemistry
- Chemical Biology
- Theoretical Studies on Reaction Mechanisms and Molecular Recognition
- Structural Bioinformatics
- Chemical Modifications of Proteins and Nucleic Acids and their Biological Functions
- Molecular Spectroscopy and XCMS
- Characterization Applications in Metabolism
Academic Background & Achievements
- UCLA Postdoctoral Fellow
- Published nearly 90 SCI papers
- Awards: UCLA Outstanding Postdoctoral, Shanghai Pujiang Talent, Oriental Scholar, MOE New Century Excellent Talent
Publications
- Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis, He, B.-B.; Zhou, T.; Bu, X.-L.; Weng, J.-Y.; Xu, J.; Lin, S.-J.; Zheng, J.-T.; Zhao, Y.-L.; Xu, M.-J., 2019
- Enzyme-catalyzed inverse-electron demand Diels-Alder reaction in the biosynthesis of antifungal ilicicolin H, Zhang, Z.; Jamieson, C.; Zhao, Y.-Lei; Li, D.; Ohashi, M.; K. N. Houk, Y. Tang, 2019
- Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a “polar gate” in stereo-recognition of diaryl ketones, Zhou, J.-Y.; Wang, Y.; Xu, G.-C.; Wu, L.; Han, R.-Z.; Schwaneberg, U.; Rao, Y.-J.; Zhao, Y.-L.; Zhou, J.-H.; Ni, Y, 2018
- Enzyme engineering based on X-ray structures and kinetic profiling of substrate libraries: alcohol dehydrogenases for stereospecific synthesis of a broad range of chiral alcohols, Nie, Y.; Wang, S.; Xu, Y.; Luo, S.; Zhao, Y.-L.; Xiao, R.; Montelione, G.; Hunt, J.; Szyperski, T., 2018
- Theoretical studies on the catalytic mechanism and substrate diversity for macrocyclization of pikromycin thioesterase, Shi, T.; Liu, L.; Tao, W.; Luo, S.; Fan, S.; Wang, X.-L.; Bai, L.; Zhao, Y.-L., 2018
- Theoretical studies on the mechanism of thioesterase-catalyzed macrocyclization in erythromycin biosynthesis, Chen, X.-P.; Shi, T.; Wang, X.-L.; Wang, J.; Chen, Q.; Bai, L.; Zhao Y.-L., 2016
- Multicomponent Kinetic Analysis and Theoretical Studies on the Phenolic Intermediates in the Oxidation of Eugenol and Isoeugenol Catalyzed by Laccase, Qi, Y.-B; Wang, X.-L.; Shi, T.; Liu, S.; Xu, Z.-H.; Li, XQ; Shi, XL; Xu, P.; Zhao Y.-L., 2015
- D-Isonucleotide (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago2-PAZ domain and enhances in vitro potency of siRNA, Huang, Y.; Tian, M.; Zhang, YC; Sheng, G.; Chen, Z.; Ma, Y.; Chen, Y.; Peng, YH; Zhao, Y.-L.; Wang, YL.; Zhang, LH; Yang, ZJ, 2015
- Theoretical Study on the Relationship between Rp-Phosphorothioation and Base-Step in S-DNA: Based on Energetic and Structural Analysis, Chen, L.; Wang, X.-L.; Shi, T.; Wu, T.; Deng, Z.; Zhao, YL, 2015
- Theoretical Study on Steric Effects of DNA Phosphorothioation: B-Helical Destabilization in Rp-Phosphorothioated DNA, Zhang, Y.-C.; Liang, J.; Lian, P.; Han, Y.; Chen, Y.; Bai, L.; Wang, Z.; Liang, J.; Deng, Z.; Zhao, YL, 2012
Awards
- 2005 UCLA Outstanding Postdoctoral
- 2005-2007 INEST Fellowship
- 2011 Shanghai Pujiang Talent
- 2012 MOE New Century Excellent Talent
