Professor | 赵一雷 | 数字化转型顾问

Name	赵一雷
Contact Information	yileizhao@sjtu.edu.cn
Language ability	中文, 英语
Province	上海

Name

赵一雷

Contact Information

yileizhao@sjtu.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	UCLA 博士后发表近90篇SCI论文获奖：UCLA优秀博士后、上海市浦江人才、东方学者、教育部新世纪优秀人才
Awards	2005年 UCLA优秀博士后 2005-2007年度美国交叉学科创新研究（INEST）Fellowship 2011年上海市浦江人才计划 2012年教育部新世纪优秀人才计划

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

UCLA 博士后
发表近90篇SCI论文
获奖：UCLA优秀博士后、上海市浦江人才、东方学者、教育部新世纪优秀人才

Awards

2005年 UCLA优秀博士后
2005-2007年度美国交叉学科创新研究（INEST）Fellowship
2011年上海市浦江人才计划
2012年教育部新世纪优秀人才计划

Areas of Focus	计算生物化学化学生物学反应机理与分子识别机制的理论研究结构生物信息学蛋白质和核酸的化学修饰与生物学功能分子光谱和XCMS 生物代谢中的表征应用
Publications	Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis, He, B.-B.; Zhou, T.; Bu, X.-L.; Weng, J.-Y.; Xu, J.; Lin, S.-J.; Zheng, J.-T.; Zhao, Y.-L.; Xu, M.-J., 2019 Enzyme-catalyzed inverse-electron demand Diels-Alder reaction in the biosynthesis of antifungal ilicicolin H, Zhang, Z.; Jamieson, C.; Zhao, Y.-Lei; Li, D.; Ohashi, M.; K. N. Houk, Y. Tang, 2019 Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a “polar gate” in stereo-recognition of diaryl ketones, Zhou, J.-Y.; Wang, Y.; Xu, G.-C.; Wu, L.; Han, R.-Z.; Schwaneberg, U.; Rao, Y.-J.; Zhao, Y.-L.; Zhou, J.-H.; Ni, Y, 2018 Enzyme engineering based on X-ray structures and kinetic profiling of substrate libraries: alcohol dehydrogenases for stereospecific synthesis of a broad range of chiral alcohols, Nie, Y.; Wang, S.; Xu, Y.; Luo, S.; Zhao, Y.-L.; Xiao, R.; Montelione, G.; Hunt, J.; Szyperski, T., 2018 Theoretical studies on the catalytic mechanism and substrate diversity for macrocyclization of pikromycin thioesterase, Shi, T.; Liu, L.; Tao, W.; Luo, S.; Fan, S.; Wang, X.-L.; Bai, L.; Zhao, Y.-L., 2018 Theoretical studies on the mechanism of thioesterase-catalyzed macrocyclization in erythromycin biosynthesis, Chen, X.-P.; Shi, T.; Wang, X.-L.; Wang, J.; Chen, Q.; Bai, L.; Zhao Y.-L., 2016 Multicomponent Kinetic Analysis and Theoretical Studies on the Phenolic Intermediates in the Oxidation of Eugenol and Isoeugenol Catalyzed by Laccase, Qi, Y.-B; Wang, X.-L.; Shi, T.; Liu, S.; Xu, Z.-H.; Li, XQ; Shi, XL; Xu, P.; Zhao Y.-L., 2015 D-Isonucleotide (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago2-PAZ domain and enhances in vitro potency of siRNA, Huang, Y.; Tian, M.; Zhang, YC; Sheng, G.; Chen, Z.; Ma, Y.; Chen, Y.; Peng, YH; Zhao, Y.-L.; Wang, YL.; Zhang, LH; Yang, ZJ, 2015 Theoretical Study on the Relationship between Rp-Phosphorothioation and Base-Step in S-DNA: Based on Energetic and Structural Analysis, Chen, L.; Wang, X.-L.; Shi, T.; Wu, T.; Deng, Z.; Zhao, YL, 2015 Theoretical Study on Steric Effects of DNA Phosphorothioation: B-Helical Destabilization in Rp-Phosphorothioated DNA, Zhang, Y.-C.; Liang, J.; Lian, P.; Han, Y.; Chen, Y.; Bai, L.; Wang, Z.; Liang, J.; Deng, Z.; Zhao, YL, 2012

