Professor | Yi-Lei Zhao | Asia Growth Partners

Name	Yi-Lei Zhao
Contact Information	yileizhao@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yi-Lei Zhao

Contact Information

yileizhao@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	UCLA Postdoctoral Fellow Published nearly 90 SCI papers Awards: UCLA Outstanding Postdoctoral, Shanghai Pujiang Talent, Oriental Scholar, MOE New Century Excellent Talent
Awards	2005 UCLA Outstanding Postdoctoral 2005-2007 INEST Fellowship 2011 Shanghai Pujiang Talent 2012 MOE New Century Excellent Talent

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

UCLA Postdoctoral Fellow
Published nearly 90 SCI papers
Awards: UCLA Outstanding Postdoctoral, Shanghai Pujiang Talent, Oriental Scholar, MOE New Century Excellent Talent

Awards

2005 UCLA Outstanding Postdoctoral
2005-2007 INEST Fellowship
2011 Shanghai Pujiang Talent
2012 MOE New Century Excellent Talent

Areas of Focus	Computational Biochemistry Chemical Biology Theoretical Studies on Reaction Mechanisms and Molecular Recognition Structural Bioinformatics Chemical Modifications of Proteins and Nucleic Acids and their Biological Functions Molecular Spectroscopy and XCMS Characterization Applications in Metabolism
Publications	Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis, He, B.-B.; Zhou, T.; Bu, X.-L.; Weng, J.-Y.; Xu, J.; Lin, S.-J.; Zheng, J.-T.; Zhao, Y.-L.; Xu, M.-J., 2019 Enzyme-catalyzed inverse-electron demand Diels-Alder reaction in the biosynthesis of antifungal ilicicolin H, Zhang, Z.; Jamieson, C.; Zhao, Y.-Lei; Li, D.; Ohashi, M.; K. N. Houk, Y. Tang, 2019 Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a “polar gate” in stereo-recognition of diaryl ketones, Zhou, J.-Y.; Wang, Y.; Xu, G.-C.; Wu, L.; Han, R.-Z.; Schwaneberg, U.; Rao, Y.-J.; Zhao, Y.-L.; Zhou, J.-H.; Ni, Y, 2018 Enzyme engineering based on X-ray structures and kinetic profiling of substrate libraries: alcohol dehydrogenases for stereospecific synthesis of a broad range of chiral alcohols, Nie, Y.; Wang, S.; Xu, Y.; Luo, S.; Zhao, Y.-L.; Xiao, R.; Montelione, G.; Hunt, J.; Szyperski, T., 2018 Theoretical studies on the catalytic mechanism and substrate diversity for macrocyclization of pikromycin thioesterase, Shi, T.; Liu, L.; Tao, W.; Luo, S.; Fan, S.; Wang, X.-L.; Bai, L.; Zhao, Y.-L., 2018 Theoretical studies on the mechanism of thioesterase-catalyzed macrocyclization in erythromycin biosynthesis, Chen, X.-P.; Shi, T.; Wang, X.-L.; Wang, J.; Chen, Q.; Bai, L.; Zhao Y.-L., 2016 Multicomponent Kinetic Analysis and Theoretical Studies on the Phenolic Intermediates in the Oxidation of Eugenol and Isoeugenol Catalyzed by Laccase, Qi, Y.-B; Wang, X.-L.; Shi, T.; Liu, S.; Xu, Z.-H.; Li, XQ; Shi, XL; Xu, P.; Zhao Y.-L., 2015 D-Isonucleotide (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago2-PAZ domain and enhances in vitro potency of siRNA, Huang, Y.; Tian, M.; Zhang, YC; Sheng, G.; Chen, Z.; Ma, Y.; Chen, Y.; Peng, YH; Zhao, Y.-L.; Wang, YL.; Zhang, LH; Yang, ZJ, 2015 Theoretical Study on the Relationship between Rp-Phosphorothioation and Base-Step in S-DNA: Based on Energetic and Structural Analysis, Chen, L.; Wang, X.-L.; Shi, T.; Wu, T.; Deng, Z.; Zhao, YL, 2015 Theoretical Study on Steric Effects of DNA Phosphorothioation: B-Helical Destabilization in Rp-Phosphorothioated DNA, Zhang, Y.-C.; Liang, J.; Lian, P.; Han, Y.; Chen, Y.; Bai, L.; Wang, Z.; Liang, J.; Deng, Z.; Zhao, YL, 2012

