2006.9-2013.3 PhD: Zhejiang University School of Medicine
2002.9-2006.6 Bachelor's: Shaanxi Normal University, Biology Base Class
Selected for the National Youth Talent Program
2022.3-present - Zhejiang University School of Medicine - Researcher of the 'Hundred Talents Program'
2015.10-2021.9 - University of Rochester - Postdoctoral Researcher/Associate Researcher
2013.5-2015.9 - University of Haifa/Zhejiang University - Postdoctoral Researcher
Research
Longevity and anti-cancer mechanisms in non-classical model animals Epigenetic mechanisms of transposons in aging and cancer
Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle, Zhao Y, Zheng Z, Zhang Z, Xu Y, Hillpot E, Lin YS, Zakusilo FT, Lu JY, Ablaeva J, Biashad SA, Miller RA, Nevo E, Seluanov A, Gorbunova V, 2023
DNA damage and repair in age-related inflammation, Zhao Y, Simon M, Seluanov A, Gorbunova V, 2023
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat, Zhao Y, Oreskovic E, Zhang Q, Lu Q, Gilman A, Lin YS, He J, Zheng Z, Lu JY, Lee J, Ke Z, Ablaeva J, Sweet M, Horvath S, Zhang Z, Nevo E, Seluanov A, Gorbunova V, 2021
Revelations about aging and disease from unconventional vertebrate model organisms, Zhao Y, Seluanov A, Gorbunova V, 2021
Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence, Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Serrano M, de Magalhaes J, Nevo E, Gladyshev V, Seluanov A, Gorbunova V, 2018
Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalax, Zhao Y, Tang JW, Yang Z, Cao YB, Ren JL, Ben-Abu Y, Li K, Chen XQ, Du JZ, Nevo E, 2016
Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau, Zhao Y, Ren JL, Wang MY, Zhang ST, Liu Y, Li M, Cao YB, Zu HY, Chen XC, Wu CI, Nevo E, Chen XQ, Du JZ, 2013
DNA methylation networks underlying mammalian traits, Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Mammalian Methylation Consortium, Ernst J, Seluanov A, Gorbunova V, Yang XW, Raj K, Horvath S, 2023
Universal DNA methylation age across mammalian tissues, Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Mammalian Methylation Consortium, Ernst J, Raj K, Horvath S, 2023
Selection of p53 pathway in adaptive evolution and reproductive isolation in incipient sympatric speciation of Drosophila at Evolution Canyon, Zhao Y, Song L, Wang J, Fang X, Li X, Han L, Beiles A, Cao YB, Nevo E, 2023
CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia, Wang TY, Xia FY, Gong JW, Xu XK, Lv MC, Chatoo M, Shamsi BH, Zhang MC, Liu QR, Liu TX, Zhang DD, Lu XJ, Zhao Y, Du JZ, Chen XQ, 2022
Comparative transcriptomics reveals circadian rhythm and somatic reprogramming as two pillars of longevity regulation, Lu JY, Simon M, Zhao Y, Ablaeva J, Corson N, Choi Y, Schork N, Miller R, Seluanov A, Gorbunova V, 2022
DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders, Horvath S, Haghani A, Macoretta N, Ablaeva J, Zoller JA, Li CZ, Zhang J, Takasugi M, Zhao Y, Rydkina E, Zhang Z, Emmrich S, Raj K, Seluanov A, Faulkes CG, Gorbunova V, 2022
Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation, Zhang Q, Tombline G, Ablaeva J, Zhang L, Zhou X, Smith Z, Zhao Y, Xiaoli AM, Wang Z, Lin J-R, Jabalameli MR, Mitra J, Nguyen N, Vijg J, Seluanov A, Gladyshev VN, Gorbunova V, Zhang ZD, 2021
Proteomics of Long-Lived Mammals, Tombline G, Gigas J, Macoretta N, Zacher M, Emmrich S, Zhao Y, Seluanov A, Gorbunova V, 2020
Functional Diversity of p53 in Human and Wild Animals, Li Y, Zhang MC, Xu XK, Zhao Y, Mahanand C, Zhu T, Deng H, Nevo E, Du JZ, Chen XQ, 2019
The integration of multiple signaling pathways provides for bidirectional control of CRHR1 gene transcription in rat pituitary cell during hypoxia, Shi YJ, Ma ZQ, Tang JW, Zhao Y, Wang X, Liu Q, Wang PP, John C, Chen XQ, Du JZ, 2017
Transcriptome, genetic editing, and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax, Li K, Wang L, Knisbacher BA, Xu Q, Levanon EY, Wang H, Frenkel-Morgenstern M, Tagore S, Fang X, Bazak L, Buchumenski I, Zhao Y, Lövy M, Li X, Han L, Frenkel Z, Beiles A, Cao YB, Wang ZL, Nevo E, 2016
Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax, Li K, Hong W, Jiao H, Wang GD, Rodriguez KA, Buffenstein R, Zhao Y, Nevo E, Zhao H, 2015
Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus, Zhang ST, Zhao Y, Hu XF, Liu ZY, Chen XC, Chen XQ, Du JZ, 2013
CRHR1 mediates p53 transcription induced by high altitude hypoxia through ERK 1/2 signaling in rat hepatic cells, Zhao Y, Wang MY, Hao K, Chen XQ, Du JZ, 2013
High-altitude hypoxia induces disorders of the brain-endocrine-immune network through activation of corticotropin-releasing factor and its type-1 receptors, Chen XQ, Kong FP, Zhao Y, Du JZ, 2012
Cellular adaptation to hypoxia and p53 transcription regulation, Zhao Y, Chen XQ, Du JZ, 2009
Keywords
LongevityAnti-CancerNon-Classical Model AnimalsEpigeneticsTransposonsAgingCancerMechanismsResearchDisease Prevention
