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Yang Zhao
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Longevity
Anti-Cancer
Non-Classical Model Animals
Epigenetics
Transposons
Aging
Cancer
Mechanisms
Research
Disease Prevention
Areas of Focus
- Longevity and anti-cancer mechanisms in non-classical model animals
- Epigenetic mechanisms of transposons in aging and cancer
Work Experience
- 2022.3-present - Zhejiang University School of Medicine - Researcher of the 'Hundred Talents Program'
- 2015.10-2021.9 - University of Rochester - Postdoctoral Researcher/Associate Researcher
- 2013.5-2015.9 - University of Haifa/Zhejiang University - Postdoctoral Researcher
Academic Background & Achievements
- 2006.9-2013.3 PhD: Zhejiang University School of Medicine
- 2002.9-2006.6 Bachelor's: Shaanxi Normal University, Biology Base Class
- Selected for the National Youth Talent Program
Publications
- Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle, Zhao Y, Zheng Z, Zhang Z, Xu Y, Hillpot E, Lin YS, Zakusilo FT, Lu JY, Ablaeva J, Biashad SA, Miller RA, Nevo E, Seluanov A, Gorbunova V, 2023
- DNA damage and repair in age-related inflammation, Zhao Y, Simon M, Seluanov A, Gorbunova V, 2023
- Transposon-triggered innate immune response confers cancer resistance to the blind mole rat, Zhao Y, Oreskovic E, Zhang Q, Lu Q, Gilman A, Lin YS, He J, Zheng Z, Lu JY, Lee J, Ke Z, Ablaeva J, Sweet M, Horvath S, Zhang Z, Nevo E, Seluanov A, Gorbunova V, 2021
- Revelations about aging and disease from unconventional vertebrate model organisms, Zhao Y, Seluanov A, Gorbunova V, 2021
- Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence, Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Serrano M, de Magalhaes J, Nevo E, Gladyshev V, Seluanov A, Gorbunova V, 2018
- Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalax, Zhao Y, Tang JW, Yang Z, Cao YB, Ren JL, Ben-Abu Y, Li K, Chen XQ, Du JZ, Nevo E, 2016
- Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau, Zhao Y, Ren JL, Wang MY, Zhang ST, Liu Y, Li M, Cao YB, Zu HY, Chen XC, Wu CI, Nevo E, Chen XQ, Du JZ, 2013
- DNA methylation networks underlying mammalian traits, Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Mammalian Methylation Consortium, Ernst J, Seluanov A, Gorbunova V, Yang XW, Raj K, Horvath S, 2023
- Universal DNA methylation age across mammalian tissues, Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Mammalian Methylation Consortium, Ernst J, Raj K, Horvath S, 2023
- Selection of p53 pathway in adaptive evolution and reproductive isolation in incipient sympatric speciation of Drosophila at Evolution Canyon, Zhao Y, Song L, Wang J, Fang X, Li X, Han L, Beiles A, Cao YB, Nevo E, 2023
- CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia, Wang TY, Xia FY, Gong JW, Xu XK, Lv MC, Chatoo M, Shamsi BH, Zhang MC, Liu QR, Liu TX, Zhang DD, Lu XJ, Zhao Y, Du JZ, Chen XQ, 2022
- Comparative transcriptomics reveals circadian rhythm and somatic reprogramming as two pillars of longevity regulation, Lu JY, Simon M, Zhao Y, Ablaeva J, Corson N, Choi Y, Schork N, Miller R, Seluanov A, Gorbunova V, 2022
- DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders, Horvath S, Haghani A, Macoretta N, Ablaeva J, Zoller JA, Li CZ, Zhang J, Takasugi M, Zhao Y, Rydkina E, Zhang Z, Emmrich S, Raj K, Seluanov A, Faulkes CG, Gorbunova V, 2022
- Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation, Zhang Q, Tombline G, Ablaeva J, Zhang L, Zhou X, Smith Z, Zhao Y, Xiaoli AM, Wang Z, Lin J-R, Jabalameli MR, Mitra J, Nguyen N, Vijg J, Seluanov A, Gladyshev VN, Gorbunova V, Zhang ZD, 2021
- Proteomics of Long-Lived Mammals, Tombline G, Gigas J, Macoretta N, Zacher M, Emmrich S, Zhao Y, Seluanov A, Gorbunova V, 2020
- Functional Diversity of p53 in Human and Wild Animals, Li Y, Zhang MC, Xu XK, Zhao Y, Mahanand C, Zhu T, Deng H, Nevo E, Du JZ, Chen XQ, 2019
- The integration of multiple signaling pathways provides for bidirectional control of CRHR1 gene transcription in rat pituitary cell during hypoxia, Shi YJ, Ma ZQ, Tang JW, Zhao Y, Wang X, Liu Q, Wang PP, John C, Chen XQ, Du JZ, 2017
- Transcriptome, genetic editing, and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax, Li K, Wang L, Knisbacher BA, Xu Q, Levanon EY, Wang H, Frenkel-Morgenstern M, Tagore S, Fang X, Bazak L, Buchumenski I, Zhao Y, Lövy M, Li X, Han L, Frenkel Z, Beiles A, Cao YB, Wang ZL, Nevo E, 2016
- Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax, Li K, Hong W, Jiao H, Wang GD, Rodriguez KA, Buffenstein R, Zhao Y, Nevo E, Zhao H, 2015
- Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus, Zhang ST, Zhao Y, Hu XF, Liu ZY, Chen XC, Chen XQ, Du JZ, 2013
- CRHR1 mediates p53 transcription induced by high altitude hypoxia through ERK 1/2 signaling in rat hepatic cells, Zhao Y, Wang MY, Hao K, Chen XQ, Du JZ, 2013
- High-altitude hypoxia induces disorders of the brain-endocrine-immune network through activation of corticotropin-releasing factor and its type-1 receptors, Chen XQ, Kong FP, Zhao Y, Du JZ, 2012
- Cellular adaptation to hypoxia and p53 transcription regulation, Zhao Y, Chen XQ, Du JZ, 2009
