1997-2001 Bachelor in Biochemistry: East China Normal University
2001-2006 PhD in Life Sciences: East China Normal University
2005-2006 Joint PhD training at NIH/NIAID, USA
Published 40 SCI papers as first or corresponding author in prestigious journals
2010-2021 Researcher at School of Life Sciences, East China Normal University
2021-Present Professor at School of Life Sciences, East China Normal University
2016: Shanghai Women's Achievement Award
2014: Shanghai Dawn Scholar
2013: National Ten Thousand Talent Program for Young Top-notch Talent
2011: Ministry of Education New Century Excellent Talents Support Plan
2011: Shanghai Distinguished Professor (Oriental Scholar)
2011: Shanghai Youth Science and Technology Star
2009: Albert M. Kligman Travel Fellowship, USA
2007: Shanghai Outstanding Doctoral Thesis
2006: Outstanding Graduate Research at NIH, USA
2005-2006: Graduate Partnerships Program Fellowship (NIAID, NIH)
Research
Skin Immunology Pathogenic mechanisms of inflammatory skin diseases such as psoriasis, atopic dermatitis, and acne
When SLC46A2 delivers cargo into keratinocytes, Wang X, Lai Y*, 2023
IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifiers IL-36R-mediated skin inflammation, Ni X, Xu Y, Wang W, Kong B, Ouyang J, Chen J, Yan M, Wu Y, Chen Q, Wang X, Li H, Gao X, Guo H, Cui L, Chen Z, Shi Y, Zhu R, Li W, Shi T, Wang L-F, Huang J, Dong C, Lai Y*, 2022
The relapse of psoriasis: mechanisms and mysteries, Tian D & Lai Y*, 2022
Crosstalk between keratinocytes and immune cells in inflammatory skin diseases, Ni X & Lai Y*, 2021
Keratinocyte: a trigger or an executor of psoriasis?, Ni X & Lai Y*, 2020
Lipopeptide 78 from Staphylococcus epidermidis activates β-catenin to inhibit skin inflammation, Li D, Wang W, Wu Y, Ma X, Zhou W, Lai Y*, 2019
Interleukin-36γ induced by the TLR3-SLUG-VDR axis promotes wound healing via REG3A, Jiang Z, Liu Y, Li C, Chang L, Wang W, Wang Z, Gao X, Ryffel B, Wu Y, Lai Y*, 2017
TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury, Lei H, Wang Y, Zhang T, Chang L, Wu Y, Lai Y*, 2017
Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes, Wu Y, Quan Y, Liu Y, Liu K, Li H, Jiang Z, Zhang T, Lei H, Radek KA, Li D, Wang Z, Lu J, Wang W, Ji S, Xia Z, Lai Y*, 2016
Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases, Lai Y & Dong C, 2016
Staphylococcal LTA-induced miR-143 inhibits Propionibacterium acnes-mediated inflammatory response in skin, Xia X, Li Z, Liu K, Wu Y, Jiang D*, Lai Y*, 2016
Oral antibiotic treatment induces skin microbiota dysbiosis and influences wound healing, Zhang M, Jiang Z, Li D, Jiang D, Wu Y, Ren H, Peng H, Lai Y*, 2015
Interleukin-33 increases antibacterial defense by activation of inducible nitric oxide synthase in skin, Li C, Li H, Jiang Z, Zhang T, Wang Y, Li Z, Wu Y, Ji S, Xiao S, Ryffel B, Radek KA, Xia Z*, Lai Y*, 2014
A novel lipopeptide from skin commensal activates TLR2/CD36-p38 MAPK signaling to increase antibacterial defense against bacterial infection, Li D, Lei H, Li Z, Li H, Wang Y, Lai Y*, 2013
The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury, Lai Y*, Li D, Li C, Muhleisen B, Radek KA, Park HJ, Jiang Z, Li Z, Lei H, Quan Y, Zhang T, Wu Y, Kotol P, Morizane S, Hata TR, Iwatsuki K, Tang C, Gallo RL, 2012
Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections, Lai Y, Gallo RL, 2010
Commensal skin bacteria as the probiotic of the cutaneous immune response, Lai Y, Gallo RL, 2010
Commensal bacteria regulate TLR3-dependent inflammation after skin injury, Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu Z-R, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang C-M, Ryan AF, Gallo RL, 2009
AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense, Lai Y, Gallo RL, 2009
Toll-like receptors in skin infections and inflammatory diseases, Lai Y, Gallo RL, 2008
Gram-positive three-component antimicrobial peptide-sensing system, Li M, Lai Y, Villaruz AE, Cha DJ, Sturdevant DE, Otto M, 2007
The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci, Lai Y, Villaruz AE, Li M, Cha DJ, Sturdevant DE, Otto M, 2007
Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide, Lai YP, Peng YF, Zuo Y, Li J, Huang J, Wang LF, Wu ZR, 2005
A new approach to random mutagenesis in vitro, Lai YP, Huang J, Wang LF, Li J, Wu ZR, 2004
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis, Zhu Y, Wu Z, Yan W, Shao F, Ke B, Jiang X, Gao J, Guo W, Lai Y, Ma H, Chen D, Xu Q, Sun Y, 2021
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization, Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J, 2021
Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation, Su Y, Huang J, Zhao X, Lu H, Wang W, Yang X, Shi Y, Wang X, Lai Y, Dong C, 2019
Lipopolysaccharides Inhibit REG3A Self-Aggregation on Gold Nanoparticles: A Combined Study of Multivariate Analysis on Time-Resolved Localized Surface Plasmon Resonance Spectra and Molecular Modeling, Han Z, Ren X, Huang Q, Shi T, Lai Y, Zhao YL, 2019
An interleukin-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation, Xu M, Lu H, Lee YH, Wu Y, Liu K, Shi Y, An H, Zhang J, Wang X, Lai Y, Dong C, 2018
Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells, Li C, Maillet I, Mackowiak C, Viala C, Di Padova F, Li M, Togbe D, Quesniaux V, Lai Y, Ryffel B, 2017
NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis, Yan S, Xu Z, Lou F, Zhang L, Ke F