Areas of Focus

计算生物化学
化学生物学
反应机理与分子识别机制的理论研究
结构生物信息学
蛋白质和核酸的化学修饰与生物学功能
分子光谱和XCMS
生物代谢中的表征应用

Publications

Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis, He, B.-B.; Zhou, T.; Bu, X.-L.; Weng, J.-Y.; Xu, J.; Lin, S.-J.; Zheng, J.-T.; Zhao, Y.-L.; Xu, M.-J., 2019
Enzyme-catalyzed inverse-electron demand Diels-Alder reaction in the biosynthesis of antifungal ilicicolin H, Zhang, Z.; Jamieson, C.; Zhao, Y.-Lei; Li, D.; Ohashi, M.; K. N. Houk, Y. Tang, 2019
Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a “polar gate” in stereo-recognition of diaryl ketones, Zhou, J.-Y.; Wang, Y.; Xu, G.-C.; Wu, L.; Han, R.-Z.; Schwaneberg, U.; Rao, Y.-J.; Zhao, Y.-L.; Zhou, J.-H.; Ni, Y, 2018
Enzyme engineering based on X-ray structures and kinetic profiling of substrate libraries: alcohol dehydrogenases for stereospecific synthesis of a broad range of chiral alcohols, Nie, Y.; Wang, S.; Xu, Y.; Luo, S.; Zhao, Y.-L.; Xiao, R.; Montelione, G.; Hunt, J.; Szyperski, T., 2018
Theoretical studies on the catalytic mechanism and substrate diversity for macrocyclization of pikromycin thioesterase, Shi, T.; Liu, L.; Tao, W.; Luo, S.; Fan, S.; Wang, X.-L.; Bai, L.; Zhao, Y.-L., 2018
Theoretical studies on the mechanism of thioesterase-catalyzed macrocyclization in erythromycin biosynthesis, Chen, X.-P.; Shi, T.; Wang, X.-L.; Wang, J.; Chen, Q.; Bai, L.; Zhao Y.-L., 2016
Multicomponent Kinetic Analysis and Theoretical Studies on the Phenolic Intermediates in the Oxidation of Eugenol and Isoeugenol Catalyzed by Laccase, Qi, Y.-B; Wang, X.-L.; Shi, T.; Liu, S.; Xu, Z.-H.; Li, XQ; Shi, XL; Xu, P.; Zhao Y.-L., 2015
D-Isonucleotide (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago2-PAZ domain and enhances in vitro potency of siRNA, Huang, Y.; Tian, M.; Zhang, YC; Sheng, G.; Chen, Z.; Ma, Y.; Chen, Y.; Peng, YH; Zhao, Y.-L.; Wang, YL.; Zhang, LH; Yang, ZJ, 2015
Theoretical Study on the Relationship between Rp-Phosphorothioation and Base-Step in S-DNA: Based on Energetic and Structural Analysis, Chen, L.; Wang, X.-L.; Shi, T.; Wu, T.; Deng, Z.; Zhao, YL, 2015
Theoretical Study on Steric Effects of DNA Phosphorothioation: B-Helical Destabilization in Rp-Phosphorothioated DNA, Zhang, Y.-C.; Liang, J.; Lian, P.; Han, Y.; Chen, Y.; Bai, L.; Wang, Z.; Liang, J.; Deng, Z.; Zhao, YL, 2012

计算生物化学化学生物学理论反应机制分子识别生物信息学

楼悦 - 上海师范大学

Area of Focus
不育 | 分子 | 植物 | 遗传学 | 拟南芥 | 绒毡层 | 细胞分化 | 转录因子 | 发育 | 生物学

王全华 - 上海师范大学

Area of Focus
遗传学 | 育种 | 蔬菜 | 分子 | 生物学 | 种质 | 资源 | 创新 | 评价 | 农业

黄伟华 - 上海师范大学

Area of Focus
叶绿体 | 发育 | 光合作用 | 分子 | 调控 | 植物 | 内含子 | 剪接 | 机制 | 生物学

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