Areas of Focus

Computational Biochemistry
Chemical Biology
Theoretical Studies on Reaction Mechanisms and Molecular Recognition
Structural Bioinformatics
Chemical Modifications of Proteins and Nucleic Acids and their Biological Functions
Molecular Spectroscopy and XCMS
Characterization Applications in Metabolism

Publications

Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis, He, B.-B.; Zhou, T.; Bu, X.-L.; Weng, J.-Y.; Xu, J.; Lin, S.-J.; Zheng, J.-T.; Zhao, Y.-L.; Xu, M.-J., 2019
Enzyme-catalyzed inverse-electron demand Diels-Alder reaction in the biosynthesis of antifungal ilicicolin H, Zhang, Z.; Jamieson, C.; Zhao, Y.-Lei; Li, D.; Ohashi, M.; K. N. Houk, Y. Tang, 2019
Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a “polar gate” in stereo-recognition of diaryl ketones, Zhou, J.-Y.; Wang, Y.; Xu, G.-C.; Wu, L.; Han, R.-Z.; Schwaneberg, U.; Rao, Y.-J.; Zhao, Y.-L.; Zhou, J.-H.; Ni, Y, 2018
Enzyme engineering based on X-ray structures and kinetic profiling of substrate libraries: alcohol dehydrogenases for stereospecific synthesis of a broad range of chiral alcohols, Nie, Y.; Wang, S.; Xu, Y.; Luo, S.; Zhao, Y.-L.; Xiao, R.; Montelione, G.; Hunt, J.; Szyperski, T., 2018
Theoretical studies on the catalytic mechanism and substrate diversity for macrocyclization of pikromycin thioesterase, Shi, T.; Liu, L.; Tao, W.; Luo, S.; Fan, S.; Wang, X.-L.; Bai, L.; Zhao, Y.-L., 2018
Theoretical studies on the mechanism of thioesterase-catalyzed macrocyclization in erythromycin biosynthesis, Chen, X.-P.; Shi, T.; Wang, X.-L.; Wang, J.; Chen, Q.; Bai, L.; Zhao Y.-L., 2016
Multicomponent Kinetic Analysis and Theoretical Studies on the Phenolic Intermediates in the Oxidation of Eugenol and Isoeugenol Catalyzed by Laccase, Qi, Y.-B; Wang, X.-L.; Shi, T.; Liu, S.; Xu, Z.-H.; Li, XQ; Shi, XL; Xu, P.; Zhao Y.-L., 2015
D-Isonucleotide (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago2-PAZ domain and enhances in vitro potency of siRNA, Huang, Y.; Tian, M.; Zhang, YC; Sheng, G.; Chen, Z.; Ma, Y.; Chen, Y.; Peng, YH; Zhao, Y.-L.; Wang, YL.; Zhang, LH; Yang, ZJ, 2015
Theoretical Study on the Relationship between Rp-Phosphorothioation and Base-Step in S-DNA: Based on Energetic and Structural Analysis, Chen, L.; Wang, X.-L.; Shi, T.; Wu, T.; Deng, Z.; Zhao, YL, 2015
Theoretical Study on Steric Effects of DNA Phosphorothioation: B-Helical Destabilization in Rp-Phosphorothioated DNA, Zhang, Y.-C.; Liang, J.; Lian, P.; Han, Y.; Chen, Y.; Bai, L.; Wang, Z.; Liang, J.; Deng, Z.; Zhao, YL, 2012

Computational Biochemistry Chemical Biology Theoretical Reaction Mechanisms Molecular Recognition Bioinformatics

Weiman Xing - Shanghai Normal University

Jie Xu - Shanghai Jiao Tong University

Yuan Xiaobing - East China Normal University

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